LOCUS       NP_003101                613 aa            linear   PRI 27-APR-2025
DEFINITION  transcription factor Sp2 [Homo sapiens].
ACCESSION   NP_003101 NP_612415
VERSION     NP_003101.3
DBSOURCE    REFSEQ: accession NM_003110.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 613)
  AUTHORS   Zheng,R., Zhu,P., Gu,J., Ni,B., Sun,H., He,K., Bian,J., Shao,Y. and
            Du,J.
  TITLE     Transcription factor Sp2 promotes TGFB-mediated interstitial cell
            osteogenic differentiation in bicuspid aortic valves through a
            SMAD-dependent pathway
  JOURNAL   Exp Cell Res 411 (1), 112972 (2022)
   PUBMED   34914964
  REMARK    GeneRIF: Transcription factor Sp2 promotes TGFB-mediated
            interstitial cell osteogenic differentiation in bicuspid aortic
            valves through a SMAD-dependent pathway.
REFERENCE   2  (residues 1 to 613)
  AUTHORS   Da,C.M., Liao,H.Y., Deng,Y.S., Zhao,G.H., Ma,L. and Zhang,H.H.
  TITLE     Transcription Factor SP2 Regulates Ski-mediated Astrocyte
            Proliferation In Vitro
  JOURNAL   Neuroscience 479, 22-34 (2021)
   PUBMED   34687796
  REMARK    GeneRIF: Transcription Factor SP2 Regulates Ski-mediated Astrocyte
            Proliferation In Vitro.
REFERENCE   3  (residues 1 to 613)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 613)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (residues 1 to 613)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 613)
  AUTHORS   Bakovic,M., Waite,K.A. and Vance,D.E.
  TITLE     Functional significance of Sp1, Sp2, and Sp3 transcription factors
            in regulation of the murine CTP:phosphocholine cytidylyltransferase
            alpha promoter
  JOURNAL   J Lipid Res 41 (4), 583-594 (2000)
   PUBMED   10744779
REFERENCE   7  (residues 1 to 613)
  AUTHORS   Rotheneder,H., Geymayer,S. and Haidweger,E.
  TITLE     Transcription factors of the Sp1 family: interaction with E2F and
            regulation of the murine thymidine kinase promoter
  JOURNAL   J Mol Biol 293 (5), 1005-1015 (1999)
   PUBMED   10547281
REFERENCE   8  (residues 1 to 613)
  AUTHORS   Philipsen,S. and Suske,G.
  TITLE     A tale of three fingers: the family of mammalian Sp/XKLF
            transcription factors
  JOURNAL   Nucleic Acids Res 27 (15), 2991-3000 (1999)
   PUBMED   10454592
  REMARK    Review article
REFERENCE   9  (residues 1 to 613)
  AUTHORS   Scohy,S., Van Vooren,P., Szpirer,C. and Szpirer,J.
  TITLE     Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1),
            10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2
            gene to human chromosome bands 17q21.3-->q22 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 273-274 (1998)
   PUBMED   9730617
REFERENCE   10 (residues 1 to 613)
  AUTHORS   Kingsley,C. and Winoto,A.
  TITLE     Cloning of GT box-binding proteins: a novel Sp1 multigene family
            regulating T-cell receptor gene expression
  JOURNAL   Mol Cell Biol 12 (10), 4251-4261 (1992)
   PUBMED   1341900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB451570.1, BC016680.2,
            M97190.1 and BC033814.2.
            
            On Feb 9, 2007 this sequence version replaced NP_003101.2.
            
            Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF
            transcription factors. Sp family proteins are sequence-specific
            DNA-binding proteins characterized by an amino-terminal
            trans-activation domain and three carboxy-terminal zinc finger
            motifs. This protein contains the least conserved DNA-binding
            domain within the Sp subfamily of proteins, and its DNA sequence
            specificity differs from the other Sp proteins. It localizes
            primarily within subnuclear foci associated with the nuclear
            matrix, and can activate or in some cases repress expression from
            different promoters. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033814.2, SRR1163657.302502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376741.5/ ENSP00000365931.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..613
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     Protein         1..613
                     /product="transcription factor Sp2"
                     /calculated_mol_wt=64769
     Region          1..32
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02086.3)"
     Region          9..526
                     /region_name="SP2_N"
                     /note="N-terminal domain of transcription factor
                     Specificity Protein (SP) 2; cd22540"
                     /db_xref="CDD:411776"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q02086.3)"
     Region          225..258
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02086.3)"
     Region          361..369
                     /region_name="9aaTAD, inactive.
                     /evidence=ECO:0000269|PubMed:31375868"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02086.3)"
     Region          372..404
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02086.3)"
     Region          530..549
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(534,536,538,540..541,544..545,548,564,566,570..571,
                     574..575,578,592,594,596,598..599,602..603,606)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          542..568
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          557..579
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          571..594
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          585..607
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          587..607
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..613
                     /gene="SP2"
                     /coded_by="NM_003110.6:52..1893"
                     /db_xref="CCDS:CCDS11521.2"
                     /db_xref="GeneID:6668"
                     /db_xref="HGNC:HGNC:11207"
                     /db_xref="MIM:601801"
ORIGIN      
        1 msdpqtsmaa taavspsdyl qpaasttqds qpsplallaa tcskigppav eaavtppapp
       61 qptprklvpi kpaplplspg knsfgilssk gnilqiqgsq lsasypggql vfaiqnptmi
      121 nkgtrsnani qyqavpqiqa snsqtiqvqp nltnqiqiip gtnqaiitps psshkpvpik
      181 papiqksstt ttpvqsganv vkltggggnv tltlpvnnlv nasdtgaptq lltespptpl
      241 sktnkkarkk slpasqppva vaeqvetvli ettadniiqa gnnllivqsp gggqpavvqq
      301 vqvvppkaeq qqvvqipqqa lrvvqaasat lptvpqkpsq nfqiqaaept ptqvyirtps
      361 gevqtvlvqd sppataaats nttcsspasr aphlsgtskk hsaailrker plpkiapags
      421 iislnaaqla aaaqamqtin ingvqvqgvp vtitntggqq qltvqnvsgn nltisglspt
      481 qiqlqmeqal agetqpgekr rrmactcpnc kdgekrsgeq gkkkhvchip dcgktfrkts
      541 llrahvrlht gerpfvcnwf fcgkrftrsd elqrhartht gdkrfecaqc qkrfmrsdhl
      601 tkhykthlvt knl
//
