LOCUS       NM_138402               2656 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens SP140 nuclear body protein like (SP140L), transcript
            variant 1, mRNA.
ACCESSION   NM_138402
VERSION     NM_138402.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2656)
  AUTHORS   Saare,M., Hamarik,U., Venta,R., Panarina,M., Zucchelli,C.,
            Pihlap,M., Remm,A., Kisand,K., Toots,U., Moll,K., Salupere,R.,
            Musco,G., Uibo,R. and Peterson,P.
  TITLE     SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an
            Autoantigen in Primary Biliary Cirrhosis
  JOURNAL   J Immunol Res 2015, 526518 (2015)
   PUBMED   26347895
  REMARK    GeneRIF: our results show that SP140L is phylogenetically recent
            member of SP100 proteins and acts as an autoantigen in primary
            biliary cirrhosis patients.
REFERENCE   2  (bases 1 to 2656)
  AUTHORS   McGue,M., Zhang,Y., Miller,M.B., Basu,S., Vrieze,S., Hicks,B.,
            Malone,S., Oetting,W.S. and Iacono,W.G.
  TITLE     A genome-wide association study of behavioral disinhibition
  JOURNAL   Behav Genet 43 (5), 363-373 (2013)
   PUBMED   23942779
REFERENCE   3  (bases 1 to 2656)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2656)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB240458.1, AU130836.1, BQ232706.1, CR987282.1, BQ690359.1,
            AK023116.1 and AC009949.9.
            
            On May 20, 2020 this sequence version replaced NM_138402.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2561877.1,
                                           SRR14038193.1013174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415673.7/ ENSP00000397911.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-592               DB240458.1         1-592
            593-744             AU130836.1         4-155
            745-1051            BQ232706.1         79-385
            1052-1363           CR987282.1         237-548
            1364-2032           BQ690359.1         1-669
            2033-2235           AK023116.1         2458-2660
            2236-2236           AC009949.9         138291-138291
            2237-2654           AK023116.1         2662-3079
            2655-2656           AC009949.9         138710-138711
FEATURES             Location/Qualifiers
     source          1..2656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..2656
                     /gene="SP140L"
                     /note="SP140 nuclear body protein like"
                     /db_xref="GeneID:93349"
                     /db_xref="HGNC:HGNC:25105"
                     /db_xref="MIM:617747"
     exon            1..109
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1820
                     /gene="SP140L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear body protein SP140-like protein; SP140L-1 protein;
                     SP140L-2 protein; SP140L-3 protein"
                     /codon_start=1
                     /product="nuclear body protein SP140-like protein isoform
                     1"
                     /protein_id="NP_612411.4"
                     /db_xref="CCDS:CCDS46538.1"
                     /db_xref="GeneID:93349"
                     /db_xref="HGNC:HGNC:25105"
                     /db_xref="MIM:617747"
                     /translation="MAGGGSDLSTRGLNGGVSQVANEMNHLPAHSQSLQRLFTEDQDV
                     DEGLVYDTVFKHFKRHKLEISNAIKKTFPFLEGLRDRELITNKMFEDSEDSCRNLVPV
                     QRVVYNVLSELEKTFNLSVLEALFSEVNMQEYPDLIHIYKSFKNAIQDKLSFQESDRK
                     EREERPDIKLSLKQGEVPESPEARKESDQACGKMDTVDIANNSTLGKPKRKRRKKKGH
                     GWSRMGTRTQKNNQQNDNSKADGQLVSSEKKANMNLKDLSKIRGRKRGKPGTHFTQSD
                     RAPQKRVRSRASRKHKDETVDFQAPLLPVTCGGVKGILHKEKLEQGTLAKCIQTEDGK
                     WFTPMEFEIKGGYARSKNWRLSVRCGGWPLRRLMEEGSLPNPPRIYYRNKKRILKSQN
                     NSSVDPCMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVESEKTPWNCIFCRMKE
                     SPGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGL
                     KEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGLRLEAEFEKD
                     FKEVFAIQETNGNS"
     exon            110..184
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            185..347
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            348..516
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            517..600
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            601..660
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            661..714
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            715..780
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            781..861
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            862..936
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1041
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1184
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1232
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1274
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1390
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1499
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1577
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1721
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..2656
                     /gene="SP140L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2632..2637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP140L"
                     /note="hexamer: ATTAAA"
     polyA_site      2656
                     /gene="SP140L"
                     /note="major polyA site"
ORIGIN      
        1 acactgcacg caggctgggc cgactgggga gctcataggc caggctctga cacccaggca
       61 gggcctaggg tgggacgatg gcaggtgggg gcagcgacct gagcaccagg gggctgaacg
      121 gaggtgtttc acaagtagca aatgagatga accatcttcc tgcacacagc caaagtctgc
      181 aaaggctgtt cacggaagac caggatgtag atgagggact tgtctatgac actgtattca
      241 agcacttcaa aagacataag ctggagatat caaatgcaat aaaaaagaca tttccattcc
      301 ttgagggcct ccgcgatcgg gaactcatca caaataaaat gtttgaagat tctgaagatt
      361 cttgtagaaa cctggtccct gtacaaagag tggtgtacaa tgttctcagt gaactggaga
      421 agacatttaa cctgtcagtt ttggaagcac tgttcagcga ggtcaacatg caggaatacc
      481 ccgatttaat tcacatttat aaaagcttca aaaatgcaat ccaagacaaa ttgtctttcc
      541 aagaaagtga tcgaaaagaa agggaagaga ggcctgacat caaactaagt cttaaacaag
      601 gagaagtgcc agaaagcccg gaagcaagga aggaaagtga ccaagcatgt ggcaaaatgg
      661 atactgtgga tattgcaaac aactctactt tgggaaaacc caagaggaaa agaagaaaaa
      721 agaaggggca tggctggagc agaatgggaa cgagaacgca gaaaaacaac caacaaaatg
      781 ataacagcaa agccgatggc cagctggtct cgagtgaaaa gaaggcgaac atgaatctga
      841 aagacctttc caagattagg gggagaaaga gaggcaaacc tggaacccac tttactcaga
      901 gtgacagagc tccacagaaa agagtccgat caagagcttc aagaaagcac aaagatgaaa
      961 ctgtggattt tcaggctcct ttacttccag tgacctgtgg tggggtgaag ggaattttac
     1021 ataaggagaa attggaacaa ggaaccttgg caaagtgtat acagactgag gatggaaaat
     1081 ggttcacccc catggaattt gaaatcaaag gaggctacgc aagatcaaag aactggaggc
     1141 tgagtgtgcg ctgtggcggg tggcccctac gacggctgat ggaggaagga tctctaccta
     1201 atcctccaag aatatattac aggaacaaaa agagaatact gaagtctcaa aacaatagct
     1261 cagttgaccc ttgtatgaga aacttggatg agtgtgaggt gtgccgggac ggaggggagc
     1321 tgttctgttg cgacacttgt tcaagagtct tccatgagga ctgccacatc ccacctgtgg
     1381 aaagtgagaa gaccccgtgg aattgcatct tctgcaggat gaaggagtct ccgggaagcc
     1441 aacagtgttg tcaggaatct gaggtcctgg agaggcagat gtgtcctgag gaacagttga
     1501 aatgtgagtt cctcctcttg aaagtctatt gctgttctga gagctccttt tttgccaaga
     1561 ttccatacta ttattatatt agagaggcgt gtcaaggcct gaaggagccc atgtggttgg
     1621 ataaaatcaa gaaaaggctg aatgagcacg gttaccccca agtggagggg tttgtacaag
     1681 acatgcgcct catcttccag aaccacaggg cctcttacaa gtataaggat tttggccaaa
     1741 tgggacttag actggaggct gaatttgaga aggatttcaa ggaagtgttt gctattcagg
     1801 aaacaaatgg gaacagttga ctggtttagt ggatgctgaa ggccttcagg aaatatgcta
     1861 ctggttgcca ctgacttcaa actgagagca cttgggaaat agcacatgca gggagaggct
     1921 tttctctgag cctccctcat ctgcccaaaa acaaatcctc aaaagaaatt tgatcatcat
     1981 gaatcccatc cccaagaatc tcatcaacca gggaagagga actgagatca cagggaagga
     2041 gattggaggt gataccagca cagacagact ctcacctctt ctcctgaggt ctgctccaga
     2101 caacatttat tactcacaag acctttttcc tccgtttttt ttttgagatg gagtctcaca
     2161 cagtcacccg ggattggaat gcaatggcgc gatctcagct cactgcaacc tctgcctccc
     2221 ggattcaagt gattctcctg tctcagcctc ccaagtagct gggattacag tgcctgccac
     2281 catgcccagc taattttttg catttttagt agagacgggg tttcactatg ttggccaggc
     2341 tggtctcgaa ctcctgacct catgagccgc ccgccttggc ctcccaaagt gctgggacgt
     2401 gacaggagtg agccaccaca cctggccact cgcaagacct tttatctgaa aaccagccaa
     2461 gctttattca cgacacactt cttcccttca ctctcccact tctgtggtca actccctgca
     2521 gaactcccaa actgccgttc ttttcgatag ctcacgatgg tgtatgagtg tcaatcatct
     2581 gacccttctt ggagtctcat atttcgtgga actcctgtgc aaacatatat tattaaattt
     2641 tttttcctcc tgtcaa
//
