LOCUS       NP_009168                867 aa            linear   PRI 15-OCT-2024
DEFINITION  nuclear body protein SP140 isoform 1 [Homo sapiens].
ACCESSION   NP_009168
VERSION     NP_009168.4
DBSOURCE    REFSEQ: accession NM_007237.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 867)
  AUTHORS   Nakamura,H., Hikichi,H., Seto,S., Hijikata,M. and Keicho,N.
  TITLE     Transcriptional regulators SP110 and SP140 modulate inflammatory
            response genes in Mycobacterium tuberculosis-infected human
            macrophages
  JOURNAL   Microbiol Spectr 12 (10), e0010124 (2024)
   PUBMED   39162523
  REMARK    GeneRIF: Transcriptional regulators SP110 and SP140 modulate
            inflammatory response genes in Mycobacterium tuberculosis-infected
            human macrophages.
REFERENCE   2  (residues 1 to 867)
  AUTHORS   Tanagala,K.K.K., Morin-Baxter,J., Carvajal,R., Cheema,M., Dubey,S.,
            Nakagawa,H., Yoon,A., Cheng,Y.L., Taylor,A., Nickerson,J., Mintz,A.
            and Momen-Heravi,F.
  TITLE     SP140 inhibits STAT1 signaling, induces IFN-gamma in
            tumor-associated macrophages, and is a predictive biomarker of
            immunotherapy response
  JOURNAL   J Immunother Cancer 10 (12) (2022)
   PUBMED   36600652
  REMARK    GeneRIF: SP140 inhibits STAT1 signaling, induces IFN-gamma in
            tumor-associated macrophages, and is a predictive biomarker of
            immunotherapy response.
REFERENCE   3  (residues 1 to 867)
  AUTHORS   Fraschilla,I., Amatullah,H., Rahman,R.U. and Jeffrey,K.L.
  TITLE     Immune chromatin reader SP140 regulates microbiota and risk for
            inflammatory bowel disease
  JOURNAL   Cell Host Microbe 30 (10), 1370-1381 (2022)
   PUBMED   36130593
  REMARK    GeneRIF: Immune chromatin reader SP140 regulates microbiota and
            risk for inflammatory bowel disease.
REFERENCE   4  (residues 1 to 867)
  AUTHORS   Amatullah,H., Fraschilla,I., Digumarthi,S., Huang,J.,
            Adiliaghdam,F., Bonilla,G., Wong,L.P., Rivard,M.E., Beauchamp,C.,
            Mercier,V., Goyette,P., Sadreyev,R.I., Anthony,R.M., Rioux,J.D. and
            Jeffrey,K.L.
  TITLE     Epigenetic reader SP140 loss of function drives Crohn's disease due
            to uncontrolled macrophage topoisomerases
  JOURNAL   Cell 185 (17), 3232-3247 (2022)
   PUBMED   35952671
  REMARK    GeneRIF: Epigenetic reader SP140 loss of function drives Crohn's
            disease due to uncontrolled macrophage topoisomerases.
REFERENCE   5  (residues 1 to 867)
  AUTHORS   Zucchelli,C., Tamburri,S., Quilici,G., Palagano,E., Berardi,A.,
            Saare,M., Peterson,P., Bachi,A. and Musco,G.
  TITLE     Structure of human Sp140 PHD finger: an atypical fold interacting
            with Pin1
  JOURNAL   FEBS J 281 (1), 216-231 (2014)
   PUBMED   24267382
REFERENCE   6  (residues 1 to 867)
  AUTHORS   Granito,A., Yang,W.H., Muratori,L., Lim,M.J., Nakajima,A.,
            Ferri,S., Pappas,G., Quarneti,C., Bianchi,F.B., Bloch,D.B. and
            Muratori,P.
  TITLE     PML nuclear body component Sp140 is a novel autoantigen in primary
            biliary cirrhosis
  JOURNAL   Am J Gastroenterol 105 (1), 125-131 (2010)
   PUBMED   19861957
REFERENCE   7  (residues 1 to 867)
  AUTHORS   Di Bernardo,M.C., Crowther-Swanepoel,D., Broderick,P., Webb,E.,
            Sellick,G., Wild,R., Sullivan,K., Vijayakrishnan,J., Wang,Y.,
            Pittman,A.M., Sunter,N.J., Hall,A.G., Dyer,M.J., Matutes,E.,
            Dearden,C., Mainou-Fowler,T., Jackson,G.H., Summerfield,G.,
            Harris,R.J., Pettitt,A.R., Hillmen,P., Allsup,D.J., Bailey,J.R.,
            Pratt,G., Pepper,C., Fegan,C., Allan,J.M., Catovsky,D. and
            Houlston,R.S.
  TITLE     A genome-wide association study identifies six susceptibility loci
            for chronic lymphocytic leukemia
  JOURNAL   Nat Genet 40 (10), 1204-1210 (2008)
   PUBMED   18758461
REFERENCE   8  (residues 1 to 867)
  AUTHORS   Madani,N., Millette,R., Platt,E.J., Marin,M., Kozak,S.L.,
            Bloch,D.B. and Kabat,D.
  TITLE     Implication of the lymphocyte-specific nuclear body protein Sp140
            in an innate response to human immunodeficiency virus type 1
  JOURNAL   J Virol 76 (21), 11133-11138 (2002)
   PUBMED   12368356
  REMARK    GeneRIF: the nuclear body protein Sp140, was found specifically in
            all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1
            infection induced its partial dispersal from nuclear bodies into
            cytosolic colocalization with Vif
REFERENCE   9  (residues 1 to 867)
  AUTHORS   Bloch,D.B., de la Monte,S.M., Guigaouri,P., Filippov,A. and
            Bloch,K.D.
  TITLE     Identification and characterization of a leukocyte-specific
            component of the nuclear body
  JOURNAL   J Biol Chem 271 (46), 29198-29204 (1996)
   PUBMED   8910577
REFERENCE   10 (residues 1 to 867)
  AUTHORS   Dent,A.L., Yewdell,J., Puvion-Dutilleul,F., Koken,M.H., de The,H.
            and Staudt,L.M.
  TITLE     LYSP100-associated nuclear domains (LANDs): description of a new
            class of subnuclear structures and their relationship to PML
            nuclear bodies
  JOURNAL   Blood 88 (4), 1423-1426 (1996)
   PUBMED   8695863
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301267.1, BC038091.1,
            BC105960.1, U36500.1 and AC009949.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 12, 2008 this sequence version replaced NP_009168.3.
            
            Summary: This gene encodes a member of the SP100 family of
            proteins, which are share common domains including an N-terminal
            homogeneously staining region domain followed by a SP100/autoimmune
            regulator/NucP41/P75/deformed epidermal autoregulatory factor
            domain, a plant homeobox zinc finger, and a bromodomain. The
            encoded protein is interferon-inducible and is expressed at high
            levels in the nuclei of leukocytes. Variants of this gene have been
            associated with multiple sclerosis, Crohn's disease, and chronic
            lymphocytic leukemia. Alternative splicing results in multiple
            variants. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U36500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392045.8/ ENSP00000375899.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     Protein         1..867
                     /product="nuclear body protein SP140 isoform 1"
                     /note="lymphoid-specific SP100 homolog; speckled 140 kDa;
                     nuclear autoantigen Sp-140; lymphoid-restricted homolog of
                     Sp100"
                     /calculated_mol_wt=98093
     Region          38..136
                     /region_name="HSR"
                     /note="HSR domain; pfam03172"
                     /db_xref="CDD:460835"
     Region          260..341
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13342.2)"
     Region          268..>479
                     /region_name="PHA03169"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:223003"
     Region          365..432
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13342.2)"
     Region          486..580
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13342.2)"
     Region          495..514
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13342.2)"
     Region          584..660
                     /region_name="SAND"
                     /note="SAND domain; pfam01342"
                     /db_xref="CDD:460167"
     Region          692..733
                     /region_name="PHD_SP110_140"
                     /note="PHD finger found in the Sp100/Sp140 family of
                     nuclear body components; cd15626"
                     /db_xref="CDD:277096"
     Site            order(692,697..698,701..706,713)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277096"
     Site            726
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:24267382; propagated from
                     UniProtKB/Swiss-Prot (Q13342.2)"
     Region          757..860
                     /region_name="Bromo_SP100C_like"
                     /note="Bromodomain, SP100C_like subfamily. The SP100C
                     protein is a splice variant of SP100, a major component of
                     PML-SP100 nuclear bodies (NBs), which are poorly
                     understood. It is covalently modified by SUMO-1 and may
                     play a role in processes at the chromatin...; cd05501"
                     /db_xref="CDD:99933"
     Site            order(783,788,791,830,834,839)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99933"
     CDS             1..867
                     /gene="SP140"
                     /gene_synonym="LYSP100; LYSP100-A; LYSP100-B"
                     /coded_by="NM_007237.5:110..2713"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS42831.1"
                     /db_xref="GeneID:11262"
                     /db_xref="HGNC:HGNC:17133"
                     /db_xref="MIM:608602"
ORIGIN      
        1 maqqgqqgqm asgdsnlnfr mvaeiqnveg qnlqeqvcpe pifrffrenk veiasaitrp
       61 fpflmglrdr sfiseqmyeh fqeafrnlvp vtrvmycvls elektfgwsh lealfsrinl
      121 maypdlneiy rsfqnvcyeh splqmnnvnd ledrprllpy gkqensnach emddiavpqe
      181 alsssprcep gfssesceql alpkagggda edapsllpgg gvscklaiqi degeseempk
      241 llpydtevle sngmidaart ystapgekqg eeegrnsprk rnqdkekyqe spegrdketf
      301 dlktpqvtne gepekglcll pgegeegsdd csemcdgeep qeassslarc gsvsclsaet
      361 fdlktpqvtn egepekelsl lpgegeegsd dcsemcdgee rqeassslar rgsvsselen
      421 hpmneegese elassllydn vpgaeqsaye nekcscvmcf seevpgspea rtesdqacgt
      481 mdtvdianns tlgkpkrkrr kkrghgwsrm rmrrqensqq ndnskadgqv vssekkanvn
      541 lkdlskirgr krgkpgtrft qsdraaqkrv rsrasrkhkd etvdfkapll pvtcggvkgi
      601 lhkkklqqgi lvkciqtedg kwftptefei kggharsknw rlsvrcggwp lrwlmengfl
      661 pdppriryrk kkrilksqnn ssvdpcmrnl decevcrdgg elfccdtcsr vfhedchipp
      721 veaertpwnc ifcrmkespg sqqccqesev lerqmcpeeq lkceflllkv yccsessffa
      781 kipyyyyire acqglkepmw ldkikkrlne hgypqvegfv qdmrlifqnh rasykykdfg
      841 qmgfrleaef eknfkevfai qetngnn
//
