LOCUS       NM_080424               6192 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens SP110 nuclear body protein (SP110), transcript variant
            c, mRNA.
ACCESSION   NM_080424
VERSION     NM_080424.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6192)
  AUTHORS   Nakamura,H., Hikichi,H., Seto,S., Hijikata,M. and Keicho,N.
  TITLE     Transcriptional regulators SP110 and SP140 modulate inflammatory
            response genes in Mycobacterium tuberculosis-infected human
            macrophages
  JOURNAL   Microbiol Spectr 12 (10), e0010124 (2024)
   PUBMED   39162523
  REMARK    GeneRIF: Transcriptional regulators SP110 and SP140 modulate
            inflammatory response genes in Mycobacterium tuberculosis-infected
            human macrophages.
REFERENCE   2  (bases 1 to 6192)
  AUTHORS   Sengupta,I., Mondal,P., Sengupta,A., Mondal,A., Singh,V.,
            Adhikari,S., Dhang,S., Roy,S. and Das,C.
  TITLE     Epigenetic regulation of Fructose-1,6-bisphosphatase 1 by host
            transcription factor Speckled 110 kDa during hepatitis B virus
            infection
  JOURNAL   FEBS J 289 (21), 6694-6713 (2022)
   PUBMED   35653238
  REMARK    GeneRIF: Epigenetic regulation of Fructose-1,6-bisphosphatase 1 by
            host transcription factor Speckled 110 kDa during hepatitis B virus
            infection.
REFERENCE   3  (bases 1 to 6192)
  AUTHORS   Cui,X., Yuan,T., Ning,P., Han,J., Liu,Y., Feng,J., Lian,F., Hao,M.,
            Dong,L., Hao,J., Xing,L. and Wu,C.
  TITLE     Polymorphisms in the ASAP1 and SP110 Genes and Its Association with
            the Susceptibility to Pulmonary Tuberculosis in a Mongolian
            Population
  JOURNAL   J Immunol Res 2022, 2713869 (2022)
   PUBMED   36249417
  REMARK    GeneRIF: Polymorphisms in the ASAP1 and SP110 Genes and Its
            Association with the Susceptibility to Pulmonary Tuberculosis in a
            Mongolian Population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6192)
  AUTHORS   Radojevic,N., Vukcevic,B., Jovovic,A. and Vukmirovic,F.
  TITLE     HSP60, SP110 and TNF-alpha expression in Chlamydia
            pneumoniae-positive versus Chlamydia pneumoniae-negative
            atherosclerotic plaques
  JOURNAL   Pol J Pathol 72 (4), 338-345 (2021)
   PUBMED   35308005
  REMARK    GeneRIF: HSP60, SP110 and TNF-alpha expression in Chlamydia
            pneumoniae-positive versus Chlamydia pneumoniae-negative
            atherosclerotic plaques.
REFERENCE   5  (bases 1 to 6192)
  AUTHORS   Delmonte,O.M., Baldin,F., Ovchinsky,N., Marquardsen,F., Recher,M.,
            Notarangelo,L.D. and Kosinski,S.M.
  TITLE     Novel Missense Mutation inSP110Associated with Combined
            Immunodeficiency and Advanced Liver Disease Without VOD
  JOURNAL   J Clin Immunol 40 (1), 236-239 (2020)
   PUBMED   31721003
  REMARK    GeneRIF: Novel Missense Mutation inSP110Associated with Combined
            Immunodeficiency and Advanced Liver Disease Without VOD.
REFERENCE   6  (bases 1 to 6192)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   7  (bases 1 to 6192)
  AUTHORS   Bloch,D.B., Nakajima,A., Gulick,T., Chiche,J.D., Orth,D., de La
            Monte,S.M. and Bloch,K.D.
  TITLE     Sp110 localizes to the PML-Sp100 nuclear body and may function as a
            nuclear hormone receptor transcriptional coactivator
  JOURNAL   Mol Cell Biol 20 (16), 6138-6146 (2000)
   PUBMED   10913195
REFERENCE   8  (bases 1 to 6192)
  AUTHORS   Welsh,G.I., Kadereit,S., Coccia,E.M., Hovanessian,A.G. and
            Meurs,E.F.
  TITLE     Colocalization within the nucleolus of two highly related
            IFN-induced human nuclear phosphoproteins with nucleolin
  JOURNAL   Exp Cell Res 250 (1), 62-74 (1999)
   PUBMED   10388521
REFERENCE   9  (bases 1 to 6192)
  AUTHORS   Kadereit,S., Gewert,D.R., Galabru,J., Hovanessian,A.G. and
            Meurs,E.F.
  TITLE     Molecular cloning of two new interferon-induced, highly related
            nuclear phosphoproteins
  JOURNAL   J Biol Chem 268 (32), 24432-24441 (1993)
   PUBMED   7693701
REFERENCE   10 (bases 1 to 6192)
  AUTHORS   Wong,M.
  TITLE     Hepatic Veno-Occlusive Disease with Immunodeficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB474530.1, AL832300.1,
            AC009950.6, L22343.1 and AK026488.1.
            
            On Feb 13, 2020 this sequence version replaced NM_080424.3.
            
            Summary: The nuclear body is a multiprotein complex that may have a
            role in the regulation of gene transcription. This gene is a member
            of the SP100/SP140 family of nuclear body proteins and encodes a
            leukocyte-specific nuclear body component. The protein can function
            as an activator of gene transcription and may serve as a nuclear
            hormone receptor coactivator. In addition, it has been suggested
            that the protein may play a role in ribosome biogenesis and in the
            induction of myeloid cell differentiation. Alternative splicing has
            been observed for this gene and three transcript variants, encoding
            distinct isoforms, have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (c) represents the longest
            transcript and it encodes the longest protein (isoform c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026488.1, SRR18074968.2776567.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258381.11/ ENSP00000258381.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                DB474530.1         129-226
            99-445              AL832300.1         1-347
            446-446             AC009950.6         83295-83295         c
            447-1385            AL832300.1         349-1287
            1386-1386           AC009950.6         56285-56285         c
            1387-1702           AL832300.1         1289-1604
            1703-1927           L22343.1           1152-1376
            1928-2460           AK026488.1         1893-2425
            2461-6192           AC009950.6         35472-39203         c
FEATURES             Location/Qualifiers
     source          1..6192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..6192
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /note="SP110 nuclear body protein"
                     /db_xref="GeneID:3431"
                     /db_xref="HGNC:HGNC:5401"
                     /db_xref="MIM:604457"
     exon            1..111
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            112..259
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2254
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /note="isoform c is encoded by transcript variant c;
                     interferon-induced protein 75, 52kD; interferon-induced
                     protein 41, 30kD; transcriptional coactivator Sp110;
                     phosphoprotein 41; phosphoprotein 75; speckled 110 kDa;
                     interferon-induced protein 41/75"
                     /codon_start=1
                     /product="sp110 nuclear body protein isoform c"
                     /protein_id="NP_536349.3"
                     /db_xref="CCDS:CCDS2475.1"
                     /db_xref="GeneID:3431"
                     /db_xref="HGNC:HGNC:5401"
                     /db_xref="MIM:604457"
                     /translation="MFTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFEGLLDNSIIT
                     KRMYMESLEACRNLIPVSRVVHNILTQLERTFNLSLLVTLFSQINLREYPNLVTIYRS
                     FKRVGASYEWQSRDTPILLEAPTGLAEGSSLHTPLALPPPQPPQPSCSPCAPRVSEPG
                     TSSQQSDEILSESPSPSDPVLPLPALIQEGRSTSVTNDKLTSKMNAEEDSEEMPSLLT
                     STVQVASDNLIPQIRDKEDPQEMPHSPLGSMPEIRDNSPEPNDPEEPQEVSSTPSDKK
                     GKKRKRCIWSTPKRRHKKKSLPGGTASSRHGIQKKLKRVDQVPQKKDDSTCNSTVETR
                     AQKARTECARKSRSEEIIDGTSEMNEGKRSQKTPSTPRRVTQGAASPGHGIQEKLQVV
                     DKVTQRKDDSTWNSEVMMRVQKARTKCARKSRLKEKKKEKDICSSSKRRFQKNIHRRG
                     KPKSDTVDFHCSKLPVTCGEAKGILYKKKMKHGSSVKCIRNEDGTWLTPNEFEVEGKG
                     RNAKNWKRNIRCEGMTLGELLKRKNSDECEVCCQGGQLLCCGTCPRVFHEDCHIPPVE
                     AKRMLWSCTFCRMKRSSGSQQCHHVSKTLERQMQPQDQLKCEFLLLKAYCHPQSSFFT
                     GIPFNIRDYGEPFQEAMWLDLVKERLITEMYTVAWFVRDMRLMFRNHKTFYKASDFGQ
                     VGLDLEAEFEKDLKDVLGFHEANDGGFWTLP"
     exon            260..428
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            429..695
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            696..779
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            780..863
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            864..941
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1010
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1160
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1241
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1391
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1460
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1559
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1702
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1818
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1927
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..1999
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2140
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..6192
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5889..5894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /note="hexamer: TATAAA"
     polyA_site      5912
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /note="major polyA site"
     regulatory      6158..6163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
                     /note="hexamer: AATATA"
     polyA_site      6192
                     /gene="SP110"
                     /gene_synonym="IFI41; IFI75; IPR1; VODI"
ORIGIN      
        1 acagacttcc tgttttgcct gctagcatct ccctgtaact ctcccaatct tgaggagtga
       61 tccctgtccc agcccctgga aaggggcagg aacgacaaac tcaaagtcca ggatgttcac
      121 catgacaaga gccatggaag aggctctttt tcagcacttc atgcaccaga agctggggat
      181 cgcctatgcc atacacaagc catttccctt ctttgaaggc ctcctagaca actccatcat
      241 cactaagaga atgtacatgg aatctctgga agcctgtaga aatttgatcc ctgtatccag
      301 agtggtgcac aacattctca cccaactgga gaggactttt aacctgtctc ttctggtgac
      361 attgttcagt caaattaacc tgcgtgaata tcccaatctg gtgacgattt acagaagctt
      421 caaacgtgtt ggtgcttcct atgaatggca gagcagagac acaccaatcc tacttgaagc
      481 cccaactggc ctagcagaag gaagctccct ccatacccca ctggcgctgc ccccaccaca
      541 accccctcaa ccaagctgtt caccctgtgc gccaagagtc agtgagcctg gaacatcctc
      601 ccagcaaagc gatgagatcc tgagtgagtc gcccagccca tctgaccctg tcctgcctct
      661 ccctgcactc atccaggaag gaagaagcac ttcagtgacc aatgacaagt taacatccaa
      721 aatgaatgcg gaagaagact cagaagagat gcccagcctc ctcactagca ctgtgcaagt
      781 ggccagtgac aacctgatcc cccaaataag agataaagaa gaccctcaag agatgcccca
      841 ctctcccttg ggctctatgc cagagataag agataattct ccagaaccaa atgacccaga
      901 agagccccag gaggtgtcca gcacaccttc agacaagaaa ggaaagaaaa gaaaaagatg
      961 tatctggtca actccaaaaa ggagacataa gaaaaaaagc ctcccaggag ggacagcctc
     1021 atctagacac ggaatccaaa agaagctcaa aagggtggat caggttcctc aaaagaaaga
     1081 tgactcaact tgtaactcca cggtagagac aagggcccaa aaggcgagaa ctgaatgtgc
     1141 ccgaaagtcg agatcagagg agatcattga tggcacttca gaaatgaatg aaggaaagag
     1201 gtcccagaag acgcctagta caccacgaag ggtcacacaa ggggcagcct cacctgggca
     1261 tggcatccaa gagaagctcc aagtggtgga taaggtgact caaaggaaag acgactcaac
     1321 ctggaactca gaggtcatga tgagggtcca aaaggcaaga actaaatgtg cccgaaagtc
     1381 cagattgaaa gaaaagaaaa aggagaaaga tatctgttca agctcaaaaa ggagatttca
     1441 gaaaaatatt caccgaagag gaaaacccaa aagtgacact gtggattttc actgttctaa
     1501 gctccccgtg acctgtggtg aggcgaaagg gattttatat aagaagaaaa tgaaacacgg
     1561 atcctcagtg aagtgcattc ggaatgagga tggaacttgg ttaacaccaa atgaatttga
     1621 agtcgaagga aaaggaagga acgcaaagaa ctggaaacgg aatatacgtt gtgaaggaat
     1681 gaccctagga gagctgctga agcggaaaaa ctcggatgaa tgcgaggtgt gctgtcaagg
     1741 gggacaactt ctctgctgcg gtacttgtcc acgagtcttc catgaggact gtcacatccc
     1801 ccctgtggaa gccaagagga tgctgtggag ttgcaccttc tgcaggatga agaggtcttc
     1861 aggaagccaa cagtgccatc atgtatctaa gaccctggag aggcagatgc agcctcagga
     1921 ccagctgaaa tgtgagttcc tcctcttgaa ggcctactgt catccacaaa gctccttttt
     1981 tacgggcatc ccatttaata ttcgagatta cggtgagccc tttcaggaag caatgtggtt
     2041 ggacctggtt aaggaaaggc tgattacgga aatgtacacg gtggcatggt ttgtgcgaga
     2101 catgcgcctg atgtttcgca accataaaac attttacaag gcttctgact ttggccaggt
     2161 aggacttgac ttagaggcag aatttgaaaa agatctcaaa gacgtgctcg gttttcatga
     2221 agccaatgac ggcggtttct ggactcttcc ttgaccctgt tctgtaaaga ctgaagcatc
     2281 cccacctcag gattcagctg atgggaccct ggcttggact gttgattgcc agtgagtctg
     2341 ggatgtaatt ggctgccctc aggacccaaa cccagacact tcataggatt atcacaccct
     2401 ccatctttat tctttctttt tacctttaaa agtctatatc tacactaaaa aaaaaaaaaa
     2461 ttaatacttc cttaatacca tcagataccc catcatagtt cacattctcc ccactgtctc
     2521 ataagtcttt ttagagttga tttgttcaaa tcaggatcta aacaagttcc acacactgca
     2581 tttggctctc ctgtccctat gtctctttta agctataaat tgtcatgtat ttattgaaga
     2641 actcagggtt ttggtcctat tacatttttt gcaatctgga attttctggt tgcattttct
     2701 tagtggtata gtcctctctt cctctcattt tttgtaagct agaagttaga tctagaagct
     2761 tgctttaact caggttttga ggggtttgtt ttgatttggg ggttttgggg cacatgcagg
     2821 cttcacaggg gaatttagta ttatttttta tgttaaggtt ggcagcaggt gcacgtgtta
     2881 tcagcctgat catctatcac ctgatggttt tagcaatacc taaatccgtg atatcatcag
     2941 aggttgcaaa atgatgagat tcaggttttt ttttacataa ttattggtca gaattattct
     3001 gcaaatagct tctctttaac agtattcggt taccttgaaa tacaggttgt acaaaaaata
     3061 ggataaatgc ttgttttttt atttagcaat gttcaaaata atgaattgat gtcccaatat
     3121 cctctaaagg taaccaggga ttttttaatt taattatctt gaacccacat atttaaatat
     3181 acgtagcatg ctacaaacca ttgcagttaa tacctttatt gatgcttgag ttgcccactt
     3241 tttctttttt tttttttttt tttttttttg agacagagtc tcactctgtc acccaggccg
     3301 gagtacagta gcgtcatctt gactcactgc aacctcctcc tcctgggtgc aagcgattct
     3361 cctgcctcag cctccgagta gctgggatta caggcatgtg caagttcccc acttttagtg
     3421 agaaactcct caatttgcct cctgagttgt tttgaaatga ccccagaact ctttgatggt
     3481 gtattagcta tctattgctg tgtaacaaat gacctcaaag cttagctgct taaaaagaaa
     3541 aaaacatttt attgctcact attctgtgga tcaagaattc aggcatcatc catgaggatg
     3601 cttccctttg ctccacatgg tactggcaga ccccattcat acttgcacac tgtcacttct
     3661 gccacaatct attggtgaaa gcaagtcaca gggacagatt cagaaggagg gagaatagac
     3721 cttacctctt gatgcgatgg gtggcaaagt cacatttcaa aggagaatgt tgcttgggaa
     3781 gaaacattgc tgctcccatc tttagaagca atctaccata gttcaccctc tggccacagt
     3841 agttcacatc tttcccaaat gcaaaggaca ctcctctccc cacagaagtc tcactctctg
     3901 cagcattgga acaaagtcca ggacctcctt atctaaatca ggttcagatc agataaagct
     3961 tcttcgggct gggcacagtg gctcacacct gaaatcccag cactttagga ggccgaggca
     4021 ggtggatcgc ttgagtccag gagttgaaga ccagcctggg taacatggca aaacctcatc
     4081 tctacaaaaa aaaaaaaaaa aaaatctttt taattagctg ggcaaggtgg cacacacctg
     4141 tagtcccagc tactcaggag gctgaggtgg aaggatgagc ctgggaggca gaggtcgcag
     4201 tgagccaaga atgcaccact gcactccagc ctggacaaca gagaccctgc ctcaaaaaaa
     4261 aaaaaaaaaa aaggaaagaa aacaaaagaa ataggctcct caggtatggt ttattgggtg
     4321 cagctccttg ggtgcacctc ctcttgaact agaggcctgt gagctgaaaa attgtttctt
     4381 ccctgctgcc aacagtcagt gatgaaacag ggactgaaca actactatag acacttccat
     4441 tcaaacgggg aaaaaggaag cagcagtcac tcatttatag caattctgaa atccagtcaa
     4501 gcacatgttg ctagttcccc ctaatcccag ggcaggaaat tttccttgat acatgattta
     4561 tatgtatgat acacctctaa ttcccatccc atcccatcct accccacagg cttcttcctt
     4621 gtcttcctcg gttctgtatt ggtgtctccc ttctccaaca gtattattta ctcacttgct
     4681 caatccccag gtacaacaat aaaagttaac agaattttaa cactcagatc actatgaaaa
     4741 acaaactaag ttgatttcta aatttctgtg gagtttattt ttgtttgtta tagatttaat
     4801 ataccattgc agagggtatt taatgtacca ttgcagaggg tatttaatat accattgcag
     4861 aggattttac atttgtattt ataaatgaga ttgctctata gtttttacac actgtcatag
     4921 tcagatttac ggttatccta cctcggtaaa ataacttgta aaattttcta ccttttaata
     4981 tattctggaa taatttatag tgttttaaat taaccaaaag tgtgtgaccc agagttcact
     5041 ggagagacag tggtaaccac attatctgct ttctttacgg ttttcaggct atgaagatat
     5101 tctgttggtt tttgagacag ctctgctttt atgtttttct aagaagtcat ctatttcatt
     5161 tgtggttaaa agtaatatag gtggtctgcc aggcgcagtg gctcaggcct gtaatcccag
     5221 cactttggga ggctgaggcg agtggatcgc gaggtcaaga gatcgagacc agcctgacca
     5281 acgtggtgaa accccgtctc tactaaaaat acaaaaatta gccaggcgtg gtggcgggcg
     5341 cctgtagtcc cagctactca agaggctgag gcaggagaat cgcttgaacc cgggaggtgg
     5401 aggttgcagt gagccgagat cccaccactg cactccagcc tgggcaacag agtaagactc
     5461 tgtttcaaaa aaaaaaaaaa aagttatata ggtggtctta tttctgtcat attttaatat
     5521 ttctcttttt aatgttttaa tgttattttt gtctattttt tttcttctgc cttctatttt
     5581 ggaaggcatc gtaacggctt ttagttccaa tatttaccca taagttttcc caatgcattt
     5641 tgacttattt ttttaatgtc aaagtcaaaa ataaaatatc tgtaatgtgt cacatactta
     5701 aggcaatgcg tttatcactt tgatacctct cagctccctt attcctgtct tttcactctc
     5761 ttgaaataca gacatgaatt agtattaatt tttttgcttt tactctataa tgtttattct
     5821 attcaattat attatgtcat tatttgttag tttcacatta tgtaaattat ttgtcatgtc
     5881 ctatgtcata taaagtaatt caaaagcaaa aattaaaagt gtgtgttacg tgataacctg
     5941 tatttttgag aacagtatta atgtgtttct gttttcactg tttaagattc cctgctggtc
     6001 ttttcttgac acgacttctc catacttcct ttttgctctg cctttcagtc aactgaagtg
     6061 tgtctttaag taatttgaaa agaattacat ggatggtatg ttttctgatt caccatatct
     6121 tagaatgtgt tctattgttt tcataaatta ataacataat atataactta tcataacttc
     6181 tcaccttcaa aa
//
