LOCUS       NM_001251825            7536 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens Sp1 transcription factor (SP1), transcript variant 3,
            mRNA.
ACCESSION   NM_001251825
VERSION     NM_001251825.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7536)
  AUTHORS   Dang,X., Chen,X., Liang,Z., Dai,Z., Ding,W., Song,J. and Fu,J.
  TITLE     P4HA2 promotes tumor progression and is transcriptionally regulated
            by SP1 in colorectal cancer
  JOURNAL   Cancer Biol Ther 25 (1), 2361594 (2024)
   PUBMED   38857058
  REMARK    GeneRIF: P4HA2 promotes tumor progression and is transcriptionally
            regulated by SP1 in colorectal cancer.
REFERENCE   2  (bases 1 to 7536)
  AUTHORS   Chen,T., Shi,K. and Sun,S.
  TITLE     LINC01614 activated by SP1 promoted malignant behavior of
            triple-negative breast cancer cells via the WNT/b-Catenin signaling
            pathway
  JOURNAL   Rev Invest Clin 76 (4), 185-194 (2024)
   PUBMED   39419019
  REMARK    GeneRIF: LINC01614 activated by SP1 promoted malignant behavior of
            triple-negative breast cancer cells via the WNT/b-Catenin signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7536)
  AUTHORS   Pan,J., Zhang,Y., He,L., Wu,Y., Xiao,W., Zhang,J. and Xu,Y.
  TITLE     STRIP2 is regulated by the transcription factor Sp1 and promotes
            lung adenocarcinoma progression via activating the
            PI3K/AKT/mTOR/MYC signaling pathway
  JOURNAL   Genomics 116 (5), 110923 (2024)
   PUBMED   39191354
  REMARK    GeneRIF: STRIP2 is regulated by the transcription factor Sp1 and
            promotes lung adenocarcinoma progression via activating the
            PI3K/AKT/mTOR/MYC signaling pathway.
REFERENCE   4  (bases 1 to 7536)
  AUTHORS   Zhang,X., Wang,S., Li,W., Wang,J., Gong,Y., Chen,Q., Cao,S.,
            Pang,D. and Gao,S.
  TITLE     PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen
            Receptor-Negative Breast Cancer Cell
  JOURNAL   Biomolecules 14 (8), 990 (2024)
   PUBMED   39199378
  REMARK    GeneRIF: PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in
            Estrogen Receptor-Negative Breast Cancer Cell.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7536)
  AUTHORS   Hao,X. and Wu,X.
  TITLE     SP1-mediated ADAMTS5 transcription promotes IL-1beta-induced
            chondrocyte injury via Wnt/beta-catenin pathway in osteoarthritis
  JOURNAL   Mol Med Rep 30 (2) (2024)
   PUBMED   38940327
  REMARK    GeneRIF: SP1-mediated ADAMTS5 transcription promotes
            IL-1beta-induced chondrocyte injury via Wnt/beta-catenin pathway in
            osteoarthritis.
REFERENCE   6  (bases 1 to 7536)
  AUTHORS   Liu,Y., Liu,Z., Androphy,E., Chen,J. and Baleja,J.D.
  TITLE     Design and characterization of helical peptides that inhibit the E6
            protein of papillomavirus
  JOURNAL   Biochemistry 43 (23), 7421-7431 (2004)
   PUBMED   15182185
REFERENCE   7  (bases 1 to 7536)
  AUTHORS   Kamine,J. and Chinnadurai,G.
  TITLE     Synergistic activation of the human immunodeficiency virus type 1
            promoter by the viral Tat protein and cellular transcription factor
            Sp1
  JOURNAL   J Virol 66 (6), 3932-3936 (1992)
   PUBMED   1583736
REFERENCE   8  (bases 1 to 7536)
  AUTHORS   Kamine,J., Subramanian,T. and Chinnadurai,G.
  TITLE     Sp1-dependent activation of a synthetic promoter by human
            immunodeficiency virus type 1 Tat protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (19), 8510-8514 (1991)
   PUBMED   1924310
REFERENCE   9  (bases 1 to 7536)
  AUTHORS   Gumucio,D.L., Rood,K.L., Blanchard-McQuate,K.L., Gray,T.A.,
            Saulino,A. and Collins,F.S.
  TITLE     Interaction of Sp1 with the human gamma globin promoter: binding
            and transactivation of normal and mutant promoters
  JOURNAL   Blood 78 (7), 1853-1863 (1991)
   PUBMED   1912570
REFERENCE   10 (bases 1 to 7536)
  AUTHORS   Szpirer,J., Szpirer,C., Riviere,M., Levan,G., Marynen,P.,
            Cassiman,J.J., Wiese,R. and DeLuca,H.F.
  TITLE     The Sp1 transcription factor gene (SP1) and the
            1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on
            human chromosome arm 12q and rat chromosome 7
  JOURNAL   Genomics 11 (1), 168-173 (1991)
   PUBMED   1662663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073611.29, BC062539.1,
            FN908228.1, AC068889.35 and AW028976.1.
            
            On May 31, 2019 this sequence version replaced NM_001251825.1.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcription factor that binds to GC-rich motifs of many
            promoters. The encoded protein is involved in many cellular
            processes, including cell differentiation, cell growth, apoptosis,
            immune responses, response to DNA damage, and chromatin remodeling.
            Post-translational modifications such as phosphorylation,
            acetylation, glycosylation, and proteolytic processing
            significantly affect the activity of this protein, which can be an
            activator or a repressor. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2014].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (c) has the same N- and C-termini but is shorter
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1079227.1,
                                           SRR12921934.2218821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC073611.29        105940-105958
            20-123              BC062539.1         2-105
            124-2330            FN908228.1         8-2214
            2331-7412           AC068889.35        35895-40976         c
            7413-7536           AW028976.1         7-130               c
FEATURES             Location/Qualifiers
     source          1..7536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..7536
                     /gene="SP1"
                     /note="Sp1 transcription factor"
                     /db_xref="GeneID:6667"
                     /db_xref="HGNC:HGNC:11205"
                     /db_xref="MIM:189906"
     exon            1..123
                     /gene="SP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2330
                     /gene="SP1"
                     /note="isoform c is encoded by transcript variant 3;
                     specificity protein 1"
                     /codon_start=1
                     /product="transcription factor Sp1 isoform c"
                     /protein_id="NP_001238754.1"
                     /db_xref="GeneID:6667"
                     /db_xref="HGNC:HGNC:11205"
                     /db_xref="MIM:189906"
                     /translation="MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTG
                     SSSSTGGGGQGANGWQIISSSSGATPTSKEQSGSSTNGSNGSESSKNRTVSGGQYVVA
                     AAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIP
                     GANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITL
                     LPVNSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNA
                     NSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQA
                     GQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQL
                     QAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSS
                     NTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIAN
                     APGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEG
                     RGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDE
                     LQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGA
                     GSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINISGNGF"
     exon            124..278
                     /gene="SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..1647
                     /gene="SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1816
                     /gene="SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2016
                     /gene="SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..7536
                     /gene="SP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7513..7518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP1"
                     /note="hexamer: ATTAAA"
     polyA_site      7536
                     /gene="SP1"
                     /note="major polyA site"
ORIGIN      
        1 acccccccct ccctgtccgg tccgggttcg cttgcctcgt cagcgtccgc gtttttcccg
       61 gcccccccca acccccccgg acaggacccc cttgagcttg tccctcagct gccaccatga
      121 gcgaccaaga tcactccatg gatgaaatga cagctgtggt gaaaattgaa aaaggagttg
      181 gtggcaataa tgggggcaat ggtaatggtg gtggtgcctt ttcacaggct cgaagtagca
      241 gcacaggcag tagcagcagc actggaggag gagggcaggg tgccaatggc tggcagatca
      301 tctcttcctc ctctggggct acccctacct caaaggaaca gagtggcagc agtaccaatg
      361 gcagcaatgg cagtgagtct tccaagaatc gcacagtctc tggtgggcag tatgttgtgg
      421 ctgccgctcc caacttacag aaccagcaag ttctgacagg actacctgga gtgatgccta
      481 atattcagta tcaagtaatc ccacagttcc agaccgttga tgggcaacag ctgcagtttg
      541 ctgccactgg ggcccaagtg cagcaggatg gttctggtca aatacagatc ataccaggtg
      601 caaaccaaca gattatcaca aatcgaggaa gtggaggcaa catcattgct gctatgccaa
      661 acctactcca gcaggctgtc cccctccaag gcctggctaa taatgtactc tcaggacaga
      721 ctcagtatgt gaccaatgta ccagtggccc tgaatgggaa catcaccttg ctacctgtca
      781 acagcgtttc tgcagctacc ttgactccca gctctcaggc agtcacgatc agcagctctg
      841 ggtcccagga gagtggctca cagcctgtca cctcagggac taccatcagt tctgccagct
      901 tggtatcatc acaagccagt tccagctcct ttttcaccaa tgccaatagc tactcaacta
      961 ctactaccac cagcaacatg ggaattatga actttactac cagtggatca tcagggacca
     1021 actctcaagg ccagacaccc cagagggtca gtgggctaca ggggtctgat gctctgaaca
     1081 tccagcaaaa ccagacatct ggaggctcat tgcaagcagg ccagcaaaaa gaaggagagc
     1141 aaaaccagca gacacagcag caacaaattc ttatccagcc tcagctagtt caagggggac
     1201 aggccctcca ggccctccaa gcagcaccat tgtcagggca gacctttaca actcaagcca
     1261 tctcccagga aaccctccag aacctccagc ttcaggctgt tccaaactct ggtcccatca
     1321 tcatccggac accaacagtg gggcccaatg gacaggtcag ttggcagact ctacagctgc
     1381 agaacctcca agttcagaac ccacaagccc aaacaatcac cttagcccca atgcagggtg
     1441 tttccttggg gcagaccagc agcagcaaca ccactctcac acccattgcc tcagctgctt
     1501 ccattcctgc tggcacagtc actgtgaatg ctgctcaact ctcctccatg ccaggcctcc
     1561 agaccattaa cctcagtgca ttgggtactt caggaatcca ggtgcaccca attcaaggcc
     1621 tgccgttggc tatagcaaat gccccaggtg atcatggagc tcagcttggt ctccatgggg
     1681 ctggtggtga tggaatacat gatgacacag caggtggaga ggaaggagaa aacagcccag
     1741 atgcccaacc ccaagccggt cggaggaccc ggcgggaagc atgcacctgc ccctactgta
     1801 aagacagtga aggaaggggc tcgggggatc ctggcaaaaa gaaacagcat atttgccaca
     1861 tccaaggctg tgggaaagtg tatggcaaga cctctcacct gcgggcacac ttgcgctggc
     1921 atacaggcga gaggccattt atgtgtacct ggtcatactg tgggaaacgc ttcacacgtt
     1981 cggatgagct acagaggcac aaacgtacac acacaggtga gaagaaattt gcctgccctg
     2041 agtgtcctaa gcgcttcatg aggagtgacc acctgtcaaa acatatcaag acccaccaga
     2101 ataagaaggg aggcccaggt gtagctctga gtgtgggcac tttgcccctg gacagtgggg
     2161 caggttcaga aggcagtggc actgccactc cttcagccct tattaccacc aatatggtag
     2221 ccatggaggc catctgtcca gagggcattg cccgtcttgc caacagtggc atcaacgtca
     2281 tgcaggtggc agatctgcag tccattaata tcagtggcaa tggcttctga gatcaggcac
     2341 ccggggccag agacatatgg gccatacccc ttaaccccgg gatgcaaggt agcatgggtc
     2401 caagagacat ggaagagaga gccatgaagc attaaaatgc atggtgttga gaagaatcag
     2461 gagagggata caagagagga gatggggtcc cggcacccat ctgtatcatc agtgcctctt
     2521 tgaaggtggg aaacattagt gaaaattctg ttggtgccac gctttgatga gcatttgttt
     2581 gaccccagtt tcttcttaca cttcttaccc cagcctaccc ttcctgcatt tctcttctca
     2641 gctcttccat gatggattcc cccccctttc ctaaagccat catgccttga taaatatata
     2701 tgatcattga aatacttttt aacaaaaaac agattctata ttattatata tatatatata
     2761 tatataaaga tatatagaga tgcattcaca ggggttggct gggaggagga agaccattct
     2821 gtgaccaaaa taccttggtc atttttttta tattgcctta tttccctatg gctgagcctt
     2881 gttgtgacac atcaagcttt tctgtagatg ttgtcttggc ttcccaccag cttaagcgtt
     2941 catatgctct gcttttagtt catatataca tacataatgt ttttcctttc ttaattttgt
     3001 ctttttgttt gggatcagct tcttgcactc cttccctaac tcaactgttg ccgtctcatc
     3061 ttctctcatc tgatcacttc atgttttgtt tttgttactg cctggatgag gcacttctgt
     3121 caattttttc aggaccttag ttccagcagc agaatggaaa aatccttgaa gcccaggctg
     3181 atgcttgaag taactgtgga gggagtgttc aaaatactac tgacgcaggc accttcttgg
     3241 cgctggagag tcaaaggcat ctcccttcat tagctgctct gagcatcaag aattagaagt
     3301 ctttcagtgg aattgtacaa gagtcccttt gaagataata atcttggctc agtttgtata
     3361 aactgtcaaa ttttcaaata ataggtaggg ggctttcact aggaaaatca tgtgctcaga
     3421 agaggaaatg actcgtagtc aggttcagga gttagtggag tatttggact ttggtactgc
     3481 tgtcttccaa ggtagctcta agttttgatg tgtgggcttc tgagtttata ttctgaaagg
     3541 aaatacactt cttttgaaca tccccactag gttcttttcc attgtcaata aggagcatca
     3601 gccagtgaat ctgtttcagg tttccattct gcagaactcc tccaaagcat gtgctagtgg
     3661 caagacagtg gttcttatga tgttttccct taacttttcc ttgtatgttc ttgggtggtt
     3721 cctaagggaa agggaagcac atgatcatgg gaatgatagc ccagaacaaa aagaaatctt
     3781 gtcttaccac agtgttttat aggagagatt gggagaaatc atcctgtttt ctctgtgacc
     3841 tgatttcaga agagactgat ccaaaaatta taacggcagg gaacctagtg catttggcac
     3901 tgagatttaa atgcaaccag aattgtcctc aaggcccagc cataaaagca ttgtctctct
     3961 cgaccttctg gtatcttgtt agagagcttt tcactgtgag gaagtgtgga aaaatagctc
     4021 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtaat ctgttaggtt ggggataggt
     4081 tttctgctag ccaatattaa aagagacctg caataaaaaa attaccctga tctgatagaa
     4141 agcaagtgtt tttgtatgtg tgggtgaatg tgtgttcatg cccgtatatg tctacacaca
     4201 gatgacaaat tatatttgaa atcgttggaa aataaattca gatcaaaatg cctttcaggc
     4261 ccattaccta gaaatctatc ttaaaacctg ggtatgttcc taaggtcatt tctttgctta
     4321 tgctaaatta attacaatta tgaatggagg atattctact gtactttttt aaaaagaaac
     4381 tatttttgtg tttgaaagtg aaaccaacat ccagatctat agcagagtcc ttattcttct
     4441 cataaatctt tttactttgg ctacaaatag atgatggtat gattctatta tatattttat
     4501 ataaaatcca tccaaattaa gttttgggta agtgtgttgt ttaatctgaa ctatagtaac
     4561 ttaatactct aaacaatagt tcactccatt tggtcctttc tccacagatg taattatgtt
     4621 ttcaactcag gaactatggc aaggaacttt ccccagatca aattctatta acgctgagat
     4681 acaagtcatc catgcacagc cactatcata ccctttattc tcactgaaag gcagaactca
     4741 gaacctgtta ttttatgtct gtaatcatgt actttggcat cttttggagg aaaggggcag
     4801 gataactcac tggaatgtac agtattttgc tagtgcattt caaggaatgg aatcttctcc
     4861 agtatgaaat taccagatat aaaataatgt aatgatgctg aggatataag cttttagaag
     4921 gtaatttgat ggtatttctt tctcgaatga aaagctgctg gtttaccctc aaccctattc
     4981 attagcatta ccatgagtga atttatatct aattatttcc acttgccctg ttctcttcac
     5041 accaaggaag ctccagatcc agtatcttgt ttggcctcaa aacagaagca gcttcttttg
     5101 tctcccagca gtagtgagcc actcagtctc ttccacagga agtttggagc ctacattcct
     5161 tgagtcagga gcttattaca gaaaaacccc gtttccctga acttttggct aacagaaatt
     5221 aatttaactg acatgcatat tgattctgaa atttttttcc taagtttttt tcattttttt
     5281 gaatgagttt tttaaatttt ttagatgacc aaaacttgca gggcagggga tgcccagaag
     5341 agtggtgaga tagtaaaaca cttattccct catcctttca ggttttcagg ttgcccattt
     5401 atattcattt acatgtcatt tgactgtctc actttttacc cagaacagta acaacccaca
     5461 ccgtcttcct tcagggattt ccaactggca ctctgtgggt gctacacaga atgcaattta
     5521 atggatattt ctcagcctgg ttcagaataa attgatcctt tgatcccaga aagtatatac
     5581 tgaagtgtgg gataaagatt atgattaggg gagggttgga gacaaaagct gtaaattact
     5641 atggctgatt tatttctact atatacatat atattttttg cttttgtata tcctatatag
     5701 gaaactaagc attgtatttt ttttaacaaa tctaaaaaag cactatgaac tacaggtgtt
     5761 tgactttcaa aatatatttt gtattgttaa tatcttcaca ttgtgtgaat actggaagct
     5821 gcagatcttt gctaggacgc aataaattta tatacttttt gaggggttct tctggggtgc
     5881 taatcaggcc cctgttatgc ttagggggag ccctggtgct acttgcttga agttttcagt
     5941 gtaagtaccc tgatgccttt tggaccttgg gatcagatca agagttttgg agatcaggta
     6001 ccaaggaaat aaggacagtc tagctgcctc aagtgagggg ccctttgcat agctctcctt
     6061 ccccctcact gaagctgggt agcctattgg ggttgagagg gaaaatgtga aatctcagaa
     6121 tttatctccc ttagaagaga gccagtaact tatgtacaag gatgaaagaa aggtcgcagc
     6181 agtagctttg gggaaaggga ggaagatatg gcacttctcc aaccccggaa aacattgctt
     6241 ttgaaaactg ctgataaaat atgagccggt tattacttct gtttgggaga ctgtgctctc
     6301 tgtggtgcct ctcttggctc tactccacag ataccagacc tcttctaaga ggatgagcag
     6361 accagctttg aggttgacct gtttctcttt gtctgccttc ccaaaacacc agcccccagg
     6421 aagacattaa gcagccttaa gcttaaattc ctactccctc ttccaaattt ggctcacttg
     6481 ccttagatcc aaggcaggga aaggaaaaga aggggggtct ctggctttat tactccccta
     6541 agtctttact ctgacttccc caaacccaga aagattttct ccacagtgtt catttgaaag
     6601 aggagtattt tgtcccattt tccccttcct cattatcaaa cagccccagt cttccttgtc
     6661 tctgctaaga aagtagaggc atgatgatct gcctctcaac tgccctaagt cctagctaag
     6721 tatcagggga aaaaaaaaaa aaaaaagcct aacaaatggg attagactag ggctgcaagt
     6781 agtgaggatt ttgttgatac ctctgctggg atgtgtgctt tcccatatct tgccttcagg
     6841 aattacactg tgccttttcc ccagggatat gggctctgtc tacccagtgc tccagtttcc
     6901 cggtaactgc tcttgaacat tgtggacaag ggcaggtctt catatttttg atcatccctt
     6961 tctcccagtg aaatcccata gcccttacct agagtctagg gcacaaagac ttcggggaag
     7021 atacactgag attgacctga ggagacatct acacacacca gtggcagctg ccccagggcc
     7081 tgcttcccct tcctaagtct gtcatcctct ggaagggatg ggtggtgctc caatctctgg
     7141 tgcctaaaaa cccaagttta tttctctctt aacactggca ataaccagtc cacaccactg
     7201 ttgcctttta aaacctctta ataatctcat gctgtgtttg ttttgattcc aatccaatta
     7261 tcaccagggc tgtgtgggta aatgctttta aatgctctct catcttgttc ttccccctca
     7321 ccccccactc ttaggtatgt atgatgctaa tcttgtccct aagtaagttt cttcctgctc
     7381 cttttgtatc ttcctttctt gtctttcctc ctaccttttg tctcttggtg ttttgggact
     7441 tttttttttt tttttttggc cttttgtaca aagattagtt tcaatgtagt ctgtagcctc
     7501 ctttgtaaac caattaaaaa gttttttaat aaaaaa
//
