LOCUS       NM_031439               3215 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens SRY-box transcription factor 7 (SOX7), mRNA.
ACCESSION   NM_031439
VERSION     NM_031439.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3215)
  AUTHORS   Zhang,J., Zhang,W., Liu,J., Liu,Y., Jiang,Y., Ainiwaer,A., Chen,H.,
            Gu,Z., Chen,H., Mao,S., Guo,Y., Xu,T., Xu,Y., Wu,Y., Yao,X. and
            Yan,Y.
  TITLE     SOX7 inhibits the malignant progression of bladder cancer via the
            DNMT3B/CYGB axis
  JOURNAL   Mol Biomed 5 (1), 36 (2024)
   PUBMED   39227479
  REMARK    GeneRIF: SOX7 inhibits the malignant progression of bladder cancer
            via the DNMT3B/CYGB axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3215)
  AUTHORS   Liu,Y., Wang,X., Wang,Z., Gao,X., Xu,H., Gao,Y. and Niu,J.
  TITLE     System analysis based on weighted gene co-expression analysis
            identifies SOX7 as a novel regulator of hepatic stellate cell
            activation and liver fibrosis
  JOURNAL   FASEB J 38 (15), e23495 (2024)
   PUBMED   39126242
  REMARK    GeneRIF: System analysis based on weighted gene co-expression
            analysis identifies SOX7 as a novel regulator of hepatic stellate
            cell activation and liver fibrosis.
REFERENCE   3  (bases 1 to 3215)
  AUTHORS   Hao,Y., Bai,X.Y., Huo,F. and Chen,X.B.
  TITLE     [Downregulation of SETDB1 suppresses epithelial mesenchymal
            transition and invasion and metastasis in oral cancer via SOX7
            methylation]
  JOURNAL   Shanghai Kou Qiang Yi Xue 33 (1), 30-35 (2024)
   PUBMED   38583021
  REMARK    GeneRIF: [Downregulation of SETDB1 suppresses epithelial
            mesenchymal transition and invasion and metastasis in oral cancer
            via SOX7 methylation].
REFERENCE   4  (bases 1 to 3215)
  AUTHORS   Chiang,I.K.N., Graus,M.S., Kirschnick,N., Davidson,T., Luu,W.,
            Harwood,R., Jiang,K., Li,B., Wong,Y.Y., Moustaqil,M., Lesieur,E.,
            Skoczylas,R., Kouskoff,V., Kazenwadel,J., Arriola-Martinez,L.,
            Sierecki,E., Gambin,Y., Alitalo,K., Kiefer,F., Harvey,N.L. and
            Francois,M.
  TITLE     The blood vasculature instructs lymphatic patterning in a
            SOX7-dependent manner
  JOURNAL   EMBO J 42 (5), e109032 (2023)
   PUBMED   36715213
  REMARK    GeneRIF: The blood vasculature instructs lymphatic patterning in a
            SOX7-dependent manner.
REFERENCE   5  (bases 1 to 3215)
  AUTHORS   Chen,Q., Xi,X., Ma,J., Wang,X., Xia,Y., Wang,X., Deng,Y. and Li,Y.
  TITLE     The mechanism by which crocetin regulates the lncRNA
            NEAT1/miR-125b-5p/SOX7 molecular axis to inhibit high
            glucose-induced diabetic retinopathy
  JOURNAL   Exp Eye Res 222, 109157 (2022)
   PUBMED   35718188
  REMARK    GeneRIF: The mechanism by which crocetin regulates the lncRNA
            NEAT1/miR-125b-5p/SOX7 molecular axis to inhibit high
            glucose-induced diabetic retinopathy.
REFERENCE   6  (bases 1 to 3215)
  AUTHORS   Zhang,Y., Huang,S., Dong,W., Li,L., Feng,Y., Pan,L., Han,Z.,
            Wang,X., Ren,G., Su,D., Huang,B. and Lu,J.
  TITLE     SOX7, down-regulated in colorectal cancer, induces apoptosis and
            inhibits proliferation of colorectal cancer cells
  JOURNAL   Cancer Lett 277 (1), 29-37 (2009)
   PUBMED   19108950
  REMARK    GeneRIF: SOX7, down-regulated in colorectal cancer, induces
            apoptosis and inhibits proliferation of colorectal cancer cells.
REFERENCE   7  (bases 1 to 3215)
  AUTHORS   Semb,H.
  TITLE     Expandable endodermal progenitors: new tools to explore endoderm
            and its derivatives
  JOURNAL   Cell Stem Cell 3 (4), 355-356 (2008)
   PUBMED   18940723
  REMARK    GeneRIF: stable expression induces a stable expandable extra
            embryonic endoderm phenotype in hESCs
REFERENCE   8  (bases 1 to 3215)
  AUTHORS   Guo,L., Zhong,D., Lau,S., Liu,X., Dong,X.Y., Sun,X., Yang,V.W.,
            Vertino,P.M., Moreno,C.S., Varma,V., Dong,J.T. and Zhou,W.
  TITLE     Sox7 Is an independent checkpoint for beta-catenin function in
            prostate and colon epithelial cells
  JOURNAL   Mol Cancer Res 6 (9), 1421-1430 (2008)
   PUBMED   18819930
  REMARK    GeneRIF: Sox7 is a tumor suppressor that functions as an
            independent checkpoint for beta-catenin transcriptional activity.
            Inactivation of Sox7 could promote the development of a majority of
            colorectal tumors and approximately half of prostate tumors.
REFERENCE   9  (bases 1 to 3215)
  AUTHORS   Seguin,C.A., Draper,J.S., Nagy,A. and Rossant,J.
  TITLE     Establishment of endoderm progenitors by SOX transcription factor
            expression in human embryonic stem cells
  JOURNAL   Cell Stem Cell 3 (2), 182-195 (2008)
   PUBMED   18682240
  REMARK    GeneRIF: stable endoderm progenitors can be established from human
            ES cells by constitutive expression of SOX7 producing
            extraembryonic endoderm progenitors
REFERENCE   10 (bases 1 to 3215)
  AUTHORS   Takash,W., Canizares,J., Bonneaud,N., Poulat,F., Mattei,M.G.,
            Jay,P. and Berta,P.
  TITLE     SOX7 transcription factor: sequence, chromosomal localisation,
            expression, transactivation and interference with Wnt signalling
  JOURNAL   Nucleic Acids Res 29 (21), 4274-4283 (2001)
   PUBMED   11691915
  REMARK    GeneRIF: gene expression, chromosome mapping, transactivation,
            interference with Wnt signaling
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY089489.1, BC004299.1 and
            AC105001.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_031439.3.
            
            Summary: This gene encodes a member of the SOX (SRY-related
            HMG-box) family of transcription factors involved in the regulation
            of embryonic development and in the determination of the cell fate.
            The encoded protein may act as a transcriptional regulator after
            forming a protein complex with other proteins. The protein may play
            a role in tumorigenesis. A similar protein in mice is involved in
            the regulation of the wingless-type MMTV integration site family
            (Wnt) pathway. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA888228.1, SRR1660807.89138.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304501.2/ ENSP00000301921.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               HY089489.1         65-529
            466-1946            BC004299.1         456-1936
            1947-3215           AC105001.3         79661-80929         c
FEATURES             Location/Qualifiers
     source          1..3215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..3215
                     /gene="SOX7"
                     /note="SRY-box transcription factor 7"
                     /db_xref="GeneID:83595"
                     /db_xref="HGNC:HGNC:18196"
                     /db_xref="MIM:612202"
     exon            1..316
                     /gene="SOX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1245
                     /gene="SOX7"
                     /note="SRY (sex determining region Y)-box 7; SRY-box 7"
                     /codon_start=1
                     /product="transcription factor SOX-7"
                     /protein_id="NP_113627.1"
                     /db_xref="CCDS:CCDS5977.1"
                     /db_xref="GeneID:83595"
                     /db_xref="HGNC:HGNC:18196"
                     /db_xref="MIM:612202"
                     /translation="MASLLGAYPWPEGLECPALDAELSDGQSPPAVPRPPGDKGSESR
                     IRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLR
                     LQHMQDYPNYKYRPRRKKQAKRLCKRVDPGFLLSSLSRDQNALPEKRSGSRGALGEKE
                     DRGEYSPGTALPSLRGCYHEGPAGGGGGGTPSSVDTYPYGLPTPPEMSPLDVLEPEQT
                     FFSSPCQEEHGHPRRIPHLPGHPYSPEYAPSPLHCSHPLGSLALGQSPGVSMMSPVPG
                     CPPSPAYYSPATYHPLHSNLQAHLGQLSPPPEHPGFDALDQLSQVELLGDMDRNEFDQ
                     YLNTPGHPDSATGAMALSGHVPVSQVTPTGPTETSLISVLADATATYYNSYSVS"
     exon            317..3215
                     /gene="SOX7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3194..3199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX7"
                     /note="hexamer: AATAAA"
     polyA_site      3215
                     /gene="SOX7"
                     /note="major polyA site"
ORIGIN      
        1 agttggacgc cccgacccgt gcgagggcca ggtccgcgcc tgccccgcca ggcgaagcga
       61 ggcgacccgc gtgcggccat ggcttcgctg ctgggagcct acccttggcc cgagggtctc
      121 gagtgcccgg ccctggacgc cgagctgtcg gatggacaat cgccgccggc cgtcccccgg
      181 cccccggggg acaagggctc cgagagccgt atccggcggc ccatgaacgc cttcatggtt
      241 tgggccaagg acgagaggaa acggctggca gtgcagaacc cggacctgca caacgccgag
      301 ctcagcaaga tgctgggaaa gtcgtggaag gcgctgacgc tgtcccagaa gaggccgtac
      361 gtggacgagg cggagcggct gcgcctgcag cacatgcagg actaccccaa ctacaagtac
      421 cggccgcgca ggaagaagca ggccaagcgg ctgtgcaagc gcgtggaccc gggcttcctt
      481 ctgagctccc tctcccggga ccagaacgcc ctgccggaga agagaagcgg cagccggggg
      541 gcgctggggg agaaggagga caggggtgag tactcccccg gcactgccct gcccagcctc
      601 cggggctgct accacgaggg gccggctggt ggtggcggcg gcggcacccc gagcagtgtg
      661 gacacgtacc cgtacgggct gcccacacct cctgaaatgt ctcccctgga cgtgctggag
      721 ccggagcaga ccttcttctc ctccccctgc caggaggagc atggccatcc ccgccgcatc
      781 ccccacctgc cagggcaccc gtactcaccg gagtacgccc caagccctct ccactgtagc
      841 caccccctgg gctccctggc ccttggccag tcccccggcg tctccatgat gtcccctgta
      901 cccggctgtc ccccatctcc tgcctattac tccccggcca cctaccaccc actccactcc
      961 aacctccaag cccacctggg ccagctttcc ccgcctcctg agcaccctgg cttcgacgcc
     1021 ctggatcaac tgagccaggt ggaactcctg ggggacatgg atcgcaatga attcgaccag
     1081 tatttgaaca ctcctggcca cccagactcc gccacagggg ccatggccct cagtgggcat
     1141 gttccggtct cccaggtgac accaacgggt cccacagaga ccagcctcat ctccgtcctg
     1201 gctgatgcca cggccacgta ctacaacagc tacagtgtgt catagagctg gaggcgcccc
     1261 gtccggtcag ccctcgcgcc ctctccttct tgtgccttga gtggcagagg agccgtccag
     1321 ccacaccagc tttcctccca ccgctcaggg cagggaggtc tgaactgcgg ccccagagcc
     1381 tttggcctaa gctggactct ccttatccga gtgccgcctc tatccccttc cccacgttcc
     1441 agcccctgca gcccacattt taagtatatt ccttcaagtg agttttcctc cagcccctga
     1501 gagttgctgt ctcccagtgg aatgttcact gacgtctttt cttggtagcc atcatcgaaa
     1561 ctaatggggg gacagacttg atagccaagg tcccttctgg tccagttttc tgatttaggg
     1621 ttctctcaag attaataaag gaagatgggg aaatttgact cattaatgag ctcgctaacc
     1681 tacgatctgg tgataatttt gtgtgcacag cccaaggacc acgaggcttt ctgcactttc
     1741 tgcaccccct tccaaagtga ccacaaaatt tcaaagggac tcatacaatt tgagaaaaaa
     1801 cagtcaacct gatttgagaa attaaccagt atggctaact atatcacaga aaatgggatt
     1861 gagttaaaac tattttattt taaatataca ttttaaagca gttctttttt tttgttaatt
     1921 tgtttattat acacacactt caagagaata tgcacagtct aggccgggca cggtggctca
     1981 cgcctgtaat cccagcactt tgggaggccg aggcatgtgg atcacctgag gtcaggagtt
     2041 tgagaccagc ctagacaaca tggtgaaacc ttgtctctat gaaaaataca aaatttgctg
     2101 ggagtggtgg tgcatgcctg taatcccagc tacttggaag gctgaggcag gagaatgtct
     2161 tgaacctagg aggtggaggt tgcagtgagc tgagattgca ccattgcact ccagcctgtg
     2221 caacaagagt gaaactccat ttcaagaaaa aaaaaaaaaa aagaatatgc acagtctgaa
     2281 tgtataccag gagtgtgaga gacacatgcc cacttcatgc aactcctaaa ctcaaagtct
     2341 aaatcagata tttttattaa caatgacaac ttgttgccaa ctccctgttt ctaatgacca
     2401 aagacccagg gtacctaaaa ggactttgca accaagcaaa gtcactgtct tcaaatctgg
     2461 atacacactt tcccctctgt agattcaaaa ggtgcttcct tcccggctgt ctccagcttc
     2521 cttactctct tttctgggat ttctttttct cttctttctg ctcttcctcc actgctgaac
     2581 tggtccctaa ctgaaacagc ccctgactta tcccaagcat gcttccttta gctgctgtga
     2641 gaatttgtct tcctcaccag ccaggtcctc aggcaaagtc ctcagccagt gctttagagc
     2701 aacttcccgc aaatcagaaa ctcactgtga ttccaaaaat gtttctgagc cctggacccc
     2761 tgcccccaaa atattttcat ctttccccca aacctccttt aaaggagcat gcataacagt
     2821 gtgctgaaag acagttgttg gttttttgat tttagcatat tatttcctgt atgaaatatg
     2881 ttttatataa tctcctatta tttttatctt atgttttgta ttgttgataa atcctttttg
     2941 tccttctaag atgtcctatt gtaaaatcac ttataaggta tgattactct ttatgctatt
     3001 actttatatg ccatttggta ataaatagta aattgttgat gatatgattg actgatgcgc
     3061 agtccagagc atgtatgaat aatctcataa aacagtatca cagacattaa gctaaactgt
     3121 ttcgtttttt tgaaagaaca actcatactt tggaacagtt gtcaatatta atttgttgca
     3181 aatatttaat ttaaataaac atttttgtac catga
//
