LOCUS       NM_001367873            9304 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SRY-box transcription factor 6 (SOX6), transcript
            variant 6, mRNA.
ACCESSION   NM_001367873
VERSION     NM_001367873.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9304)
  AUTHORS   Lu,M.Y., Fang,C.Y., Hsieh,P.L., Chao,S.C., Liao,Y.W., Ohiro,Y.,
            Yu,C.C. and Ho,D.C.
  TITLE     MIAT promotes myofibroblastic activities and transformation in oral
            submucous fibrosis through sponging the miR-342-3p/SOX6 axis
  JOURNAL   Aging (Albany NY) 16 (19), 12909-12927 (2024)
   PUBMED   39379100
  REMARK    GeneRIF: MIAT promotes myofibroblastic activities and
            transformation in oral submucous fibrosis through sponging the
            miR-342-3p/SOX6 axis.
REFERENCE   2  (bases 1 to 9304)
  AUTHORS   Li,M., Niu,M., Fan,X., Chen,F., Cao,H., Liu,Q., Gan,S., Yue,P. and
            Gao,J.
  TITLE     LncRNA MIR181A2HG inhibits keratinocytes proliferation through
            miR-223-3p/SOX6 axis
  JOURNAL   Aging (Albany NY) 16 (11), 9846-9858 (2024)
   PUBMED   38848163
  REMARK    GeneRIF: LncRNA MIR181A2HG inhibits keratinocytes proliferation
            through miR-223-3p/SOX6 axis.
REFERENCE   3  (bases 1 to 9304)
  AUTHORS   Pastori,V., Zambanini,G., Citterio,E., Weiss,T., Nakamura,Y.,
            Cantu,C. and Ronchi,A.E.
  TITLE     Transcriptional repression of the oncofetal LIN28B gene by the
            transcription factor SOX6
  JOURNAL   Sci Rep 14 (1), 10287 (2024)
   PUBMED   38704454
  REMARK    GeneRIF: Transcriptional repression of the oncofetal LIN28B gene by
            the transcription factor SOX6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9304)
  AUTHORS   Zheng,H., Liu,M., Shi,S., Huang,H., Yang,X., Luo,Z., Song,Y.,
            Xu,Q., Li,T., Xue,L., Lu,F. and Wang,J.
  TITLE     MAP4K4 and WT1 mediate SOX6-induced cellular senescence by
            synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling
            pathway in cervical cancer
  JOURNAL   Mol Oncol 18 (5), 1327-1346 (2024)
   PUBMED   38383842
  REMARK    GeneRIF: MAP4K4 and WT1 mediate SOX6-induced cellular senescence by
            synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling
            pathway in cervical cancer.
REFERENCE   5  (bases 1 to 9304)
  AUTHORS   Li,S. and Wang,Y.
  TITLE     Regulatory mechanism of DDX5 in ox-LDL-induced endothelial cell
            injury through the miR-640/SOX6 axis
  JOURNAL   Clin Hemorheol Microcirc 88 (2), 157-170 (2024)
   PUBMED   39093065
  REMARK    GeneRIF: Regulatory mechanism of DDX5 in ox-LDL-induced endothelial
            cell injury through the miR-640/SOX6 axis.
REFERENCE   6  (bases 1 to 9304)
  AUTHORS   Ueda,R., Iizuka,Y., Yoshida,K., Kawase,T., Kawakami,Y. and Toda,M.
  TITLE     Identification of a human glioma antigen, SOX6, recognized by
            patients' sera
  JOURNAL   Oncogene 23 (7), 1420-1427 (2004)
   PUBMED   14691456
REFERENCE   7  (bases 1 to 9304)
  AUTHORS   Cohen-Barak,O., Hagiwara,N., Arlt,M.F., Horton,J.P. and
            Brilliant,M.H.
  TITLE     Cloning, characterization and chromosome mapping of the human SOX6
            gene
  JOURNAL   Gene 265 (1-2), 157-164 (2001)
   PUBMED   11255018
REFERENCE   8  (bases 1 to 9304)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 9304)
  AUTHORS   Hagiwara,N., Klewer,S.E., Samson,R.A., Erickson,D.T., Lyon,M.F. and
            Brilliant,M.H.
  TITLE     Sox6 is a candidate gene for p100H myopathy, heart block, and
            sudden neonatal death
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4180-4185 (2000)
   PUBMED   10760285
REFERENCE   10 (bases 1 to 9304)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027016.4, AC013595.11,
            AC068405.5, AC103794.2 and AC009869.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the D subfamily of sex
            determining region y-related transcription factors that are
            characterized by a conserved DNA-binding domain termed the high
            mobility group box and by their ability to bind the minor groove of
            DNA. The encoded protein is a transcriptional activator that is
            required for normal development of the central nervous system,
            chondrogenesis and maintenance of cardiac and skeletal muscle
            cells. The encoded protein interacts with other family members to
            cooperatively activate gene expression. Alternative splicing
            results in multiple transcript variants.[provided by RefSeq, Mar
            2009].
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (a). Variants 4 and 6 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.70283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000683767.1/
                                                ENSP00000507545.1
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               AC027016.4         56151-56603         c
            454-694             AC027016.4         41069-41309         c
            695-902             AC027016.4         18503-18710         c
            903-992             AC013595.11        67398-67487
            993-1165            AC068405.5         111048-111220
            1166-1234           AC068405.5         114049-114117
            1235-1355           AC103794.2         130860-130980       c
            1356-1435           AC103794.2         116666-116745       c
            1436-1558           AC103794.2         115053-115175       c
            1559-1708           AC103794.2         74809-74958         c
            1709-1892           AC103794.2         68812-68995         c
            1893-2080           AC103794.2         65571-65758         c
            2081-2189           AC103794.2         33999-34107         c
            2190-2423           AC103794.2         8054-8287           c
            2424-2640           AC103794.2         5261-5477           c
            2641-9304           AC009869.7         9992-16655
FEATURES             Location/Qualifiers
     source          1..9304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..9304
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /note="SRY-box transcription factor 6"
                     /db_xref="GeneID:55553"
                     /db_xref="HGNC:HGNC:16421"
                     /db_xref="MIM:607257"
     exon            1..453
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            454..694
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            695..902
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            903..992
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1165
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1234
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1355
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1435
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1558
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1708
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1892
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2080
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2189
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2423
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2640
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..9304
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7633..7638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /note="hexamer: AATAAA"
     polyA_site      7654
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
     regulatory      9280..9285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /note="hexamer: ATTAAA"
     polyA_site      9304
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /note="major polyA site"
ORIGIN      
        1 ataacttact gtcaactgtg aggcaaacca caaagctcca ctgttgctca gcaaataggc
       61 tctattggat gatggcttga ctagcttgta aagtttgctt aactgtagca gcagtggcag
      121 aaggtatgtg gggtactgta tctcccaaca ggccaagaga tttcacttct ttcatttact
      181 tttatgtttt taactccttt aattgttgaa caaagttaac agtgttttgt ttagcaaatt
      241 agatgttgct taaagttatg gctacaattg gtagcctgag acttggcaga gattaattag
      301 ctgtggggtt gggttttttt tttttttggt tggcagtcag aggtttcttg tgatttggga
      361 aggtgtcaaa ggtgttatgc cctcaagttc tgaagttctg gctgatgtgg taagagaaag
      421 ccggattgaa gagtggaaga gcagccactt cataagaatg tcttccaagc aagccacctc
      481 tccatttgcc tgtgcagctg atggagagga tgcaatgacc caggatttaa cctcaaggga
      541 aaaggaagag ggcagtgatc aacatgtggc ctcccatctg cctctgcacc ccataatgca
      601 caacaaacct cactctgagg agctaccaac acttgtcagt accattcaac aagatgctga
      661 ctgggacagc gttctgtcat ctcagcaaag aatggaatca gagaataata agttatgttc
      721 cctatattcc ttccgaaata cctctacctc accacataag cctgacgaag ggagtcggga
      781 ccgtgagata atgaccagtg ttacttttgg aaccccagag cgccgcaaag ggagtcttgc
      841 cgatgtggtg gacacactga aacagaagaa gcttgaggaa atgactcgga ctgaacaaga
      901 ggattcctcc tgcatggaaa aactactttc aaaagattgg aaggaaaaaa tggaaagact
      961 aaataccagt gaacttcttg gagaaattaa aggtacacct gagagcctgg cagaaaaaga
     1021 acggcagctc tccaccatga ttacccagct gatcagttta cgggagcagc tactggcagc
     1081 gcatgatgaa cagaaaaaac tggcagcgtc acaaattgag aaacaacggc agcaaatgga
     1141 ccttgctcgc caacagcaag aacagattgc gagacaacag cagcaacttc tgcaacagca
     1201 gcacaaaatt aatctcctgc agcaacagat ccaggttcag ggtcacatgc ctccgctcat
     1261 gatcccaatt tttccacatg accagcggac tctggcagca gctgctgctg cccaacaggg
     1321 attcctcttc ccccctggaa taacatacaa accaggtgat aactaccccg tacagttcat
     1381 tccatcaaca atggcagctg ctgctgcttc tggactcagc cctttacagc tccagaaggg
     1441 tcatgtctcc cacccacaaa ttaaccaaag gctaaagggc ctaagtgacc gttttggcag
     1501 gaatttggac acctttgaac atggtggtgg ccactcttac aaccacaaac agattgagca
     1561 gctctatgcc gctcagctgg ccagcatgca ggtgtcacct ggagcaaaga tgccatcaac
     1621 tccacagcca ccaaacacag cagggacggt ctcacctact gggataaaaa atgaaaagag
     1681 agggaccagc cctgtaactc aagttaagga tgaagcagca gcacagcctc tgaatctctc
     1741 atcccgaccc aagacagcag agcctgtaaa gtccccaacg tctcccaccc agaacctctt
     1801 cccagccagc aaaaccagcc ctgtcaatct gccaaacaaa agcagcatcc ctagccccat
     1861 tggaggaagc ctgggaagag gatcctcttt agatatccta tctagtctca actcccctgc
     1921 cctttttggg gatcaggata cagtgatgaa agccattcag gaggcgcgga agatgcgaga
     1981 gcagatccag cgggagcaac agcagcaaca gccacatggt gttgacggga aactgtcctc
     2041 cataaataat atggggctga acagctgcag gaatgaaaag gaaagaacgc gctttgagaa
     2101 tttggggccc cagttaacgg gaaagtcaaa tgaagatgga aaactgggcc caggtgtcat
     2161 cgaccttact cggccagaag atgcagaggg aagtaaagca atgaatggct ctgcagctaa
     2221 actacagcag tattattgtt ggccaacagg aggtgccact gtggctgaag cacgagtcta
     2281 cagggacgcc cgcggccgtg ccagcagcga gccacacatt aagcgaccaa tgaatgcatt
     2341 catggtttgg gcaaaggatg agaggagaaa aatccttcag gccttccccg acatgcataa
     2401 ctccaacatt agcaaaatct taggatctcg ctggaaatca atgtccaacc aggagaagca
     2461 accttattat gaagagcagg cccggctaag caagatccac ttagagaagt acccaaacta
     2521 taaatacaaa ccccgaccga aacgcacctg cattgttgat ggcaaaaagc ttcggattgg
     2581 ggagtataag caactgatga ggtctcggag acaggagatg aggcagttct ttactgtggg
     2641 gcaacagcct cagattccaa tcaccacagg aacaggtgtt gtgtatcctg gtgctatcac
     2701 tatggcaact accacaccat cgcctcagat gacatctgac tgctctagca cctcggccag
     2761 cccggagccc agcctcccgg tcatccagag cacttatggt atgaagacag atggcggaag
     2821 cctagctgga aatgaaatga tcaatggaga ggatgaaatg gaaatgtatg atgactatga
     2881 agatgacccc aaatcagact atagcagtga aaatgaagcc ccggaggctg tcagtgccaa
     2941 ctgaggagtt tttgtttgct gaattaaagt actctgacat ttcacccccc tccccaacaa
     3001 agagttatta aagagcccgc atgcatttgt ggctccacaa ttacatcagc agaatggtct
     3061 taattgtttc gtaaagtgtg agacagatta agttttccct gatttttcat gaacttgagt
     3121 tttttgttgt tattgttatt gttgttgttg ttgttttttt aatttaggtg aagacatatt
     3181 aaatatgaga caccaggact tgaaacttat ctcaacccgt agatgtctta caagtcttat
     3241 atttttgtct tacttttttt ttcttttgga tgttgataaa ggtttaagtt actgttttag
     3301 atggggttaa acattctcac tcaggtatgc tgtgccggcc tacaggttgt gaatgtgttt
     3361 ttattctgaa ttattttaga aaacaactga ggatttcata ttgtgaaaca gaacaagtcc
     3421 acggcgtgtg cagctgcatg tagagcatat tcaaaaggcc tcggaattcc aattttccat
     3481 ttgtagagtt aaactttgaa tgtgccaaac tttttcgtaa cttttgaatc ttaatatttt
     3541 gaaagtctta aaggagacac tgcaaagtct tagacaatct ttggcatctt aaaataaaat
     3601 agcaaaccaa catttttttt tccagaaaat ggtaaggtac tcaggaatct ggagacaaga
     3661 tattgtaagg aatgaacaag gttgccacag tgcatggacc caattgtgtt tgcctgttga
     3721 cgtgccatca gtgcgtgatg tggtatgaca tacacacacc agagcaaccg ccacaccaga
     3781 tatcgacaga gtggtcttct ctgcctgaga ccacctctca ctacatccat tatccctttg
     3841 cctttaaccc tgacattcag tcttaacaca ttttatctta aataatttat tcattccaga
     3901 atgtcaaggg tccacttgct atttattttt tttcaattgt tggtggcatt aatttaataa
     3961 ttcttgtttt tcaccttcct tccccgaaga acttttccgt ccttttcacc tccttctcct
     4021 gtgtacatag tgattttatg tccccagaac gcctggaagc atttctgaaa ccaagatatt
     4081 attaaaaacc tattattgtt tttaatcatg agtatgtatc tggctgcagg gctgtgtatt
     4141 gggatatagg tatatagtct tacacttaaa caggtatgcc cctgaggttc actgtgacct
     4201 caagtctttt gccagaattt tcccctaatt cagttcacaa gtggtagggt ctgcatcagt
     4261 ggcatttccc cctgaattcc attcagcagc aaggttcaac agtggtgact gccaggcagg
     4321 agagtcctgc ggccaaacct gaagcccaag gctcgtgggc catgcaggaa tctcagtgaa
     4381 gctgtcatgg gctggcacct ttacactgag ttgccttgtc ccagctggca catctaggga
     4441 gttcattgca aaatccccag gatgcaaaaa gccacatgac agcctcagag caaagatggt
     4501 ggcaaatagt catgatacat ctagagaatg aaagaaaact gtaagggagg agaaggaggg
     4561 gaatacattc cctatatggg atgttcctac tgttaactct ggggaacaga tagctccggg
     4621 ggcagcagat gagttcctct ggctgactct atctgtagcc acatggggac ctgcctacgt
     4681 gtgaacaaaa tgaactgcac ttatcacaca aggatttctt tgaagacatg ctactggggt
     4741 gggaagcagt gaggttttat tccccatctc ctaactacag ggagctctgc catgtcattt
     4801 tggccttcct gaaactagga caggttgtct atcggggggc ttcccccaga gaggtttagt
     4861 gggagaatgt cagtgaatgg gatagttcac ctcatgggac aacccagaat ctgatcacca
     4921 ggacatagga atggccccat cagatttctt gagccatttt gtcacttgga agaaaatagt
     4981 gtacctttgt atttatttaa gagtgctcaa ggcctaatag caataaacag gtctagccaa
     5041 gaaattacaa gctattctgt tagctgggag tgctctctat aagctgatta aggtactgat
     5101 aggaactctt tgttattcat gttggttggg gattagaaat ttgtttttgt acatttattt
     5161 caaatgagga ggaggtcatt ttttctctca aaaaatgagt atttattatt gtcttactga
     5221 tttctttgat tatatacctc tcctcctcag ttcactcttg ttttttttct ttctctttgg
     5281 cttttgcttt tgctctctct cacttctttc ttattttgtt gcattggtag agtgttgtat
     5341 ggctagcatt gtattgtatg taattaattt tgcacaaaag caaacattta gcatagtagg
     5401 ttaattttgt ttgtttttat gaccatgcca aaataatatt ctgggctggt ggagaacaaa
     5461 ggactgttct ttaggactga aacttgattt tgctcatagt aagtaaaaaa aaacaaaaaa
     5521 cacacacact cacagatgtt gtttcgtaag tgttataagc actggatata aatggtattt
     5581 tttatcactt ctgactaatg tgaaactgtt gtacgaaaac tacatgaaca aaagtcatct
     5641 gtttcgactc gtgtgggctt gcctcacagt tgccggattt gagtcatttt tatgtcttgt
     5701 tatttcattt atttatgcaa aatacatgtg tgtatgaaca ctttgtttta gctccagctc
     5761 tgcctcagta ctggggttca tttactttta gccatgttct taaaaatgaa aggctattca
     5821 ggaatgatct gattgtaaac gtctttttca ttggatcaaa cagtaatgct gtatttgaat
     5881 ctaaattttg tgtataagca gtttatttat tagccaagtt tggctctaaa tatccatgga
     5941 aattaagaat gacaatcata gggatcaatt cattttattt tcagtggggc ttaaacaaag
     6001 tttatatgac tttaccatct cattttagat ttttctaatt gtgtaaatat aacatagaaa
     6061 tagaatttat ttttggttca tgaatactta gtgagatata agttatgtat ttcctttttg
     6121 ttctctatcc atagatgttg gtccaaactg aaagttgatg agtcactgtg cctctcgggg
     6181 tagtgagtta tcagctacag tgagagagca gtgtttggcc tgcagctggg acagcaaaac
     6241 gtttcaccag ggttctcatg cagttcagaa cccactgtcc acagatccag acatttccct
     6301 tttttcttac agaaagttga tgattggaca tactaaattt ccactacagt taggagacag
     6361 tcagtttgct ttgggagtct acataaatct tctaagatag ttctgtgacc atttaatagc
     6421 aagaagcatg aatgccacta caaaggcaaa aatccacctc tgagatcggc cgttaataaa
     6481 cgtcccgtca tgtcagttta gattcaagaa tgttaagcaa ctttgttttt gcggtgctcc
     6541 ctatttcata gtatcttcaa atcaaaaata aaaattatct ccattttgtt aaagaactta
     6601 cagggtcagg gttctccttg tcacttagaa ttgggacact gccaggcaat cctctcccaa
     6661 aaaaaaaaaa aaaaaaaaat agccatatgg aatggaagga aaaggagaaa agaaggaaga
     6721 aaggaaaaaa gtaggaaggg agagagaaaa aaaaggtcgc tttgcggata cgagccgcta
     6781 ggctgacaac ttttctattt cattggcaga tatgaagcag tgtcttttcc agtaaggtac
     6841 ggaagctttg ttgttttcat gtgtacccag ctcagccttt tagaagcacc tcggtttgct
     6901 tcattaggta tttgatactc tccagccttg tcctcaggcc tgatttgatt tgccagggtc
     6961 ctgacaccaa agcccaggcc aagttctaaa ttcaggtgtg ggctcacagt gctattgagc
     7021 ttgtcgaatt ctggcctccc ctgaacatta gccccacggg agcctgaggg tgtttgaaaa
     7081 gggcgtgatc actctagggc tgaaattaaa ggctgctttc ttttccttct gaagccaggc
     7141 tgcttcttcg gagtacaccc tcctgagcca ggagcacaag cactagcaga aagcagggat
     7201 tgtttcagga aagcccattt accctcagta ggaaggcagc ctggtcactt gaacagcaca
     7261 gctgaggctg cttctctcaa tttactcatt ttgcaaagaa ttgacctcta ccaactcatt
     7321 agggagagga aaaagaatca cttagtaatt ttaaatcata tgagaagtcc tgtaccaagt
     7381 gccaacaact gcaaagaaat gcagctagag gaatgtattg aaattactac tgggtcttcc
     7441 tttttaatga gaaaatgaca aaaatggttg ctgtagccct gcctgatttt gtacacgttt
     7501 gtctaagaat tgagttggca cttaagctca cttctcaaag tataataata ttgtatgacc
     7561 tcatttgtcc tttcacaaaa gcacttgcat catttcctta agtcatctgc tccctgacat
     7621 gttttcttcc ctaataaaca acttctgtct gttattcctg ccaatgatgt tctgtttctg
     7681 atgccatatc ctattgagcg tgcccctgta ctaatatcat tgaaaatatt gatatgcaaa
     7741 cacatttcct tttcatcccc attctatctt tccctttggg gacagattgc tttccaaaag
     7801 ctcatgaaca aatatttgga atgctggtac ctttggggca gaggtaaggg tgggcggggt
     7861 gggggcagaa aggtaatgct taatgcagat aactcttcta atcagtgtcc atggcaatat
     7921 gaacgcttga agaaaactca gtgacatatc ttgctcagta gtttcttatt cctgaagaac
     7981 cacaagcata aagtgaggcc tcagtgctgg tgctcttgga gtatggggaa tgtgcaaata
     8041 tttaactgtt ttgtatgctg cacattgcag gtctgctcat gtgcattctc cctttgtctt
     8101 cctttgtcat atgtgttttt gcttttttga aagtgcagtc tttattgtac cctcctccag
     8161 cttgtagcaa attagaatgc ttagcattta tgttcattca ttattgtatt tgccatgtaa
     8221 aatttttatt accttagaca agcttataag ctgttactac ataacttatc ttactgtaac
     8281 tcttttattt cccccgacgt tgtaatttgt ttgtgatgta tattgtgaaa ttgtattcta
     8341 tgttaattta atcagcacaa ttcactgaca tgctggactg acatgctggc tgctgtttca
     8401 aagtgtaaag tttgtgtagg gctgttggga caactgcaac tctgttgtca aggtactgtg
     8461 ctttggttcc tatagcaaca ctgggtgtgg cccttgaatt gctaagggca tttaatacat
     8521 cctggagcaa attttaactg cagattttct ttgtagaaat tctatgtata atgcaggtac
     8581 ctacttggcc catggctggt aactatttgg gcaattagaa aaaaagaaaa aaacataaaa
     8641 actagtgtct attgctgctt tgaatatgtt tgaaagtctg aaaatgtaaa tagtttatca
     8701 aaaaaaaatc ttgtacagtc cagtgtaaag tttttaaatg accttaaggg ttgccatcac
     8761 atctttctca cactctcctc ttgataataa taataataaa aagtttgcta aggattaaag
     8821 aaatgggaaa aataaaaaaa atctcttcaa atttacagga atgaatcatt gttcttagct
     8881 ttgttgcata cacaaacttc ttggattttg ttgtgcagta ttgacgtgag ataaagctca
     8941 acattgaata atctttcagt ggtacttttc aaagtcttcc cctcctctgc ctcataatta
     9001 agggaaaaga caaaattgaa agacacactg tctttatcta tcctggtgta tgttggcacc
     9061 ttagctactt tttttttttc ctttttgcac aaggtgcttt cctgatatgt tcaacatgcc
     9121 atctttgggt gataatgtat atgccgtgat ggggctcagg ccccttaggg gagtgtctat
     9181 aagaactgcc tatttatgct catttacctc aagactgtcc tctctaccct aatctagttg
     9241 tcatcactcc atcttttgta ctgctgttga cacttacaaa ttaaagataa attttgtttt
     9301 atga
//
