LOCUS       NP_001354802             828 aa            linear   PRI 27-APR-2025
DEFINITION  transcription factor SOX-6 isoform a [Homo sapiens].
ACCESSION   NP_001354802
VERSION     NP_001354802.1
DBSOURCE    REFSEQ: accession NM_001367873.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 828)
  AUTHORS   Lu,M.Y., Fang,C.Y., Hsieh,P.L., Chao,S.C., Liao,Y.W., Ohiro,Y.,
            Yu,C.C. and Ho,D.C.
  TITLE     MIAT promotes myofibroblastic activities and transformation in oral
            submucous fibrosis through sponging the miR-342-3p/SOX6 axis
  JOURNAL   Aging (Albany NY) 16 (19), 12909-12927 (2024)
   PUBMED   39379100
  REMARK    GeneRIF: MIAT promotes myofibroblastic activities and
            transformation in oral submucous fibrosis through sponging the
            miR-342-3p/SOX6 axis.
REFERENCE   2  (residues 1 to 828)
  AUTHORS   Li,M., Niu,M., Fan,X., Chen,F., Cao,H., Liu,Q., Gan,S., Yue,P. and
            Gao,J.
  TITLE     LncRNA MIR181A2HG inhibits keratinocytes proliferation through
            miR-223-3p/SOX6 axis
  JOURNAL   Aging (Albany NY) 16 (11), 9846-9858 (2024)
   PUBMED   38848163
  REMARK    GeneRIF: LncRNA MIR181A2HG inhibits keratinocytes proliferation
            through miR-223-3p/SOX6 axis.
REFERENCE   3  (residues 1 to 828)
  AUTHORS   Pastori,V., Zambanini,G., Citterio,E., Weiss,T., Nakamura,Y.,
            Cantu,C. and Ronchi,A.E.
  TITLE     Transcriptional repression of the oncofetal LIN28B gene by the
            transcription factor SOX6
  JOURNAL   Sci Rep 14 (1), 10287 (2024)
   PUBMED   38704454
  REMARK    GeneRIF: Transcriptional repression of the oncofetal LIN28B gene by
            the transcription factor SOX6.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 828)
  AUTHORS   Zheng,H., Liu,M., Shi,S., Huang,H., Yang,X., Luo,Z., Song,Y.,
            Xu,Q., Li,T., Xue,L., Lu,F. and Wang,J.
  TITLE     MAP4K4 and WT1 mediate SOX6-induced cellular senescence by
            synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling
            pathway in cervical cancer
  JOURNAL   Mol Oncol 18 (5), 1327-1346 (2024)
   PUBMED   38383842
  REMARK    GeneRIF: MAP4K4 and WT1 mediate SOX6-induced cellular senescence by
            synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling
            pathway in cervical cancer.
REFERENCE   5  (residues 1 to 828)
  AUTHORS   Li,S. and Wang,Y.
  TITLE     Regulatory mechanism of DDX5 in ox-LDL-induced endothelial cell
            injury through the miR-640/SOX6 axis
  JOURNAL   Clin Hemorheol Microcirc 88 (2), 157-170 (2024)
   PUBMED   39093065
  REMARK    GeneRIF: Regulatory mechanism of DDX5 in ox-LDL-induced endothelial
            cell injury through the miR-640/SOX6 axis.
REFERENCE   6  (residues 1 to 828)
  AUTHORS   Ueda,R., Iizuka,Y., Yoshida,K., Kawase,T., Kawakami,Y. and Toda,M.
  TITLE     Identification of a human glioma antigen, SOX6, recognized by
            patients' sera
  JOURNAL   Oncogene 23 (7), 1420-1427 (2004)
   PUBMED   14691456
REFERENCE   7  (residues 1 to 828)
  AUTHORS   Cohen-Barak,O., Hagiwara,N., Arlt,M.F., Horton,J.P. and
            Brilliant,M.H.
  TITLE     Cloning, characterization and chromosome mapping of the human SOX6
            gene
  JOURNAL   Gene 265 (1-2), 157-164 (2001)
   PUBMED   11255018
REFERENCE   8  (residues 1 to 828)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (residues 1 to 828)
  AUTHORS   Hagiwara,N., Klewer,S.E., Samson,R.A., Erickson,D.T., Lyon,M.F. and
            Brilliant,M.H.
  TITLE     Sox6 is a candidate gene for p100H myopathy, heart block, and
            sudden neonatal death
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4180-4185 (2000)
   PUBMED   10760285
REFERENCE   10 (residues 1 to 828)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027016.4, AC013595.11,
            AC068405.5, AC103794.2 and AC009869.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the D subfamily of sex
            determining region y-related transcription factors that are
            characterized by a conserved DNA-binding domain termed the high
            mobility group box and by their ability to bind the minor groove of
            DNA. The encoded protein is a transcriptional activator that is
            required for normal development of the central nervous system,
            chondrogenesis and maintenance of cardiac and skeletal muscle
            cells. The encoded protein interacts with other family members to
            cooperatively activate gene expression. Alternative splicing
            results in multiple transcript variants.[provided by RefSeq, Mar
            2009].
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (a). Variants 4 and 6 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.70283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000683767.1/
                                                ENSP00000507545.1
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     Protein         1..828
                     /product="transcription factor SOX-6 isoform a"
                     /note="SRY-box containing gene 6; transcription factor
                     SOX-6; SRY-box 6; SRY (sex determining region Y)-box 6"
                     /calculated_mol_wt=91791
     Region          1..51
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P35712.3)"
     Site            119
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P35712.3)"
     Region          380..470
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P35712.3)"
     Site            399
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P35712.3)"
     Site            401
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P40645; propagated from
                     UniProtKB/Swiss-Prot (P35712.3)"
     Site            439
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P35712.3)"
     Site            442
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P40645; propagated from
                     UniProtKB/Swiss-Prot (P35712.3)"
     Region          619..696
                     /region_name="HMG-box_EGL13-like"
                     /note="high mobility group (HMG)-box found in
                     Caenorhabditis elegans protein egg laying defective 13
                     (EGL-13) and similar proteins; cd22042"
                     /db_xref="CDD:438848"
     Site            order(620,622..623,625..626,628..629,633,636,640,647..649,
                     652..653,656,659..660,678,688,690..693)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438848"
     Region          753..828
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P35712.3)"
     CDS             1..828
                     /gene="SOX6"
                     /gene_synonym="HSSOX6; SOXD; TOLCAS"
                     /coded_by="NM_001367873.1:458..2944"
                     /note="isoform a is encoded by transcript variant 6"
                     /db_xref="CCDS:CCDS91447.1"
                     /db_xref="GeneID:55553"
                     /db_xref="HGNC:HGNC:16421"
                     /db_xref="MIM:607257"
ORIGIN      
        1 msskqatspf acaadgedam tqdltsreke egsdqhvash lplhpimhnk phseelptlv
       61 stiqqdadwd svlssqqrme sennklcsly sfrntstsph kpdegsrdre imtsvtfgtp
      121 errkgsladv vdtlkqkkle emtrteqeds scmekllskd wkekmerlnt sellgeikgt
      181 peslaekerq lstmitqlis lreqllaahd eqkklaasqi ekqrqqmdla rqqqeqiarq
      241 qqqllqqqhk inllqqqiqv qghmpplmip ifphdqrtla aaaaaqqgfl fppgitykpg
      301 dnypvqfips tmaaaaasgl splqlqkghv shpqinqrlk glsdrfgrnl dtfehggghs
      361 ynhkqieqly aaqlasmqvs pgakmpstpq ppntagtvsp tgiknekrgt spvtqvkdea
      421 aaqplnlssr pktaepvksp tsptqnlfpa sktspvnlpn kssipspigg slgrgssldi
      481 lsslnspalf gdqdtvmkai qearkmreqi qreqqqqqph gvdgklssin nmglnscrne
      541 kertrfenlg pqltgksned gklgpgvidl trpedaegsk amngsaaklq qyycwptgga
      601 tvaearvyrd argrasseph ikrpmnafmv wakderrkil qafpdmhnsn iskilgsrwk
      661 smsnqekqpy yeeqarlski hlekypnyky kprpkrtciv dgkklrigey kqlmrsrrqe
      721 mrqfftvgqq pqipittgtg vvypgaitma tttpspqmts dcsstsaspe pslpviqsty
      781 gmktdggsla gnemingede memyddyedd pksdyssene apeavsan
//
