LOCUS       NM_006940               7076 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens SRY-box transcription factor 5 (SOX5), transcript
            variant 1, mRNA.
ACCESSION   NM_006940
VERSION     NM_006940.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7076)
  AUTHORS   Wang,Z., Wei,B. and Ma,S.
  TITLE     EGR1/LINC00839/SOX5 axis modulates migration, invasion and
            Gemcitabine resistance of bladder cancer cells
  JOURNAL   Cancer Biol Ther 24 (1), 2270106 (2023)
   PUBMED   37862152
  REMARK    GeneRIF: EGR1/LINC00839/SOX5 axis modulates migration, invasion and
            Gemcitabine resistance of bladder cancer cells.
REFERENCE   2  (bases 1 to 7076)
  AUTHORS   Tenorio-Castano,J., Gomez,A.S., Coronado,M., Rodriguez-Martin,P.,
            Parra,A., Pascual,P., Cazalla,M., Gallego,N., Arias,P.,
            Morales,A.V., Nevado,J. and Lapunzina,P.
  TITLE     Lamb-Shaffer syndrome: 20 Spanish patients and literature review
            expands the view of neurodevelopmental disorders caused by SOX5
            haploinsufficiency
  JOURNAL   Clin Genet 104 (6), 637-647 (2023)
   PUBMED   37702321
  REMARK    GeneRIF: Lamb-Shaffer syndrome: 20 Spanish patients and literature
            review expands the view of neurodevelopmental disorders caused by
            SOX5 haploinsufficiency.
            Review article
REFERENCE   3  (bases 1 to 7076)
  AUTHORS   Liang,Q., Chu,F., Zhang,L., Jiang,Y., Li,L. and Wu,H.
  TITLE     circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and
            Inhibits the Development of Gastric Cancer with Cisplatin
            Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition
  JOURNAL   Gut Liver 17 (3), 389-403 (2023)
   PUBMED   35975639
  REMARK    GeneRIF: circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance
            and Inhibits the Development of Gastric Cancer with Cisplatin
            Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
REFERENCE   4  (bases 1 to 7076)
  AUTHORS   Wu,L., Yang,Z., Dai,G., Fan,B., Yuan,J., Liu,Y., Liu,P. and Ou,Z.
  TITLE     SOX5 promotes cell growth and migration through modulating the
            DNMT1/p21 pathway in bladder cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (7), 987-998 (2022)
   PUBMED   35880568
  REMARK    GeneRIF: SOX5 promotes cell growth and migration through modulating
            the DNMT1/p21 pathway in bladder cancer.
REFERENCE   5  (bases 1 to 7076)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7076)
  AUTHORS   Rakhmanov,M., Sic,H., Kienzler,A.K., Fischer,B., Rizzi,M.,
            Seidl,M., Melkaoui,K., Unger,S., Moehle,L., Schmit,N.E.,
            Deshmukh,S.D., Ayata,C.K., Schuh,W., Zhang,Z., Cosset,F.L.,
            Verhoeyen,E., Peter,H.H., Voll,R.E., Salzer,U., Eibel,H. and
            Warnatz,K.
  TITLE     High levels of SOX5 decrease proliferative capacity of human B
            cells, but permit plasmablast differentiation
  JOURNAL   PLoS One 9 (6), e100328 (2014)
   PUBMED   24945754
  REMARK    GeneRIF: These findings describe for the first time a functional
            role of SOX5 during late B cell development reducing the
            proliferative capacity and thus potentially affecting the
            differentiation of B cells.
            GeneRIF: Identified two new splice variants of SOX5 in human B
            cells, encoding the known L-SOX5B isoform and a new shorter isoform
            L-SOX5F. SOX5 limits the proliferative capacity of human primary B
            lymphocytes and potentially affects the differentiation of human B
            cells during the germinal center responses.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7076)
  AUTHORS   Lefebvre,V., Li,P. and de Crombrugghe,B.
  TITLE     A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in
            chondrogenesis and cooperatively activate the type II collagen gene
  JOURNAL   EMBO J 17 (19), 5718-5733 (1998)
   PUBMED   9755172
REFERENCE   8  (bases 1 to 7076)
  AUTHORS   Wunderle,V.M., Critcher,R., Ashworth,A. and Goodfellow,P.N.
  TITLE     Cloning and characterization of SOX5, a new member of the human SOX
            gene family
  JOURNAL   Genomics 36 (2), 354-358 (1996)
   PUBMED   8812465
REFERENCE   9  (bases 1 to 7076)
  AUTHORS   Connor,F., Cary,P.D., Read,C.M., Preston,N.S., Driscoll,P.C.,
            Denny,P., Crane-Robinson,C. and Ashworth,A.
  TITLE     DNA binding and bending properties of the post-meiotically
            expressed Sry-related protein Sox-5
  JOURNAL   Nucleic Acids Res 22 (16), 3339-3346 (1994)
   PUBMED   8078769
REFERENCE   10 (bases 1 to 7076)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB081589.1, BX098902.1,
            AC087244.17 and BM988193.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006940.5.
            
            Summary: This gene encodes a member of the SOX (SRY-related
            HMG-box) family of transcription factors involved in the regulation
            of embryonic development and in the determination of the cell fate.
            The encoded protein may act as a transcriptional regulator after
            forming a protein complex with other proteins. The encoded protein
            may play a role in chondrogenesis. A pseudogene of this gene is
            located on chromosome 8. Multiple transcript variants encoding
            distinct isoforms have been identified for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a, also called L-SOX5A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.166242.1,
                                           SRR1803616.167655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451604.7/ ENSP00000398273.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4228              AB081589.1         34-4261
            4229-4607           BX098902.1         1-379               c
            4608-6603           AC087244.17        92052-94047
            6604-7076           BM988193.1         18-490              c
FEATURES             Location/Qualifiers
     source          1..7076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..7076
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /note="SRY-box transcription factor 5"
                     /db_xref="GeneID:6660"
                     /db_xref="HGNC:HGNC:11201"
                     /db_xref="MIM:604975"
     exon            1..107
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2361
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription factor SOX-5; SRY (sex determining region
                     Y)-box 5; SRY-box 5"
                     /codon_start=1
                     /product="transcription factor SOX-5 isoform a"
                     /protein_id="NP_008871.3"
                     /db_xref="CCDS:CCDS8699.1"
                     /db_xref="GeneID:6660"
                     /db_xref="HGNC:HGNC:11201"
                     /db_xref="MIM:604975"
                     /translation="MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEES
                     DGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFA
                     PHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPE
                     ETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLA
                     AHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLP
                     PLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLG
                     PLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVA
                     QPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYL
                     NDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQL
                     AVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVW
                     AKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYK
                     YKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIA
                     MAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYD
                     EEEDDPDVDYGSDSENHIAGQAN"
     exon            108..339
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            340..550
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            551..637
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            638..810
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            811..879
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1000
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1086
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1233
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1411
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1557
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1666
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1840
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2057
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..7076
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2672..2677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /note="hexamer: AATAAA"
     polyA_site      2700
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
     regulatory      7051..7056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /note="hexamer: AATAAA"
     polyA_site      7076
                     /gene="SOX5"
                     /gene_synonym="L-SOX5; L-SOX5B; L-SOX5F; LAMSHF"
                     /note="major polyA site"
ORIGIN      
        1 acttgacagg ttcagttgga gacgatcata ggtggctgct gtgacaaagg gaaattgtgc
       61 ttttccagca tgcttactga ccctgattta cctcaggagt ttgaaaggat gtcttccaag
      121 cgaccagcct ctccgtatgg ggaagcagat ggagaggtag ccatggtgac aagcagacag
      181 aaagtggaag aagaggagag tgacgggctc ccagcctttc accttccctt gcatgtgagt
      241 tttcccaaca agcctcactc tgaggaattt cagccagttt ctctgctgac gcaagagact
      301 tgtggccata ggactcccac ttctcagcac aatacaatgg aagttgatgg caataaagtt
      361 atgtcttcat ttgccccaca caactcatct acctcacctc agaaggcaga agaaggtggg
      421 cgacagagtg gcgagtcctt gtctagtaca gccctgggaa ctcctgaacg gcgcaagggc
      481 agtttagctg atgttgttga caccttgaag cagaggaaaa tggaagagct catcaaaaac
      541 gagccggaag aaacccccag tattgaaaaa ctactctcaa aggactggaa agacaagctt
      601 cttgcaatgg gatcggggaa ctttggcgaa ataaaaggga ctcccgagag cttagctgag
      661 aaagaaaggc aactcatggg tatgatcaac cagctgacca gcctccgaga gcagctgttg
      721 gctgcccacg atgagcagaa gaaactagct gcctctcaga ttgagaaaca gcgtcagcaa
      781 atggagctgg ccaagcagca acaagaacaa attgcaagac agcagcagca gcttctacag
      841 caacaacaca aaatcaattt gctccagcaa cagatccagg ttcaaggtca gctgccgcca
      901 ttaatgattc ccgtattccc tcctgatcaa cggacactgg ctgcagctgc ccagcaagga
      961 ttcctcctcc ctccaggctt cagctataag gctggatgta gtgaccctta ccctgttcag
     1021 ctgatcccaa ctaccatggc agctgctgcc gcagcaacac caggcttagg cccactccaa
     1081 ctgcagcagt tatatgctgc ccagctagct gcaatgcagg tatctccagg agggaagctg
     1141 ccaggcatac cccaaggcaa ccttggtgct gctgtatctc ctaccagcat tcacacagac
     1201 aagagcacaa acagcccacc acccaaaagc aaggatgaag tggcacagcc actgaaccta
     1261 tcagctaaac ccaagacctc tgatggcaaa tcacccacat cacccacctc tccccatatg
     1321 ccagctctga gaataaacag tggggcaggc cccctcaaag cctctgtccc agcagcgtta
     1381 gctagtcctt cagccagagt tagcacaata ggttacttaa atgaccatga tgctgtcacc
     1441 aaggcaatcc aagaagctcg gcaaatgaag gagcaactcc gacgggaaca acaggtgctt
     1501 gatgggaagg tggctgttgt gaatagtctg ggtctcaata actgccgaac agaaaaggaa
     1561 aaaacaacac tggagagtct gactcagcaa ctggcagtta aacagaatga agaaggaaaa
     1621 tttagccatg caatgatgga tttcaatctg agtggagatt ctgatggaag tgctggagtc
     1681 tcagagtcaa gaatttatag ggaatcccga gggcgtggta gcaatgaacc ccacataaag
     1741 cgtccaatga atgccttcat ggtgtgggct aaagatgaac ggagaaagat ccttcaagcc
     1801 tttcctgaca tgcacaactc caacatcagc aagatattgg gatctcgctg gaaagctatg
     1861 acaaacctag agaaacagcc atattatgag gagcaagccc gtctcagcaa gcagcacctg
     1921 gagaagtacc ctgactataa gtacaagccc aggccaaagc gcacctgcct ggtggatggc
     1981 aaaaagctgc gcattggtga atacaaggca atcatgcgca acaggcggca ggaaatgcgg
     2041 cagtacttca atgttgggca acaagcacag atccccattg ccactgctgg tgttgtgtac
     2101 cctggagcca tcgccatggc tgggatgccc tcccctcacc tgccctcgga gcactcaagc
     2161 gtgtctagca gcccagagcc tgggatgcct gttatccaga gcacttacgg tgtgaaagga
     2221 gaggagccac atatcaaaga agagatacag gccgaggaca tcaatggaga aatttatgat
     2281 gagtacgacg aggaagagga tgatccagat gtagattatg ggagtgacag tgaaaaccat
     2341 attgcaggac aagccaactg ataagggtca aaagattgtt gtgaccttag gacttaaaga
     2401 agccctaact ggttcatcct taccagtggc caagcacatt aactttctca tacactgact
     2461 gttactttaa ctgttagtct taaatagttg ggacatcagc tgactaatag acctcagcct
     2521 caaaaggctt ggaaagaaaa aacaaataca acaagcaaac aacaatatca acaacaagag
     2581 attgaaataa gctatgggta aaataatgcc agtaattcag ctgctacatc caagcactga
     2641 agtcttaccc gtcaactttt tttttttttt aaataaactt tatggctgtt tgttctacaa
     2701 tgttctagaa attctcactc aggtacacag tgccaacaag tggcttgtga atgtgttttg
     2761 ttgttttgtg ctacaatttt taaaaagaaa aaagttttgt tttgtttttt ggggtttctg
     2821 ggttttttcc ttttcttttt ctttcctttc attttttttc tttgtaatgc acctgacaga
     2881 aaaaaaagaa aaatgaattt ctctttactt ctctccacct tctccatctc tctactttaa
     2941 agatggaagt ctgtgcatga ggggaaagag ggaaaaagag cctgttttta acttccttgc
     3001 tatccaccac aaaataagca attattttct ttagaggact ttatctattg cacaccacac
     3061 tacatctttg agcaagtgcc aaatttgtac tgaagtgttg accaagttca ttttttctct
     3121 ttactttttc cttttccttc ttaagttagg acagtgttaa atcttagaca atcccttgaa
     3181 aaacctgaaa taccagcagc tggtgagatt tgactttttt ttttaatgga aactgtaggt
     3241 gctgttctca ggtgaaaaga gagagagaga gagagacata agaaatttag agaaaaatat
     3301 tttctgatct tggatttttg tgtgtatgta tgtatgtgat tatggtacta ataataggaa
     3361 taacgttgga ccattgtgag ttaaacccac atctggggat gaaatcccac atcctcccaa
     3421 gtgactggtc tagaaataat cttgaccttg actttgcact tcaaatgaca acttaaccaa
     3481 gtatagggct cagaaattat atttttaaat gtctgattat tattggatgg atcaggtggc
     3541 cctgtgtaat agaggtgtgc atgtataaca tggaagctac tagcaaactg ctcccagatg
     3601 tcctttctcc ctggtcagtt ggttccatta acgtttgcta cttagtgatt tttgtttttc
     3661 ctgttgatat tttgagcaaa acaatcattg ttttcattga atatatttgg ccattttttc
     3721 agacaaatag aattagctta tttcttcaac attccatcct ttcccgatca ggaaatgaaa
     3781 ctgatgattt tataaggtat ttttcacccc tccatgaagt gaggtggagg cctttagcat
     3841 ttcagaagtg tgggccatat gtagttcatg ccataaaaag taggatttaa ttaaaagtca
     3901 ttgcagccca ataaaatgga gcctggctgc acccagggat ccttgccact gctcttccct
     3961 tgctgtcaga ttaatccact gaagtccaac tttggttcaa gcagagtatt tgcaaagagc
     4021 aacaactgaa tgtgatggga ctgcttatgt agattttgcc agccaaatgc caaggcagtt
     4081 gtagggcctg tacaaataaa tgcaaaatca tttcaagtca attgccatta tttgtattga
     4141 agtatcagat agatagtaaa tactgcaact agtagcttga tgtgctatag ttttcactcc
     4201 agtcatcatt ttcctatctc accccccgaa acaccaccct aaagttggat ttttacatat
     4261 aaataaaaaa agaatccctt ttatttttct ctctctcaga agacttgctc tggggttttg
     4321 cttggaggag ctgatcatat cctgcatgtc agagatttca ttttgtttgt ttttctgttt
     4381 gtttgttttt gatgacttta tttacatttg aactgcctct ttttgctagt gttgtaatga
     4441 tgatgatgat aaaataataa taataatagt aataataata ataatggtca gctgttccca
     4501 gattagtaag ttatgtataa tttattttat ttctcccttt ctattttatt ctgctctgat
     4561 ttggaagtgc agccaataag ctgttagata tttaaaacaa atttccatct ccaactcata
     4621 tatgtatgta tatgtatata tatatataca tatatataca cacatataca cacacacaca
     4681 cacatttacc cacaatttta cttctctttc cgtaagtttt ctctttttta agaattttgg
     4741 ccccaacaat atcagttctg atgtttaaaa caaaggagtg aattaatagg agggtcgtgt
     4801 tcaatcttaa ttaacttatg ctctcatcac tcattttagt tatttaattg ccacagtcat
     4861 ctagagccaa tttttttttg tttttgtttg ttttgttttt aagcactctg gataaggaaa
     4921 aaatagacac ttgtttttat atcattttta tgtacaatgt gaaaacagat ttttaaaaaa
     4981 tttgttctct gtctttgtta acaaattcct tccgatttat gtgggttcac ctctcacgtt
     5041 tgctggatac ttactttaca ccatgttatg aaagatgctt tgttttcatt tcatgagttt
     5101 gggctacaag aatactttgt tttagctcca ggtagatgcc attgaaggca ttcatggctg
     5161 aaatcaattc taacacactt accgatgaat tgacaacact ttggtgtttg gtcttttttt
     5221 tgttatattt tgttttattt gaaggggaaa acaaaattgt taatggtgac ttttaactgc
     5281 tgaaattcaa aatttgattt tagttaggtt tatgtccgag actaaactgt gcatgaaccg
     5341 aaacaaaaag caagttcata ccgctgcatt ctgttctctt gttctgacgg ttaattcact
     5401 ggacatcaaa ttttctttgc cctagttttc cccaaaagaa aacaaaagca aaaatagtta
     5461 tattaatgtt gaaagtgctt tgaagtcact tgataaaagg tgctatgaat agcaacttac
     5521 tgtgttacta cattgccttt ttggcattgg ttgatttata attttggtaa aggatcctaa
     5581 aaccctgtat tctttttctg tgccccataa tgaccaaaaa agataaagaa aatgagagta
     5641 agatcaaaag atcaaactaa aacataaaca gtctccttcc tgtctgcttt cttacctatc
     5701 tgttcacact ttatctcttt ccctttctct ctctctctca catgcgcgcg cgcgcgcgcg
     5761 cacacacaca cacacacaca cttgccccaa cactgagaaa taatcttgcc agaattctgg
     5821 tttttatagt tgttgtagtc cgtttctcta aaaatagtcc tgttttcata tgaatctaag
     5881 agaacattac cggagaaaat aaagttactc atttatagtt actaataata agttagtgat
     5941 taacttacca caattggata aaatataaaa ctattcttca gcacatttat acctaaatta
     6001 gtgaagtcca tttgtgaagt tcatttggca tctgcagtta agagttaacc atgtataaaa
     6061 tccctcccaa agaacataat catcgttaga accaaatcct cttataaaga acaaatataa
     6121 aaaagttttc tgtggtgaag ctattttata gatttgattt ccggagtaga attttacctt
     6181 aattcactta aagaaaatta accatttttt ggtccaactt cagatatttt cttaatccag
     6241 aagctgtgac tgttcccaga agaaacctct tatatcacat ttaaaacata aaaaataatt
     6301 acactttcac tcattctaat gggtaaattg ttgaattgta ataaacaact gtatatttac
     6361 aaacaggttt ataaggtatt tgtctatcaa attaataata aaataaaact tacggggtct
     6421 gcaaggaaaa ctatgaaggc cacttaaagt ggttcaggta tccctttgtc ttgtagggca
     6481 tagctgttgg tttagccagg cttttacagt atttaatttt aaagtatcct ataactatca
     6541 acttcccagg ttgaagacga tgtgttgagt ttcctactga ttgattgatt cctgtcctcc
     6601 ccagtgtttc cgtcactggt tcactaaaac agtatttata tagctccact ggctctaaag
     6661 ctcttagtcc ttctaatatt ttggatttta caagtaaaaa tggaaaaaaa atagaaaaga
     6721 gacaatcaaa tgcctggagc ttaaaacaaa gtatgtgcaa cctaccatct cacttgaaat
     6781 ttaataaaat aataagtaat tatgtaaata taacatagag ttatagattt atattttgtt
     6841 cataacacat agtgtaatat aagttgtata ttttcatgtt tttggtttta tgttatcatt
     6901 catgccacaa taaaaataaa acaggagttt atgtgctctt aaaaaaaaga tgtgggttgc
     6961 caccaacctg tttttcgttt ttgttttttg tttattttat tttatttttt tgcattctcc
     7021 tttttcagta ttactgccat gcaaggcacc aataaaaaca gcaaatgtgt tcttta
//
