LOCUS       NM_003107               4869 bp    mRNA    linear   PRI 01-MAR-2025
DEFINITION  Homo sapiens SRY-box transcription factor 4 (SOX4), mRNA.
ACCESSION   NM_003107
VERSION     NM_003107.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4869)
  AUTHORS   Jing,N., Tao,Z., Du,X., Wen,Z., Gao,W.Q., Dong,B. and Fang,Y.X.
  TITLE     Targeting SOX4/PCK2 signaling suppresses neuroendocrine
            trans-differentiation of castration-resistant prostate cancer
  JOURNAL   Biol Direct 19 (1), 56 (2024)
   PUBMED   39014441
  REMARK    GeneRIF: Targeting SOX4/PCK2 signaling suppresses neuroendocrine
            trans-differentiation of castration-resistant prostate cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4869)
  AUTHORS   Song,C., Wang,G., Liu,M., Han,S., Dong,M., Peng,M., Wang,W.,
            Wang,Y., Xu,Y. and Liu,L.
  TITLE     Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic
            insight into IQGAP1 phosphorylation and pancreatic Cancer
            progression
  JOURNAL   J Transl Med 22 (1), 602 (2024)
   PUBMED   38943117
  REMARK    GeneRIF: Deciphering the SOX4/MAPK1 regulatory axis: a
            phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic
            Cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4869)
  AUTHORS   Chen,Y., Li,B.X., Niu,T.T., Yang,S.J., Wu,L.C., Shi,L.H., Zou,D.B.,
            Wu,N.N., Sheng,L.X., Yan,X., Ouyang,G.F. and Mu,Q.T.
  TITLE     Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through
            the miR-652-3p/SOX4 Axis
  JOURNAL   Curr Med Sci 44 (3), 611-622 (2024)
   PUBMED   38842772
  REMARK    GeneRIF: Circ_0012152 Accelerates Acute Myeloid Leukemia
            Progression through the miR-652-3p/SOX4 Axis.
REFERENCE   4  (bases 1 to 4869)
  AUTHORS   Wang,Y., Yang,J., Wu,C., Guo,Y., Ding,Y. and Zou,X.
  TITLE     LncRNA SNHG14 silencing attenuates the progression of diabetic
            nephropathy via the miR-30e-5p/SOX4 axis
  JOURNAL   J Diabetes 16 (6), e13565 (2024)
   PUBMED   38751373
  REMARK    GeneRIF: LncRNA SNHG14 silencing attenuates the progression of
            diabetic nephropathy via the miR-30e-5p/SOX4 axis.
REFERENCE   5  (bases 1 to 4869)
  AUTHORS   Wang,S., Zhu,X., Hao,Y., Su,T.T. and Shi,W.
  TITLE     ALKBH5-mediated m6A modification of circFOXP1 promotes gastric
            cancer progression by regulating SOX4 expression and sponging
            miR-338-3p
  JOURNAL   Commun Biol 7 (1), 565 (2024)
   PUBMED   38745044
  REMARK    GeneRIF: ALKBH5-mediated m6A modification of circFOXP1 promotes
            gastric cancer progression by regulating SOX4 expression and
            sponging miR-338-3p.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4869)
  AUTHORS   Wotton,D., Lake,R.A., Farr,C.J. and Owen,M.J.
  TITLE     The high mobility group transcription factor, SOX4, transactivates
            the human CD2 enhancer
  JOURNAL   J Biol Chem 270 (13), 7515-7522 (1995)
   PUBMED   7706298
REFERENCE   7  (bases 1 to 4869)
  AUTHORS   van de Wetering,M., Oosterwegel,M., van Norren,K. and Clevers,H.
  TITLE     Sox-4, an Sry-like HMG box protein, is a transcriptional activator
            in lymphocytes
  JOURNAL   EMBO J 12 (10), 3847-3854 (1993)
   PUBMED   8404853
REFERENCE   8  (bases 1 to 4869)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
REFERENCE   9  (bases 1 to 4869)
  AUTHORS   Farr,C.J., Easty,D.J., Ragoussis,J., Collignon,J., Lovell-Badge,R.
            and Goodfellow,P.N.
  TITLE     Characterization and mapping of the human SOX4 gene
  JOURNAL   Mamm Genome 4 (10), 577-584 (1993)
   PUBMED   8268656
REFERENCE   10 (bases 1 to 4869)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM817788.1, X70683.1,
            CN419098.1, CX873598.1, HY065060.1, AL136179.15, CF147018.1 and
            AJ420500.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003107.2.
            
            Summary: This intronless gene encodes a member of the SOX
            (SRY-related HMG-box) family of transcription factors involved in
            the regulation of embryonic development and in the determination of
            the cell fate. The encoded protein may act as a transcriptional
            regulator after forming a protein complex with other proteins, such
            as syndecan binding protein (syntenin). The protein may function in
            the apoptosis pathway leading to cell death as well as to
            tumorigenesis and may mediate downstream effects of parathyroid
            hormone (PTH) and PTH-related protein (PTHrP) in bone development.
            The solution structure has been resolved for the HMG-box of a
            similar mouse protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X70683.1, SRR1163658.196647.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244745.4/ ENSP00000244745.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               BM817788.1         11-448
            439-2341            X70683.1           5-1907
            2342-2794           CN419098.1         6-458
            2795-3222           CX873598.1         11-438              c
            3223-3557           HY065060.1         122-456
            3558-3565           AL136179.15        13006-13013
            3566-3780           CF147018.1         164-378
            3781-3791           AL136179.15        13229-13239
            3792-4869           AJ420500.1         121-1198
FEATURES             Location/Qualifiers
     source          1..4869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..4869
                     /gene="SOX4"
                     /gene_synonym="CSS10; EVI16"
                     /note="SRY-box transcription factor 4"
                     /db_xref="GeneID:6659"
                     /db_xref="HGNC:HGNC:11200"
                     /db_xref="MIM:184430"
     exon            1..4869
                     /gene="SOX4"
                     /gene_synonym="CSS10; EVI16"
                     /inference="alignment:Splign:2.1.0"
     CDS             785..2209
                     /gene="SOX4"
                     /gene_synonym="CSS10; EVI16"
                     /note="SRY-related HMG-box gene 4; ecotropic viral
                     integration site 16; SRY (sex determining region Y)-box 4;
                     SRY-box 4"
                     /codon_start=1
                     /product="transcription factor SOX-4"
                     /protein_id="NP_003098.1"
                     /db_xref="CCDS:CCDS4547.1"
                     /db_xref="GeneID:6659"
                     /db_xref="HGNC:HGNC:11200"
                     /db_xref="MIM:184430"
                     /translation="MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGG
                     KADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKD
                     SDKIPFIREAERLRLKHMADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGG
                     SGGGGHGGGGGGGSSNAGGGGGGASGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKL
                     ILAGGGGGGKAAAAAAASFAAEQAGAAALLPLGAAADHHSLYKARTPSASASASSAAS
                     ASAALAAPGKHLAEKKVKRVYLFGGLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSP
                     DAPSLSGRSSAASSPAAGRSPADHRGYASLRAASPAPSSAPSHASSSASSHSSSSSSS
                     GSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYC
                     TPEVSEMISGDWLESSISNLVFTY"
     regulatory      4841..4846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX4"
                     /gene_synonym="CSS10; EVI16"
                     /note="hexamer: AATAAA"
     polyA_site      4869
                     /gene="SOX4"
                     /gene_synonym="CSS10; EVI16"
                     /note="major polyA site"
ORIGIN      
        1 gctctaagct gcagcaagag aaactgtgtg tgaggggaag aggcctgttt cgctgtcggg
       61 tctctagttc ttgcacgctc tttaagagtc tgcactggag gaactcctgc cattaccagc
      121 tcccttcttg cagaagggag ggggaaacat acatttattc atgccagtct gttgcatgca
      181 ggctttttgg cttcctacct tgcaacaaaa taattgcacc aactccttag tgccgattcc
      241 gcccacagag agtcctggag ccacagtctt ttttgctttg cattgtagga gagggactaa
      301 gtgctagaga ctatgtcgct ttcctgagct accgagagcg ctcgtgaact ggaatcaact
      361 gcttcaggga aaaagaaaaa aaaaaaaaaa agacttgcct gggaggccgc gagaaacttg
      421 cattggaagc ttcagcaacc agcattcgag aaactcctct ctactttagc acggtctcca
      481 gactcagccg agagacagca aactgcagcg cggtgagaga gcgagagaga gggagagaga
      541 gactctccag cctgggaact ataactcctc tgcgagaggc ggagaactcc ttccccaaat
      601 cttttgggga cttttctctc tttacccacc tccgcccctg cgaggagttg aggggccagt
      661 tcggccgccg cgcgcgtctt cccgttcggc gtgtgcttgg cccggggaac cgggagggcc
      721 cggcgatcgc gcggcggccg ccgcgagggt gtgagcgcgc gtgggcgccc gccgagccga
      781 ggccatggtg cagcaaacca acaatgccga gaacacggaa gcgctgctgg ccggcgagag
      841 ctcggactcg ggcgccggcc tcgagctggg aatcgcctcc tcccccacgc ccggctccac
      901 cgcctccacg ggcggcaagg ccgacgaccc gagctggtgc aagaccccga gtgggcacat
      961 caagcgaccc atgaacgcct tcatggtgtg gtcgcagatc gagcggcgca agatcatgga
     1021 gcagtcgccc gacatgcaca acgccgagat ctccaagcgg ctgggcaaac gctggaagct
     1081 gctcaaagac agcgacaaga tccctttcat tcgagaggcg gagcggctgc gcctcaagca
     1141 catggctgac taccccgact acaagtaccg gcccaggaag aaggtgaagt ccggcaacgc
     1201 caactccagc tcctcggccg ccgcctcctc caagccgggg gagaagggag acaaggtcgg
     1261 tggcagtggc gggggcggcc atgggggcgg cggcggcggc gggagcagca acgcgggggg
     1321 aggaggcggc ggtgcgagtg gcggcggcgc caactccaaa ccggcgcaga aaaagagctg
     1381 cggctccaaa gtggcgggcg gcgcgggcgg tggggttagc aaaccgcacg ccaagctcat
     1441 cctggcaggc ggcggcggcg gcgggaaagc agcggctgcc gccgccgcct ccttcgccgc
     1501 cgaacaggcg ggggccgccg ccctgctgcc cctgggcgcc gccgccgacc accactcgct
     1561 gtacaaggcg cggactccca gcgcctcggc ctccgcctcc tcggcagcct cggcctccgc
     1621 agcgctcgcg gccccgggca agcacctggc ggagaagaag gtgaagcgcg tctacctgtt
     1681 cggcggcctg ggcacgtcgt cgtcgcccgt gggcggcgtg ggcgcgggag ccgaccccag
     1741 cgaccccctg ggcctgtacg aggaggaggg cgcgggctgc tcgcccgacg cgcccagcct
     1801 gagcggccgc agcagcgccg cctcgtcccc cgccgccggc cgctcgcccg ccgaccaccg
     1861 cggctacgcc agcctgcgcg ccgcctcgcc cgccccgtcc agcgcgccct cgcacgcgtc
     1921 ctcctcggcc tcgtcccact cctcctcttc ctcctcctcg ggctcctcgt cctccgacga
     1981 cgagttcgaa gacgacctgc tcgacctgaa ccccagctca aactttgaga gcatgtccct
     2041 gggcagcttc agttcgtcgt cggcgctcga ccgggacctg gattttaact tcgagcccgg
     2101 ctccggctcg cacttcgagt tcccggacta ctgcacgccc gaggtgagcg agatgatctc
     2161 gggagactgg ctcgagtcca gcatctccaa cctggttttc acctactgaa gggcgcgcag
     2221 gcagggagaa gggccggggg gggtaggaga ggagaaaaaa aaagtgaaaa aaagaaacga
     2281 aaaggacaga cgaagagttt aaagagaaaa gggaaaaaag aaagaaaaag taagcagggc
     2341 tggcttcgcc cgcgttctcg tcgtcggatc aaggagcgcg gcggcgtttt ggacccgcgc
     2401 tcccatcccc caccttcccg ggccggggac ccactctgcc cagccggagg gacgcggagg
     2461 aggaagaggg tagacagggg cgacctgtga ttgttgttat tgatgttgtt gttgatggca
     2521 aaaaaaaaaa agcgacttcg agtttgctcc cctttgcttg aagagacccc ctcccccttc
     2581 caacgagctt ccggacttgt ctgcaccccc agcaagaagg cgagttagtt ttctagagac
     2641 ttgaaggagt ctcccccttc ctgcatcacc accttggttt tgttttattt tgcttcttgg
     2701 tcaagaaagg aggggagaac ccagcgcacc cctccccccc tttttttaaa cgcgtgatga
     2761 agacagaagg ctccggggtg acgaatttgg ccgatggcag atgttttggg ggaacgccgg
     2821 gactgagaga ctccacgcag gcgaattccc gtttggggct tttttttcct ccctcttttc
     2881 cccttgcccc ctctgcagcc ggaggaggag atgttgaggg gaggaggcca gccagtgtga
     2941 ccggcgctag gaaatgaccc gagaaccccg ttggaagcgc agcagcggga gctaggggcg
     3001 ggggcggagg aggacacgaa ctggaagggg gttcacggtc aaactgaaat ggatttgcac
     3061 gttggggagc tggcggcggc ggctgctggg cctccgcctt cttttctacg tgaaatcagt
     3121 gaggtgagac ttcccagacc ccggaggcgt ggaggagagg agactgtttg atgtggtaca
     3181 ggggcagtca gtggagggcg agtggtttcg gaaaaaaaaa aagaaaaaaa gaaaaaaaaa
     3241 gaaaaaaaaa agattttttt cttctcttaa tcggaatcgt gatggtgttg gattatttca
     3301 atggtggggt taatatagca tgttatcctg tctatctttt aaagatttct gtataagact
     3361 gttgagcagt ttttaaaata gtgtaggata atataaaaag cagatagatg gcgctatgtt
     3421 tgattcctac aacgaaatta tcaccagctt tttttcattc ttaactcttt aaaggattca
     3481 aacgcaactc aaatctgtgc tggactttaa aaaaacaatt caggaccaaa ttttttctca
     3541 gtgtgtgtgt ttattcctta taggtgtaaa tgagaagacg tgtttttttc cttcaccgat
     3601 gctccatcct cgtatttctt tttccttgta aatgtaatca gatgccattt tatatgtgga
     3661 cgtatttata ctggccaaac atattttttc ttttgtccct ttttttcttt cctttctttt
     3721 tacttccttt atttctttat tccttccttt tccttttttt cttttttttt tctttttttt
     3781 tttttttttt tggtagttgt tgttacccac gccattttac gtctccttca ctgaagggct
     3841 agagttttaa cttttaattt tttatattta aatgtagact tttgacactt ttaaaaaaca
     3901 aaaaaagaca agagagatga aaacgtttga ttattttctc agtgtatttt tgtaaaaaat
     3961 atataaaggg ggtgttaatc ggtgtaaatc gctgtttgga tttcctgatt ttataacagg
     4021 gcggctggtt aatatctcac acagtttaaa aaatcagccc ctaatttctc catgtttaca
     4081 cttcaatctg caggcttctt aaagtgacag tatcccttaa cctgccacca gtgtccaccc
     4141 tccggccccc gtcttgtaaa aaggggagga gaattagcca aacactgtaa gcttttaaga
     4201 aaaacaaagt tttaaacgaa atactgctct gtccagaggc tttaaaactg gtgcaattac
     4261 agcaaaaagg gattctgtag ctttaacttg taaaccacat cttttttgca ctttttttat
     4321 aagcaaaaac gtgccgttta aaccactgga tctatctaaa tgccgatttg agttcgcgac
     4381 actatgtact gcgtttttca ttcttgtatt tgactattta atcctttcta cttgtcgcta
     4441 aatataattg ttttagtctt atggcatgat gatagcatat gtgttcaggt ttatagctgt
     4501 tgtgtttaaa aattgaaaaa agtggaaaac atctttgtac atttaagtct gtattataat
     4561 aagcaaaaag attgtgtgta tgtatgttta atataacatg acaggcacta ggacgtctgc
     4621 ctttttaagg cagttccgtt aagggttttt gtttttaaac ttttttttgc catccatcct
     4681 gtgcaatatg ccgtgtagaa tatttgtctt aaaattcaag gccacaaaaa caatgtttgg
     4741 gggaaaaaaa agaaaaaatc atgccagcta atcatgtcaa gttcactgcc tgtcagattg
     4801 ttgatatata ccttctgtaa ataacttttt ttgagaagga aataaaatca gctggaactg
     4861 aaccctaaa
//
