LOCUS       NM_007084               2924 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens SRY-box transcription factor 21 (SOX21), mRNA.
ACCESSION   NM_007084
VERSION     NM_007084.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Yu,D., Zhao,Z., Wang,L., Qiao,S., Yang,Z., Wen,Q. and Zhu,G.
  TITLE     SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression
            via up-regulation of SOX21
  JOURNAL   J Transl Med 20 (1), 511 (2022)
   PUBMED   36335356
  REMARK    GeneRIF: SOX21-AS1 activated by STAT6 promotes pancreatic cancer
            progression via up-regulation of SOX21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Eenjes,E., Tibboel,D., Wijnen,R.M.H., Schnater,J.M. and
            Rottier,R.J.
  TITLE     SOX2 and SOX21 in Lung Epithelial Differentiation and Repair
  JOURNAL   Int J Mol Sci 23 (21), 13064 (2022)
   PUBMED   36361852
  REMARK    GeneRIF: SOX2 and SOX21 in Lung Epithelial Differentiation and
            Repair.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Eenjes,E., Buscop-van Kempen,M., Boerema-de Munck,A., Edel,G.G.,
            Benthem,F., de Kreij-de Bruin,L., Schnater,M., Tibboel,D.,
            Collins,J. and Rottier,R.J.
  TITLE     SOX21 modulates SOX2-initiated differentiation of epithelial cells
            in the extrapulmonary airways
  JOURNAL   Elife 10, e57325 (2021)
   PUBMED   34286693
  REMARK    GeneRIF: SOX21 modulates SOX2-initiated differentiation of
            epithelial cells in the extrapulmonary airways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2924)
  AUTHORS   Moradi,K., Babaei,E., Hosseinpour Feizi,M.A., Safaralizadeh,R. and
            Rezvani,N.
  TITLE     Quantitative detection of SRY-Box 21 (SOX21) gene promoter
            methylation as a stool-based noninvasive biomarker for early
            diagnosis of colorectal cancer by MethyLight method
  JOURNAL   Indian J Cancer 58 (2), 217-224 (2021)
   PUBMED   33402569
  REMARK    GeneRIF: Quantitative detection of SRY-Box 21 (SOX21) gene promoter
            methylation as a stool-based noninvasive biomarker for early
            diagnosis of colorectal cancer by MethyLight method.
REFERENCE   5  (bases 1 to 2924)
  AUTHORS   Moradi,K., Babaei,E., Rezvani,N., Safaralizadeh,R., Bashiri,H. and
            Feizi,M.A.H.
  TITLE     High potential of SOX21 gene promoter methylation as an epigenetic
            biomarker for early detection of colorectal cancer
  JOURNAL   Indian J Cancer 57 (2), 166-171 (2020)
   PUBMED   32445320
  REMARK    GeneRIF: High potential of SOX21 gene promoter methylation as an
            epigenetic biomarker for early detection of colorectal cancer.
REFERENCE   6  (bases 1 to 2924)
  AUTHORS   Schepers,G.E., Teasdale,R.D. and Koopman,P.
  TITLE     Twenty pairs of sox: extent, homology, and nomenclature of the
            mouse and human sox transcription factor gene families
  JOURNAL   Dev Cell 3 (2), 167-170 (2002)
   PUBMED   12194848
  REMARK    Review article
REFERENCE   7  (bases 1 to 2924)
  AUTHORS   Malas,S., Duthie,S., Deloukas,P. and Episkopou,V.
  TITLE     The isolation and high-resolution chromosomal mapping of human
            SOX14 and SOX21; two members of the SOX gene family related to
            SOX1, SOX2, and SOX3
  JOURNAL   Mamm Genome 10 (9), 934-937 (1999)
   PUBMED   10441749
REFERENCE   8  (bases 1 to 2924)
  AUTHORS   Cremazy,F., Soullier,S., Berta,P. and Jay,P.
  TITLE     Further complexity of the human SOX gene family revealed by the
            combined use of highly degenerate primers and nested PCR
  JOURNAL   FEBS Lett 438 (3), 311-314 (1998)
   PUBMED   9827568
REFERENCE   9  (bases 1 to 2924)
  AUTHORS   Stevanovic,M., Lovell-Badge,R., Collignon,J. and Goodfellow,P.N.
  TITLE     SOX3 is an X-linked gene related to SRY
  JOURNAL   Hum Mol Genet 2 (12), 2013-2018 (1993)
   PUBMED   8111369
REFERENCE   10 (bases 1 to 2924)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137061.12, HY124230.1, CX869660.1, DB493621.1, AI418194.1 and
            DB542438.1.
            
            On May 17, 2019 this sequence version replaced NM_007084.3.
            
            Summary: SRY-related HMG-box (SOX) genes encode a family of
            DNA-binding proteins containing a 79-amino acid HMG (high mobility
            group) domain that shares at least 50% sequence identity with the
            DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins
            are divided into 6 subgroups based on sequence similarity within
            and outside of the HMG domain. For additional background
            information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM,
            Apr 2004].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376945.4/ ENSP00000366144.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL137061.12        75995-75996         c
            3-209               HY124230.1         4-210
            210-462             CX869660.1         442-694             c
            463-463             AL137061.12        75534-75534         c
            464-753             DB493621.1         13-302
            754-754             AL137061.12        75243-75243         c
            755-965             DB493621.1         304-514
            966-2622            AL137061.12        73375-75031         c
            2623-2829           AI418194.1         119-325             c
            2830-2864           DB542438.1         350-384
            2865-2924           AI418194.1         24-83               c
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..2924
                     /gene="SOX21"
                     /gene_synonym="SOX25"
                     /note="SRY-box transcription factor 21"
                     /db_xref="GeneID:11166"
                     /db_xref="HGNC:HGNC:11197"
                     /db_xref="MIM:604974"
     exon            1..2924
                     /gene="SOX21"
                     /gene_synonym="SOX25"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..1327
                     /gene="SOX21"
                     /gene_synonym="SOX25"
                     /note="SOX-A; SRY (sex determining region Y)-box 21;
                     SRY-box 21"
                     /codon_start=1
                     /product="transcription factor SOX-21"
                     /protein_id="NP_009015.1"
                     /db_xref="CCDS:CCDS9473.1"
                     /db_xref="GeneID:11166"
                     /db_xref="HGNC:HGNC:11197"
                     /db_xref="MIM:604974"
                     /translation="MSKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGA
                     EWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGLGG
                     VADAEHPALKAGAGLHAGAGGGLVPESLLANPEKAAAAAAAAAARVFFPQSAAAAAAA
                     AAAAAAGSPYSLLDLGSKMAEISSSSSGLPYASSLGYPTAGAGAFHGAAAAAAAAAAA
                     AGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYILLPGMGKPQLDPYPAAYAAAL
                     "
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX21"
                     /gene_synonym="SOX25"
                     /note="hexamer: AATAAA"
     polyA_site      2924
                     /gene="SOX21"
                     /gene_synonym="SOX25"
                     /note="major polyA site"
ORIGIN      
        1 aaacactcca gccgctgaga gccccctttg gcacttggca gcacgcggcg gcgggctcct
       61 cggctcaact tcgaggagtc tccgcgacgc aacttttggg gacgctttgc atttaagaga
      121 gaacgaccga ggaggaggag cgctctgccc ggccgccgct acctgcgggg agctcaccag
      181 caaacgccac tgcagacgaa ggacccaaag aacgtaaagg gcaaactgcc gccgcgggga
      241 gggggcaccg ccgagaagtt agagtgtccc agagacaacc tgctcgagcg ctcggccgga
      301 gacactaagg cggcccgggg cgcggcgtgg ccctgggctg gtcccccagc cccctcctcc
      361 ggggcgggag cgacgccggg gcgcgacgag ccccggccgg ccgagcgggt ctccgcgggc
      421 agccaacatt gatttcctcc gggccgaggg cgagggcccg ggaggcggcg ggctgcagcc
      481 gcggcagggc gagagcatgt ccaagccggt ggaccacgtc aagcggccca tgaacgcctt
      541 catggtgtgg tcgcgggctc agcggcgcaa gatggcccag gagaacccca agatgcacaa
      601 ctcggagatc agcaagcgct tgggcgccga gtggaaactg ctcacagagt cggagaagcg
      661 gccgttcatc gacgaggcca agcgtctacg cgccatgcac atgaaggagc accccgacta
      721 caagtaccgg ccgcggcgca agcccaagac gctgctcaag aaggacaagt tcgccttccc
      781 ggtgccctac ggcctgggcg gcgtggcgga cgccgagcac cctgcgctca aggcgggcgc
      841 cgggctgcac gcgggggcgg gcggcggcct ggtgcctgag tcgctgctcg ccaatcccga
      901 gaaggcggcc gcggccgccg ccgctgccgc cgcacgcgtc ttcttcccgc agtcggccgc
      961 tgccgccgcc gctgccgccg ccgccgccgc cgcgggcagc ccctactcgc tgctcgacct
     1021 gggctccaaa atggcagaga tctcgtcgtc ctcgtccggc ctcccgtacg cgtcgtcgct
     1081 gggctacccg accgcgggcg cgggcgcctt ccacggcgcg gcggcggcgg ctgcagcggc
     1141 ggccgccgcc gccggggggc acacgcactc gcaccccagc ccgggcaacc cgggctacat
     1201 gatcccgtgc aactgcagcg cgtggcccag ccccgggctg cagccgccgc tcgcctacat
     1261 cctgctgccg ggcatgggca agccccagct ggacccctac cccgcggcct acgctgccgc
     1321 gctatgaccc cgcggggccg cctcgcgagg accggtgtgc acacgtgtac atatgtatag
     1381 gtacgagcgc tgcggcctcc ccgtgcgccc tcccgcgacc gggggcccgg tttgtatgta
     1441 catagaatgt ataggtgcca ggtagaggca gagaggccag gcggggcagg agtggccaag
     1501 cgcgcaaggg cgcgggcgag caggcctgtg aattcgcagg atcatttcag acccgcactt
     1561 cggcagccaa ctcgaaagca ggcggttgtg tgcggcagca gttggcgttt gctttgcact
     1621 tcggaacctg ttgcgttttg acccacggag gtggaggagt aactttttga catgttggcc
     1681 tttccagttt tgttggaagt ttcatggtcg gttttgtttt tgtttctcat tcttcttcct
     1741 cgcccctcag ccccccaacc cccaaccccc tcccggtccg tgttgcatgc acgctgttca
     1801 aatgtgaggt ctgaaatggc tggcacacgg gaaaagctgc ttgtgtcatt cgtttctggg
     1861 agtgggatgg ctctgagcag cctcgcctcc ctgtttgtac tatttgaact ttgcagatct
     1921 ctgttctctc aagcagaact cccaaccaga tccattcttg accagtgacc ggctcgaatc
     1981 tggccttttg tgtgagatga tcacggtttc ttttgtttat cacgccattt gcaaatcaga
     2041 gcaagagctc tttctcaagg gcaagaaacg caaacaagaa atatttgtga gatgaaagtt
     2101 gtcaattgga ttttcttcct aaacaaacaa caacaacaaa ctactagaag tctccctgag
     2161 tccactcgct tggatttctg acacagttta caaaaaagga aaaaggcact gctcctattt
     2221 tcccttatgg ctgagttcac cttaagattg taaatgtgta tatgtcagtg aaaacattga
     2281 ggcttggaaa atgtgttatt ttcgttgccc taagtttgag tcgactttag actcaaaaac
     2341 attttgagcg aatatcaaag ttaactttta aaaattgcga aactatttca gaatcgcaat
     2401 tttatcgaag attaaatcag acttttttgt ctggtaatta tatatttatt atttagcaaa
     2461 actgaagaaa aaaagcacag aattgtttca acagatgtct ctcattttca gctagcattt
     2521 ctctcccaag ttgagctggt ttaatgtgtt ttggatttcc ctcctcaatt ggcttatttt
     2581 ttagatcacc tgcaattcat ttgcaaattg caataaaaca cattttagaa aaaaggaacc
     2641 ttcaattatt agctttgttt ctttttaaat gtatatattt tgactaatgt ttgtgaatga
     2701 agttggctaa catgtattta gtttcatttt ggctttatgt aatataaagt ttttaaaatt
     2761 ttaaatatgg ttttaacctt tatgtgtaaa tgattttcta gtgtgacctt ctaatttaat
     2821 attagacgtc taaggtatat ctgtaaatta gaatccgact atcactctgt tcattttttt
     2881 tgaacaaaga gtttaaataa agcctgaacc agggaaaaga aaaa
//
