LOCUS       NM_003106               2512 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SRY-box transcription factor 2 (SOX2), mRNA.
ACCESSION   NM_003106
VERSION     NM_003106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Schaefer,T., Mittal,N., Wang,H., Ataman,M., Candido,S.,
            Lotscher,J., Velychko,S., Tintignac,L., Bock,T., Borsch,A.,
            Bassler,J., Rao,T.N., Zmajkovic,J., Roffeis,S., Loliger,J.,
            Jacob,F., Dumlin,A., Schurch,C., Schmidt,A., Skoda,R.C.,
            Wymann,M.P., Hess,C., Scholer,H.R., Zaehres,H., Hurt,E., Zavolan,M.
            and Lengerke,C.
  TITLE     Nuclear and cytosolic fractions of SOX2 synergize as
            transcriptional and translational co-regulators of cell fate
  JOURNAL   Cell Rep 43 (10), 114807 (2024)
   PUBMED   39368083
  REMARK    GeneRIF: Nuclear and cytosolic fractions of SOX2 synergize as
            transcriptional and translational co-regulators of cell fate.
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Ormsbee Golden,B.D., Gonzalez,D.V., Yochum,G.S., Coulter,D.W. and
            Rizzino,A.
  TITLE     SOX2 represses c-MYC transcription by altering the co-activator
            landscape of the c-MYC super-enhancer and promoter regions
  JOURNAL   J Biol Chem 300 (9), 107642 (2024)
   PUBMED   39122009
  REMARK    GeneRIF: SOX2 represses c-MYC transcription by altering the
            co-activator landscape of the c-MYC super-enhancer and promoter
            regions.
REFERENCE   3  (bases 1 to 2512)
  AUTHORS   Kainulainen,K., Niskanen,E.A., Kinnunen,J., Maki-Mantila,K.,
            Hartikainen,K., Paakinaho,V., Malinen,M., Ketola,K. and
            Pasonen-Seppanen,S.
  TITLE     Secreted factors from M1 macrophages drive prostate cancer stem
            cell plasticity by upregulating NANOG, SOX2, and CD44 through
            NFkappaB-signaling
  JOURNAL   Oncoimmunology 13 (1), 2393442 (2024)
   PUBMED   39175947
  REMARK    GeneRIF: Secreted factors from M1 macrophages drive prostate cancer
            stem cell plasticity by upregulating NANOG, SOX2, and CD44 through
            NFkappaB-signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2512)
  AUTHORS   Silveira,A.C.J., Guimaraes,L.S., VON Held,R., Silva,E.B.D.,
            Silveira,F.M., Oliveira Neto,Z.C., Scariot,R., Winckler,C.,
            Kuchler,E.C., Brancher,J.A., Antunes,L.A.A. and Antunes,L.S.
  TITLE     Do SOD2 and SOD3 gene polymorphisms impact the oral health-related
            quality of life in Para athletes?
  JOURNAL   Braz Oral Res 38, e074 (2024)
   PUBMED   39109770
  REMARK    GeneRIF: Do SOD2 and SOD3 gene polymorphisms impact the oral
            health-related quality of life in Para athletes?
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2512)
  AUTHORS   Helland,R., Berglund,G.I., Otlewski,J., Apostoluk,W.,
            Andersen,O.A., Willassen,N.P. and Smalas,A.O.
  TITLE     High-resolution structures of three new trypsin-squash-inhibitor
            complexes: a detailed comparison with other trypsins and their
            complexes
  JOURNAL   Acta Crystallogr D Biol Crystallogr 55 (Pt 1), 139-148 (1999)
   PUBMED   10089404
REFERENCE   6  (bases 1 to 2512)
  AUTHORS   Yuan,H., Corbi,N., Basilico,C. and Dailey,L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   7  (bases 1 to 2512)
  AUTHORS   Stevanovic,M., Zuffardi,O., Collignon,J., Lovell-Badge,R. and
            Goodfellow,P.
  TITLE     The cDNA sequence and chromosomal location of the human SOX2 gene
  JOURNAL   Mamm Genome 5 (10), 640-642 (1994)
   PUBMED   7849401
REFERENCE   8  (bases 1 to 2512)
  AUTHORS   Scott,D.A.
  TITLE     Esophageal Atresia / Tracheoesophageal Fistula Overview - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301753
REFERENCE   9  (bases 1 to 2512)
  AUTHORS   Bardakjian,T., Weiss,A. and Schneider,A.
  TITLE     Microphthalmia/Anophthalmia/Coloboma Spectrum - RETIRED CHAPTER,
            FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301552
REFERENCE   10 (bases 1 to 2512)
  AUTHORS   Williamson,K.A., Yates,T.M. and FitzPatrick,D.R.
  TITLE     SOX2 Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF305585.1, DA388996.1,
            BC013923.2, AC117415.7 and CN430685.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003106.3.
            
            Summary: This intronless gene encodes a member of the SRY-related
            HMG-box (SOX) family of transcription factors involved in the
            regulation of embryonic development and in the determination of
            cell fate. The product of this gene is required for stem-cell
            maintenance in the central nervous system, and also regulates gene
            expression in the stomach. Mutations in this gene have been
            associated with optic nerve hypoplasia and with syndromic
            microphthalmia, a severe form of structural eye malformation. This
            gene lies within an intron of another gene called SOX2 overlapping
            transcript (SOX2OT). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.293043.1,
                                        SRR3476690.254255.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325404.3/ ENSP00000323588.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BF305585.1         12-12
            2-363               DA388996.1         1-362
            364-1506            BC013923.2         3-1145
            1507-2500           AC117415.7         94398-95391         c
            2501-2512           CN430685.1         446-457
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..2512
                     /gene="SOX2"
                     /gene_synonym="ANOP3; MCOPS3"
                     /note="SRY-box transcription factor 2"
                     /db_xref="GeneID:6657"
                     /db_xref="HGNC:HGNC:11195"
                     /db_xref="MIM:184429"
     exon            1..2512
                     /gene="SOX2"
                     /gene_synonym="ANOP3; MCOPS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..1390
                     /gene="SOX2"
                     /gene_synonym="ANOP3; MCOPS3"
                     /note="transcription factor SOX2; SRY-related HMG-box gene
                     2; sex determining region Y-box 2; SRY (sex determining
                     region Y)-box 2; SRY-box 2"
                     /codon_start=1
                     /product="transcription factor SOX-2"
                     /protein_id="NP_003097.1"
                     /db_xref="CCDS:CCDS3239.1"
                     /db_xref="GeneID:6657"
                     /db_xref="HGNC:HGNC:11195"
                     /db_xref="MIM:184429"
                     /translation="MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRP
                     MNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHM
                     KEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSY
                     AHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMN
                     GSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISM
                     YLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM"
     regulatory      2484..2489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX2"
                     /gene_synonym="ANOP3; MCOPS3"
                     /note="hexamer: AATAAA"
     polyA_site      2512
                     /gene="SOX2"
                     /gene_synonym="ANOP3; MCOPS3"
                     /note="major polyA site"
ORIGIN      
        1 gatggttgtc tattaacttg ttcaaaaaag tatcaggagt tgtcaaggca gagaagagag
       61 tgtttgcaaa agggggaaag tagtttgctg cctctttaag actaggactg agagaaagaa
      121 gaggagagag aaagaaaggg agagaagttt gagccccagg cttaagcctt tccaaaaaat
      181 aataataaca atcatcggcg gcggcaggat cggccagagg aggagggaag cgcttttttt
      241 gatcctgatt ccagtttgcc tctctctttt tttcccccaa attattcttc gcctgatttt
      301 cctcgcggag ccctgcgctc ccgacacccc cgcccgcctc ccctcctcct ctccccccgc
      361 ccgcgggccc cccaaagtcc cggccgggcc gagggtcggc ggccgccggc gggccgggcc
      421 cgcgcacagc gcccgcatgt acaacatgat ggagacggag ctgaagccgc cgggcccgca
      481 gcaaacttcg gggggcggcg gcggcaactc caccgcggcg gcggccggcg gcaaccagaa
      541 aaacagcccg gaccgcgtca agcggcccat gaatgccttc atggtgtggt cccgcgggca
      601 gcggcgcaag atggcccagg agaaccccaa gatgcacaac tcggagatca gcaagcgcct
      661 gggcgccgag tggaaacttt tgtcggagac ggagaagcgg ccgttcatcg acgaggctaa
      721 gcggctgcga gcgctgcaca tgaaggagca cccggattat aaataccggc cccggcggaa
      781 aaccaagacg ctcatgaaga aggataagta cacgctgccc ggcgggctgc tggcccccgg
      841 cggcaatagc atggcgagcg gggtcggggt gggcgccggc ctgggcgcgg gcgtgaacca
      901 gcgcatggac agttacgcgc acatgaacgg ctggagcaac ggcagctaca gcatgatgca
      961 ggaccagctg ggctacccgc agcacccggg cctcaatgcg cacggcgcag cgcagatgca
     1021 gcccatgcac cgctacgacg tgagcgccct gcagtacaac tccatgacca gctcgcagac
     1081 ctacatgaac ggctcgccca cctacagcat gtcctactcg cagcagggca cccctggcat
     1141 ggctcttggc tccatgggtt cggtggtcaa gtccgaggcc agctccagcc cccctgtggt
     1201 tacctcttcc tcccactcca gggcgccctg ccaggccggg gacctccggg acatgatcag
     1261 catgtatctc cccggcgccg aggtgccgga acccgccgcc cccagcagac ttcacatgtc
     1321 ccagcactac cagagcggcc cggtgcccgg cacggccatt aacggcacac tgcccctctc
     1381 acacatgtga gggccggaca gcgaactgga ggggggagaa attttcaaag aaaaacgagg
     1441 gaaatgggag gggtgcaaaa gaggagagta agaaacagca tggagaaaac ccggtacgct
     1501 caaaaagaaa aaggaaaaaa aaaaatccca tcacccacag caaatgacag ctgcaaaaga
     1561 gaacaccaat cccatccaca ctcacgcaaa aaccgcgatg ccgacaagaa aacttttatg
     1621 agagagatcc tggacttctt tttgggggac tatttttgta cagagaaaac ctggggaggg
     1681 tggggagggc gggggaatgg accttgtata gatctggagg aaagaaagct acgaaaaact
     1741 ttttaaaagt tctagtggta cggtaggagc tttgcaggaa gtttgcaaaa gtctttacca
     1801 ataatattta gagctagtct ccaagcgacg aaaaaaatgt tttaatattt gcaagcaact
     1861 tttgtacagt atttatcgag ataaacatgg caatcaaaat gtccattgtt tataagctga
     1921 gaatttgcca atatttttca aggagaggct tcttgctgaa ttttgattct gcagctgaaa
     1981 tttaggacag ttgcaaacgt gaaaagaaga aaattattca aatttggaca ttttaattgt
     2041 ttaaaaattg tacaaaagga aaaaattaga ataagtactg gcgaaccatc tctgtggtct
     2101 tgtttaaaaa gggcaaaagt tttagactgt actaaatttt ataacttact gttaaaagca
     2161 aaaatggcca tgcaggttga caccgttggt aatttataat agcttttgtt cgatcccaac
     2221 tttccatttt gttcagataa aaaaaaccat gaaattactg tgtttgaaat attttcttat
     2281 ggtttgtaat atttctgtaa atttattgtg atattttaag gttttccccc ctttattttc
     2341 cgtagttgta ttttaaaaga ttcggctctg tattatttga atcagtctgc cgagaatcca
     2401 tgtatatatt tgaactaata tcatccttat aacaggtaca ttttcaactt aagtttttac
     2461 tccattatgc acagtttgag ataaataaat ttttgaaata tggacactga aa
//
