LOCUS       NM_022454               2346 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens SRY-box transcription factor 17 (SOX17), mRNA.
ACCESSION   NM_022454
VERSION     NM_022454.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Ream,M.W., Randolph,L.N., Jiang,Y., Chang,Y., Bao,X. and Lian,X.L.
  TITLE     Direct programming of human pluripotent stem cells into endothelial
            progenitors with SOX17 and FGF2
  JOURNAL   Stem Cell Reports 19 (4), 579-595 (2024)
   PUBMED   38518781
  REMARK    GeneRIF: Direct programming of human pluripotent stem cells into
            endothelial progenitors with SOX17 and FGF2.
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Grath,A. and Dai,G.
  TITLE     SOX17/ETV2 improves the direct reprogramming of adult fibroblasts
            to endothelial cells
  JOURNAL   Cell Rep Methods 4 (3), 100732 (2024)
   PUBMED   38503291
  REMARK    GeneRIF: SOX17/ETV2 improves the direct reprogramming of adult
            fibroblasts to endothelial cells.
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Goto,N., Westcott,P.M.K., Goto,S., Imada,S., Taylor,M.S., Eng,G.,
            Braverman,J., Deshpande,V., Jacks,T., Agudo,J. and Yilmaz,O.H.
  TITLE     SOX17 enables immune evasion of early colorectal adenomas and
            cancers
  JOURNAL   Nature 627 (8004), 636-645 (2024)
   PUBMED   38418875
  REMARK    GeneRIF: SOX17 enables immune evasion of early colorectal adenomas
            and cancers.
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Yi,D., Liu,B., Ding,H., Li,S., Li,R., Pan,J., Ramirez,K., Xia,X.,
            Kala,M., Ye,Q., Lee,W.H., Frye,R.E., Wang,T., Zhao,Y., Knox,K.S.,
            Glembotski,C.C., Fallon,M.B. and Dai,Z.
  TITLE     E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension
  JOURNAL   Hypertension 80 (11), 2357-2371 (2023)
   PUBMED   37737027
  REMARK    GeneRIF: E2F1 Mediates SOX17 Deficiency-Induced Pulmonary
            Hypertension.
REFERENCE   5  (bases 1 to 2346)
  AUTHORS   Luo,Y.Y., Jie,H.Y., Huang,K.J., Cai,B., Zhou,X., Liang,M.Y.,
            Zhou,C.Q. and Mai,Q.Y.
  TITLE     The dynamic expression of SOX17 in germ cells from human female
            foetus and adult ovaries after specification
  JOURNAL   Front Endocrinol (Lausanne) 14, 1124143 (2023)
   PUBMED   37576970
  REMARK    GeneRIF: The dynamic expression of SOX17 in germ cells from human
            female foetus and adult ovaries after specification.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2346)
  AUTHORS   Sinner,D., Kordich,J.J., Spence,J.R., Opoka,R., Rankin,S.,
            Lin,S.C., Jonatan,D., Zorn,A.M. and Wells,J.M.
  TITLE     Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor
            activity and proliferation of colon carcinoma cells
  JOURNAL   Mol Cell Biol 27 (22), 7802-7815 (2007)
   PUBMED   17875931
REFERENCE   7  (bases 1 to 2346)
  AUTHORS   Sinner,D., Rankin,S., Lee,M. and Zorn,A.M.
  TITLE     Sox17 and beta-catenin cooperate to regulate the transcription of
            endodermal genes
  JOURNAL   Development 131 (13), 3069-3080 (2004)
   PUBMED   15163629
REFERENCE   8  (bases 1 to 2346)
  AUTHORS   Schepers,G.E., Teasdale,R.D. and Koopman,P.
  TITLE     Twenty pairs of sox: extent, homology, and nomenclature of the
            mouse and human sox transcription factor gene families
  JOURNAL   Dev Cell 3 (2), 167-170 (2002)
   PUBMED   12194848
  REMARK    Review article
REFERENCE   9  (bases 1 to 2346)
  AUTHORS   Wilson,M. and Koopman,P.
  TITLE     Matching SOX: partner proteins and co-factors of the SOX family of
            transcriptional regulators
  JOURNAL   Curr Opin Genet Dev 12 (4), 441-446 (2002)
   PUBMED   12100890
  REMARK    Review article
REFERENCE   10 (bases 1 to 2346)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of human SOX17
  JOURNAL   Int J Mol Med 9 (2), 153-157 (2002)
   PUBMED   11786926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK025905.1, DA874945.1 and
            AC091076.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022454.3.
            
            Summary: This gene encodes a member of the SOX (SRY-related
            HMG-box) family of transcription factors involved in the regulation
            of embryonic development and in the determination of the cell fate.
            The encoded protein may act as a transcriptional regulator after
            forming a protein complex with other proteins. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025905.1, ERR279836.7817.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297316.5/ ENSP00000297316.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AK025905.1         1-124
            125-545             DA874945.1         123-543
            546-1668            AK025905.1         546-1668
            1669-2346           AC091076.7         131175-131852       c
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..2346
                     /gene="SOX17"
                     /gene_synonym="VUR3"
                     /note="SRY-box transcription factor 17"
                     /db_xref="GeneID:64321"
                     /db_xref="HGNC:HGNC:18122"
                     /db_xref="MIM:610928"
     exon            1..511
                     /gene="SOX17"
                     /gene_synonym="VUR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1449
                     /gene="SOX17"
                     /gene_synonym="VUR3"
                     /note="SRY-related HMG-box transcription factor SOX17; SRY
                     (sex determining region Y)-box 17; SRY-box 17"
                     /codon_start=1
                     /product="transcription factor SOX-17"
                     /protein_id="NP_071899.1"
                     /db_xref="CCDS:CCDS6159.1"
                     /db_xref="GeneID:64321"
                     /db_xref="HGNC:HGNC:18122"
                     /db_xref="MIM:610928"
                     /translation="MSSPDAGYASDDQSQTQSALPAVMAGLGPCPWAESLSPIGDMKV
                     KGEAPANSGAPAGAAGRAKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKML
                     GKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGGFLHGLA
                     EPQAAALGPEGGRVAMDGLGLQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYP
                     LPTPDTSPLDGVDPDPAFFAAPMPGDCPAAGTYSYAQVSDYAGPPEPPAGPMHPRLGP
                     EPAGPSIPGLLAPPSALHVYYGAMGSPGAGGGRGFQMQPQHQHQHQHQHHPPGPGQPS
                     PPPEALPCRDGTDPSQPAELLGEVDRTEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSH
                     GAISSVVSDASSAVYYCNYPDV"
     exon            512..2346
                     /gene="SOX17"
                     /gene_synonym="VUR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX17"
                     /gene_synonym="VUR3"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="SOX17"
                     /gene_synonym="VUR3"
                     /note="major polyA site"
     regulatory      2318..2323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX17"
                     /gene_synonym="VUR3"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="SOX17"
                     /gene_synonym="VUR3"
ORIGIN      
        1 gcagtgtcac taggccggct gggggccctg ggtacgctgt agaccagacc gcgacaggcc
       61 agaacacggg cggcggcttc gggccgggag acccgcgcag ccctcggggc atctcagtgc
      121 ctcactcccc accccctccc ccgggtcggg ggaggcggcg cgtccggcgg agggttgagg
      181 ggagcggggc aggcctggag cgccatgagc agcccggatg cgggatacgc cagtgacgac
      241 cagagccaga cccagagcgc gctgcccgcg gtgatggccg ggctgggccc ctgcccctgg
      301 gccgagtcgc tgagccccat cggggacatg aaggtgaagg gcgaggcgcc ggcgaacagc
      361 ggagcaccgg ccggggccgc gggccgagcc aagggcgagt cccgtatccg gcggccgatg
      421 aacgctttca tggtgtgggc taaggacgag cgcaagcggc tggcgcagca gaatccagac
      481 ctgcacaacg ccgagttgag caagatgctg ggcaagtcgt ggaaggcgct gacgctggcg
      541 gagaagcggc ccttcgtgga ggaggcagag cggctgcgcg tgcagcacat gcaggaccac
      601 cccaactaca agtaccggcc gcggcggcgc aagcaggtga agcggctgaa gcgggtggag
      661 ggcggcttcc tgcacggcct ggctgagccg caggcggccg cgctgggccc cgagggcggc
      721 cgcgtggcca tggacggcct gggcctccag ttccccgagc agggcttccc cgccggcccg
      781 ccgctgctgc ctccgcacat gggcggccac taccgcgact gccagagtct gggcgcgcct
      841 ccgctcgacg gctacccgtt gcccacgccc gacacgtccc cgctggacgg cgtggacccc
      901 gacccggctt tcttcgccgc cccgatgccc ggggactgcc cggcggccgg cacctacagc
      961 tacgcgcagg tctcggacta cgctggcccc ccggagcctc ccgccggtcc catgcacccc
     1021 cgactcggcc cagagcccgc gggtccctcg attccgggcc tcctggcgcc acccagcgcc
     1081 cttcacgtgt actacggcgc gatgggctcg cccggggcgg gcggcgggcg cggcttccag
     1141 atgcagccgc aacaccagca ccagcaccag caccagcacc accccccggg ccccggacag
     1201 ccgtcgcccc ctccggaggc actgccctgc cgggacggca cggaccccag tcagcccgcc
     1261 gagctcctcg gggaggtgga ccgcacggaa tttgaacagt atctgcactt cgtgtgcaag
     1321 cctgagatgg gcctccccta ccaggggcat gactccggtg tgaatctccc cgacagccac
     1381 ggggccattt cctcggtggt gtccgacgcc agctccgcgg tatattactg caactatcct
     1441 gacgtgtgac aggtccctga tccgccccag cctgcaggcc agaagcagtg ttacacactt
     1501 cctggaggag ctaaggaaat cctcagactc ctgggttttt gttgttgctg ttgttgtttt
     1561 ttaaaaggtg tgttggcata taatttatgg taatttattt tgtctgccac ttgaacagtt
     1621 tgggggggtg aggtttcatt taaaatttgt tcagagattt gtttcccata gttggattgt
     1681 caaaacccta tttccaagtt caagttaact agctttgaat gtgtcccaaa acagcttcct
     1741 ccatttcctg aaagtttatt gatcaaagaa atgttgtcct gggtgtgttt tttcaatctt
     1801 ctaaaaaata aaatctggaa tcctgctttt ttgctctact agtacctctg tcacactagt
     1861 cttatcaaaa accagttctt aagatcaatg ttaagtttat tagttaatgt aaatttctca
     1921 tcctcgaaaa gggtgaacat aaatgccttt aaggagtata tctaaaaata aacattagga
     1981 tatctaagtt tgatgtaatt gtttcaggaa ggaaaaaaga aaagcattct ggaatgagcc
     2041 tacttcaagt aatcttagtt tctaaaacta acagttaata ttttcaattc cagtatatca
     2101 ctttaagtag aaggggatgt ccaagtaatt ttggttttct aactgttgaa tcataagctt
     2161 gacctgcccc cagaggcttt ttggatgttt ttatctgtgt tttgccatct ctttacactc
     2221 ctcgacattc agtttacctt aatcttcaca tttttacacc ttgggaagtg gcaagcatcg
     2281 ctgggtttaa gataaaggag tcacaaaaac taatcaaaat aaaatttgca ttatgacaac
     2341 ttttaa
//
