LOCUS       NM_006942               1320 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens SRY-box transcription factor 15 (SOX15), mRNA.
ACCESSION   NM_006942
VERSION     NM_006942.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Hu,J., Li,X., Xu,K., Chen,J., Zong,S., Zhang,H., Li,H., Zhang,G.,
            Guo,Z., Zhao,X., Jiang,Y. and Jing,Z.
  TITLE     CircVPS8 promotes the malignant phenotype and inhibits ferroptosis
            of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and
            HNF4A
  JOURNAL   Oncogene 43 (36), 2679-2695 (2024)
   PUBMED   39098847
  REMARK    GeneRIF: CircVPS8 promotes the malignant phenotype and inhibits
            ferroptosis of glioma stem cells by acting as a scaffold for MKRN1,
            SOX15 and HNF4A.
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Cen,H.X., Cai,S.M., Jiang,H.Y., Liao,Z.M. and Han,D.G.
  TITLE     [The Mechanism of miR-1294 Targeting SOX15 to Regulate
            Wnt/beta-catenin Signaling Pathway and Promote the Proliferation of
            Acute Lymphoblastic Leukemia Cells in Children]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 31 (2), 344-351 (2023)
   PUBMED   37096504
  REMARK    GeneRIF: [The Mechanism of miR-1294 Targeting SOX15 to Regulate
            Wnt/beta-catenin Signaling Pathway and Promote the Proliferation of
            Acute Lymphoblastic Leukemia Cells in Children].
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Ding,Y., Feng,Y., Huang,Z., Zhang,Y., Li,X., Liu,R., Li,H.,
            Wang,T., Ding,Y., Jia,Z. and Yang,J.
  TITLE     SOX15 transcriptionally increases the function of AOC1 to modulate
            ferroptosis and progression in prostate cancer
  JOURNAL   Cell Death Dis 13 (8), 673 (2022)
   PUBMED   35922412
  REMARK    GeneRIF: SOX15 transcriptionally increases the function of AOC1 to
            modulate ferroptosis and progression in prostate cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Ozaydin,A., Soysal,A., Seyhan,B., Arikan,S., Dalay,N. and Buyru,N.
  TITLE     Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than
            Methylation in Papillary Thyroid Cancer
  JOURNAL   Dis Markers 2021, 1588220 (2021)
   PUBMED   34603557
  REMARK    GeneRIF: Epigenetic Silencing of SOX15 Is Controlled by miRNAs
            rather than Methylation in Papillary Thyroid Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Zhang,D., Guo,S., Wang,H. and Hu,Y.
  TITLE     SOX15 exerts antitumor function in glioma by inhibiting cell
            proliferation and invasion via downregulation of Wnt/beta-catenin
            signaling
  JOURNAL   Life Sci 255, 117792 (2020)
   PUBMED   32416168
  REMARK    GeneRIF: These data demonstrate that SOX15 functions as a potential
            tumor-suppressor in glioma by inhibiting cell proliferation and
            invasion via the downregulation of Wnt/beta-catenin signaling
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Cremazy,F., Soullier,S., Berta,P. and Jay,P.
  TITLE     Further complexity of the human SOX gene family revealed by the
            combined use of highly degenerate primers and nested PCR
  JOURNAL   FEBS Lett 438 (3), 311-314 (1998)
   PUBMED   9827568
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   Hiraoka,Y., Ogawa,M., Sakai,Y., Taniguchi,K., Fujii,T., Umezawa,A.,
            Hata,J. and Aiso,S.
  TITLE     Isolation and expression of a human SRY-related cDNA hSOX20
  JOURNAL   Biochim Biophys Acta 1396 (2), 132-137 (1998)
   PUBMED   9540826
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Critcher,R., Stitson,R.N., Wade-Martins,R., Easty,D.J. and
            Farr,C.J.
  TITLE     Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by
            fluorescence in situ hybridization; refinement of the human SOX4
            location to 6p22.3 and of SOX20 to chromosome 17p12.3
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 294-295 (1998)
   PUBMED   9730625
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Meyer,J., Wirth,J., Held,M., Schempp,W. and Scherer,G.
  TITLE     SOX20, a new member of the SOX gene family, is located on
            chromosome 17p13
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 246-249 (1996)
   PUBMED   8978787
REFERENCE   10 (bases 1 to 1320)
  AUTHORS   Goze,C., Poulat,F. and Berta,P.
  TITLE     Partial cloning of SOX-11 and SOX-12, two new human SOX genes
  JOURNAL   Nucleic Acids Res 21 (12), 2943 (1993)
   PUBMED   8332506
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB006867.1 and AC016876.10.
            
            On May 17, 2019 this sequence version replaced NM_006942.1.
            
            Summary: This gene encodes a member of the SOX (SRY-related
            HMG-box) family of transcription factors involved in the regulation
            of embryonic development and in the determination of the cell fate.
            The encoded protein may act as a transcriptional regulator after
            forming a protein complex with other proteins. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000985.2, AB006867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250055.3/ ENSP00000355354.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1318              AB006867.1         77-1394
            1319-1320           AC016876.10        6194-6195
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1320
                     /gene="SOX15"
                     /gene_synonym="SOX20; SOX26; SOX27"
                     /note="SRY-box transcription factor 15"
                     /db_xref="GeneID:6665"
                     /db_xref="HGNC:HGNC:11196"
                     /db_xref="MIM:601297"
     exon            1..951
                     /gene="SOX15"
                     /gene_synonym="SOX20; SOX26; SOX27"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1120
                     /gene="SOX15"
                     /gene_synonym="SOX20; SOX26; SOX27"
                     /note="SRY (sex determining region Y)-box 20; protein
                     SOX-15; SRY (sex determining region Y)-box 15; SRY-box 15"
                     /codon_start=1
                     /product="transcription factor SOX-15"
                     /protein_id="NP_008873.1"
                     /db_xref="CCDS:CCDS32549.1"
                     /db_xref="GeneID:6665"
                     /db_xref="HGNC:HGNC:11196"
                     /db_xref="MIM:601297"
                     /translation="MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTL
                     PLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEA
                     KRLRARHLRDYPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRG
                     FGYRPPSYSTAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTP
                     YNPPLAGAPMPLTHL"
     exon            952..1320
                     /gene="SOX15"
                     /gene_synonym="SOX20; SOX26; SOX27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1297..1302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX15"
                     /gene_synonym="SOX20; SOX26; SOX27"
                     /note="hexamer: ATTAAA"
     polyA_site      1320
                     /gene="SOX15"
                     /gene_synonym="SOX20; SOX26; SOX27"
                     /note="major polyA site"
ORIGIN      
        1 gccacaaacg ctgagcccag gtgggagagg tctggcctat ccgcgcctgg cagctgtcgg
       61 aactccggag accacaaagg ggtttatggt ttaccccctc cacggaaggt cggtctgatc
      121 gcagctgcgg gtcggggaga gggaccgggg gtcccccagt cagtaggcct cagaacacct
      181 cttcagtgcc ggggcaccag acagcggatt ttgcattcga ctctccccaa agtgtgccga
      241 acaggttgga agcaaaggct ccggtttaag ctctgggctt ggggataaaa tacacttttt
      301 aaggacccaa gttcctcggc aacgactcca gactgggaag acctttccat tttcaggatc
      361 gacgcttcac gttgagggga gggcattcag gacgccctct taaggcttct cccaacccat
      421 ggcgctacca ggctcctcac aggaccaggc ctggagcctg gagcctccgg ctgccacggc
      481 tgctgcctcc tcatcttcgg gaccccagga gcgggagggc gctgggagcc ccgcggcccc
      541 cgggacgctg cccctggaga aggtgaagcg gccgatgaac gcgttcatgg tgtggagctc
      601 cgctcagcgc cgccagatgg cgcagcagaa ccccaagatg cacaactccg agatctccaa
      661 gcgcctgggc gcgcagtgga agctgctgga cgaggacgag aagcggccct tcgtggagga
      721 ggccaagcgg ctccgcgccc gacacctgcg cgactacccc gactacaagt accggcctcg
      781 gcgcaaggcc aagagctcgg gcgccggacc ttcccgctgc ggacagggaa gaggcaacct
      841 ggccagcggc ggcccgctct gggggccggg gtacgcgacc acccaaccga gcagaggctt
      901 tgggtacaga ccccccagct actcgacagc ctacctgcct ggcagctatg gctcttccca
      961 ctgcaaactg gaagccccct caccgtgctc cctccctcag agtgacccta ggctccaggg
     1021 ggaactgctg cccacctata cccactacct gccccctggc tctcccactc catacaaccc
     1081 tccccttgct ggtgccccca tgcccctaac ccacctctaa ccctcatgga cgcagacctc
     1141 acgggacggg cctcatcctc cttttttaat ccagcagcat cccctacccc aggctgtcaa
     1201 ccctttctcc tgttggacta cagttcagag gcagcctgca gtcctcccat gatagccagg
     1261 gagagccgca caacatacaa ttatattttt ggtagtatta aacagttttg tattattcaa
//
