LOCUS       NM_006943               4673 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens SRY-box transcription factor 12 (SOX12), mRNA.
ACCESSION   NM_006943
VERSION     NM_006943.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4673)
  AUTHORS   Zhang,X., Wang,G., Li,X., Liu,Y., Wu,X., Zhou,Y., Liu,J., Wang,H.,
            Jiao,R., Chen,Y. and Wang,Q.
  TITLE     LncRNA H19 Promotes Gastric Cancer Metastasis via miR-148-3p/SOX-12
            Axis
  JOURNAL   Anal Cell Pathol (Amst) 2024, 6217134 (2024)
   PUBMED   39184399
  REMARK    GeneRIF: LncRNA H19 Promotes Gastric Cancer Metastasis via
            miR-148-3p/SOX-12 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4673)
  AUTHORS   Qiu,H., Yang,D., Li,X. and Feng,F.
  TITLE     LncRNA CASC9 promotes cell proliferation and invasion in
            osteosarcoma through targeting miR-874-3p/SOX12 axis
  JOURNAL   J Orthop Surg Res 17 (1), 460 (2022)
   PUBMED   36266695
  REMARK    GeneRIF: LncRNA CASC9 promotes cell proliferation and invasion in
            osteosarcoma through targeting miR-874-3p/SOX12 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4673)
  AUTHORS   Xu,J., Ou,R., Nie,G., Wen,J., Ling,L., Mo,L., Xu,R., Lv,M.,
            Zhao,L., Lai,W. and Xu,Y.
  TITLE     LINC01063 functions as an oncogene in melanoma through regulation
            of miR-5194-mediated SOX12 expression
  JOURNAL   Melanoma Res 32 (4), 218-230 (2022)
   PUBMED   35256570
  REMARK    GeneRIF: LINC01063 functions as an oncogene in melanoma through
            regulation of miR-5194-mediated SOX12 expression.
REFERENCE   4  (bases 1 to 4673)
  AUTHORS   Zhao,C., Ling,X., Xia,Y., Yan,B. and Guan,Q.
  TITLE     LncRNA UCA1 promotes SOX12 expression in breast cancer by
            regulating m6A modification of miR-375 by METTL14 through DNA
            methylation
  JOURNAL   Cancer Gene Ther 29 (7), 1043-1055 (2022)
   PUBMED   35022519
  REMARK    GeneRIF: LncRNA UCA1 promotes SOX12 expression in breast cancer by
            regulating m(6)A modification of miR-375 by METTL14 through DNA
            methylation.
REFERENCE   5  (bases 1 to 4673)
  AUTHORS   Lyu,X., Zhang,X., Sun,L.B., Cao,X.M. and Zhang,X.H.
  TITLE     Identification of SOX6 and SOX12 as Prognostic Biomarkers for Clear
            Cell Renal Cell Carcinoma: A Retrospective Study Based on TCGA
            Database
  JOURNAL   Dis Markers 2021, 7190301 (2021)
   PUBMED   34868396
  REMARK    GeneRIF: Identification of SOX6 and SOX12 as Prognostic Biomarkers
            for Clear Cell Renal Cell Carcinoma: A Retrospective Study Based on
            TCGA Database.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4673)
  AUTHORS   Dy,P., Penzo-Mendez,A., Wang,H., Pedraza,C.E., Macklin,W.B. and
            Lefebvre,V.
  TITLE     The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping
            expression patterns and molecular properties
  JOURNAL   Nucleic Acids Res 36 (9), 3101-3117 (2008)
   PUBMED   18403418
REFERENCE   7  (bases 1 to 4673)
  AUTHORS   Weiss,M.A.
  TITLE     Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA
            recognition
  JOURNAL   Mol Endocrinol 15 (3), 353-362 (2001)
   PUBMED   11222737
  REMARK    Review article
REFERENCE   8  (bases 1 to 4673)
  AUTHORS   Bowles,J., Schepers,G. and Koopman,P.
  TITLE     Phylogeny of the SOX family of developmental transcription factors
            based on sequence and structural indicators
  JOURNAL   Dev Biol 227 (2), 239-255 (2000)
   PUBMED   11071752
  REMARK    Review article
REFERENCE   9  (bases 1 to 4673)
  AUTHORS   Jay,P., Sahly,I., Goze,C., Taviaux,S., Poulat,F., Couly,G.,
            Abitbol,M. and Berta,P.
  TITLE     SOX22 is a new member of the SOX gene family, mainly expressed in
            human nervous tissue
  JOURNAL   Hum Mol Genet 6 (7), 1069-1077 (1997)
   PUBMED   9215677
REFERENCE   10 (bases 1 to 4673)
  AUTHORS   Singh,U. and Owen,J.J.
  TITLE     Studies on the effect of various agents on the maturation of thymus
            stem cells
  JOURNAL   Eur J Immunol 5 (4), 286-288 (1975)
   PUBMED   185058
  REMARK    GeneRIF: Functional analysis of the orthologous mouse gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034548.25, BC067361.1,
            HY104751.1 and BU078462.1.
            
            On Aug 11, 2020 this sequence version replaced NM_006943.3.
            
            Summary: Members of the SOX family of transcription factors are
            characterized by the presence of a DNA-binding high mobility group
            (HMG) domain, homologous to the HMG box of sex-determining region Y
            (SRY). Forming a subgroup of the HMG domain superfamily, SOX
            proteins have been implicated in cell fate decisions in a diverse
            range of developmental processes. SOX transcription factors have
            diverse tissue-specific expression patterns during early
            development and have been proposed to act as target-specific
            transcription factors and/or as chromatin structure regulatory
            elements. The protein encoded by this gene was identified as a SOX
            family member based on conserved domains, and its expression in
            various tissues suggests a role in both differentiation and
            maintenance of several cell types. [provided by RefSeq, Jan 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U35612.1, ERR3218375.48561.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342665.5/ ENSP00000347646.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL034548.25        80230-80248
            20-26               BC067361.1         13-19
            27-298              HY104751.1         1-272
            299-3011            BC067361.1         186-2898
            3012-4465           AL034548.25        83241-84694
            4466-4673           BU078462.1         8-215               c
FEATURES             Location/Qualifiers
     source          1..4673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..4673
                     /gene="SOX12"
                     /gene_synonym="SOX22"
                     /note="SRY-box transcription factor 12"
                     /db_xref="GeneID:6666"
                     /db_xref="HGNC:HGNC:11198"
                     /db_xref="MIM:601947"
     exon            1..4673
                     /gene="SOX12"
                     /gene_synonym="SOX22"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1321
                     /gene="SOX12"
                     /gene_synonym="SOX22"
                     /note="SOX-22 protein; SRY-related HMG-box gene 22; SRY
                     (sex determining region Y)-box 12; SRY-box 12"
                     /codon_start=1
                     /product="transcription factor SOX-12"
                     /protein_id="NP_008874.2"
                     /db_xref="CCDS:CCDS12995.1"
                     /db_xref="GeneID:6666"
                     /db_xref="HGNC:HGNC:11198"
                     /db_xref="MIM:601947"
                     /translation="MVQQRGARAKRDGGPPPPGPGPAEEGAREPGWCKTPSGHIKRPM
                     NAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMA
                     DYPDYKYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAA
                     APEDDDEDDDEELLEVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAAS
                     PTPSEDEEPEEEEEEAAAAEEGEEETVASGEESLGFLSRLPPGPAGLDCSALDRDPDL
                     QPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY"
     regulatory      3158..3163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX12"
                     /gene_synonym="SOX22"
                     /note="hexamer: AATAAA"
     polyA_site      3178
                     /gene="SOX12"
                     /gene_synonym="SOX22"
                     /note="major polyA site"
     regulatory      4652..4657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX12"
                     /gene_synonym="SOX22"
                     /note="hexamer: AATAAA"
     polyA_site      4673
                     /gene="SOX12"
                     /gene_synonym="SOX22"
ORIGIN      
        1 actgaaaggc gtcggcggcc gggcggggag cggcgcgcgc gggccgcggc ggagccagag
       61 gctgcaggaa gagcccgcgg gggcccggag ggtgcgattc ctcggccccc gcaaaacaat
      121 gtgtgttgtg agccaggacg caacttgccg gaggcggcgg gggcgcgccg agcccgcctg
      181 agaccgcgct gaccttctcc ccccgccgtc cgttgggccc gagcgcccag ctcctcgctc
      241 cccagttcgc gggggccggg ccgagccgcg gggcggggcc gcccctccgt cgccgctgcc
      301 tcctccccca cccccagccg cggaggatgc ggacggcccc cggcggcgtc tagcggcccc
      361 gggcccaggc gcgatggtgc agcagcgggg cgcgagggcc aagcgggacg gcgggccgcc
      421 gcccccggga cccgggccgg ccgaggaggg ggcgcgcgag cccggctggt gcaagacccc
      481 gagcggccac atcaagaggc cgatgaacgc attcatggtg tggtcgcagc acgaacggcg
      541 gaagatcatg gaccagtggc ccgacatgca caacgccgag atctccaagc gcctgggccg
      601 ccgctggcag ctgctgcagg actcggagaa gatcccgttc gtgcgggagg cggagcggct
      661 gcggctcaag cacatggcgg attacccgga ctacaagtac cggccgcgca aaaagagcaa
      721 gggggcgccc gccaaggcgc ggccccgccc ccccggtggt agcggtggcg gcagccggct
      781 caagcccggg ccgcagctgc ctggccgcgg gggccgccga gcagcgggag ggcctttggg
      841 gggcggggcg gcggcgcccg aggacgacga tgaagacgac gacgaggagc tgctggaagt
      901 gcgcctggtc gagaccccgg ggcgggagct gtggaggatg gtcccggcgg gacgggccgc
      961 tcggggacaa gcggagcgcg cccaagggcc gtcgggcgag ggggcggccg ccgccgccgc
     1021 cgcctccccg acaccgtcgg aggacgagga gccggaggaa gaggaggagg aggcggcagc
     1081 ggctgaggaa ggtgaagagg agacggtggc gtcgggggag gagtcgctgg gctttctgtc
     1141 caggctgccc cctggcccgg ccggcctgga ctgcagcgcc ctggatcgcg acccggacct
     1201 gcagcctccc tcgggcacgt cgcacttcga gttcccggac tactgcaccc ccgaggttac
     1261 cgagatgatc gcgggggact ggcgcccgtc tagcatcgca gacctggttt tcacctactg
     1321 agcccaccgt cagcggggcg cgcacgcccc caaaccagct gtttacatac aggaatcagg
     1381 tattggggcc cctcggaggc cgaggctggc accccatctc ccgcgcagcc tgccccctcc
     1441 tggacgtgcc catcccccct cagatccaga catgcccctc ccccgcagac acaccccaag
     1501 gcagcccaac ccccacccct tccccgacac ccaagcccct ccccacgtcg ccccctcctg
     1561 cacagccacc agcagccagc cccctccgat acacctcccg tcctctccta cagacctgca
     1621 cccctccccc cttttgcaca cgcccctcct cgtggccgga ggacccgccc cctcctttgc
     1681 tccggaatct ctcctccctc gcccggcccg ccttctctgg gttagggggg cgatgcggcc
     1741 gggtggcaac gcacgcgcct cctgcgcccc tcccttccct ggggggaggg gcgcacccct
     1801 tttatccccg gagcgctagg gcccgcccct ccgctggggc ccaccccctt cgtgcgcatg
     1861 cttaatgctt ctggggagga gggggctggt cccagcggag ccgcactctt cgcccgctcc
     1921 gggcaaaagc gggggcgagt gtagagcgat cctgggaaat cctttgatcc gggagcccta
     1981 ggtttcctct ccagccaacg gggcgtcgct gccttaatgg gaggagcact cggaagggtt
     2041 ggtttgggcc tgaaactctc ccaagtggca tagccccttt tccggtatgg ggtctcctac
     2101 acccacgcgc accacctctc cggtcgcgtg gctgcctcta cagcctacct atacgtccct
     2161 ttttcccccc aactgggaat tgagaggtaa ggtctttctc tggaaatcca gcagtagagg
     2221 aagggaccac ccaagaaaac taaaaaccaa ggcaccttac cagtctgtct ggggacagga
     2281 tccctgctgc accttcccca ccccctcctg ggaagtgccc cctcacctca gggcacccgc
     2341 aacctgggct cctccctgag cgcaccggcc cttcctgtca cccaggtcca ccctcagtac
     2401 tcaagctgca gtatacagcg ggaaaaactg aggcactttg gtgctagggg tttgggactg
     2461 aggcgtggag agcagatgtg atggcaggaa gactctcgct tttaaacatc tggtttggga
     2521 gagaccatcg acttggccag tgagactgag aatggattcc gagtagtgat gggccgtttg
     2581 cacctcggtt tttccacgtg agaaatgggg agaacgctgc tgttaggagg aagttgtgtc
     2641 cagttcaggg tgccctcggg agccctgtcc ctgttgctgt ggcccctctc acgccgccat
     2701 ctctctgccc cgccccgccc ctccggcctc cccacacccc ccttgccctc actacctgta
     2761 tctcaccggc gtgtgttcac cctcccgggt ggctcacaca ctctcattca cacacacaaa
     2821 tctcaggaac aaacggtccc agagtcctcc ggacccctgc ccagggtctc tgcaggtctc
     2881 tgccccacgc gttcccgtcg ctgacaaagc caccagctgc ctcctttaag cttggtgctc
     2941 cggctctggg cctttcttgc gctctatttt tttttttttt ttttttaaga aaaacaacaa
     3001 caacaaaaaa agacaatgaa aaaaaaaacg tcatgtgagt gaagagatgt cactgtctgt
     3061 ggtcttggag aactagtctc gtagctgagg ggtggggtcc ctctgtctgg ggcactggca
     3121 cccacagcag gactccgcca gtctgatgcc aggactgaat aaagtgtatt tgccccgacc
     3181 ttgccctgtg gttctgcatg tctgtgctct tcctcaaccc tccctaaaca gtttgccaga
     3241 ttcaagtccg tgtgatttgg gcccgagctg ggtgtcccag ggcaagccac cttgcctgtc
     3301 taggcctcta tgtcaggact ccctggcctt catgaagaat agcaaactca tccctgtagg
     3361 gaccaggcag gtaacataga cgagtgactc tgggtggaca gtggtgtcat gacccacttc
     3421 aaggggccta cctcctgcca gttgtgaccc tgtgggaatg cagtccacag tggccaggtg
     3481 gccagatttt tcaagaaaag ctggatggat gtttctgagt catcttaatt tcaaaatgag
     3541 actcatattt taaaatttct gtgggccaaa tgaaacaagt atgcaggcag gtctggtccg
     3601 agggggctgg cttggccatg cctttctgtg cctttaatga ggactaagaa gcaagattgg
     3661 gccacactgt ctggactcaa agcccagctc caccactgag cacccgtgtg actctttcca
     3721 tatgtataac gtggggataa taataatagc tgcttcacag gatgaaatga agtttgaggt
     3781 gagaagcatt caccatggtg cccatcgtgt tactccattg tcagaggagg aaacggggtc
     3841 aggcaggaaa gcaacttaaa ggagggcctg caagcagcca gggtcagaga cagggcttgg
     3901 ttctgcttcc tggtgaagca tggcttcggg gtgctgcctc tccctccctg tttgaatctg
     3961 cagattgtgt taggccccca gctgagggcc tggagtggtg ggattggtcc cagtgcctgg
     4021 cgcacattgg cctgcagagt agattaactg aatgaccaaa gagcaacaga agtctagtga
     4081 ttcttgtctt tgaggttctg actggtgttt tacaactgag tccaaggctt ttccctcctt
     4141 tgtccctctg acacccctcc ccctaattct catctgtcag atccagtgta ttcctaagct
     4201 gggacaaagc ctctgttttc ccagtaggag ccagggctga gtgtggaaat tacagtgact
     4261 gcttcttctc agcttctctg gttgaaagca agctggcgaa gtaagaggag gtagagttga
     4321 gaaggtgtgg aagataggga cagctgcccc cagaactccc ttcaagggag gacttcccca
     4381 gctatgggaa gtgccatcag ggtggccgca gctgcagaga gccacttcac ctgagaccac
     4441 gcccttcctg gggcagcctg tatctggtgt ctgagtgagg catggtataa acacctggtc
     4501 atttcaatcc aacatgggac ggacactgac agacagtact cccagcaggc ccaggccagc
     4561 cagggcttcg tcaggcctgc agcacaattt gacttcctat gcccaggcct gcttcctctt
     4621 cttcctcttc ttttcacagg tgcttattcc taataaacat cttgcaaccc aaa
//
