LOCUS       NM_003108               9002 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SRY-box transcription factor 11 (SOX11), mRNA.
ACCESSION   NM_003108 XM_938075
VERSION     NM_003108.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9002)
  AUTHORS   Sureda-Gomez,M., Iaccarino,I., De Bolos,A., Meyer,M., Balsas,P.,
            Richter,J., Rodriguez,M.L., Lopez,C., Carreras-Caballe,M.,
            Glaser,S., Nadeu,F., Jares,P., Clot,G., Siciliano,M.C., Bellan,C.,
            Tornambe,S., Boccacci,R., Leoncini,L., Campo,E., Siebert,R.,
            Amador,V. and Klapper,W.
  TITLE     SOX11 expression is restricted to EBV-negative Burkitt lymphoma and
            is associated with molecular genetic features
  JOURNAL   Blood 144 (2), 187-200 (2024)
   PUBMED   38620074
  REMARK    GeneRIF: SOX11 expression is restricted to EBV-negative Burkitt
            lymphoma and is associated with molecular genetic features.
REFERENCE   2  (bases 1 to 9002)
  AUTHORS   Treekitkarnmongkol,W., Shah,V., Kai,K., Katayama,H., Wong,J.,
            Ladha,F.A., Nguyen,T., Menegaz,B., Lu,W., Yang,F., Mino,B.,
            Tang,X., Gagea,M., Batra,H., Raso,M.G., Wistuba,I.I.,
            Krishnamurthy,S., Pinder,S.E., Sawyer,E.J., Thompson,A.M. and
            Sen,S.
  TITLE     Epigenetic activation of SOX11 is associated with recurrence and
            progression of ductal carcinoma in situ to invasive breast cancer
  JOURNAL   Br J Cancer 131 (1), 171-183 (2024)
   PUBMED   38760444
  REMARK    GeneRIF: Epigenetic activation of SOX11 is associated with
            recurrence and progression of ductal carcinoma in situ to invasive
            breast cancer.
REFERENCE   3  (bases 1 to 9002)
  AUTHORS   Abdelrazak Morsy,M.H., Lilienthal,I., Lord,M., Merrien,M.,
            Wasik,A.M., Sureda-Gomez,M., Amador,V., Johansson,H.J., Lehtio,J.,
            Garcia-Torre,B., Martin-Subero,J.I., Tsesmetzis,N., Tao,S.,
            Schinazi,R.F., Kim,B., Sorteberg,A.L., Wickstrom,M., Sheppard,D.,
            Rassidakis,G.Z., Taylor,I.A., Christensson,B., Campo,E., Herold,N.
            and Sander,B.
  TITLE     SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1
            ara-CTPase activity in mantle cell lymphoma
  JOURNAL   Blood 143 (19), 1953-1964 (2024)
   PUBMED   38237141
  REMARK    GeneRIF: SOX11 is a novel binding partner and endogenous inhibitor
            of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
REFERENCE   4  (bases 1 to 9002)
  AUTHORS   De Bolos,A., Sureda-Gomez,M., Carreras-Caballe,M., Rodriguez,M.L.,
            Clot,G., Bea,S., Gine,E., Campo,E., Balsas,P. and Amador,V.
  TITLE     SOX11/PRDX2 axis modulates redox homeostasis and chemoresistance in
            aggressive mantle cell lymphoma
  JOURNAL   Sci Rep 14 (1), 7863 (2024)
   PUBMED   38570586
  REMARK    GeneRIF: SOX11/PRDX2 axis modulates redox homeostasis and
            chemoresistance in aggressive mantle cell lymphoma.
            Erratum:[Sci Rep. 2024 Jun 11;14(1):13426. doi:
            10.1038/s41598-024-61080-9.. PMID: 38862588]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9002)
  AUTHORS   Smith,H., Al-Jawahiri,R., Stokes,L., Freeth,M., Fricke,S.,
            Matthews,D. and McNeill,A.
  TITLE     Impaired communication ability in SOX11 syndrome
  JOURNAL   J Intellect Disabil Res 68 (3), 285-292 (2024)
   PUBMED   37916390
  REMARK    GeneRIF: Impaired communication ability in SOX11 syndrome.
REFERENCE   6  (bases 1 to 9002)
  AUTHORS   Azuma,T., Ao,S., Saito,Y., Yano,K., Seki,N., Wakao,H., Masuho,Y.
            and Muramatsu,M.
  TITLE     Human SOX11, an upregulated gene during the neural differentiation,
            has a long 3' untranslated region
  JOURNAL   DNA Res 6 (5), 357-360 (1999)
   PUBMED   10574465
REFERENCE   7  (bases 1 to 9002)
  AUTHORS   Kuhlbrodt,K., Herbarth,B., Sock,E., Enderich,J.,
            Hermans-Borgmeyer,I. and Wegner,M.
  TITLE     Cooperative function of POU proteins and SOX proteins in glial
            cells
  JOURNAL   J Biol Chem 273 (26), 16050-16057 (1998)
   PUBMED   9632656
REFERENCE   8  (bases 1 to 9002)
  AUTHORS   Jay,P., Goze,C., Marsollier,C., Taviaux,S., Hardelin,J.P.,
            Koopman,P. and Berta,P.
  TITLE     The human SOX11 gene: cloning, chromosomal assignment and tissue
            expression
  JOURNAL   Genomics 29 (2), 541-545 (1995)
   PUBMED   8666406
REFERENCE   9  (bases 1 to 9002)
  AUTHORS   Goze,C., Poulat,F. and Berta,P.
  TITLE     Partial cloning of SOX-11 and SOX-12, two new human SOX genes
  JOURNAL   Nucleic Acids Res 21 (12), 2943 (1993)
   PUBMED   8332506
REFERENCE   10 (bases 1 to 9002)
  AUTHORS   Santiago,J.V.
  TITLE     Overview of the complications of diabetes
  JOURNAL   Clin Chem 32 (10 Suppl), B48-B53 (1986)
   PUBMED   3530540
  REMARK    GeneRIF: Overview of the complications of diabetes.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108025.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_003108.3.
            
            Summary: This intronless gene encodes a member of the SOX
            (SRY-related HMG-box) family of transcription factors involved in
            the regulation of embryonic development and in the determination of
            the cell fate. The encoded protein may act as a transcriptional
            regulator after forming a protein complex with other proteins. The
            protein may function in the developing nervous system and play a
            role in tumorigenesis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322002.5/ ENSP00000322568.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9002              AC108025.4         80602-89603
FEATURES             Location/Qualifiers
     source          1..9002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.2"
     gene            1..9002
                     /gene="SOX11"
                     /gene_synonym="CSS9; IDDMOH; MRD27"
                     /note="SRY-box transcription factor 11"
                     /db_xref="GeneID:6664"
                     /db_xref="HGNC:HGNC:11191"
                     /db_xref="MIM:600898"
     exon            1..9002
                     /gene="SOX11"
                     /gene_synonym="CSS9; IDDMOH; MRD27"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1664
                     /gene="SOX11"
                     /gene_synonym="CSS9; IDDMOH; MRD27"
                     /note="SRY (sex-determining region Y)-box 11; SRY-related
                     HMG-box gene 11; SRY-box 11"
                     /codon_start=1
                     /product="transcription factor SOX-11"
                     /protein_id="NP_003099.1"
                     /db_xref="CCDS:CCDS1654.1"
                     /db_xref="GeneID:6664"
                     /db_xref="HGNC:HGNC:11191"
                     /db_xref="MIM:600898"
                     /translation="MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKT
                     ASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREA
                     ERLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTS
                     KGSSKKCGKLKAPAAAGAKAGAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVK
                     CVFLDEDDDDDDDDDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVP
                     ASPTLSSSAESPEGASLYDEVRAGATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPA
                     SSRSVSTSSSSSSGSSSGSSGEDADDLMFDLSLNFSQSAHSASEQQLGGGAAAGNLSL
                     SLVDKDLDSFSEGSLGSHFEFPDYCTPELSEMIAGDWLEANFSDLVFTY"
     regulatory      3231..3236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX11"
                     /gene_synonym="CSS9; IDDMOH; MRD27"
                     /note="hexamer: AATAAA"
     polyA_site      3256
                     /gene="SOX11"
                     /gene_synonym="CSS9; IDDMOH; MRD27"
                     /note="major polyA site"
     regulatory      8978..8983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOX11"
                     /gene_synonym="CSS9; IDDMOH; MRD27"
                     /note="hexamer: AATAAA"
     polyA_site      9002
                     /gene="SOX11"
                     /gene_synonym="CSS9; IDDMOH; MRD27"
                     /note="major polyA site"
ORIGIN      
        1 gcagaaggag cgcgcgcgcc tgggagagct cggggtccgg cgcttgcggt aggagccacg
       61 agccggagag aggggtcccg ggctgcctcg accgccgtcg ccaccgcctc tcctgtcgcg
      121 accgcagctc ccaccgcgcc ggcggccgtc gtcgccgaag ccaccacagc cgctgtgtgc
      181 agcctggaag ggggggcggg ggggaggggg ggagccgcga aagcggggtg ccgaggactt
      241 tgcaacttgc ccaggaaggt ggaggggtgg gagggggagg gggacctccg cacgagaccc
      301 agcggcccgg gttggagcgt ccagccctgc agcggatcat ggtgcagcag gcggagagct
      361 tggaagcgga gagcaacctg ccccgggagg cgctggacac ggaggagggc gaattcatgg
      421 cttgcagccc ggtggccctg gacgagagcg acccagactg gtgcaagacg gcgtcgggcc
      481 acatcaagcg gccgatgaac gcgttcatgg tatggtccaa gatcgaacgc aggaagatca
      541 tggagcagtc tccggacatg cacaacgccg agatctccaa gaggctgggc aagcgctgga
      601 aaatgctgaa ggacagcgag aagatcccgt tcatccggga ggcggagcgg ctgcggctca
      661 agcacatggc cgactacccc gactacaagt accggccccg gaaaaagccc aaaatggacc
      721 cctcggccaa gcccagcgcc agccagagcc cagagaagag cgcggccggc ggcggcggcg
      781 ggagcgcggg cggaggcgcg ggcggtgcca agacctccaa gggctccagc aagaaatgcg
      841 gcaagctcaa ggcccccgcg gccgcgggcg ccaaggcggg cgcgggcaag gcggcccagt
      901 ccggggacta cgggggcgcg ggcgacgact acgtgctggg cagcctgcgc gtgagcggct
      961 cgggcggcgg cggcgcgggc aagacggtca agtgcgtgtt tctggatgag gacgacgacg
     1021 acgacgacga cgacgacgag ctgcagctgc agatcaaaca ggagccggac gaggaggacg
     1081 aggaaccacc gcaccagcag ctcctgcagc cgccggggca gcagccgtcg cagctgctga
     1141 gacgctacaa cgtcgccaaa gtgcccgcca gccctacgct gagcagctcg gcggagtccc
     1201 ccgagggagc gagcctctac gacgaggtgc gggccggcgc gacctcgggc gccgggggcg
     1261 gcagccgcct ctactacagc ttcaagaaca tcaccaagca gcacccgccg ccgctcgcgc
     1321 agcccgcgct gtcgcccgcg tcctcgcgct cggtgtccac ctcctcgtcc agcagcagcg
     1381 gcagcagcag cggcagcagc ggcgaggacg ccgacgacct gatgttcgac ctgagcttga
     1441 atttctctca aagcgcgcac agcgccagcg agcagcagct ggggggcggc gcggcggccg
     1501 ggaacctgtc cctgtcgctg gtggataagg atttggattc gttcagcgag ggcagcctgg
     1561 gctcccactt cgagttcccc gactactgca cgccggagct gagcgagatg atcgcggggg
     1621 actggctgga ggcgaacttc tccgacctgg tgttcacata ttgaaaggcg cccgctgctc
     1681 gctctttctc tcggagggtg cagagctggg ttccttggga ggaagttgta gtggtgatga
     1741 tgatgatgat aatgatgatg atgatggtgg tgttgatggt ggcggtggta gggtggaggg
     1801 gagagaagaa gatgctgatg atattgataa gatgtcgtga cgcaaagaaa ttggaaaaca
     1861 tgatgaaaat tttggtggag ttaaagtgaa atgagtagtt tttaaacatt tttcctgtcc
     1921 tttttttgtc ccccctccct tcctttatcg tgtctcaagg tagttgcata cctagtctgg
     1981 agttgtgatt attttcccaa aaaatgtgtt tttgtaatta ctatttcttt ttcctgaaat
     2041 tcgtgattgc aacaaaggca gagggggcgg ggcgggggag gggaggtagg acccgctccg
     2101 gaaggcgctg tttgaagctt gtcggtcttt gaagtctgga agacgtctgc agaggaccct
     2161 tttggcagca caactgttac tctagggagt tggtggagat attttttttt cttaagagaa
     2221 cttaaagaac tggtgatttt tttttaacaa aaaaagggac cattgcaact tttgttaatt
     2281 taattttttt tttttttttt tttttttttt tttttggagg gagaaaactg atgtcttcta
     2341 tgcatccgat tcttaacaaa actgcaggga gcttgaaaaa atgcagactg tacaaacgct
     2401 tacaaaaaaa aaaactgtga actgacttaa gatcagagtt tacttttcag atcaaattgt
     2461 ttatggtttt acaaatgtga tttctacttg ccaacttttt ttttgtaact tgttccctta
     2521 tacctccttg attgaatacc agacagccta gacctcagta caaaaggtat tgaaacattt
     2581 ttgatacata acagacctca gtctttttta aaaattaata tattttcagg cgtatttttg
     2641 tacagtgaaa agggaacatt cttgctgtgt tttttcagta agactttcag gcacttcttc
     2701 ccttttgatt tctttttttt cctctgtttt ttagcatgca agtatgttgg tacgttatgt
     2761 cctggtttaa aaaggattaa aattttaaaa taatccttgc atctaaaggc cttgtggttt
     2821 aaaaaaaaaa agcaaacttt tttttgtaca gctatagtag agatttgttc aatatttgta
     2881 ggtaaagatt tattgaaaat ggtgatatag acctcagagc tgttatctta gtttaaagat
     2941 tgtatatgta ctgtactata gtaggacttt atgtatctca tacgctgtga tgtggatggg
     3001 gccccagatg gaaggtttga aactggattc tcgattttta gcaaaaaaga aaaaaaaaag
     3061 gcacatagtt taaaaagttt ctcattttgt gcaatataat ctaaataaag tacagaccat
     3121 ctgcatattt tgtagcaaat ggtggcaaag cagactcaat gcactgtcga catcattgcc
     3181 tgtttttttt tttttttttt tgtgctggaa gtctgtatct tgacaatttt aataaatcag
     3241 ctggaactga tagaaactcg catcgccaat agtctctatg gaagtcaaac tggaggtcct
     3301 gttgtcgcag agcattcggt ggtgaggctg ttgtgtgcgc ggatgagggg aggtggcagg
     3361 agagaattct acatttaggg ggttaggctg aaaagtgttc aattagcagg ctgatttctt
     3421 tttcctcttc cgctagttgt gaaagacagg ggaagggtgt tctttctctc tgccctccct
     3481 ttccatctcc agctccccat ttcctttctc acctcctcct ccactccctg cctcttctcc
     3541 ccacccatcc tggcgggcgg gctgcgcgga ggctcgggag ctggccgggg aggggcggat
     3601 ggaggggcct gggttgccag ctcccttggt cggggtcctg ctcgctgggg cttgtgtgtt
     3661 ctctgcggcg ggccgcgtcc ccgctgagcc tcgcggtgac agccgccttt ggcagcgagc
     3721 gctcggggca cttctatccc cgcctctcaa agggtgggga cagccgtttc cagatttgaa
     3781 ttttttctgt tctttatttt taacgctgca tcttcgcgtg tgctcagagg tggttgttgg
     3841 cggagaacgc cgccgcagtg tttgacctct agcggtgaag ggggaagggg aagaggaaag
     3901 gagagaagtg gtcggtgtct gtttccttct gtcccccggg gccgtggagc tgtcggaggg
     3961 aaggaggacg gtgcggggcc gcagggggcg cggggcgcgg cgggacccag gctacgagcg
     4021 ggagggaggc gggagtcggg ggaagacgcg gcaggccggc cgagggcacc ccgaggaaca
     4081 tggcatggcc tctgtgcgat ccgagtcgcg gtctccgggg tgcctgggag ggccgaacca
     4141 ctggtgaggg cgtggggagc agggggtggc agagggcacc cgggcggtag tccgggacgc
     4201 gcaaggcaga gccctgacgc tccgggtccc cgtgcctggc tcttcttgcc tcgccaccgc
     4261 gtgctcctgg gcgcgccccg ccgcgggccc ttgaggcgcg cggagacacc agcgctggct
     4321 tcccgggccc gcgggccggg gagggaagcc tcggggctgc ggggtgagag gaagaaagca
     4381 aacccgggga gcaggcggct gccgcacccg cgcaccccgg gccctcacca cgccctcccc
     4441 gcgcgccggc tcaggggctg ccccggaatc agctccccgg ggccgccgca acgaaggtgg
     4501 atccgcatct tgattgttct ccgggagcct cctgggggct ccggcggcgg cgcgggcgcg
     4561 acccatcccg ctggcgctcc ccgctcgctg aaccccgttt gcctgtccac accccctcgc
     4621 tccccaccat ttttcctgac cggcctgtgt ccccgagccc tcgcggcagg cccgagcagg
     4681 cgatcgcggc cgggcacgcg cgccccgggc tcccgccccc cttccgagca tccgccgcct
     4741 cttttctgct gggtctggga ggagggaggc tgggaggccg ctcggggccc agcgtgccag
     4801 ccccggagtt cagcctcccg agctgcggcg cccgcagcgg aggaggtttt cagtggctga
     4861 ttgaaactca ctgcaaaatc accacgactc tttcacctac tgagatgatt gaccgaggtt
     4921 tggccttcca tttttactga gatttggcga gaccgaatgg aagcgtccgc acagtaactg
     4981 cagctgctag gccagagggg ccccggcgcc cttcccgcct cccctcccgc ttgcttttgc
     5041 cttactcgat cttaccacca cccctccccc ggccccccga ctgagaactc gggcctctca
     5101 cccgcccccc agcctcccgc tctgggcgag cctcctcccc agcccccacc cctgggatgc
     5161 gaagccagca agcttttgct gcagatggac aggtttcttt tctgtggctt tttcctttcg
     5221 ataaaccatc agatttcagt agtacatttg ggaaaagaag gggctgatgg cgttaaccag
     5281 gttctcaata tagaactgga tttctggagt tgtttacctt accccacacc ccctcaacat
     5341 gtagactaat gcagccattg gtggtacatt tattttagcc acggataatt gaaccagcgg
     5401 tttacaattg acacgtgctc cgtgctggtg attttatgtg gcagccctct gctgcagttc
     5461 cgaaacttgt tggcaacgta aacccattga taggctgatc tatgtatttt gaaagcctga
     5521 aaacttggca tgtcttttct gttttaatca tagatgaatc ttggacattt tctgtggtga
     5581 ggtggaaact ttaagtaaat tagtaaagta ataatttggc ttcagaatgg gaagagatag
     5641 tcaagatttt ttttttttaa agccatgtgg cctaacttga tacaaaaata aaagtaattg
     5701 tttggcaatc taaatttaaa acctgttaga actcaggaca ggcgcttcaa tgcgcttttt
     5761 aacaatattt aaggctgttt tgatgagtgc gttgtgagaa tcatcttaat gaattcttta
     5821 ttgagtgtct aaaacatagt ataatacaca tggtattctt gccactggat agtcttcaat
     5881 aaaagtttaa ttgatttttt tttgttggtc tcttaagtaa gtcttatttt taactaagca
     5941 ttgacagaat atcttaaaat ggtaacctgg gggtggcggg tgggtgctgt gtgcacggca
     6001 gcctagccag tggggatcct gctgtttatt ataagtagtt cacagactct gatggcattt
     6061 tggtaagctt tccatcttta agaaattgaa ccagcattct cttattaatt ctttaaactg
     6121 tggaagtaat ttccagttct tacactctga tacgcatccc ttttatttaa aaaaaaaaaa
     6181 aatgctaata aaaggcagtg tacttaaact gtgctttgca aatattgtgt atgttatgaa
     6241 tgactacaga cactgggcaa attatttgta gaatgattat cctttagcta gagaaagaaa
     6301 tcattacaac tcttttgggc agagatgttt ctttttaatg ttaatcaagg ggaagtgatt
     6361 taaatatgca taaatgtagc agtcagggtg atttagttgc ttttttcatg aaagaaaaag
     6421 actcaaaaga caagacttat ttttctcttc tgggacttga aatcataatc atctgatatt
     6481 agtacagtac aagaaattta catttgtttt ttacttcaga atttaagtga cttttgccca
     6541 aggaatttga gaaataaggc aaataagttg ctctatttta aagtagtcat tcaatataaa
     6601 tatattatat caatcttaac ttttttattc tctgatatga ttaataatat gtatattctt
     6661 acttttcttc taatgggcat atgtatcctt gtggacactt tgagagaggt tttcttggac
     6721 tctcccattt atagaatctt tatactcttt tactgtgtgg ttccctgctt ttaacagatt
     6781 tctgaggcaa atatatttgt gcttttttct tatgtaggaa gaccagcgaa aatagtttac
     6841 tgagttgtca attttatcag tagataagaa actttcttta ttacagtttc agggaagatt
     6901 ttttcaggat atttctcagt tattctaagg gccaaatttt gtaaaatttc cattaggaat
     6961 gtcagtttca aatacccttt gtatagccta agcctgtgag gataacaaga atgagcctta
     7021 cctatcctaa cacagggatt tacaagttcc caaagtaacc gtctccatgt aactcttgac
     7081 atacttttct gagatttggc ttatttttat tattggttat ttctcactgt tcattctatt
     7141 tgatttattc tacaacatcc ccttttattt aatgatctgg aaaattctgc tctttgataa
     7201 caactcagga tttttttgtt cagttttggt ttttgcccct tcctgtggag cctacatttt
     7261 caaccacaat aaagatgaaa caaaatttat gaaactgagc tctcttccat tttacttact
     7321 gctggctttt tttttttttt ttttccttga ttcctaccat accttcgttt ttttcattgt
     7381 acttttttaa cactacctat atccattagc tgcctaatta gttttatctg ttccatgtgg
     7441 atgcagtgag tttataagag aatttcacaa acaagtagtt ttttagtgaa cttaaaataa
     7501 acagaatttt aaaggagacc tatttttata ctcaataaaa gcacaaaagt gcagaaagta
     7561 taaaacggct tacaaaggga gacacaagct cataatgttc catgtataaa agtaataact
     7621 ttattgggta gagatattct tacaagatct agcacctctg ccagtgcaca gataggactg
     7681 ttttaaatga tttgggaact tttggttgcc tgcagttgtg aacagagaac ttctctacag
     7741 agaaacaaac cactaaaagc aatatgaccg agttgagatg tggtttccaa tgagcaattg
     7801 gtgaatttaa gcaacctgga tgtgcatatg tggaggctcc cgtctcactg tttgatcaaa
     7861 cttcttttat gtagtcacgt agacttgatt ttttctgctg tgaaaatgaa aaaataaagc
     7921 aatatgacaa aaagtttaaa aatgcataaa aaataggatt tcctctaggc tcctcgaaga
     7981 gattttttta atatgatgct tgtcttactt tcttagacac gttacatttc cccttccaaa
     8041 aaaaaaaaaa aggacaactg gaagtaattt atcatataaa gaattttgat caaatagata
     8101 ttgacaaagg gccctctgtc acatttttct tcatccagct tttgttcaaa aacagtatgc
     8161 ctcctccctt gaatcacata gggagaaacg ttatactcca ttctcattaa tttcccattt
     8221 tgtctacttt tactcttgta catatgttgt gggtttaaga gtcttttgca tttgttctgt
     8281 gacacctttt tttgaattga ctgttttaaa acggaggcct attttttccg gtttgggact
     8341 cctagtggtt atggcatccc ataatgcttc gtgacggcca ccaggacaga accacctgat
     8401 gttttagagc agttttcagc atgacactgt taacaagtgt gtattttcca aggccacatg
     8461 aaacttactt tcttagccac tccaggtttg ggagcagaaa agctgaaaaa cccttttgtg
     8521 tagaagtctg agtggtttgt gggggggacc ttttttagag tttgcatgcc agcgcacggc
     8581 ctattgctgt gaaacagaga gaaggtaaag ctacctgagg cagtgcgctg gaggatgaag
     8641 tgtttgatag cactaggggg gaaagaaaat gcatggcaaa gtttcgtctt ctcgtagact
     8701 atctagcatg cagagtgtag tgtgttgaaa cggtgtatga cattgctgta tcaaagttgt
     8761 aaaattaagc attatttatt gaaaactatg tatttttttg taaaaacctg atcacataga
     8821 gaatatcagt ggcttgtgct tgtgcttcga tctaaccagc ttcttgaccc accccccctt
     8881 ggtatgcagt gttaatgctc agggttgaaa atagtacact ccaatgtctc ttttgcaaga
     8941 gtttttcaca gaggattaca tttgttcaaa agactctaat aaaattgtgt gatcaatctt
     9001 ca
//
