LOCUS       NM_023016               4627 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens sosondowah ankyrin repeat domain family member C
            (SOWAHC), mRNA.
ACCESSION   NM_023016
VERSION     NM_023016.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4627)
  AUTHORS   Zhu,Q., Wang,J., Zhang,Q., Wang,F., Fang,L., Song,B., Xie,C. and
            Liu,J.
  TITLE     Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential
            prognostic biomarkers in lung squamous cell carcinoma
  JOURNAL   Mol Med Rep 21 (3), 1285-1295 (2020)
   PUBMED   32016477
  REMARK    GeneRIF: Methylationdriven genes PMPCAP1, SOWAHC and ZNF454 as
            potential prognostic biomarkers in lung squamous cell carcinoma.
REFERENCE   2  (bases 1 to 4627)
  AUTHORS   Maeso,I., Irimia,M., Tena,J.J., Gonzalez-Perez,E., Tran,D.,
            Ravi,V., Venkatesh,B., Campuzano,S., Gomez-Skarmeta,J.L. and
            Garcia-Fernandez,J.
  TITLE     An ancient genomic regulatory block conserved across bilaterians
            and its dismantling in tetrapods by retrogene replacement
  JOURNAL   Genome Res 22 (4), 642-655 (2012)
   PUBMED   22234889
REFERENCE   3  (bases 1 to 4627)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066772.1, AC011753.6, AK023346.1 and AK025523.1.
            
            On Nov 23, 2018 this sequence version replaced NM_023016.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK025523.1, BC066772.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356454.5/ ENSP00000365830.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               BC066772.1         31-279
            250-444             AC011753.6         69706-69900
            445-1864            BC066772.1         474-1893
            1865-2583           AK023346.1         175-893
            2584-3132           AK025523.1         2583-3131
            3133-3652           AK023346.1         1443-1962
            3653-3670           AK025523.1         3652-3669
            3671-4624           BC066772.1         3699-4652
            4625-4627           AC011753.6         74081-74083
FEATURES             Location/Qualifiers
     source          1..4627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..4627
                     /gene="SOWAHC"
                     /gene_synonym="ANKRD57; C2orf26"
                     /note="sosondowah ankyrin repeat domain family member C"
                     /db_xref="GeneID:65124"
                     /db_xref="HGNC:HGNC:26149"
     exon            1..4627
                     /gene="SOWAHC"
                     /gene_synonym="ANKRD57; C2orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1704
                     /gene="SOWAHC"
                     /gene_synonym="ANKRD57; C2orf26"
                     /note="ankyrin repeat domain-containing protein 57;
                     ankyrin repeat domain 57; protein sosondowah homolog C"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein SOWAHC"
                     /protein_id="NP_075392.2"
                     /db_xref="CCDS:CCDS33270.1"
                     /db_xref="GeneID:65124"
                     /db_xref="HGNC:HGNC:26149"
                     /translation="MEGPAEWGPEAALGPEAVLRFLAERGGRALHAELVQHFRGALGG
                     EPEQRARARAHFKELVNAVATVRVDPADGAKYVHLKKRFCEGPSEPSGDPPRIQVTAE
                     PEAPDGPAGPEARDRLPDAAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRD
                     VQPLPRTPAPGPSEDLELPPHGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKR
                     SVCPGGSSPGSSSGGGRGRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSAS
                     DGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNI
                     DARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEIKN
                     LVGALDEGDGESAAGSGGGRWRLSKVLPSHLITYKLSHALEDGGDHHHHHHSAEGWVG
                     GKAKDPGRKASGSSSGRIKPRLNKIRFRTQIVHTTPSFRDPEQPLEGRGEEGVGEERP
                     VKGHSPFTLRPKSNVFG"
     regulatory      4607..4612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOWAHC"
                     /gene_synonym="ANKRD57; C2orf26"
                     /note="hexamer: AATAAA"
     polyA_site      4627
                     /gene="SOWAHC"
                     /gene_synonym="ANKRD57; C2orf26"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgtag gctggcagcc cgctgagccc gccagactcc gccgccgtcg ggagccggcc
       61 gctgggagcc cgtcgctatg ggaccgcgct gagccgcccg ctggcggggg agcagcgcgg
      121 tcgaggatgg aggggccggc agagtggggc cccgaggcgg cgctgggccc cgaggcggtg
      181 ctgcgcttcc tggcggagcg cgggggccgg gccctgcacg ccgagctggt gcagcacttc
      241 aggggcgccc taggcggcga accggagcag cgcgcccgcg cccgcgcgca cttcaaggag
      301 ctggtgaacg ccgtggccac tgtgcgcgtc gatcccgccg acggcgccaa gtacgtgcac
      361 ctcaagaaga ggttctgtga agggccgtcc gagccctccg gggacccgcc gcgaatccag
      421 gtgaccgccg agcccgaggc ccccgacggc cctgccgggc ccgaggcgcg cgatcggctc
      481 cccgacgcgg cggccccgga gtcgctccct ggacagggcc gcgagctggg cgagggagag
      541 ccccccgccc ccgcgcactg gccgcccctg agcgccgggg ctcgcaggaa gaactcgcgg
      601 cgcgacgtgc agcccctacc gcggactcca gccccggggc ccagcgagga cctggagctc
      661 ccgccacatg gctgcgagga ggcggacagg ggcagctccc ttgtgggggc taccgcacag
      721 aggccggccc gccagaacct ccgtgacctg gtgatgggca gctccccgca gctgaagagg
      781 agcgtgtgtc ccgggggcag cagcccgggc agctcctccg ggggaggacg cggcagaggc
      841 gggggcgact cagacagcgc atcggtggcc tcgtcgtccg cggaggagga gagcagcggc
      901 ggaggctccg tgacgctgga ccccctggag cacgcgtgga tgctctctgc ctccgatggc
      961 aagtgggaca gcctggaggg cttgctcacc tgcgagcccg gcctgctggt caagcgggac
     1021 ttcattaccg gcttcacttg cctgcactgg gccgccaagc acggcaggca ggagcttctg
     1081 gccatgctag tcaacttcgc caacaaacac cagctgccgg tgaacatcga cgccaggacg
     1141 agcgggggtt acaccgccct gcacttggca gccatgcacg gccacgtgga ggtggtgaag
     1201 ctgctggtgg gggcctacga cgccgatgtg gacatcaggg actacagtgg gaaaaaggcc
     1261 tcccagtacc tgagtcggag catcgccgag gagatcaaga acctggtggg agccctggac
     1321 gagggtgacg gggaaagcgc cgcgggtagc ggcggcgggc gctggaggct ttcaaaggtg
     1381 cttccctcgc atctcatcac ctacaaactc tcacacgccc tagaagatgg aggggaccat
     1441 caccaccatc accactcggc tgaggggtgg gtcggaggca aagccaagga tccagggcgc
     1501 aaagcctcgg gcagctctag tggacgtata aaacccagac tcaacaaaat ccgattcaga
     1561 acccagatcg tccacaccac accctctttc agggacccag agcagccgct ggagggcagg
     1621 ggggaggagg gagtggggga ggaacgacct gttaaaggcc actcgccctt cacattgaga
     1681 ccaaagtcca atgtatttgg gtaaaaattg cttcttttag aaaatgcaaa ggtttatttg
     1741 tcttaataaa ttgaatacta ggtgttgtaa ggaagtgaga ccagaaggac aagctaaatt
     1801 atgcattctt acttgaggga tcggaatgga tggggcggag ttctcttcag gctagccttc
     1861 tgggaaaagt ggatgtcttt ttcagagatt catcatacct tgacctgtac ctcttctctg
     1921 ccctccactt ccctgccctg gagtccgttt ctggagacta gaaatgtatc taaattgggg
     1981 gaacagaatg aatgaattaa tgaatgagag ttcctttgct ttaaccattc ctggatgcct
     2041 gcaaagtaag gaataatgca gtttttatgt atctgatttt ataaggggtt actctttcaa
     2101 gagtaacaaa aaaatgcaaa ctgtaatgaa actacattgt atttctaagt gtgaaaacga
     2161 caggctgccc cgtttttact aattgcattt gcattttaag gtactactga aggtcagatc
     2221 aaagttgaaa tgcaaaaata ctaattagag aataatgtga ataaaatggg aatcttcttg
     2281 gtattttatg tgtattgtaa gtagcagtta aattattttt ttaaaagcaa tttcagtttt
     2341 aatcactgaa caaaagaaac aggcaacatt cacttctgta gtatggtttc cacctatctc
     2401 taacaccact attaaggtac accagtgtta aggtacatta ataactacac aaaattttat
     2461 ttaaagagaa cacttagcag cctatgatag ttttcaataa aatgttgcct ctctttcgga
     2521 ttctcactaa cttttgttac tattctaaaa gtttgaattt gctggggtgt ttattctgag
     2581 gattatttaa ccattgttct atttggcata accctattta atggtgctta gagctgaatt
     2641 acctacagaa actgtttctg gtttaaataa ttagcacaaa ttggcctaag tattcatgag
     2701 cccatgtttc tgtgaagtaa ttattaaacc aacttaatga ttcttatgta aggtacactt
     2761 tttattttaa tacattggta gtctctatga cttgtagcaa tgttttacaa atgtttaaaa
     2821 tgctaaactt aattttccaa gcttttcttg acaattagat acctatcctg tagttactga
     2881 aaatctgggt agtaaatcta cccaattaaa atggcacttt ataaaaggga atagagaaga
     2941 gatgggacta tttctatatt taaatgctgc tggctattcc tttgtatata aatgaaaaat
     3001 accattcatt aaaattaagt actcgtttaa gtatggttct taattacatt tcattcattt
     3061 atattagagt aaatggcttc ataactactt taaaatttaa cccacaagca tattaaatct
     3121 gtttgttata agattggaaa caatttttga gagggactaa tttaaacaag tcctccttta
     3181 gtcttttggg tcgcgtagtt gctgaaacct aagtacctgc agcctacagg ataaggaagt
     3241 tcacagcctg cggggtgaat gaacccatgt gtgaactgca cagagcaatt catagaaaat
     3301 gcatagaaat ttgtaacact ttggtcacat ctgtctctag atggtcattg aatttgttta
     3361 aagatggatg aaaggccagg catggtggct catgcctgta atcccagcac tttgggaggc
     3421 cgaggcaggt ggatcacttg aggccaggag tttgaaacca gcctggccaa catggtgaaa
     3481 acctgtctct actaaaaata caaaaattag ccgagcgtgg tggtgcgtgc ctgtagtccc
     3541 agctacttag gaggctgagg catgagaatc acttaaacct gagaggtgga ggttgcagtt
     3601 gagccaagat cacgacactg cactccagcc tgggcaacgg agactctgtc tcaaaaaaaa
     3661 aaaaaaaaaa gatgaatgaa aatatgaaat atataaacta gtatccattt atttgcattt
     3721 attgtgggat ttcagatatg aacggtgtaa atttgagaag cacttatgca tacatgtggg
     3781 tgaaaaacca atctaatttt gtataaataa aaacaggctc ctggaaggtg aaaagtagtc
     3841 atttgttcta aatctataca tattacttgt atctagtgca gaataagcta taacatccca
     3901 ttgaggaatc ttaaatttca tagacatgta aagctgaagt aactctaaag agcagatgct
     3961 tcagaaccat cagaaggttc tggtcaacag tcagtattat ctcttaaatg tatatgttgg
     4021 tcactaattg cacaaaatct ataatttgcc agggctttag agattgagtc aatatgtcat
     4081 ttaccatggt tttcccactg aaggctttaa cttttctgat aaaataatat tttaaatttt
     4141 caaaaaccca ttcctgagga gaactacttc tagcattcct tttcatgatg tgcttttgtg
     4201 cagtaagtag cattttcggc tacttaactt tacattcctc ttatttttca gtttccagtc
     4261 aagattataa aaagcaaatg attgatataa tttgatattc atagagttgt gcctaccttt
     4321 aatggaaaaa tacatgtcag atacttagat gtttattgat atgagactat gtggttaaaa
     4381 aacccaagta tgtccatgtg tttcttataa ggtacacttg aaactagtga gtgtttgtca
     4441 catttcactt tcatggtata taaaatgcag tttgcatata taacttgaat atctggtact
     4501 agttttttca cgcctgcaat cttggagtct aggttgcctt gtctctccta tttttaaata
     4561 agtgaaattt gggagattgt aaaatctgta aagtttgttt tgtgaaaata aaatgttcac
     4621 agtagaa
//
