LOCUS       NM_001029870            3993 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sosondowah ankyrin repeat domain family member B
            (SOWAHB), mRNA.
ACCESSION   NM_001029870 XM_293687
VERSION     NM_001029870.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3993)
  AUTHORS   Ruan,B., Feng,X., Chen,X., Dong,Z., Wang,Q., Xu,K., Tian,J.,
            Liu,J., Chen,Z., Shi,W., Wang,M., Qian,L. and Ding,Q.
  TITLE     Identification of a Set of Genes Improving Survival Prediction in
            Kidney Renal Clear Cell Carcinoma through Integrative Reanalysis of
            Transcriptomic Data
  JOURNAL   Dis Markers 2020, 8824717 (2020)
   PUBMED   33110456
  REMARK    GeneRIF: Identification of a Set of Genes Improving Survival
            Prediction in Kidney Renal Clear Cell Carcinoma through Integrative
            Reanalysis of Transcriptomic Data.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3993)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3993)
  AUTHORS   Boueiz,A., Lutz,S.M., Cho,M.H., Hersh,C.P., Bowler,R.P.,
            Washko,G.R., Halper-Stromberg,E., Bakke,P., Gulsvik,A., Laird,N.M.,
            Beaty,T.H., Coxson,H.O., Crapo,J.D., Silverman,E.K., Castaldi,P.J.
            and DeMeo,D.L.
  CONSRTM   COPDGene and ECLIPSE Investigators
  TITLE     Genome-Wide Association Study of the Genetic Determinants of
            Emphysema Distribution
  JOURNAL   Am J Respir Crit Care Med 195 (6), 757-771 (2017)
   PUBMED   27669027
REFERENCE   4  (bases 1 to 3993)
  AUTHORS   Maeso,I., Irimia,M., Tena,J.J., Gonzalez-Perez,E., Tran,D.,
            Ravi,V., Venkatesh,B., Campuzano,S., Gomez-Skarmeta,J.L. and
            Garcia-Fernandez,J.
  TITLE     An ancient genomic regulatory block conserved across bilaterians
            and its dismantling in tetrapods by retrogene replacement
  JOURNAL   Genome Res 22 (4), 642-655 (2012)
   PUBMED   22234889
REFERENCE   5  (bases 1 to 3993)
  AUTHORS   Li,J., Mahajan,A. and Tsai,M.D.
  TITLE     Ankyrin repeat: a unique motif mediating protein-protein
            interactions
  JOURNAL   Biochemistry 45 (51), 15168-15178 (2006)
   PUBMED   17176038
  REMARK    Review article
REFERENCE   6  (bases 1 to 3993)
  AUTHORS   Mosavi,L.K., Cammett,T.J., Desrosiers,D.C. and Peng,Z.Y.
  TITLE     The ankyrin repeat as molecular architecture for protein
            recognition
  JOURNAL   Protein Sci 13 (6), 1435-1448 (2004)
   PUBMED   15152081
  REMARK    Review article
REFERENCE   7  (bases 1 to 3993)
  AUTHORS   Hryniewicz-Jankowska,A., Czogalla,A., Bok,E. and Sikorsk,A.F.
  TITLE     Ankyrins, multifunctional proteins involved in many cellular
            pathways
  JOURNAL   Folia Histochem Cytobiol 40 (3), 239-249 (2002)
   PUBMED   12219834
  REMARK    Review article
REFERENCE   8  (bases 1 to 3993)
  AUTHORS   Sedgwick,S.G. and Smerdon,S.J.
  TITLE     The ankyrin repeat: a diversity of interactions on a common
            structural framework
  JOURNAL   Trends Biochem Sci 24 (8), 311-316 (1999)
   PUBMED   10431175
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104687.3 and BC137255.1.
            
            On May 17, 2019 this sequence version replaced NM_001029870.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC137241.1, DRR138528.13694.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334306.4/ ENSP00000334879.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC104687.3         49685-49902         c
            219-2918            BC137255.1         1-2700
            2919-3993           AC104687.3         45910-46984         c
FEATURES             Location/Qualifiers
     source          1..3993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..3993
                     /gene="SOWAHB"
                     /gene_synonym="ANKRD56"
                     /note="sosondowah ankyrin repeat domain family member B"
                     /db_xref="GeneID:345079"
                     /db_xref="HGNC:HGNC:32958"
     exon            1..3993
                     /gene="SOWAHB"
                     /gene_synonym="ANKRD56"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2677
                     /gene="SOWAHB"
                     /gene_synonym="ANKRD56"
                     /note="ankyrin repeat domain-containing protein 56;
                     ankyrin repeat domain 56; protein sosondowah homolog B"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein SOWAHB"
                     /protein_id="NP_001025041.1"
                     /db_xref="CCDS:CCDS34017.1"
                     /db_xref="GeneID:345079"
                     /db_xref="HGNC:HGNC:32958"
                     /translation="MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQH
                     QHRRELFKGFVNSVAAVRQDPDGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGA
                     APCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKG
                     GGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHS
                     ATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALL
                     PGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPDN
                     FLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLSLQ
                     DLDDFVDQESDGSEESSSGPKDSPGASEEGLQVVLGTPDRGKLRNPAGGLSVSRKEGS
                     PSRSPQGLRNRGDGHISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLS
                     SSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPSPRVDAGLSLKLAEVKAVVAERGWRHS
                     LWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEWIVKLASGSWIQVWTLFWEDPQLAL
                     HKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGH
                     QGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLLGAPRGKPIFPVYPLVGS
                     SSPTRKAKSKEISRSVTRKTSFAALLKSQHNKWKLANQYEKFHSPREREEYSD"
     regulatory      3959..3964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOWAHB"
                     /gene_synonym="ANKRD56"
                     /note="hexamer: ATTAAA"
     polyA_site      3993
                     /gene="SOWAHB"
                     /gene_synonym="ANKRD56"
                     /note="major polyA site"
ORIGIN      
        1 aactttcgct gtgaggactc gttgcgagag gctagagtcg cgcaggggcg gcctcggagc
       61 cgccctctct cacgcagact gccgcgggga ctcagccttg gggccacccg gaggggaccc
      121 acggccctcc tggcgcgctc acgggctgcg ggcagcgctg gcctccgcgg ctgatggggg
      181 cggctagtgc cgccccgggc gcaggtgaca ctcgcccggc cagggtttcc tctggctggg
      241 gagagccccg ggagggcgag actcagacac ctctggggcg gaggacaagg cagcgatggc
      301 ccgagagctg agccaggagg cactactgga ctttctgtgc caggctgggg gccgcgtgac
      361 caacgctgcc ttgctgagcc acttcaagag ctttctccga gaccccgacg cgtcccccag
      421 ccagcaccag caccgccgcg agctcttcaa gggcttcgtc aactcggtcg ccgcagtgcg
      481 ccaggacccc gacggcacca agtacgtggt gctcaagagg agatacaggg accttttggg
      541 ggaggagggg ctgcagcgac cccgcgagcc gcccgcggcc gcccccagtg cagggggagc
      601 tgcgccctgc tccccgcgag gcgcgcgccg gggggagccg ccccagcagc agcccaggcg
      661 gcggcggcgc gagaaggagc cggaggagga gccagcaggt gcagcagcca gagccgccga
      721 cgcagcttgc aatggactcc cgggcagcga ctcccgtagg gcgcccggga agggcggcgg
      781 atcgaagggc agtcccggac agaggccgcc ggtgcccgca gctgcagcgg caggggccca
      841 ggcgagagcg agctgcgcgg cggcgaagac gcagggccgc tgctgctggg aatgcctcca
      901 gaacaacctg gctgtactgc cgggagagct cggcgcactc ccgcactcgg ccaccgcgga
      961 ggagaagccg gcacgggctc tgcctgccca ggatgaccgc ggggcttcca gggagcggga
     1021 agaaggcgcg ctagctgagc cggcgcctgt gcctgcagtg gctcactcgc ctcccgccac
     1081 cgtcgaggct gcgacaagca gggcttcccc gcctgctctc ctgcccggcc ccgctccccg
     1141 cggagaccgg ccggagctgc tgacccccag ctccctgcat tattcgaccc tgcagcagca
     1201 gcagcagcgc actcgagagt gggtggccag gcacccgcag gtgcccgagg cccgtgatca
     1261 gggccctatc cgcgcctggt cggtgctgcc agacaacttc ctccagctgc ccttggaacc
     1321 cggctccacg gagcctaatt cagagccgcc agacccctgt ctttcctcgc actctctctt
     1381 tcctgttgtt ccggatgagt cctgggaatc ctgggcgggg aacccttcat tgactgtctt
     1441 tcgcagcatt cgttgtcagc tgtccctcca agatctggat gactttgtgg accaggagag
     1501 tgatggcagt gaggagagca gcagtgggcc caaagactcc ccgggggctt ctgaagaggg
     1561 gctgcaggtt gtcttgggaa ccccagatag ggggaagctc aggaatccag ctgggggcct
     1621 ttctgtatct cggaaggagg gcagccccag ccggagccct cagggtctca gaaacagagg
     1681 ggatggtcac atctctcagc aggtccctgc aggggctaat ggccttgcag gccaccccct
     1741 gaagcctttg ccttggccag ttcctaagtt aaggaggtcc ctcaggagga gctctctggc
     1801 agggagagcc aaattgtcct cctctgatga ggagtacctc gatgagggct tgctgaaaag
     1861 aagtcggcgc ccacctcgat ccaggaagcc ctccaaggca ggaacggcac ccagcccaag
     1921 ggttgatgca ggtttatcac taaaacttgc agaggttaag gctgttgtgg ccgagcgggg
     1981 ttggcgacac agcctgtggg tccccagtgg ggaggggtct gcagccttgg ccccccacag
     2041 aacttctgag cacaaatcat ccctggttcc actagatgcc agggagcatg agtggattgt
     2101 gaagcttgcc agtggctcct ggattcaggt gtggactttg ttctgggagg accctcaact
     2161 ggccttgcac aaagactttt tgactgggta cactgcgttg cactggatag ccaaacatgg
     2221 tgacctcagg gcccttcagg acttggtgtc tggagcaaag aaggcaggga ttgtccttga
     2281 tgtaaacgtg aggtccagtt gtggatatac cccgctgcac cttgcagcca ttcacggcca
     2341 ccagggggtc atcaaattgc tagtgcaaag gttggcttct cgggtaaatg tcagggacag
     2401 cagtgggaag aagccatggc agtatctaac cagtaatacc tctggggaaa tatggcagct
     2461 gttgggagct cctcggggca agcccatttt ccctgtctat cccttagttg gaagttcttc
     2521 ccctaccaga aaggccaaga gcaaggaaat atctagaagt gtcacccgaa aaacttcctt
     2581 cgctgcacta ctcaaaagtc agcacaacaa gtggaaactg gccaaccagt atgagaaatt
     2641 ccacagtcca agggaaagag aagagtatag tgactgaggt gggtctctct gtccaacatg
     2701 caggcagcac tccctcatcc tgctcagtga gagaattcag ggggaataga aaagctgctg
     2761 agagttggta aagaggatgg tcgagtgaga tggtgttgac ctccctggat cttatgtcac
     2821 tacatcctgg acctcaagag ggtcatccaa gctttttgaa agctgaactc cttgactgga
     2881 gaaacctaga caagaggcgg ggccaggtgc ttgatatcta ggaggcattc ttcctcttcc
     2941 cttgccacca tggagctggg cacagtaagc catattgttt cctgaagcag gagtcccagg
     3001 ccttggctag agagggaaca gatgtctaac aaaaagagaa gcaattcgag gaattgatga
     3061 agcacaatta aaatcctctc tggctagtag ctctctggct tctgttcatt tgaagaataa
     3121 atcttggctg acagtgggaa gcaccaggtt tgaaatcaga tggctttatt tttctttttt
     3181 tggcatttaa atcagtgaaa taaaattatt actggagagc acagttcgat ttaagagatt
     3241 cctcagccct gttctcaagt cttcttttga attccatgca tggtggttaa tgggtaaaat
     3301 gattaatgcc tcctttgggt cttctcactg atcagagaag cagctgggta agatccagtt
     3361 atgacttgga ctccattcct aagaggaatg actgtcattc aggccctgct tttttgtatc
     3421 aacccgaagg gaactttcca aatgtaaaaa ccatgtggct catttacata gtgactgaaa
     3481 ccatctttca tggaaactcc ctgtgtaaca aacagaatta tcgttactag ttttcagagg
     3541 tttgaatggc caacgtttgt actcataaaa agagagaaat gatttcactc tggggaaaca
     3601 gtaagggtta agagaatgca tccttaccag gactatctaa gccgctaaat ataattgtat
     3661 ttgcactaaa cttgttgcca attaagatta aatattagcc tttaagtact ctatatctaa
     3721 catgaagtgc tcctttttaa ttgcttttga agagaccgat aacttgtgag ttcatggagt
     3781 gagaaaatgg ctagtctata aacgtcagta gagcatcaag atttcagaat aagttcaaag
     3841 agggctgaaa tacatgttca agtggaaatt gttaattttt tatgggaatg ttttcatgag
     3901 atgtgacaat gatgctgtat tttaagtctt tttgtgtttc ttctggttat ttgcccccat
     3961 taaaagatca atagatcttt ataatttatt ata
//
