LOCUS       NM_015464               1758 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA.
ACCESSION   NM_015464
VERSION     NM_015464.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Liu,C., Yang,J., Zhu,F., Zhao,Z. and Gao,L.
  TITLE     Exosomal circ_0001190 Regulates the Progression of Gastric Cancer
            via miR-586/SOSTDC1 Axis
  JOURNAL   Biochem Genet 60 (6), 1895-1913 (2022)
   PUBMED   35138469
  REMARK    GeneRIF: Exosomal circ_0001190 Regulates the Progression of Gastric
            Cancer via miR-586/SOSTDC1 Axis.
REFERENCE   2  (bases 1 to 1758)
  AUTHORS   Li,C., Wang,M., Shi,Y. and Xin,H.
  TITLE     SOSTDC1 acts as a tumor inhibitor in acute myeloid leukemia by
            downregulating the Wnt/beta-catenin pathway
  JOURNAL   Environ Toxicol 37 (8), 1934-1943 (2022)
   PUBMED   35442555
  REMARK    GeneRIF: SOSTDC1 acts as a tumor inhibitor in acute myeloid
            leukemia by downregulating the Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 1758)
  AUTHORS   Liu,M., Deng,H., Zhao,Y., Li,C. and Liu,H.
  TITLE     Impact of microRNA-21-5p on the growth of thyroid cancer cells via
            targeting the recombinant sclerostin domain containing protein 1
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 46 (10), 1054-1062 (2021)
   PUBMED   34911834
  REMARK    GeneRIF: Impact of microRNA-21-5p on the growth of thyroid cancer
            cells via targeting the recombinant sclerostin domain containing
            protein 1.', trans 'RNA-21-5p1.
REFERENCE   4  (bases 1 to 1758)
  AUTHORS   Gipson,G.R., Kattamuri,C., Czepnik,M. and Thompson,T.B.
  TITLE     Characterization of the different oligomeric states of the DAN
            family antagonists SOSTDC1 and SOST
  JOURNAL   Biochem J 477 (17), 3167-3182 (2020)
   PUBMED   32779697
  REMARK    GeneRIF: Characterization of the different oligomeric states of the
            DAN family antagonists SOSTDC1 and SOST.
REFERENCE   5  (bases 1 to 1758)
  AUTHORS   Valensi,M., Goldman,G., Marchant,D., Van Den Berghe,L., Jonet,L.,
            Daruich,A., Robert,M.P., Krejci,E., Klein,C., Mascarelli,F.,
            Versaux-Botteri,C., Moulin,A., Putterman,M., Guimiot,F., Molina,T.,
            Terris,B., Bremond-Gignac,D., Behar-Cohen,F. and Abitbol,M.M.
  TITLE     Sostdc1 is expressed in all major compartments of developing and
            adult mammalian eyes
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 257 (11), 2401-2427 (2019)
   PUBMED   31529323
  REMARK    GeneRIF: As rat Sostdc1 and human SOSTDC1 are dual antagonists of
            the Wnt/beta-catenin and BMP signaling pathways, these results
            underscore the potential crucial roles of these pathways and their
            antagonists, such as Sostdc1 and SOSTDC1, in developing and adult
            mammalian normal eyes as well as in syndromic and nonsyndromic
            congenital eye diseases.
REFERENCE   6  (bases 1 to 1758)
  AUTHORS   Blish,K.R., Wang,W., Willingham,M.C., Du,W., Birse,C.E.,
            Krishnan,S.R., Brown,J.C., Hawkins,G.A., Garvin,A.J.,
            D'Agostino,R.B. Jr., Torti,F.M. and Torti,S.V.
  TITLE     A human bone morphogenetic protein antagonist is down-regulated in
            renal cancer
  JOURNAL   Mol Biol Cell 19 (2), 457-464 (2008)
   PUBMED   18032587
  REMARK    GeneRIF: This screen identified a bone morphogenetic protein (BMP)
            antagonist, SOSTDC1 (sclerostin domain-containing-1) as
            down-regulated in kidney tumors.
REFERENCE   7  (bases 1 to 1758)
  AUTHORS   Yanagita,M.
  TITLE     BMP antagonists: their roles in development and involvement in
            pathophysiology
  JOURNAL   Cytokine Growth Factor Rev 16 (3), 309-317 (2005)
   PUBMED   15951218
  REMARK    Review article
REFERENCE   8  (bases 1 to 1758)
  AUTHORS   Goto,M. and Eddy,E.M.
  TITLE     Speriolin is a novel spermatogenic cell-specific centrosomal
            protein associated with the seventh WD motif of Cdc20
  JOURNAL   J Biol Chem 279 (40), 42128-42138 (2004)
   PUBMED   15280373
REFERENCE   9  (bases 1 to 1758)
  AUTHORS   Yanagita,M., Oka,M., Watabe,T., Iguchi,H., Niida,A., Takahashi,S.,
            Akiyama,T., Miyazono,K., Yanagisawa,M. and Sakurai,T.
  TITLE     USAG-1: a bone morphogenetic protein antagonist abundantly
            expressed in the kidney
  JOURNAL   Biochem Biophys Res Commun 316 (2), 490-500 (2004)
   PUBMED   15020244
  REMARK    GeneRIF: USAG1 is expressed in the kidney and functions as a bone
            morphogenetic protein antagonist.
REFERENCE   10 (bases 1 to 1758)
  AUTHORS   Laurikkala,J., Kassai,Y., Pakkasjarvi,L., Thesleff,I. and Itoh,N.
  TITLE     Identification of a secreted BMP antagonist, ectodin, integrating
            BMP, FGF, and SHH signals from the tooth enamel knot
  JOURNAL   Dev Biol 264 (1), 91-105 (2003)
   PUBMED   14623234
  REMARK    GeneRIF: Data suggest that ectodin is a novel bone morphogenetic
            protein (BMP) inhibitor which integrates BMP signaling with the SHH
            and FGF signal pathways
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF361494.1, AI927000.1 and
            AI540640.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015464.2.
            
            Summary: This gene is a member of the sclerostin family and encodes
            an N-glycosylated, secreted protein with a C-terminal cystine
            knot-like domain. This protein functions as a bone morphogenetic
            protein (BMP) antagonist. Specifically, it directly associates with
            BMPs, prohibiting them from binding their receptors, thereby
            regulating BMP signaling during cellular proliferation,
            differentiation, and programmed cell death. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361494.1, SRR1660803.121045.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307068.5/ ENSP00000304930.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1257              AF361494.1         112-1368
            1258-1655           AI927000.1         42-439              c
            1656-1758           AI540640.1         15-117              c
FEATURES             Location/Qualifiers
     source          1..1758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.2"
     gene            1..1758
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
                     /note="sclerostin domain containing 1"
                     /db_xref="GeneID:25928"
                     /db_xref="HGNC:HGNC:21748"
                     /db_xref="MIM:609675"
     exon            1..275
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..691
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
                     /note="uterine sensitization-associated protein-1;
                     ectodermal BMP inhibitor; cystine-knot containing secreted
                     protein; wise"
                     /codon_start=1
                     /product="sclerostin domain-containing protein 1
                     precursor"
                     /protein_id="NP_056279.1"
                     /db_xref="CCDS:CCDS5360.1"
                     /db_xref="GeneID:25928"
                     /db_xref="HGNC:HGNC:21748"
                     /db_xref="MIM:609675"
                     /translation="MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHP
                     SSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAG
                     ECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVV
                     TACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS"
     exon            276..1758
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1676..1681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
                     /note="hexamer: AATAAA"
     polyA_site      1696
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
                     /note="major polyA site"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
                     /note="hexamer: AATAAA"
     polyA_site      1758
                     /gene="SOSTDC1"
                     /gene_synonym="CDA019; DAND7; ECTODIN; USAG1"
ORIGIN      
        1 acagttacag tgcagaagca gaagcaaaag aattaaccag ctcttcagtc aagcaaatcc
       61 tctactcacc atgcttcctc ctgccattca tttctatctc cttccccttg catgcatcct
      121 aatgaaaagc tgtttggctt ttaaaaatga tgccacagaa atcctttatt cacatgtggt
      181 taaacctgtt ccagcacacc ccagcagcaa cagcacgttg aatcaagcca gaaatggagg
      241 caggcatttc agtaacactg gactggatcg gaacactcgg gttcaagtgg gttgccggga
      301 actgcgttcc accaaataca tctctgatgg ccagtgcacc agcatcagcc ctctgaagga
      361 gctggtgtgt gctggcgagt gcttgcccct gccagtgctc cctaactgga ttggaggagg
      421 ctatggaaca aagtactgga gcaggaggag ctcccaggag tggcggtgtg tcaatgacaa
      481 aacccgtacc cagagaatcc agctgcagtg ccaagatggc agcacacgca cctacaaaat
      541 cacagtagtc actgcctgca agtgcaagag gtacacccgg cagcacaacg agtccagtca
      601 caactttgag agcatgtcac ctgccaagcc agtccagcat cacagagagc ggaaaagagc
      661 cagcaaatcc agcaagcaca gcatgagtta gaactcagac tcccataact agacttacta
      721 gtaaccatct gctttacaga tttgattgct tggaagactc aagcctgcca ctgctgtttt
      781 ctcacttgaa agtatatgct ttctgctttg atcaaaccca gcaagctgtc ttaagtatca
      841 ggaccttctt tgggaatagt ttttcctttt caagtttttc aagatgtagg tatatccatg
      901 aatgcaattt gcatttaaat tccacgtatc ctgtagtttt aattcctcat tgttcttaaa
      961 agactgttga tactataaac atcagtgaat cattatattt taaaacagaa aagggcttct
     1021 cagataccct ccatctactg gcccatcccc tctcctaaac aaaactcctt caaaacaggt
     1081 taaaaaaaat atgttgtcat gaatcttcac agtaacattt cagaaaggtg cttttttggt
     1141 actcttcatg ggaacagttt agcagccatg agtgatcttc ctttgaaaga gaatgaaaga
     1201 ccctgtgaca tttcacttca aaaataagcc ctgtagctct ttacggtcgc atagtatgaa
     1261 attataccct gcatgctgac cctcgcttgg aatggaatgc cagaaatgca tggcagcagc
     1321 taataagtaa agctgattaa ctatttattt gtcaatgtta ttatttaatg agctttcaca
     1381 tgtgatttgt ttcaaaactt taatttttta atgttttgaa actttttcat ggacctaaat
     1441 attttcctat atgatttgtg gttgattaga aatatgaaat acatgttgta gatatgtaaa
     1501 atgaatattt tagtctcctt attacatata tgttcatggt gaactttatc aatagtatgg
     1561 atctttttaa atcaataaga tgctttgtaa agttgaaata agtaatactt tcttgtttaa
     1621 tctgtgcaat cagaaggtgt cttgaccttc aattcaattg gtttctttta acaaaaataa
     1681 acactgctaa aagttattgt tgttgcctct aacatgtata aagggtgcaa aaattgtaga
     1741 ataaatgtat aagggtaa
//
