LOCUS       XM_047431715            5604 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SOS Ras/Rho guanine nucleotide exchange
            factor 2 (SOS2), transcript variant X3, mRNA.
ACCESSION   XM_047431715
VERSION     XM_047431715.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     gene            1..5604
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /note="SOS Ras/Rho guanine nucleotide exchange factor 2;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 32 ESTs, 414 long SRA reads, 2
                     Proteins, and 97% coverage of the annotated genomic
                     feature by RNAseq alignments, including 2 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
     CDS             296..4390
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /codon_start=1
                     /product="son of sevenless homolog 2 isoform X3"
                     /protein_id="XP_047287671.1"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
                     /translation="MQQAPQPYEFFSEENSPKWRGLLVSALRKMESRFFARLGCSGAI
                     LAHCNLHLSGSSDSPASASRVAGTTGVCHHAQVQEQVHPTLSANEESLYYIEELIFQL
                     LNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPS
                     LKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKP
                     LVTTFYSASMSLFQIPHVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEER
                     QYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTD
                     ESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQQLKA
                     CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIK
                     KMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQT
                     RLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNN
                     WMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQS
                     RSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPE
                     PEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLEL
                     LERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKP
                     GQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIR
                     HTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVY
                     RLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEE
                     GNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSA
                     SEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHP
                     TPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGS
                     NSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDP
                     PAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINC
                     PFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPP
                     APPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ"
ORIGIN      
        1 agaagcgggc cagcgccgcc gggaaaggag gtcgccgccc ggggtcgccc gggcttgcgg
       61 gtcgccgcgc ttcctctgcg ggcgctgcgg gaggcgaggg ccgcctcggc ggaggaagcc
      121 gaccccgggg tctccgccag cccgccggcg ccgcctccga gccgcctcgg ccgtagcctc
      181 ggcccgggcg ggaggcggcg gccgccggcg aggcgaggcg gcccgcgccc tgcctgtcag
      241 gccaccggcc cggcccgcgg gctgcccccg atgcggaggc gctgtcgccg gggccatgca
      301 gcaggcgccg cagccttacg agttcttcag cgaggagaac agtccgaaat ggcggggact
      361 gttggtctcg gccctgcgga agatggagtc tcgctttttt gccaggctgg ggtgtagtgg
      421 tgcaatcttg gctcactgca acctccacct ctcaggttca agtgattctc ctgcctcagc
      481 ctcccgagta gctgggacta caggcgtgtg ccaccacgcc caggttcagg aacaagtgca
      541 tcccactctc tcagctaatg aagagtctct ctattatatt gaagagctga tttttcagct
      601 gcttaataaa ttatgcatgg cccagccaag gactgttcaa gatgtagagg agcgagttca
      661 gaagaccttt cctcacccaa ttgataaatg ggccattgct gatgcacaat ctgctataga
      721 aaaacgaaaa cgaagaaatc ctcttttact gcctgtggac aaaatccatc cttcgttgaa
      781 ggaagtatta gggtacaaag tggactacca tgtatcccta tatattgtgg ctgtactaga
      841 gtatatctca gctgatattt taaaattggc tggtaattat gtttttaata tccggcatta
      901 tgaaatatct cagcaggaca ttaaagtgtc aatgtgtgcg gataagcctc tggtaaccac
      961 attctactct gcctctatga gtttgttcca gattccacat gttttgatgg acatgtttga
     1021 tcaggatgac ataggtttgg tttctctctg tgaagatgaa cctagttctt ctggtgaatt
     1081 aaactactat gatcttgtca gaactgaaat cgcagaagaa agacagtatc tacgggaatt
     1141 aaatatgatc ataaaagtgt ttcgagaagc ctttctttct gatagaaagc tgtttaaacc
     1201 ttctgatatc gaaaagattt ttagtaacat ttcagatata catgaattga ctgtgaaact
     1261 tttaggtttg attgaagaca cagttgaaat gactgatgaa agcagtcctc atcccttagc
     1321 tggcagctgt tttgaagatt tggcagaaga gcaagcattt gatccttatg aaacattatc
     1381 acaggacatt ctttcaccag agtttcatga acatttcaat aaattgatgg ccagacctgc
     1441 agttgctcta cactttcagc aattgaaagc atgtagtgaa gaacaagaag acagagaatg
     1501 tttgaaccaa gctattactg ctctcatgaa tctccaaggt agcatggacc gaatttacaa
     1561 gcagtattca cctagacgtc gacctggaga tcctgtttgc cctttttata gtcaccaatt
     1621 aagaagcaaa cacctggcta tcaaaaaaat gaatgaaatt cagaaaaata tcgatggatg
     1681 ggaaggcaaa gatattggac agtgttgtaa tgaattcatt atggagggac cattgacaag
     1741 aatcggtgcc aaacatgaac ggcatatttt tctgtttgat ggcttaatga tcagttgtaa
     1801 acctaatcat ggccagactc ggcttccagg ttacagtagt gcagaataca ggttaaaaga
     1861 aaaatttgtc atgaggaaaa tacaaatttg tgataaagaa gatacttgtg agcacaagca
     1921 tgcatttgaa ttagtatcca aagatgagaa cagcataata tttgctgcta agtctgctga
     1981 agaaaaaaac aactggatgg cagcccttat ttctcttcat tatcgtagta ctctagatcg
     2041 aatgttagat tcagtattat tgaaagaaga aaatgagcaa ccactgagat taccaagtcc
     2101 tgaagtatat cgttttgtag taaaagactc tgaggaaaac attgtttttg aagacaactt
     2161 gcaaagtaga agtggcatcc ccattattaa aggaggaact gtagtgaaat taattgaaag
     2221 gttaacatat catatgtatg cagatcccaa ttttgttcgt acttttctta ccacatatcg
     2281 ttcattttgt aaaccacagg aattgctgag cttactgatt gaacggtttg aaattccaga
     2341 gccagaacct actgacgcag acaaattggc aatagagaaa ggcgagcagc caatcagtgc
     2401 agaccttaaa agatttcgca aggaatatgt ccaaccagta caacttagga tcttaaatgt
     2461 atttcggcat tgggttgaac atcattttta tgactttgaa agagacttgg aattgcttga
     2521 aagactagaa tccttcattt caagtgtaag agggaaagct atgaaaaaat gggtagagtc
     2581 aattgctaag atcatcagga ggaagaagca agctcaggca aacggagtaa gccataatat
     2641 tacctttgaa agtccacctc caccaattga atggcatatc agcaaaccag gacagtttga
     2701 aacatttgat ctcatgacac ttcatccaat agaaattgca cgtcagctga cacttttgga
     2761 gtctgatctt tacaggaaag ttcaaccgtc tgaacttgta gggagtgtgt ggaccaaaga
     2821 agataaagaa ataaattctc caaatttatt aaaaatgatt cgccatacca caaatctcac
     2881 cctctggttt gaaaaatgca ttgtggaagc agaaaatttt gaagaacggg tggcagtact
     2941 aagtagaatt atagaaattc tgcaagtttt tcaagatttg aataatttca atggcgtatt
     3001 ggagatagtc agtgcagtaa attcagtgtc agtatacaga ctagaccata cctttgaggc
     3061 actgcaggaa aggaaaagga aaattttgga cgaagctgtg gaattaagtc aagatcactt
     3121 taaaaaatac ctagtaaaac ttaagtcaat caatccacct tgtgtgcctt tttttggaat
     3181 atatttaaca aatattctga agaccgaaga agggaataat gattttttaa aaaagaaagg
     3241 gaaagattta atcaatttca gtaagaggag gaaagtagct gaaattactg gagaaattca
     3301 gcagtatcag aatcagcctt actgtttacg gatagaacca gatatgagga gattctttga
     3361 aaaccttaac cccatgggaa gtgcatctga aaaagagttt acagattatt tgttcaacaa
     3421 gtcactagaa attgaacctc gaaactgcaa acagccacct cgatttccta ggaaatcaac
     3481 tttttcctta aaatctcctg gaataaggcc taacacaggc cgacatggct ctacctcagg
     3541 tactttacga ggtcacccaa caccattaga aagagaacca tgtaaaataa gctttagtcg
     3601 gattgctgaa actgagctgg aatcaacagt gtcagcacca acctctccaa atacaccatc
     3661 tactccacca gtatctgctt cttcagacct tagtgtattt ttagatgtgg atctcaacag
     3721 ctcctgtggc agcaatagca tctttgctcc agtgcttttg ccacattcaa agtctttctt
     3781 tagttcatgt ggtagtttac ataaactaag tgaagagccc ctgattcctc ctcctcttcc
     3841 tcctcgaaaa aagtttgatc atgatgcttc aaattccaag ggaaatatga aatctgatga
     3901 tgatcctcct gctattccac cgagacagcc tcctcctcca aaggtaaaac ccagagttcc
     3961 tgttcctact ggtgcatttg atgggcctct gcatagtcca cctccgccac caccaagaga
     4021 tcctcttcct gatacccctc caccagttcc ccttcggcct ccagaacact ttataaactg
     4081 tccatttaat cttcagccac ctccactggg gcatcttcac agagattcag actggctcag
     4141 agacattagt acgtgtccaa attcgccaag cactcctcct agcacaccct ctccaagggt
     4201 accgcgtcga tgctatgtgc tcagttctag tcagaataat cttgctcatc ctccagctcc
     4261 ccctgttcca ccaaggcaga attcaagccc tcatctgcca aaactgccac caaagactta
     4321 caaacgggag ctttcgcacc ccccattgta cagactgcct ttgctagaaa atgcagaaac
     4381 tccccaatga ccttagccat atgtagtcat tgacactgga atggtatttg taaagttttt
     4441 tttttaattt attcaaaaaa agacatagta ttttagtact ttttacaaat aatgctctta
     4501 caaaaatgct actgatcaaa taagctttta agaattggaa aaataaaaat acaaaagtcc
     4561 ttcaccatta tcctcaggtg atcagtagca ttgccttgtc ttggatcctc agtgctgcca
     4621 aaaggccagt ataaagaatt tatatttgca ctgtaaactc tgcaaaaata tggtttaaag
     4681 tgacatgatt gcactgaaaa gggatagtgc ttttgtgaaa tttttcaaat ttgagtaata
     4741 gatgcctttt taaggcagtg aatttacaca aatatgggag gggtatatgg tgttactgat
     4801 ttttaaacct ctttgaccat cttctagttt ttacttctag tttttacatc taggagaatt
     4861 gtgaataaca ccaactgttc ttaaactctt taatgccatg tcttaaatgc cggtatttgc
     4921 tgctgaagac aaaaatgaaa agtaggatga aaataataga atggcactgt aagtgtttat
     4981 tattttgtca aaatgtaaac aaagactaca taacccaatg atggagggaa aaagggcatg
     5041 tatctcattc agatgtgcct tttgtttttg cagactatga cgtctttagc taatgaattg
     5101 cctattgtta tggaaaacag ttaatatgcc atgtatgtac agttttgttt atattgtata
     5161 tttaaagata ctgctaataa cctatataaa tttaagtgac ttgaggccta taatacaatc
     5221 tgctacttta ctaattcata aattcaaaaa aaattctatg gcataggaac caactgcctt
     5281 gccttcaaga cctagtaact ttctctataa atctcgtgtt aactgaaatt ttttttaaat
     5341 atatttttta gattggtaat atttaaacca gcaaatactt aaagctttat taaacatttt
     5401 aatcagataa gtgagtaaag cttttatttg ccatttggat gccttcgttc aaagtgatag
     5461 agtgttttgc tgatagtgct gtagcagcag ttgtaaagta gccaaaagcc acgttgttta
     5521 tttactggtt tgtggccttt tactgtgctt tgtatcagag ttcttaacaa gattaataaa
     5581 tcaccccagt cttaattttt aaaa
//
