LOCUS       NM_006939               5508 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens SOS Ras/Rho guanine nucleotide exchange factor 2
            (SOS2), transcript variant 1, mRNA.
ACCESSION   NM_006939 XM_043720
VERSION     NM_006939.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5508)
  AUTHORS   Lin,Q., Qiu,M., Wei,X., Xiang,Z., Zhou,Z., Ji,I., Liang,X.,
            Zhou,X., Wen,Q., Liu,Y. and Yu,H.
  TITLE     Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway
            genes predict survival of HBV-related hepatocellular carcinoma
            patients
  JOURNAL   Arch Toxicol 97 (6), 1599-1611 (2023)
   PUBMED   37029817
  REMARK    GeneRIF: Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS
            pathway genes predict survival of HBV-related hepatocellular
            carcinoma patients.
REFERENCE   2  (bases 1 to 5508)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 5508)
  AUTHORS   Gentile,M., Fanelli,T., Lepri,F.R., Gentile,A., Orsini,P.,
            Volpe,P., Novelli,A. and Ficarella,R.
  TITLE     First prenatal case of Noonan syndrome with SOS2 mutation:
            Implications of early diagnosis for genetic counseling
  JOURNAL   Am J Med Genet A 185 (6), 1897-1902 (2021)
   PUBMED   33750022
  REMARK    GeneRIF: First prenatal case of Noonan syndrome with SOS2 mutation:
            Implications of early diagnosis for genetic counseling.
REFERENCE   4  (bases 1 to 5508)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5508)
  AUTHORS   Yamamoto,G.L., Aguena,M., Gos,M., Hung,C., Pilch,J., Fahiminiya,S.,
            Abramowicz,A., Cristian,I., Buscarilli,M., Naslavsky,M.S.,
            Malaquias,A.C., Zatz,M., Bodamer,O., Majewski,J., Jorge,A.A.,
            Pereira,A.C., Kim,C.A., Passos-Bueno,M.R. and Bertola,D.R.
  TITLE     Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome
  JOURNAL   J Med Genet 52 (6), 413-421 (2015)
   PUBMED   25795793
  REMARK    GeneRIF: We identified two novel genes, SOS2 and LZTR1, associated
            with Noonan syndrome, thereby expanding the molecular spectrum of
            RASopathies.
REFERENCE   6  (bases 1 to 5508)
  AUTHORS   Ingham,R.J., Krebs,D.L., Barbazuk,S.M., Turck,C.W., Hirai,H.,
            Matsuda,M. and Gold,M.R.
  TITLE     B cell antigen receptor signaling induces the formation of
            complexes containing the Crk adapter proteins
  JOURNAL   J Biol Chem 271 (50), 32306-32314 (1996)
   PUBMED   8943292
REFERENCE   7  (bases 1 to 5508)
  AUTHORS   Yang,S.S., Van Aelst,L. and Bar-Sagi,D.
  TITLE     Differential interactions of human Sos1 and Sos2 with Grb2
  JOURNAL   J Biol Chem 270 (31), 18212-18215 (1995)
   PUBMED   7629138
REFERENCE   8  (bases 1 to 5508)
  AUTHORS   Webb,G.C., Jenkins,N.A., Largaespada,D.A., Copeland,N.G.,
            Fernandez,C.S. and Bowtell,D.D.
  TITLE     Mammalian homologues of the Drosophila Son of sevenless gene map to
            murine chromosomes 17 and 12 and to human chromosomes 2 and 14,
            respectively
  JOURNAL   Genomics 18 (1), 14-19 (1993)
   PUBMED   8276400
REFERENCE   9  (bases 1 to 5508)
  AUTHORS   Chardin,P., Camonis,J.H., Gale,N.W., van Aelst,L., Schlessinger,J.,
            Wigler,M.H. and Bar-Sagi,D.
  TITLE     Human Sos1: a guanine nucleotide exchange factor for Ras that binds
            to GRB2
  JOURNAL   Science 260 (5112), 1338-1343 (1993)
   PUBMED   8493579
REFERENCE   10 (bases 1 to 5508)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109758.3, AI419975.1,
            BC117261.1 and R20624.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006939.3.
            
            Summary: This gene encodes a regulatory protein that is involved in
            the positive regulation of ras proteins. Mutations in this gene are
            associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117261.1, AB209277.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216373.10/ ENSP00000216373.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AL109758.3         170540-170736       c
            198-269             AI419975.1         1-72
            270-4328            BC117261.1         1-4059
            4329-5382           AL109758.3         56414-57467         c
            5383-5508           R20624.1           31-156              c
FEATURES             Location/Qualifiers
     source          1..5508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..5508
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /note="SOS Ras/Rho guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
     exon            1..382
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..4294
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide releasing factor; son of sevenless
                     homolog 2"
                     /codon_start=1
                     /product="son of sevenless homolog 2 isoform 1"
                     /protein_id="NP_008870.2"
                     /db_xref="CCDS:CCDS9697.1"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
                     /translation="MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEES
                     LYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNP
                     LLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQ
                     DIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELN
                     MIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPL
                     AGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVR
                     YVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQY
                     SPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTR
                     IGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEH
                     KHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLR
                     LPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRT
                     FLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQP
                     VQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQ
                     AQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQ
                     PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEI
                     LQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYL
                     VKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQY
                     QNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKST
                     FSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNT
                     PSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIP
                     PPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPP
                     PPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTP
                     PSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY
                     RLPLLENAETPQ"
     exon            383..508
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..640
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..805
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1009
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1153
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1264
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1363
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1491
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..2147
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2229
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2352
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2456
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2679
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2799
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2962
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3080
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3253
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3370
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3632
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3674
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3784
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..5508
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5479..5484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /note="hexamer: AATAAA"
     polyA_site      5508
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /note="major polyA site"
ORIGIN      
        1 agaagcgggc cagcgccgcc gggaaaggag gtcgccgccc ggggtcgccc gggcttgcgg
       61 gtcgccgcgc ttcctctgcg ggcgctgcgg gaggcgaggg ccgcctcggc ggaggaagcc
      121 gaccccgggg tctccgccag cccgccggcg ccgcctccga gccgcctcgg ccgtagcctc
      181 ggcccgggcg ggaggcggcg gccgccggcg aggcgaggcg gcccgcgccc tgcctgtcag
      241 gccaccggcc cggcccgcgg gctgcccccg atgcggaggc gctgtcgccg gggccatgca
      301 gcaggcgccg cagccttacg agttcttcag cgaggagaac agtccgaaat ggcggggact
      361 gttggtctcg gccctgcgga aggttcagga acaagtgcat cccactctct cagctaatga
      421 agagtctctc tattatattg aagagctgat ttttcagctg cttaataaat tatgcatggc
      481 ccagccaagg actgttcaag atgtagagga gcgagttcag aagacctttc ctcacccaat
      541 tgataaatgg gccattgctg atgcacaatc tgctatagaa aaacgaaaac gaagaaatcc
      601 tcttttactg cctgtggaca aaatccatcc ttcgttgaag gaagtattag ggtacaaagt
      661 ggactaccat gtatccctat atattgtggc tgtactagag tatatctcag ctgatatttt
      721 aaaattggct ggtaattatg tttttaatat ccggcattat gaaatatctc agcaggacat
      781 taaagtgtca atgtgtgcgg ataaggtttt gatggacatg tttgatcagg atgacatagg
      841 tttggtttct ctctgtgaag atgaacctag ttcttctggt gaattaaact actatgatct
      901 tgtcagaact gaaatcgcag aagaaagaca gtatctacgg gaattaaata tgatcataaa
      961 agtgtttcga gaagcctttc tttctgatag aaagctgttt aaaccttctg atatcgaaaa
     1021 gatttttagt aacatttcag atatacatga attgactgtg aaacttttag gtttgattga
     1081 agacacagtt gaaatgactg atgaaagcag tcctcatccc ttagctggca gctgttttga
     1141 agatttggca gaagagcaag catttgatcc ttatgaaaca ttatcacagg acattctttc
     1201 accagagttt catgaacatt tcaataaatt gatggccaga cctgcagttg ctctacactt
     1261 tcagtccatt gctgatggtt ttaaagaggc agttcgttat gtccttccac gtcttatgct
     1321 ggtgccagtg tatcactgtt ggcactactt tgagttacta aagcaattga aagcatgtag
     1381 tgaagaacaa gaagacagag aatgtttgaa ccaagctatt actgctctca tgaatctcca
     1441 aggtagcatg gaccgaattt acaagcagta ttcacctaga cgtcgacctg gagatcctgt
     1501 ttgccctttt tatagtcacc aattaagaag caaacacctg gctatcaaaa aaatgaatga
     1561 aattcagaaa aatatcgatg gatgggaagg caaagatatt ggacagtgtt gtaatgaatt
     1621 cattatggag ggaccattga caagaatcgg tgccaaacat gaacggcata tttttctgtt
     1681 tgatggctta atgatcagtt gtaaacctaa tcatggccag actcggcttc caggttacag
     1741 tagtgcagaa tacaggttaa aagaaaaatt tgtcatgagg aaaatacaaa tttgtgataa
     1801 agaagatact tgtgagcaca agcatgcatt tgaattagta tccaaagatg agaacagcat
     1861 aatatttgct gctaagtctg ctgaagaaaa aaacaactgg atggcagccc ttatttctct
     1921 tcattatcgt agtactctag atcgaatgtt agattcagta ttattgaaag aagaaaatga
     1981 gcaaccactg agattaccaa gtcctgaagt atatcgtttt gtagtaaaag actctgagga
     2041 aaacattgtt tttgaagaca acttgcaaag tagaagtggc atccccatta ttaaaggagg
     2101 aactgtagtg aaattaattg aaaggttaac atatcatatg tatgcagatc ccaattttgt
     2161 tcgtactttt cttaccacat atcgttcatt ttgtaaacca caggaattgc tgagcttact
     2221 gattgaacgg tttgaaattc cagagccaga acctactgac gcagacaaat tggcaataga
     2281 gaaaggcgag cagccaatca gtgcagacct taaaagattt cgcaaggaat atgtccaacc
     2341 agtacaactt aggatcttaa atgtatttcg gcattgggtt gaacatcatt tttatgactt
     2401 tgaaagagac ttggaattgc ttgaaagact agaatccttc atttcaagtg taagagggaa
     2461 agctatgaaa aaatgggtag agtcaattgc taagatcatc aggaggaaga agcaagctca
     2521 ggcaaacgga gtaagccata atattacctt tgaaagtcca cctccaccaa ttgaatggca
     2581 tatcagcaaa ccaggacagt ttgaaacatt tgatctcatg acacttcatc caatagaaat
     2641 tgcacgtcag ctgacacttt tggagtctga tctttacagg aaagttcaac cgtctgaact
     2701 tgtagggagt gtgtggacca aagaagataa agaaataaat tctccaaatt tattaaaaat
     2761 gattcgccat accacaaatc tcaccctctg gtttgaaaaa tgcattgtgg aagcagaaaa
     2821 ttttgaagaa cgggtggcag tactaagtag aattatagaa attctgcaag tttttcaaga
     2881 tttgaataat ttcaatggcg tattggagat agtcagtgca gtaaattcag tgtcagtata
     2941 cagactagac catacctttg aggcactgca ggaaaggaaa aggaaaattt tggacgaagc
     3001 tgtggaatta agtcaagatc actttaaaaa atacctagta aaacttaagt caatcaatcc
     3061 accttgtgtg cctttttttg gaatatattt aacaaatatt ctgaagaccg aagaagggaa
     3121 taatgatttt ttaaaaaaga aagggaaaga tttaatcaat ttcagtaaga ggaggaaagt
     3181 agctgaaatt actggagaaa ttcagcagta tcagaatcag ccttactgtt tacggataga
     3241 accagatatg aggagattct ttgaaaacct taaccccatg ggaagtgcat ctgaaaaaga
     3301 gtttacagat tatttgttca acaagtcact agaaattgaa cctcgaaact gcaaacagcc
     3361 acctcgattt cctaggaaat caactttttc cttaaaatct cctggaataa ggcctaacac
     3421 aggccgacat ggctctacct caggtacttt acgaggtcac ccaacaccat tagaaagaga
     3481 accatgtaaa ataagcttta gtcggattgc tgaaactgag ctggaatcaa cagtgtcagc
     3541 accaacctct ccaaatacac catctactcc accagtatct gcttcttcag accttagtgt
     3601 atttttagat gtggatctca acagctcctg tggcagcaat agcatctttg ctccagtgct
     3661 tttgccacat tcaaagtctt tctttagttc atgtggtagt ttacataaac taagtgaaga
     3721 gcccctgatt cctcctcctc ttcctcctcg aaaaaagttt gatcatgatg cttcaaattc
     3781 caagggaaat atgaaatctg atgatgatcc tcctgctatt ccaccgagac agcctcctcc
     3841 tccaaaggta aaacccagag ttcctgttcc tactggtgca tttgatgggc ctctgcatag
     3901 tccacctccg ccaccaccaa gagatcctct tcctgatacc cctccaccag ttccccttcg
     3961 gcctccagaa cactttataa actgtccatt taatcttcag ccacctccac tggggcatct
     4021 tcacagagat tcagactggc tcagagacat tagtacgtgt ccaaattcgc caagcactcc
     4081 tcctagcaca ccctctccaa gggtaccgcg tcgatgctat gtgctcagtt ctagtcagaa
     4141 taatcttgct catcctccag ctccccctgt tccaccaagg cagaattcaa gccctcatct
     4201 gccaaaactg ccaccaaaga cttacaaacg ggagctttcg caccccccat tgtacagact
     4261 gcctttgcta gaaaatgcag aaactcccca atgaccttag ccatatgtag tcattgacac
     4321 tggaatggta tttgtaaagt ttttttttta atttattcaa aaaaagacat agtattttag
     4381 tactttttac aaataatgct cttacaaaaa tgctactgat caaataagct tttaagaatt
     4441 ggaaaaataa aaatacaaaa gtccttcacc attatcctca ggtgatcagt agcattgcct
     4501 tgtcttggat cctcagtgct gccaaaaggc cagtataaag aatttatatt tgcactgtaa
     4561 actctgcaaa aatatggttt aaagtgacat gattgcactg aaaagggata gtgcttttgt
     4621 gaaatttttc aaatttgagt aatagatgcc tttttaaggc agtgaattta cacaaatatg
     4681 ggaggggtat atggtgttac tgatttttaa acctctttga ccatcttcta gtttttactt
     4741 ctagttttta catctaggag aattgtgaat aacaccaact gttcttaaac tctttaatgc
     4801 catgtcttaa atgccggtat ttgctgctga agacaaaaat gaaaagtagg atgaaaataa
     4861 tagaatggca ctgtaagtgt ttattatttt gtcaaaatgt aaacaaagac tacataaccc
     4921 aatgatggag ggaaaaaggg catgtatctc attcagatgt gccttttgtt tttgcagact
     4981 atgacgtctt tagctaatga attgcctatt gttatggaaa acagttaata tgccatgtat
     5041 gtacagtttt gtttatattg tatatttaaa gatactgcta ataacctata taaatttaag
     5101 tgacttgagg cctataatac aatctgctac tttactaatt cataaattca aaaaaaattc
     5161 tatggcatag gaaccaactg ccttgccttc aagacctagt aactttctct ataaatctcg
     5221 tgttaactga aatttttttt aaatatattt tttagattgg taatatttaa accagcaaat
     5281 acttaaagct ttattaaaca ttttaatcag ataagtgagt aaagctttta tttgccattt
     5341 ggatgccttc gttcaaagtg atagagtgtt ttgctgatag tgctgtagca gcagttgtaa
     5401 agtagccaaa agccacgttg tttatttact ggtttgtggc cttttactgt gctttgtatc
     5461 agagttctta acaagattaa taaatcaccc cagtcttaat ttttaaaa
//
