LOCUS       NM_002959               6990 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens sortilin 1 (SORT1), transcript variant 1, mRNA.
ACCESSION   NM_002959
VERSION     NM_002959.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6990)
  AUTHORS   Vukolova,Y., Gubareva,I., Galati,G. and Germanova,O.
  TITLE     Diagnostic utility of sortilin & other biomarkers in the diagnosis
            of carotid & coronary atherosclerosis in individuals with arterial
            hypertension
  JOURNAL   Indian J Med Res 159 (5), 511-518 (2024)
   PUBMED   39382416
  REMARK    GeneRIF: Diagnostic utility of sortilin & other biomarkers in the
            diagnosis of carotid & coronary atherosclerosis in individuals with
            arterial hypertension.
REFERENCE   2  (bases 1 to 6990)
  AUTHORS   Bolduan,F., Wetzel,A., Giesecke,Y., Eichhorn,I., Alenina,N.,
            Bader,M., Willnow,T.E., Wiedenmann,B. and Sigal,M.
  TITLE     Elevated sortilin expression discriminates functional from
            non-functional neuroendocrine tumors and enables therapeutic
            targeting
  JOURNAL   Front Endocrinol (Lausanne) 15, 1331231 (2024)
   PUBMED   38694940
  REMARK    GeneRIF: Elevated sortilin expression discriminates functional from
            non-functional neuroendocrine tumors and enables therapeutic
            targeting.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6990)
  AUTHORS   Atak,M., Sevim Nalkiran,H., Bostan,M. and Uydu,H.A.
  TITLE     The association of Sort1 expression with LDL subfraction and
            inflammation in patients with coronary artery disease
  JOURNAL   Acta Cardiol 79 (2), 159-166 (2024)
   PUBMED   38095557
  REMARK    GeneRIF: The association of Sort1 expression with LDL subfraction
            and inflammation in patients with coronary artery disease.
REFERENCE   4  (bases 1 to 6990)
  AUTHORS   Georgoula,M., Ntavaroukas,P., Androutsopoulou,A., Xiromerisiou,G.,
            Kalala,F., Speletas,M., Asprodini,E., Vasilaki,A. and
            Papoutsopoulou,S.
  TITLE     Sortilin Expression Levels and Peripheral Immunity: A Potential
            Biomarker for Segregation between Parkinson's Disease Patients and
            Healthy Controls
  JOURNAL   Int J Mol Sci 25 (3), 1791 (2024)
   PUBMED   38339069
  REMARK    GeneRIF: Sortilin Expression Levels and Peripheral Immunity: A
            Potential Biomarker for Segregation between Parkinson's Disease
            Patients and Healthy Controls.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6990)
  AUTHORS   Carlo,A.S., Nykjaer,A. and Willnow,T.E.
  TITLE     Sorting receptor sortilin-a culprit in cardiovascular and
            neurological diseases
  JOURNAL   J Mol Med (Berl) 92 (9), 905-911 (2014)
   PUBMED   24838608
  REMARK    GeneRIF: This article describes the molecular mechanisms of
            sortilin action in protein sorting and signaling and how modulation
            of receptor function may offer therapeutic strategies for treatment
            of diseases of the cardiovascular and nervous systems. [review]
            Review article
REFERENCE   6  (bases 1 to 6990)
  AUTHORS   Mazella,J., Zsurger,N., Navarro,V., Chabry,J., Kaghad,M., Caput,D.,
            Ferrara,P., Vita,N., Gully,D., Maffrand,J.P. and Vincent,J.P.
  TITLE     The 100-kDa neurotensin receptor is gp95/sortilin, a
            non-G-protein-coupled receptor
  JOURNAL   J Biol Chem 273 (41), 26273-26276 (1998)
   PUBMED   9756851
REFERENCE   7  (bases 1 to 6990)
  AUTHORS   Tauris,J., Ellgaard,L., Jacobsen,C., Nielsen,M.S., Madsen,P.,
            Thogersen,H.C., Gliemann,J., Petersen,C.M. and Moestrup,S.K.
  TITLE     The carboxy-terminal domain of the receptor-associated protein
            binds to the Vps10p domain of sortilin
  JOURNAL   FEBS Lett 429 (1), 27-30 (1998)
   PUBMED   9657377
REFERENCE   8  (bases 1 to 6990)
  AUTHORS   Lin,B.Z., Pilch,P.F. and Kandror,K.V.
  TITLE     Sortilin is a major protein component of Glut4-containing vesicles
  JOURNAL   J Biol Chem 272 (39), 24145-24147 (1997)
   PUBMED   9305862
REFERENCE   9  (bases 1 to 6990)
  AUTHORS   Petersen,C.M., Nielsen,M.S., Nykjaer,A., Jacobsen,L., Tommerup,N.,
            Rasmussen,H.H., Roigaard,H., Gliemann,J., Madsen,P. and
            Moestrup,S.K.
  TITLE     Molecular identification of a novel candidate sorting receptor
            purified from human brain by receptor-associated protein affinity
            chromatography
  JOURNAL   J Biol Chem 272 (6), 3599-3605 (1997)
   PUBMED   9013611
REFERENCE   10 (bases 1 to 6990)
  AUTHORS   Zsurger,N., Mazella,J. and Vincent,J.P.
  TITLE     Solubilization and purification of a high affinity neurotensin
            receptor from newborn human brain
  JOURNAL   Brain Res 639 (2), 245-252 (1994)
   PUBMED   8205478
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC023542.1, DB045034.1,
            DA023768.1 and AL390252.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002959.6.
            
            Summary: This gene encodes a member of the VPS10-related sortilin
            family of proteins. The encoded preproprotein is proteolytically
            processed by furin to generate the mature receptor. This receptor
            plays a role in the trafficking of different proteins to either the
            cell surface, or subcellular compartments such as lysosomes and
            endosomes. Expression levels of this gene may influence the risk of
            myocardial infarction in human patients. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.167059.1,
                                           SRR1660803.40652.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256637.8/ ENSP00000256637.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               BC023542.1         24-642
            620-772             DB045034.1         359-511
            773-994             BC023542.1         796-1017
            995-1397            DA023768.1         155-557
            1398-2623           BC023542.1         1421-2646
            2624-6990           AL390252.9         62825-67191         c
FEATURES             Location/Qualifiers
     source          1..6990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..6990
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /note="sortilin 1"
                     /db_xref="GeneID:6272"
                     /db_xref="HGNC:HGNC:11186"
                     /db_xref="MIM:602458"
     exon            1..332
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2522
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; neurotensin receptor 3; glycoprotein 95; 100
                     kDa NT receptor"
                     /codon_start=1
                     /product="sortilin isoform 1 preproprotein"
                     /protein_id="NP_002950.3"
                     /db_xref="CCDS:CCDS798.1"
                     /db_xref="GeneID:6272"
                     /db_xref="HGNC:HGNC:11186"
                     /db_xref="MIM:602458"
                     /translation="MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPA
                     APLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAPGEDEECGRVRDFVAKLANNTHQ
                     HVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDL
                     INNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLT
                     QMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGS
                     CKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQG
                     DTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDR
                     HLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDA
                     TAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYIS
                     DDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDP
                     IYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHS
                     TDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRP
                     ENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKC
                     TSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQH
                     AEANGVDGVDALDTASHTNKSGYHDDSDEDLLE"
     exon            333..392
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..466
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            467..569
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..734
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..808
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..858
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..989
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1134
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1290
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1397
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1500
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1669
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1860
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2050
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2167
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2276
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2383
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2507
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..6990
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6962..6967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /note="hexamer: AATAAA"
     polyA_site      6990
                     /gene="SORT1"
                     /gene_synonym="Gp95; LDLCQ6; NT3; NTR3"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcgtcg gcggcattcg gcggcgatgg agcggccctg gggagctgcg gacggcctct
       61 cgcgctggcc ccatggcctc ggcctcctcc tcctcctgca gctgctgccg ccgtcgaccc
      121 tcagccagga ccggctggac gcgccgccgc cgcccgctgc gccgctgccg cgctggtctg
      181 gccccatcgg ggtgagctgg gggctgcggg cggccgcagc cgggggcgcg tttccccgcg
      241 gcggccgttg gcgtcgcagc gcgccgggcg aggacgagga gtgcggccgg gtccgggact
      301 tcgtcgccaa gctggccaac aacacgcacc agcatgtgtt tgatgatctc agaggctcag
      361 tatccttgtc ctgggttgga gatagcactg gggtcattct agtcttgact accttccatg
      421 taccactggt aattatgact tttggacagt ccaagctata tcgaagtgag gattatggga
      481 agaactttaa ggatattaca gatctcatca ataacacctt tattcggact gaatttggca
      541 tggctattgg tcctgagaac tctggaaagg tggtgttaac agcagaggtg tctggaggaa
      601 gtcgtggagg aagaatcttt agatcatcag attttgcgaa gaattttgtg caaacagatc
      661 tcccttttca tcctctcact cagatgatgt atagccctca gaattctgat tatcttttag
      721 ctctcagcac tgaaaatggc ctgtgggtgt ccaagaattt tgggggaaaa tgggaagaaa
      781 tccacaaagc agtatgtttg gccaaatggg gatcagacaa caccatcttc tttacaacct
      841 atgcaaatgg ctcctgcaaa gctgaccttg gggctctgga attatggaga acttcagact
      901 tgggaaaaag cttcaaaact attggtgtga aaatctactc atttggtctt gggggacgtt
      961 tcctttttgc ctctgtgatg gctgataagg atacaacaag aaggatccac gtttcaacag
     1021 atcaagggga cacatggagc atggcccagc tcccctccgt gggacaggaa cagttctatt
     1081 ctattctggc agcaaatgat gacatggtat tcatgcatgt agatgaacct ggagacactg
     1141 ggtttggcac aatctttacc tcagatgatc gaggcattgt ctattccaag tctttggacc
     1201 gacatctcta cactaccaca ggcggagaga cggactttac caacgtgacc tccctccgcg
     1261 gcgtctacat aacaagcgtg ctctccgaag ataattctat ccagaccatg atcacttttg
     1321 accaaggagg aaggtggacg cacctgagga agcctgaaaa cagtgaatgt gatgctacag
     1381 caaaaaacaa gaatgagtgc agccttcata ttcatgcttc ctacagcatc tcccagaaac
     1441 tgaatgttcc aatggcccca ctctcagagc cgaatgccgt aggcattgtc attgctcatg
     1501 gtagcgtggg ggatgccatc tcagtgatgg ttccagatgt gtacatctca gatgatgggg
     1561 gttactcctg gacaaagatg ctggaaggac cccactatta caccatcctg gattctggag
     1621 gcatcattgt ggccattgag cacagcagcc gtcctatcaa tgtgattaag ttctccacag
     1681 acgaaggtca atgctggcaa acctacacgt tcaccaggga ccccatctat ttcactggcc
     1741 tagcttcaga acctggagct aggtccatga atatcagcat ttggggcttc acagaatctt
     1801 tcctgaccag ccagtgggtc tcctacacca ttgattttaa agatatcctt gaaaggaact
     1861 gtgaagagaa ggactatacc atatggctgg cacactccac agaccctgaa gattatgaag
     1921 atggctgcat tttgggctac aaagaacagt ttctgcggct acgcaagtca tccgtgtgtc
     1981 agaatggtcg agactatgtt gtgaccaagc agccctccat ctgcctctgt tccctggagg
     2041 actttctctg tgattttggc tactaccgtc cagaaaatga ctccaagtgt gtggaacagc
     2101 cagaactgaa gggccacgac ctggagtttt gtctgtacgg aagagaagaa cacctaacaa
     2161 caaatgggta ccggaaaatt ccaggggaca aatgccaggg tggggtaaat ccagttcgag
     2221 aagtaaaaga cttgaaaaag aaatgcacaa gcaacttttt gagtccggaa aaacagaatt
     2281 ccaagtcaaa ttctgttcca attatcctgg ccatcgtggg attgatgctg gtcacagtcg
     2341 tagcaggagt gctcattgtg aagaaatatg tctgtggggg aaggttcctg gtgcatcgat
     2401 actctgtgct gcagcagcat gcagaggcca atggtgtgga tggtgtggat gctttggaca
     2461 cagcctccca cactaataaa agtggttatc atgatgactc agatgaggac ctcttggaat
     2521 agctcttcag aggagctgga cccagcatgg atggtggaac cacagtacct cttacactcc
     2581 ctgtggctcc aacttcagga aataaatttc ccattgcgag ggacccagct ctgtttctgc
     2641 tgcttccatc aaagccaaaa ggacctacac taaagaaatg cagggtgggg gtggggaacc
     2701 ctgagcactt ttttacaatt ggctctgaga aaaagggaga cattttaaat tctttaactt
     2761 cttatttctc gtcctgtctc tttgcaaagt atgggctttt ttgtttttgt tttttaaggg
     2821 aaacgaaatg gaattcgaag ggaccttttc actaacccca cttctgtgtg ttctgcatgg
     2881 cgcctgcccc agggcatctg ccaactccag tatcagctct cacagtgtac ttggtaccat
     2941 ccctgggctc tgctggcgag acgaaacagc tgtagagatg aaaacaggct gcagaggctg
     3001 gcacagcctg gccggctttt ctccatctgg ggacagtcct actccaagaa cactgcacac
     3061 cagctcctca cacagatccc acttactctt tttttttttt tcagagacca cagaccacag
     3121 tgatttttct tttcccttgt ttaattaggc aatacccttg ttaattgccc tttggcaact
     3181 aacttaacca tgtgcttccc acacagtaca tcaggaaaac ttacagggca atatttttaa
     3241 cttggggcag gaagaaggga gcagcagaga attgactaga tatagcacct attaaaagag
     3301 aactcttgct tcttctgaga tttttcaagc tgtgctttgt gtgtgtgcca gtagacttac
     3361 gcaaggacag ggtacaaact tagctggaag tctgcccagg ctgaatgatc tcttccctag
     3421 agttgattgt cgggtacaca gtgtgaaccc ccgaagacgg aacctcacag tcttccatgt
     3481 tcccttctta actgtcgtgt ggctcgttgc taaatcatga caatggctgc ctatctgctg
     3541 cttcttaggt tgctgttgta catggaacca ggactagaga ttttttcaga tttatagact
     3601 taaaaaatta gaattttatt accaggcttt ccttctcacc ccttttttct gactttgcca
     3661 agtaatttgt tgacacgaaa attttggagg aaccaattga aaacacactt ccagtctaga
     3721 tgatgctttg tgtgatacat taagttctta ttttggatta aaagaagttt tccatttgat
     3781 acctctctaa attaaataaa ttatagaatg tagttgggtg gattttgggg tggccatata
     3841 gtaatggaaa gctgcaataa ttagttttaa tacagcttga atatttgcta tatagaaata
     3901 tagtatggaa agtttttggt cttaatgtag ctactgtgcg ggtcacagtt tctcccaatg
     3961 attatgactg ggacattctt tggtagatac catttgctac tagtttattt tgtggctaga
     4021 aagtcagttt tgtgtgtttt tttttttttt tatttgaagt gccaaattaa ctttagtcag
     4081 aatgtgagca gatggctaag ttctctcctc cccagaatgg attaacagct gcgtggaaag
     4141 tgggggagag agtggatgga gacttttaga gatgttaaaa ctgcagtaga atgaaatgag
     4201 tcagggagct tcagttagaa aataaagttg aggcagtttt tgtgaagata atatggttag
     4261 ggctggagtg cactagtctt tttgcttatt cattttgcat ggttttaaaa ttaaaaataa
     4321 ttccgaagat acaccagctc acaaatgaaa acgtcagcct ctgccccacc ctccctcctg
     4381 cccaaagtga atttggtact cagaaaagaa ctgtttatac cactcacctt tctcccagca
     4441 tgtactcact gtgggcagat gcaccaatac atggtaatcc tcttactcat tttaagacgt
     4501 aggaaactca atattcttct ctaaccatat acgatagggc tcttcgcttt taatgatatc
     4561 tgggatttct gtggaacttg gcaaattttc agagcacctt cactcacata atgtcatttg
     4621 aacctcacaa tgttcttggg atggagtcag ttgttcaggg tccccgtgtg tgtgataagc
     4681 agtgctggct ggctgtcttc agaactcttg gaaatcttta cacatgcgag tgctaaccac
     4741 tttgagcaag gctgccttct tgtagatgac ttgctgttct ttatgacagg gatcagtggc
     4801 atttgtttcc tagcagtatt tagcaccttt ttgccacctt ggtgaacaga aaattgtatt
     4861 ttcctgtctt tcatggctga aaacaaaagt aatgggaatt ttaaatacgt ttgcagaaac
     4921 tgcccctccc ctcattgagg gtcactgctc aagagtgcag gagtggactc tccactgatg
     4981 ggtctccctc cccatcctgg tttccacccc gggctggcta gctctgttgg tttgaagact
     5041 gacagccagc ctggctcatt ctcattattg gctagttagc tttctttatc aacctgctca
     5101 ctcacaaatg tgtgccctca gccagagagt aagaaagccc aaatctgtta cagcttctaa
     5161 aaaaatagat ttctaatttg tcctactcat gttaggagca ttatctttga aggtaaaaca
     5221 tagtgtatca ttgtgtaaac tcccaggctt gatgtagcag aagagatcat ttctggaggc
     5281 ttcagcaatg gaatttagca ttataagaga gattggacaa accagtccaa agtggtccga
     5341 gttcttaaat ccaggtaggg aactcactct tctttcttct ctggacctaa ttgggcattg
     5401 ggctttagtg agaccacaga ccaggcccgt ctctcctgta ggcttttaat tcaatggcaa
     5461 ctctatttca aagaataaaa gcctttggag agttgcggca gttctggggg cgggctcagg
     5521 agagtccata gatcagccgt aactggaacg tagaatctac gtctgcctct gaatggactt
     5581 cccacctcct ctctcttgct ctgatgcttg cctctgggcc tctccatgcc caaggtggtc
     5641 tttcatcctt gacaggctgg taatgtgctg gccacctcca gctcctgcat cgagtctgta
     5701 aaccagagct ggttctcatg gccttcgtca cgataccagg atacggaggg gagcccaggg
     5761 ccatccatac ccaccccagg gtaacggggc tggcctggca ttagtcatta tttagtttcc
     5821 aggccaacca tccagataga gattccctct ttcctttgag cagtgctctc aagagctccg
     5881 tgcctgtcca caatgaccta gagtgcatcc tgctcattgt cagtgtagcc cctcgcccct
     5941 atattcatcc aggatacttg gaagtgctaa aataggaagg gattcggctt tcaactttgc
     6001 taccatcttc cctgaagcag gaaaatgaac atggacttaa atgttctttg aaaaaaccaa
     6061 agttttaaga tttgctgtgt gatgaagtga cagggagggc cggagtcagc aggtgccaga
     6121 ctttctgttc tgtctgccat gggtttgtcc agctcaggta gctctaggag caccatcctg
     6181 ccctagcaga gcccaggcct tgccctcatg aagcatcatt gaaatagcag gagcatgttg
     6241 atttcttggt taggttgcat tataataaca agagtcagaa cattaattcg aaacaacttg
     6301 cagtatgcat ttcttcacac cagtacattc ttaagtgtac ttgtttataa ggaataacat
     6361 aaactaatct gtacctttat atatatgtgt gtgtacatat atacatatat aaactgtata
     6421 gtgtacatgg taatgattta ttgctatgcc ccagatcctt aatgtagttc tcatcctccg
     6481 catgccctca gccacaagcg ggtgactgac tgttccctga tgatttggcc cacctcctgt
     6541 gtttggacct ctagggagga gggttttggt catactctcc ttatcctcgt gcacagaaat
     6601 gctcagggtc cccatgtgcc tgttgttcag ccctctctct tgttcccttt ctgagcatgt
     6661 ggtccttccc caggctgtgg gacagctgcc ttcccacgaa agtgtaaagc agtattaaga
     6721 tcattactgc atgtgcccta aaaacccaag ttttctattc ccttaggaca gaaaattgca
     6781 tgtgaggtgg gataatcgag tttcagtgac ccacgtcagt tacacattaa agccagaccc
     6841 catgataaaa ttccacaaaa tggaaataaa actcaaattt ctttagcatt gtgtaaataa
     6901 atctgaatgt gtttaacttt gtactggtaa ttttctgtat atttggaata tttgggttaa
     6961 aaataaaaca gactggactt tgttacctga
//
