LOCUS       NM_003105              10863 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sortilin related receptor 1 (SORL1), mRNA.
ACCESSION   NM_003105
VERSION     NM_003105.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10863)
  AUTHORS   Jensen,A.M.G., Raska,J., Fojtik,P., Monti,G., Lunding,M.,
            Bartova,S., Pospisilova,V., van der Lee,S.J., Van Dongen,J.,
            Bossaerts,L., Van Broeckhoven,C., Dols-Icardo,O., Lleo,A.,
            Bellini,S., Ghidoni,R., Hulsman,M., Petsko,G.A., Sleegers,K.,
            Bohaciakova,D., Holstege,H. and Andersen,O.M.
  TITLE     The SORL1 p.Y1816C variant causes impaired endosomal dimerization
            and autosomal dominant Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2408262121 (2024)
   PUBMED   39226352
  REMARK    GeneRIF: The SORL1 p.Y1816C variant causes impaired endosomal
            dimerization and autosomal dominant Alzheimer's disease.
REFERENCE   2  (bases 1 to 10863)
  AUTHORS   Kaminska,P., Ovesen,P.L., Jakiel,M., Obrebski,T., Schmidt,V.,
            Draminski,M., Bilska,A.G., Bieniek,M., Anink,J., Paterczyk,B.,
            Jensen,A.M.G., Piatek,S., Andersen,O.M., Aronica,E., Willnow,T.E.,
            Kaminska,B., Dabrowski,M.J. and Malik,A.R.
  TITLE     SorLA restricts TNFalpha release from microglia to shape a
            glioma-supportive brain microenvironment
  JOURNAL   EMBO Rep 25 (5), 2278-2305 (2024)
   PUBMED   38499808
  REMARK    GeneRIF: SorLA restricts TNFalpha release from microglia to shape a
            glioma-supportive brain microenvironment.
REFERENCE   3  (bases 1 to 10863)
  AUTHORS   Mishra,S., Jayadev,S. and Young,J.E.
  TITLE     Differential effects of SORL1 deficiency on the endo-lysosomal
            network in human neurons and microglia
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 379 (1899), 20220389 (2024)
   PUBMED   38368935
  REMARK    GeneRIF: Differential effects of SORL1 deficiency on the
            endo-lysosomal network in human neurons and microglia.
            Review article
REFERENCE   4  (bases 1 to 10863)
  AUTHORS   Fazeli,E., Fazeli,E., Fojtik,P., Holstege,H. and Andersen,O.M.
  TITLE     Functional characterization of SORL1 variants in cell-based assays
            to investigate variant pathogenicity
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 379 (1899), 20220377 (2024)
   PUBMED   38368933
  REMARK    GeneRIF: Functional characterization of SORL1 variants in
            cell-based assays to investigate variant pathogenicity.
REFERENCE   5  (bases 1 to 10863)
  AUTHORS   Glerup,S., Nykjaer,A. and Vaegter,C.B.
  TITLE     Sortilins in neurotrophic factor signaling
  JOURNAL   Handb Exp Pharmacol 220, 165-189 (2014)
   PUBMED   24668473
  REMARK    Review article
REFERENCE   6  (bases 1 to 10863)
  AUTHORS   Jacobsen,L., Madsen,P., Jacobsen,C., Nielsen,M.S., Gliemann,J. and
            Petersen,C.M.
  TITLE     Activation and functional characterization of the mosaic receptor
            SorLA/LR11
  JOURNAL   J Biol Chem 276 (25), 22788-22796 (2001)
   PUBMED   11294867
REFERENCE   7  (bases 1 to 10863)
  AUTHORS   Hampe,W., Riedel,I.B., Lintzel,J., Bader,C.O., Franke,I. and
            Schaller,H.C.
  TITLE     Ectodomain shedding, translocation and synthesis of SorLA are
            stimulated by its ligand head activator
  JOURNAL   J Cell Sci 113 Pt 24, 4475-4485 (2000)
   PUBMED   11082041
REFERENCE   8  (bases 1 to 10863)
  AUTHORS   Motoi,Y., Aizawa,T., Haga,S., Nakamura,S., Namba,Y. and Ikeda,K.
  TITLE     Neuronal localization of a novel mosaic apolipoprotein E receptor,
            LR11, in rat and human brain
  JOURNAL   Brain Res 833 (2), 209-215 (1999)
   PUBMED   10375696
REFERENCE   9  (bases 1 to 10863)
  AUTHORS   Morwald,S., Yamazaki,H., Bujo,H., Kusunoki,J., Kanaki,T.,
            Seimiya,K., Morisaki,N., Nimpf,J., Schneider,W.J. and Saito,Y.
  TITLE     A novel mosaic protein containing LDL receptor elements is highly
            conserved in humans and chickens
  JOURNAL   Arterioscler Thromb Vasc Biol 17 (5), 996-1002 (1997)
   PUBMED   9157966
REFERENCE   10 (bases 1 to 10863)
  AUTHORS   Jacobsen,L., Madsen,P., Moestrup,S.K., Lund,A.H., Tommerup,N.,
            Nykjaer,A., Sottrup-Jensen,L., Gliemann,J. and Petersen,C.M.
  TITLE     Molecular characterization of a novel human hybrid-type receptor
            that binds the alpha2-macroglobulin receptor-associated protein
  JOURNAL   J Biol Chem 271 (49), 31379-31383 (1996)
   PUBMED   8940146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000977.4, KF459541.1 and
            AP000664.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003105.5.
            
            Summary: This gene encodes a mosaic protein that belongs to at
            least two families: the vacuolar protein sorting 10 (VPS10)
            domain-containing receptor family, and the low density lipoprotein
            receptor (LDLR) family. The encoded protein also contains
            fibronectin type III repeats and an epidermal growth factor repeat.
            The encoded preproprotein is proteolytically processed to generate
            the mature receptor, which likely plays roles in endocytosis and
            sorting. Mutations in this gene may be associated with Alzheimer's
            disease. [provided by RefSeq, Feb 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.51261.1, Y08110.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260197.12/ ENSP00000260197.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AP000977.4         6534-6836
            304-420             AP000977.4         24227-24343
            421-546             AP000977.4         32338-32463
            547-708             AP000977.4         42252-42413
            709-776             AP000977.4         44263-44330
            777-957             AP000977.4         51089-51269
            958-1059            AP000977.4         67223-67324
            1060-1229           AP000977.4         68372-68541
            1230-1422           AP000977.4         74877-75069
            1423-1540           AP000977.4         76806-76923
            1541-1614           AP000977.4         77136-77209
            1615-1664           AP000977.4         86684-86733
            1665-1703           KF459541.1         96-134              c
            1704-1882           AP000977.4         97768-97946
            1883-2069           AP000977.4         99463-99649
            2070-2198           AP000977.4         104180-104308
            2199-2284           AP000977.4         104805-104890
            2285-2457           AP000977.4         108157-108329
            2458-2589           AP000977.4         109407-109538
            2590-2681           AP000977.4         111534-111625
            2682-2928           AP000977.4         112811-113057
            2929-3067           AP000977.4         113739-113877
            3068-3241           AP000977.4         121160-121333
            3242-3355           AP000977.4         124377-124490
            3356-3478           AP000977.4         128461-128583
            3479-3598           AP000977.4         131501-131620
            3599-3724           AP000977.4         137678-137803
            3725-3832           AP000977.4         140442-140549
            3833-3964           AP000977.4         142240-142371
            3965-4096           AP000977.4         143479-143610
            4097-4231           AP000977.4         144260-144394
            4232-4387           AP000977.4         145221-145376
            4388-4537           AP000977.4         149843-149992
            4538-4669           AP000977.4         158413-158544
            4670-4796           AP000977.4         159333-159459
            4797-4966           AP000977.4         159622-159791
            4967-5079           AP000977.4         161065-161177
            5080-5184           AP000977.4         161406-161510
            5185-5257           AP000977.4         162324-162396
            5258-5340           AP000977.4         165296-165378
            5341-5437           AP000977.4         166956-167052
            5438-5622           AP000977.4         169091-169275
            5623-5742           AP000977.4         172994-173113
            5743-5907           AP000977.4         173973-174137
            5908-6082           AP000977.4         175284-175458
            6083-6189           AP000977.4         176382-176488
            6190-6382           AP000664.4         86-278
            6383-6595           AP000664.4         2556-2768
            6596-10863          AP000664.4         4497-8764
FEATURES             Location/Qualifiers
     source          1..10863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..10863
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /note="sortilin related receptor 1"
                     /db_xref="GeneID:6653"
                     /db_xref="HGNC:HGNC:11185"
                     /db_xref="MIM:602005"
     exon            1..303
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..6663
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /note="mosaic protein LR11; LDLR relative with 11
                     ligand-binding repeats; sorting protein-related receptor
                     containing LDLR class A repeats; low-density lipoprotein
                     receptor relative with 11 ligand-binding repeats;
                     sortilin-related receptor, L(DLR class) A repeats
                     containing"
                     /codon_start=1
                     /product="sortilin-related receptor preproprotein"
                     /protein_id="NP_003096.2"
                     /db_xref="CCDS:CCDS8436.1"
                     /db_xref="GeneID:6653"
                     /db_xref="HGNC:HGNC:11185"
                     /db_xref="MIM:602005"
                     /translation="MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQ
                     DRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSH
                     NQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRS
                     EAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNL
                     LLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYST
                     VFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKP
                     MRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYY
                     SPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTW
                     EFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATG
                     SVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTN
                     EGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVP
                     CTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDY
                     ECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGD
                     VEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYE
                     HNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKI
                     EVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYH
                     LVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNE
                     IYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLC
                     LPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCSNG
                     NCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGD
                     NSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNF
                     QCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDC
                     SDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE
                     FHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCEN
                     GHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTW
                     VCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGH
                     QDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDE
                     LTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKT
                     NTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGV
                     IVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAV
                     TSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFW
                     AFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVR
                     PPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVS
                     KDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDS
                     PDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSS
                     IKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYL
                     GNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAAR
                     STDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGD
                     DLGEDDEDAPMITGFSDDVPMVIA"
     exon            304..420
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..546
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..708
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..776
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..957
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1059
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1229
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1422
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1540
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1614
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1703
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1882
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2069
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2198
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2284
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2457
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2589
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2681
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2928
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3067
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3241
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3355
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3478
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3598
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3724
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3832
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3964
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4096
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..4231
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4387
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4537
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4538..4669
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4670..4796
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4966
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..5079
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5080..5184
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..5257
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5340
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5341..5437
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..5622
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5623..5742
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5743..5907
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5908..6082
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6083..6189
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6190..6382
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6383..6595
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6596..10863
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10750..10755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /note="hexamer: AATAAA"
     regulatory      10770..10775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /note="hexamer: AAGAAA"
     polyA_site      10778
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /note="major polyA site"
     polyA_site      10790
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
     regulatory      10831..10836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
                     /note="hexamer: AATAAA"
     polyA_site      10863
                     /gene="SORL1"
                     /gene_synonym="C11orf32; gp250; LR11; LRP9; SORLA;
                     SorLA-1"
ORIGIN      
        1 agtagcgttc gcccgaacat ggcgacacgg agcagcagga gggagtcgcg actcccgttc
       61 ctattcaccc tggtcgcact gctgccgccc ggagctctct gcgaagtctg gacgcagagg
      121 ctgcacggcg gcagcgcgcc cttgccccag gaccggggct tcctcgtggt gcagggcgac
      181 ccgcgcgagc tgcggctgtg ggcgcgcggg gatgccaggg gggcgagccg cgcggacgag
      241 aagccgctcc ggaggaaacg gagcgctgcc ctgcagcccg agcccatcaa ggtgtacgga
      301 caggttagtc tgaatgattc ccacaatcag atggtggtgc actgggctgg agagaaaagc
      361 aacgtgatcg tggccttggc ccgagatagc ctggcattgg cgaggcccaa gagcagtgat
      421 gtgtacgtgt cttacgacta tggaaaatca ttcaagaaaa tttcagacaa gttaaacttt
      481 ggcttgggaa ataggagtga agctgttatc gcccagttct accacagccc tgcggacaac
      541 aagcggtaca tctttgcaga cgcttatgcc cagtacctct ggatcacgtt tgacttctgc
      601 aacactcttc aaggcttttc catcccattt cgggcagctg atctcctcct acacagtaag
      661 gcctccaacc ttctcttggg ctttgacagg tcccacccca acaagcagct gtggaagtca
      721 gatgactttg gccagacctg gatcatgatt caggaacatg tcaagtcctt ttcttgggga
      781 attgatccct atgacaaacc aaataccatc tacattgaac gacatgaacc ctctggctac
      841 tccactgtct tccgaagtac agatttcttc cagtcccggg aaaaccagga agtgatcctt
      901 gaggaagtga gagattttca gcttcgggac aagtacatgt ttgctacaaa ggtggtgcat
      961 ctcttgggca gtgaacagca gtcttctgtc cagctctggg tctcctttgg ccggaagccc
     1021 atgagagcag cccagtttgt cacaagacat cctattaatg aatattacat cgcagatgcc
     1081 tccgaggacc aggtgtttgt gtgtgtcagc cacagtaaca accgcaccaa tttatacatc
     1141 tcagaggcag aggggctgaa gttctccctg tccttggaga acgtgctcta ttacagccca
     1201 ggaggggccg gcagtgacac cttggtgagg tattttgcaa atgaaccatt tgctgacttc
     1261 caccgagtgg aaggattgca aggagtctac attgctactc tgattaatgg ttctatgaat
     1321 gaggagaaca tgagatcggt catcaccttt gacaaagggg gaacctggga gtttcttcag
     1381 gctccagcct tcacgggata tggagagaaa atcaattgtg agctttccca gggctgttcc
     1441 cttcatctgg ctcagcgcct cagtcagctc ctcaacctcc agctccggag aatgcccatc
     1501 ctgtccaagg agtcggctcc aggcctcatc atcgccactg gctcagtggg aaagaacttg
     1561 gctagcaaga caaacgtgta catctctagc agtgctggag ccaggtggcg agaggcactt
     1621 cctggacctc actactacac atggggagac cacggcggaa tcatcacggc cattgcccag
     1681 ggcatggaaa ccaacgagct aaaatacagt accaatgaag gggagacctg gaaaacattc
     1741 atcttctctg agaagccagt gtttgtgtat ggcctcctca cagaacctgg ggagaagagc
     1801 actgtcttca ccatctttgg ctcgaacaaa gagaatgtcc acagctggct gatcctccag
     1861 gtcaatgcca cggatgcctt gggagttccc tgcacagaga atgactacaa gctgtggtca
     1921 ccatctgatg agcgggggaa tgagtgtttg ctgggacaca agactgtttt caaacggcgg
     1981 accccccatg ccacatgctt caatggagag gactttgaca ggccggtggt cgtgtccaac
     2041 tgctcctgca cccgggagga ctatgagtgt gacttcggtt tcaagatgag tgaagatttg
     2101 tcattagagg tttgtgttcc agatccggaa ttttctggaa agtcatactc ccctcctgtg
     2161 ccttgccctg tgggttctac ttacaggaga acgagaggct accggaagat ttctggggac
     2221 acttgtagcg gaggagatgt tgaagcgcga ctggaaggag agctggtccc ctgtcccctg
     2281 gcagaagaga acgagttcat tctgtatgct gtgaggaaat ccatctaccg ctatgacctg
     2341 gcctcgggag ccaccgagca gttgcctctc accgggctac gggcagcagt ggccctggac
     2401 tttgactatg agcacaactg tttgtattgg tccgacctgg ccttggacgt catccagcgc
     2461 ctctgtttga atggaagcac agggcaagag gtgatcatca attctggcct ggagacagta
     2521 gaagctttgg cttttgaacc cctcagccag ctgctttact gggtagatgc aggcttcaaa
     2581 aagattgagg tagctaatcc agatggcgac ttccgactca caatcgtcaa ttcctctgtg
     2641 cttgatcgtc ccagggctct ggtcctcgtg ccccaagagg gggtgatgtt ctggacagac
     2701 tggggagacc tgaagcctgg gatttatcgg agcaatatgg atggttctgc tgcctatcac
     2761 ctggtgtctg aggatgtgaa gtggcccaat ggcatctctg tggacgacca gtggatttac
     2821 tggacggatg cctacctgga gtgcatagag cggatcacgt tcagtggcca gcagcgctct
     2881 gtcattctgg acaacctccc gcacccctat gccattgctg tctttaagaa tgaaatctac
     2941 tgggatgact ggtcacagct cagcatattc cgagcttcca aatacagtgg gtcccagatg
     3001 gagattctgg caaaccagct cacggggctc atggacatga agattttcta caaggggaag
     3061 aacactggaa gcaatgcctg tgtgcccagg ccatgcagcc tgctgtgcct gcccaaggcc
     3121 aacaacagta gaagctgcag gtgtccagag gatgtgtcca gcagtgtgct tccatcaggg
     3181 gacctgatgt gtgactgccc tcagggctat cagctcaaga acaatacctg tgtcaaacaa
     3241 gagaacacct gtcttcgcaa ccagtatcgc tgcagcaacg ggaactgtat caacagcatt
     3301 tggtggtgtg actttgacaa cgactgtgga gacatgagcg atgagagaaa ctgccctacc
     3361 accatctgtg acctggacac ccagtttcgt tgccaggagt ctgggacttg tatcccactg
     3421 tcctataaat gtgaccttga ggatgactgt ggagacaaca gtgatgaaag tcattgtgaa
     3481 atgcaccagt gccggagtga cgagtacaac tgcagttccg gcatgtgcat ccgctcctcc
     3541 tgggtatgtg acggggacaa cgactgcagg gactggtctg atgaagccaa ctgtaccgcc
     3601 atctatcaca cctgtgaggc ctccaacttc cagtgccgaa acgggcactg catcccccag
     3661 cggtgggcgt gtgacgggga tacggactgc caggatggtt ccgatgagga tccagtcaac
     3721 tgtgagaaga agtgcaatgg attccgctgc ccaaacggca cttgcatccc atccagcaaa
     3781 cattgtgatg gtctgcgtga ttgctctgat ggctccgatg aacagcactg cgagcccctc
     3841 tgtacgcact tcatggactt tgtgtgtaag aaccgccagc agtgcctgtt ccactccatg
     3901 gtctgtgacg gaatcatcca gtgccgcgac gggtccgatg aggatgcggc gtttgcagga
     3961 tgctcccaag atcctgagtt ccacaaggta tgtgatgagt tcggtttcca gtgtcagaat
     4021 ggagtgtgca tcagtttgat ttggaagtgc gacgggatgg atgattgcgg cgattattct
     4081 gatgaagcca actgcgaaaa ccccacagaa gccccaaact gctcccgcta cttccagttt
     4141 cggtgtgaga atggccactg catccccaac agatggaaat gtgacaggga gaacgactgt
     4201 ggggactggt ctgatgagaa ggattgtgga gattcacata ttcttccctt ctcgactcct
     4261 gggccctcca cgtgtctgcc caattactac cgctgcagca gtgggacctg cgtgatggac
     4321 acctgggtgt gcgacgggta ccgagattgt gcagatggct ctgacgagga agcctgcccc
     4381 ttgcttgcaa acgtcactgc tgcctccact cccacccaac ttgggcgatg tgaccgattt
     4441 gagttcgaat gccaccaacc gaagacgtgt attcccaact ggaagcgctg tgacggccac
     4501 caagattgcc aggatggccg ggacgaggcc aattgcccca cacacagcac cttgacttgc
     4561 atgagcaggg agttccagtg cgaggacggg gaggcctgca ttgtgctctc ggagcgctgc
     4621 gacggcttcc tggactgctc ggacgagagc gatgaaaagg cctgcagtga tgagttgact
     4681 gtgtacaaag tacagaatct tcagtggaca gctgacttct ctggggatgt gactttgacc
     4741 tggatgaggc ccaaaaaaat gccctctgct tcttgtgtat ataatgtcta ctacagggtg
     4801 gttggagaga gcatatggaa gactctggag acccacagca ataagacaaa cactgtatta
     4861 aaagtcttga aaccagatac cacgtatcag gttaaagtac aggttcagtg tctcagcaag
     4921 gcacacaaca ccaatgactt tgtgaccctg aggaccccag agggattgcc agatgcccct
     4981 cgaaatctcc agctgtcact ccccagggaa gcagaaggtg tgattgtagg ccactgggct
     5041 cctcccatcc acacccatgg cctcatccgt gagtacattg tagaatacag caggagtggt
     5101 tccaagatgt gggcctccca gagggctgct agtaacttta cagaaatcaa gaacttattg
     5161 gtcaacactc tatacaccgt cagagtggct gcggtgacta gtcgtggaat aggaaactgg
     5221 agcgattcta aatccattac caccataaaa ggaaaagtga tcccaccacc agatatccac
     5281 attgacagct atggtgaaaa ttatctaagc ttcaccctga ccatggagag tgatatcaag
     5341 gtgaatggct atgtggtgaa ccttttctgg gcatttgaca cccacaagca agagaggaga
     5401 actttgaact tccgaggaag catattgtca cacaaagttg gcaatctgac agctcataca
     5461 tcctatgaga tttctgcctg ggccaagact gacttggggg atagccctct ggcatttgag
     5521 catgttatga ccagaggggt tcgcccacct gcacctagcc tcaaggccaa agccatcaac
     5581 cagactgcag tggaatgtac ctggaccggc ccccggaatg tggtttatgg tattttctat
     5641 gccacgtcct ttcttgacct ctatcgcaac ccgaagagct tgactacttc actccacaac
     5701 aagacggtca ttgtcagtaa ggatgagcag tatttgtttc tggtccgtgt agtggtaccc
     5761 taccaggggc catcctctga ctacgttgta gtgaagatga tcccggacag caggcttcca
     5821 ccccgtcacc tgcatgtggt tcatacgggc aaaacctccg tggtcatcaa gtgggaatca
     5881 ccgtatgact ctcctgacca ggacttgttg tatgcagttg cagtcaaaga tctcataaga
     5941 aagactgaca ggagctacaa agtaaaatcc cgtaacagca ctgtggaata cacccttaac
     6001 aagttggagc ctggcgggaa ataccacatc attgtccaac tggggaacat gagcaaagat
     6061 tccagcataa aaattaccac agtttcatta tcagcacctg atgccttaaa aatcataaca
     6121 gaaaatgatc atgttcttct gttttggaaa agcctggctt taaaggaaaa gcattttaat
     6181 gaaagcaggg gctatgagat acacatgttt gatagtgcca tgaatatcac agcttacctt
     6241 gggaatacta ctgacaattt ctttaaaatt tccaacctga agatgggtca taattacacg
     6301 ttcaccgtcc aagcaagatg cctttttggc aaccagatct gtggggagcc tgccatcctg
     6361 ctgtacgatg agctggggtc tggtgcagat gcatctgcaa cgcaggctgc cagatctacg
     6421 gatgttgctg ctgtggtggt gcccatctta ttcctgatac tgctgagcct gggggtgggg
     6481 tttgccatcc tgtacacgaa gcaccggagg ctgcagagca gcttcaccgc cttcgccaac
     6541 agccactaca gctccaggct ggggtccgca atcttctcct ctggggatga cctgggggaa
     6601 gatgatgaag atgcccctat gataactgga ttttcagatg acgtccccat ggtgatagcc
     6661 tgaaagagct ttcctcacta gaaaccaaat ggtgtaaata ttttatttga taaagatagt
     6721 tgatggttta ttttaaaaga tgcactttga gttgcaatat gttattttta tatgggccaa
     6781 aaacaaaaaa caaaaaaaaa aaaaaggaaa gaaaggaatg aataaacttt gtagtaatca
     6841 actgtgaact tcaaaccagg ttgattttag taacccaatt gctttgattt gacattaatg
     6901 tagtcttaca gggctgtgct tgctgggcat gcttttacgt ctgtgagata atttcggttc
     6961 agtaaattgg ccaatctttt tatttttcta agacacagaa atgtatttaa taaaaacctc
     7021 gagagagtga tgggtggaac cccttctcct tgaaagtgtg tacagatatt ccattttgtt
     7081 tggatatagt ttataggaaa gtgtgtggat gtattatggc ggaaggtttc tttatgttat
     7141 tttgttaatt tattgggact ctgtgtaagg ccaggcttta gtggtcatta gacaccacat
     7201 gtgttatgag ccccttaccc atagggttgg gggtgggaag agaagcatat ttttttgcca
     7261 ttccggaagc aatccatttt tattcacttg tgtgtcatgt aatggtcttt ggcaggagag
     7321 agcactgagt cattgctgga gttcagttca acagagctgc agcttgggaa gccctgtaag
     7381 cccacagctt cctctcttat attaattgat ggaattttac tgtatgtgcc tctgtacaag
     7441 atgtagcttt gagagctaca aaatgataac actgctttat tacacactgg tttcattgtc
     7501 attgcaaaaa cttaccctgg ttgtggggga gagttctaga tctgtgccat gatccataca
     7561 ctggctaata gagtacataa tttttccatt ttccattttt tgtttttact tactactgaa
     7621 ggatctcaga tgtaaaatta tgtatttggt ttgagatggc cacttattgt ccttaaaaat
     7681 ccatactgat atatgcagtc attttgaatt ggacagtgcc ttctcttttt ttttctcctc
     7741 ttcttccatc tccctcaccc atgcccccac ccaatctaaa gagacagtgc tgtacattct
     7801 catagagata gagaagatct aaaaagttga gactactcaa tccagttaac aacagcagga
     7861 gcactagagt ttgttcattt attctctctg taaaacaagc tgtgcttttt ttcttctgcc
     7921 tttaaaatgc cacccgtgta ttcaaaccat ggccacttga tacttatgta gaatccatcg
     7981 tgggctgatg caagcccttt atttaggctt agtgttgtgg gcaccaatgt cgagcatcgt
     8041 tgtgacttgt gctgtatgat tctcactgaa gaatttcctt tcagccaaga agcagtgagg
     8101 tctgggaata ttccaaagtc atgtctctga atatgtgtcc ttgacgtgca agctttgtaa
     8161 aaccccatcc ccgcttaggt gcgaggcatc accttctcac aagtgtttag tttcttttaa
     8221 ccacaagtat cattcttggg tgataatata gtttcattct acttagggat tgtttagaaa
     8281 acaaagaaag agccaattaa attttttagt ttttgaaatt tttatttata tgtatactta
     8341 gatgagtatt ttaagctgtc gacctttagt ttgccatacg ggtaggactg tatttcatgt
     8401 taacaactgg tggtaatgat aagccttctt ctagcgtatt ttctcttctt tcctgtcact
     8461 ttcctaagtt ttttttttta aagactggaa ttttttttgg ctttatcttg tcttaccgta
     8521 gagatttgtt caaaactcta agccctacca cctccccttt aataagctct ttaaatagtt
     8581 gaatcattaa caacctggtg ggaggcaagt catttaattg aaccactagg aagtgtattt
     8641 tcttttcttt ttctgccaac tttttggtgg catttgtaaa agctgatata aaaggctctg
     8701 agatgttatt ttcagttatt ccataggcaa gcctttttac agagcatatg tctccagttg
     8761 gcagcttgag atatttccga gcatccggtt ctagctacca gtgcctccca atgcttagtg
     8821 cacagtactg tagactggcc atcacccctc tccttggaaa atgccactgt gctgtttgaa
     8881 aaaaagcagc cttttagggc tagagtattt tatataaaca gaagagctaa gttcctgaag
     8941 actaagctag atagctgcag ctatatgtaa attgtatatt tttatgaact tttgaagcac
     9001 acactcctgt ttccctctgt gtagctttgt ggggatttca tgtatatatg ctgtctgaaa
     9061 gaatccagag gttggagtgc caatagaaaa tgaaaacaaa tgccttgtac tacaggcagc
     9121 ctctgaaggt gaccacataa ctgtcttcac tgtgaccaat cggagtccct gcttgcttgt
     9181 gaagaagggg cttttgtacc ttgttggaga tgccacctca gaagttcaca ctgtgcagga
     9241 aaaaggtttt attctctcct ggcatacatt agaatgtcag atgcttgcat ccatgtggac
     9301 cacgatgggc ctctaaaaat tggtgggcag ggggtttgct tatgagtttt ctctggaaac
     9361 cgattttact cctggatgta ttgaatgccc cttgagcttt atgagatacg agtccacatg
     9421 gataaaatgt tagagagtgg agttctacag aggattccag gaagaggcca tgtctgtgca
     9481 gtcctagttc cagacaggtg agaagctcca ggaactactg gctaccttga caagctgggt
     9541 aaatagttat cattctgggt aactggttga aactctgact tttggacaag taattcctgg
     9601 ggttctgtct ttggtagcat caccagggat atttgggtgg gacagacaga agacacacag
     9661 ctgcctgttc tctcctgccc atcatgtttg gcccactaga tgaagctgta ctcagcaatt
     9721 tagggaatgt aacccttctc agaactggcc attttcaggg gaagcttggg agagcaatag
     9781 tatggtgagc cccttagaga tgagcgccta ctccttcttg gcgaatgctg ccttcagatg
     9841 cttaccaagt ggtcactgca tctagtaaga ttatatttcc agtacacttc cttagggcag
     9901 aaacaccatc ctatcaggtt tggtcagtcc cttcttcatg aagggagtca tggggaattc
     9961 ctgaaaattt tcttccttct gcagacagtt ggatgagtcc cttagagaag gcatccagag
    10021 acataactaa actgaatatc atcccatatt gattttagga attgactcta aaactctgtg
    10081 cagaatcttg tgttgggatt gtatcttgac attcctgttg tgttattttt cttaactgga
    10141 gtgtgtgctg cctttcaggt acaatttttg tgtaataaaa gccagtgcat taagtttata
    10201 tagactactt tctatgcaag actgagatat ggaatagata ggaagagata tgtactgctg
    10261 ggtacatgga cagtaagtgt gttttcagat ggagtaccag caccgaaaat gggttgaggg
    10321 aggatgggtt gtatgtatgt ttctgcccac taattttgag cagccatatt atgaattaaa
    10381 tcgtcacagc caagtaataa cccaagaatg gtatgagttt catgtgtaat agctcaaatg
    10441 gaataagcat gaatgctgga gtggaccatt atcctcaaat attctatgtc acttctcatt
    10501 taaagactct tgttatgaac tattagaaac tttaggcaaa atcaaaagta tttgcggcaa
    10561 aataaaggcc tattctactc ttatttaaag tgaaacactg tatacttgtt tctctccaaa
    10621 gcgaaattaa gtatttataa tttcaattgc ctcgataagt ttccaagtca ctgaaatctg
    10681 ctgaaggttt tactgtattg ttgcacaact ttaagataat ttttgtctca atgtcaactt
    10741 ttttcactga ataaaaattt aactgggtca agaaaacacc tctttgaaaa tccactgtct
    10801 ctgtgtgtct cgagctgttc tttagagcgc aataaagatg gctgacgcag tctccaaacc
    10861 cca
//
