LOCUS       NM_014978               5575 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sortilin related VPS10 domain containing receptor 3
            (SORCS3), mRNA.
ACCESSION   NM_014978
VERSION     NM_014978.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5575)
  AUTHORS   Kamran,M., Laighneach,A., Bibi,F., Donohoe,G., Ahmed,N.,
            Rehman,A.U. and Morris,D.W.
  TITLE     Independent Associated SNPs at SORCS3 and Its Protein Interactors
            for Multiple Brain-Related Disorders and Traits
  JOURNAL   Genes (Basel) 14 (2), 482 (2023)
   PUBMED   36833409
  REMARK    GeneRIF: Independent Associated SNPs at SORCS3 and Its Protein
            Interactors for Multiple Brain-Related Disorders and Traits.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5575)
  AUTHORS   Demontis,D., Walters,G.B., Athanasiadis,G., Walters,R.,
            Therrien,K., Nielsen,T.T., Farajzadeh,L., Voloudakis,G., Bendl,J.,
            Zeng,B., Zhang,W., Grove,J., Als,T.D., Duan,J., Satterstrom,F.K.,
            Bybjerg-Grauholm,J., Baekved-Hansen,M., Gudmundsson,O.O.,
            Magnusson,S.H., Baldursson,G., Davidsdottir,K., Haraldsdottir,G.S.,
            Agerbo,E., Hoffman,G.E., Dalsgaard,S., Martin,J., Ribases,M.,
            Boomsma,D.I., Soler Artigas,M., Roth Mota,N., Howrigan,D.,
            Medland,S.E., Zayats,T., Rajagopal,V.M., Nordentoft,M., Mors,O.,
            Hougaard,D.M., Mortensen,P.B., Daly,M.J., Faraone,S.V.,
            Stefansson,H., Roussos,P., Franke,B., Werge,T., Neale,B.M.,
            Stefansson,K. and Borglum,A.D.
  CONSRTM   ADHD Working Group of the Psychiatric Genomics Consortium;
            iPSYCH-Broad Consortium
  TITLE     Genome-wide analyses of ADHD identify 27 risk loci, refine the
            genetic architecture and implicate several cognitive domains
  JOURNAL   Nat Genet 55 (2), 198-208 (2023)
   PUBMED   36702997
  REMARK    GeneRIF: Genome-wide analyses of ADHD identify 27 risk loci, refine
            the genetic architecture and implicate several cognitive domains.
            Erratum:[Nat Genet. 2023 Apr;55(4):730. doi:
            10.1038/s41588-023-01350-w.. PMID: 36859734]
REFERENCE   3  (bases 1 to 5575)
  AUTHORS   Dong,F., Wu,C., Jiang,W., Zhai,M., Li,H., Zhai,L. and Zhang,X.
  TITLE     Cryo-EM structure studies of the human VPS10 domain-containing
            receptor SorCS3
  JOURNAL   Biochem Biophys Res Commun 624, 89-94 (2022)
   PUBMED   35940132
  REMARK    GeneRIF: Cryo-EM structure studies of the human VPS10
            domain-containing receptor SorCS3.
REFERENCE   4  (bases 1 to 5575)
  AUTHORS   Zhang,Y., Li,Y., Fan,Y., Zhang,X., Tang,Z., Qi,J., Zhao,B., Li,F.,
            Chen,X., Liang,H., Xu,H. and Li,D.
  TITLE     SorCS3 promotes the internalization of p75NTR to inhibit GBM
            progression
  JOURNAL   Cell Death Dis 13 (4), 313 (2022)
   PUBMED   35393432
  REMARK    GeneRIF: SorCS3 promotes the internalization of p75(NTR) to inhibit
            GBM progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5575)
  AUTHORS   Reitz,C.
  TITLE     The role of the retromer complex in aging-related
            neurodegeneration: a molecular and genomic review
  JOURNAL   Mol Genet Genomics 290 (2), 413-427 (2015)
   PUBMED   25332075
  REMARK    Review article
            Erratum:[Mol Genet Genomics. 2015 Apr;290(2):429. doi:
            10.1007/s00438-015-1020-z.. PMID: 25743489]
REFERENCE   6  (bases 1 to 5575)
  AUTHORS   Reitz,C., Tosto,G., Vardarajan,B., Rogaeva,E., Ghani,M.,
            Rogers,R.S., Conrad,C., Haines,J.L., Pericak-Vance,M.A.,
            Fallin,M.D., Foroud,T., Farrer,L.A., Schellenberg,G.D.,
            George-Hyslop,P.S. and Mayeux,R.
  CONSRTM   Alzheimer's Disease Genetics Consortium (ADGC)
  TITLE     Independent and epistatic effects of variants in VPS10-d receptors
            on Alzheimer disease risk and processing of the amyloid precursor
            protein (APP)
  JOURNAL   Transl Psychiatry 3 (5), e256 (2013)
   PUBMED   23673467
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5575)
  AUTHORS   Hermey,G.
  TITLE     The Vps10p-domain receptor family
  JOURNAL   Cell Mol Life Sci 66 (16), 2677-2689 (2009)
   PUBMED   19434368
  REMARK    Review article
REFERENCE   8  (bases 1 to 5575)
  AUTHORS   Westergaard,U.B., Kirkegaard,K., Sorensen,E.S., Jacobsen,C.,
            Nielsen,M.S., Petersen,C.M. and Madsen,P.
  TITLE     SorCS3 does not require propeptide cleavage to bind nerve growth
            factor
  JOURNAL   FEBS Lett 579 (5), 1172-1176 (2005)
   PUBMED   15710408
  REMARK    GeneRIF: The propeptide is not a requirement for normal processing
            of the receptor and does not prevent ligands from binding to the
            SorCS3 precursor form
REFERENCE   9  (bases 1 to 5575)
  AUTHORS   Hampe,W., Rezgaoui,M., Hermans-Borgmeyer,I. and Schaller,H.C.
  TITLE     The genes for the human VPS10 domain-containing receptors are large
            and contain many small exons
  JOURNAL   Hum Genet 108 (6), 529-536 (2001)
   PUBMED   11499680
REFERENCE   10 (bases 1 to 5575)
  AUTHORS   Hermey,G., Riedel,I.B., Hampe,W., Schaller,H.C. and
            Hermans-Borgmeyer,I.
  TITLE     Identification and characterization of SorCS, a third member of a
            novel receptor family
  JOURNAL   Biochem Biophys Res Commun 266 (2), 347-351 (1999)
   PUBMED   10600506
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB028982.1, AL353900.14 and
            BC045754.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014978.2.
            
            Summary: This gene encodes a type-I receptor transmembrane protein
            that is a member of the vacuolar protein sorting 10 receptor
            family. Proteins of this family are defined by a vacuolar protein
            sorting 10 domain at the N-terminus. The N-terminal segment of this
            domain has a consensus motif for proprotein convertase processing,
            and the C-terminal segment of this domain is characterized by ten
            conserved cysteine residues. The vacuolar protein sorting 10 domain
            is followed by a leucine-rich segment, a transmembrane domain, and
            a short C-terminal cytoplasmic domain that interacts with adaptor
            molecules. The transcript is expressed at high levels in the brain,
            and candidate gene studies suggest that genetic variation in this
            gene is associated with Alzheimer's disease. Consistent with this
            observation, knockdown of the gene in cell culture results in an
            increase in amyloid precursor protein processing. [provided by
            RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028982.1, SRR1660807.56305.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369701.8/ ENSP00000358715.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1405              AB028982.1         190-1594
            1406-1406           AL353900.14        69911-69911
            1407-5568           AB028982.1         1596-5757
            5569-5575           BC045754.1         2663-2669
FEATURES             Location/Qualifiers
     source          1..5575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.1"
     gene            1..5575
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /note="sortilin related VPS10 domain containing receptor
                     3"
                     /db_xref="GeneID:22986"
                     /db_xref="HGNC:HGNC:16699"
                     /db_xref="MIM:606285"
     exon            1..665
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..3707
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /note="VPS10 domain-containing receptor SorCS3; VPS10
                     domain receptor protein SORCS 3 (SORCS3)"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS3
                     precursor"
                     /protein_id="NP_055793.1"
                     /db_xref="CCDS:CCDS7558.1"
                     /db_xref="GeneID:22986"
                     /db_xref="HGNC:HGNC:16699"
                     /db_xref="MIM:606285"
                     /translation="MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPG
                     RPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQ
                     VEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPL
                     AKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLY
                     DFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMES
                     SILISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHE
                     RITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDIS
                     SLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAV
                     QEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKV
                     DDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISS
                     KETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMK
                     HTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQ
                     LVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSV
                     VSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVS
                     NNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTN
                     IQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPV
                     EHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAE
                     GTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIK
                     RALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNAL
                     NQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKF
                     KRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGI
                     ATIANSESTKEIPNCTSV"
     exon            666..733
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            734..833
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            834..992
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1066
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1131
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1250
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1340
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1520
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1667
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1770
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1847
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1939
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2047
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2165
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2299
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2413
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2585
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2772
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2906
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3030
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3143
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3275
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3375
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3481
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3642
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..5575
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5547..5552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /note="hexamer: AATAAA"
     polyA_site      5575
                     /gene="SORCS3"
                     /gene_synonym="SORCS"
                     /note="major polyA site"
ORIGIN      
        1 acacactcgg cagcccgagc cgcggtagcc gcagcgggat ggaggcggcg cgcacggagc
       61 gccccgcagg caggccgggg gcgccgcttg tccggacggg gctcctactc ttgtcgacgt
      121 gggtcctggc cggcgccgag atcacttggg acgcgacagg cggtcccgga cgcccggcgg
      181 ccccggcttc gcggccaccg gcgttgtctc cactctcgcc gcgggcagtg gccagccagt
      241 ggccggagga gctggcgtcg gcgcggagag ccgccgtgct ggggcgccgg gccggaccag
      301 agctgctgcc ccagcagggc ggcggcagag gcggtgagat gcaggtggaa gccggaggga
      361 catcaccggc aggcgagcgg cggggccggg gcatcccagc tcctgccaag cttggcggcg
      421 cgaggaggag tcgccgggcg cagcccccaa tcacccagga acgcggggac gcctgggcca
      481 ctgctccggc cgatggttcc agaggaagcc gtccccttgc taagggttcc cgggaggagg
      541 tgaaggcgcc gcgggctggg gggtcggcgg ctgaagacct ccggctgccc agcacctcct
      601 tcgcgctgac cggggactcg gcccacaacc aagccatggt gcactggtcg ggacacaaca
      661 gcagcgtcat acttatcctg acgaagctgt atgacttcaa cctgggcagc gtgactgaga
      721 gttcactatg gaggtcgaca gattatggca ccacctatga aaagctgaat gacaaagtgg
      781 gtttgaagac tgtcctcagt tacctctatg tcaatccaac caacaaaagg aagattatgc
      841 ttctcagtga tcctgagatg gagagcagca tattgatcag ctcagacgaa ggggcgacct
      901 atcagaagta tcggctcacc ttctatatcc agagcctgct ctttcatccc aagcaagagg
      961 actgggtgct ggcctacagt ttggatcaaa agctctacag ctccatggac tttggaagac
     1021 ggtggcaact catgcatgaa cgcatcacac ccaacaggtt ttattggtcg gtggccggat
     1081 tggataagga ggcggacctg gtgcacatgg aggtgcggac cacggatgga tatgctcact
     1141 acctcacctg caggatccag gaatgtgccg agacaactag aagtgggcct tttgcccgct
     1201 ccattgacat cagttccctg gttgtccagg atgaatatat cttcattcag gtaacaacta
     1261 gtggaagagc cagctactac gtgtcttatc gaagagaggc ctttgctcag ataaagctgc
     1321 ctaagtactc gttgccaaag gacatgcaca tcatcagtac agacgagaac caagtatttg
     1381 ctgcggtcca agaatggaac cagaacgaca cgtacaacct ctacatctca gacacgcgtg
     1441 ggatttactt cactctggcc atggagaaca tcaagagcag cagaggtcta atggggaaca
     1501 tcattattga attgtatgag gtagcaggta tcaaagggat atttctggca aacaagaagg
     1561 tggacgacca ggtgaagaca tacatcactt acaacaaagg cagggattgg cgcctgctgc
     1621 aagctccgga tgtggacctg agaggaagcc cagtgcactg cctgctgccc ttctgttcct
     1681 tacatctgca cctgcaactc tctgaaaatc catattcctc aggaagaatc tctagcaagg
     1741 agacagcccc aggacttgtg gtggctacag gcaacattgg cccggagctc tcatatactg
     1801 atattggtgt gttcatctcc tccgatgggg gcaacacatg gagacagatc tttgatgaag
     1861 agtacaatgt ctggttccta gactggggtg gtgccctcgt ggccatgaaa cacacacctc
     1921 tgccagtcag gcatttgtgg gtgagttttg atgagggcca ctcttgggac aagtatggtt
     1981 tcacttcggt tcctctcttt gttgacgggg ctctggtgga ggcaggaatg gagacccaca
     2041 tcatgacagt ttttggccac ttcagcctcc gctccgaatg gcaattggtg aaagtggact
     2101 acaaatctat cttcagccgg cattgcacca aggaggacta tcagacctgg cacctgctca
     2161 atcagggaga gccttgtgtc atgggagaaa ggaaaatatt caagaaacgt aagccaggag
     2221 ctcagtgtgc cctgggccga gaccactcag gatcagtggt ctcagaaccc tgtgtctgtg
     2281 ccaattggga cttcgagtgt gactatgggt atgagagaca tggggagagc cagtgtgtcc
     2341 cagctttctg gtacaatcca gcatccccat caaaggactg cagccttggt caaagctacc
     2401 ttaacagcac tgggtatcgg cggattgtgt ccaacaactg cacagatggg ctaagggaga
     2461 agtacaccgc caaggcccag atgtgccctg gaaaagcccc tcggggcctc catgtggtga
     2521 cgaccgatgg gcggctggtg gcagagcagg ggcacaatgc aactttcatc atcctcatgg
     2581 aggagggtga tctacaaagg acaaacatcc agcttgactt tggggatggg attgctgtgt
     2641 cctacgcaaa cttcagcccc atcgaggacg gcatcaagca cgtgtataag agtgcgggga
     2701 tcttccaggt gacagcctat gcagagaaca accttggctc agacacagct gtcctcttcc
     2761 tgcatgtggt ttgtcctgtg gagcatgttc atctccgagt tccatttgtt gccataagaa
     2821 ataaggaggt caacatcagt gcagtcgtgt ggcccagtca actggggacc cttacctatt
     2881 tctggtggtt cggcaatagc acaaagcctc tcatcacttt ggacagcagc atttccttca
     2941 cattccttgc agaaggaacc gacaccatca cagtccaggt ggctgctggg aatgccctca
     3001 tccaggacac aaaagagatt gcagttcatg aatatttcca gtcccagctt ttatcattct
     3061 ctcctaatct ggattaccac aatcctgaca ttcctgagtg gagaaaagat attggcaatg
     3121 tcatcaagcg agctctggtt aaagtaacca gtgtcccaga ggaccagatc ctcattgccg
     3181 tgtttcctgg tctccccact tcagcagagc ttttcattct tccacccaag aacctgacag
     3241 agaggaggaa aggcaatgaa ggggacctgg aacaaattgt agaaacactg tttaatgctc
     3301 tcaaccaaaa tttggtccag tttgagctga agccgggggt acaagtcatt gtgtatgtca
     3361 cacagctgac gttagctcca ttggtggact ccagtgctgg gcacagcagc tcagccatgc
     3421 ttatgctatt atcagtggta tttgttggcc tggctgtgtt tttgatctac aagtttaaaa
     3481 ggaaaatccc ttggattaac atctatgctc aagtccaaca cgacaaggag caggagatga
     3541 ttgggtcagt gagccaaagt gaaaacgccc ccaaaatcac actcagtgac tttacggagc
     3601 ctgaggagct gctggacaaa gagctggaca cgcgggtcat aggaggcatt gccactattg
     3661 caaacagcga aagcacaaag gagatcccca actgcactag tgtttaatac cagcaagcca
     3721 cgtggtcaac cacctttctg actttttatt tttgatgatt actattacta ttattatgga
     3781 aaaattaaaa tgtctttttt accttttgtt taccaagggc cccttcataa atagcaggca
     3841 aatgcctagc tttgggagaa aagggcattc ttagctgatt gaaatgagac aaagggaata
     3901 aatggctgta tttgtgctaa gagcaaagga tgcatcttcc cacagcctcc tcgctttact
     3961 ctgccattgg tagcttaaag actttctttt tccttgtggt ctcccttttt tcaaaattga
     4021 agttgggttg gctctttgtg aacctctcat ccccacagca gaatcaccaa cactctccgc
     4081 ttcccccagc acacacacat acaacacaga tcatttccca gttagatccg caggaagtag
     4141 gttggtgggg gtggatgtag ctgcagaaag catgcacaac tttgtgaaag aggccctgcc
     4201 ttgtgcatgt ccatagtgag gctacagatg gcttattgta tataattaca atgtaaatag
     4261 ctttttattt cctaagaaat aatttaatgt ttagtaaaaa agaaaacaga aaaaagaaag
     4321 atgcgtgtgt tggcttacgc actggccctc agagctgacc aacccgccag gcctgctcaa
     4381 tgcattgggt ttggatgctc tcctgttgtc tgtcacactt aactcttgca tctccttgtc
     4441 catgccatag ctggtttcta cttatgtata taaagggggg tggggggagg ggcttctctg
     4501 gggcaattga taaaggaagg actctagtga catcatagaa catggcagtc gtttttgttc
     4561 caagaatgat atgaaaggtg aagaagaggc ccactagagg cttcatactg agacccagat
     4621 gggggaaaac agcttcctct ctaaaaggaa aaacttgata tttatcagtc tgagaaaata
     4681 tttttttcta aagaaggcag tcagtggatc ttaaaatgac aatctgtttt taaattggat
     4741 tctatgaaaa tgcataatgc ttatggtgaa ttctcaggct attctgagct cagaaaagtc
     4801 ccctgggcac taggtaaagc ccagtgaatg tctcttggca tgggaggagt taaagaggtt
     4861 ggaagggaag aggcatttgt ggaattatga gttcatgcaa aactctccag gccaagtagg
     4921 ggtctagcct ttaatgatat tagtcaaagg caattttagc aaagctgtgc tatttgcttg
     4981 tcagatgtac acaacttcct taaagtcaaa tgtctgcctt cagttccctt aaggtagttc
     5041 ttgcctctgg ggtgagtggc tttcaaagcc ttttagcttt tccagcacct cagccccttc
     5101 acacatttac acataccaat ttttttcaat agggtcacgt taagccatgc tgtaagcatt
     5161 gtttttattt tcaggcttag cctgagcaca cttatttttg aaaatgatat aatgtatata
     5221 tatgggagga aaggccacat tttgtacctg ttaatttttg tgggatgttg ttcccattct
     5281 tctttgtgag acagagagaa tgtgatatag agaaatctgg ctggctacag tgtagatcag
     5341 tattaggaat atttctaaag atcctgcttt tttgtttcaa gggttaaatg gggcagacaa
     5401 ttgcaatact tgtactaaac actggaatac aaatgcatga ctcatatcta tatatacagt
     5461 atatgtacat atactgttct tggttttatt gttccacttg aatatttcta ctgtaaaaaa
     5521 aagacagtgg ttttgaaatt gttgaaaata aatgtatttt tgtacatcaa agcta
//
