LOCUS       NM_020777               6152 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens sortilin related VPS10 domain containing receptor 2
            (SORCS2), mRNA.
ACCESSION   NM_020777
VERSION     NM_020777.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6152)
  AUTHORS   Skeldal,S., Voss,L.F., Lende,J., Pedersen,S.B., Molgaard,S.,
            Kaas,M., Demange,P., Bentsen,A.H., Fuglsang,M., Sander,M.R.,
            Buttenschon,H., Gustafsen,C., Madsen,P. and Glerup,S.
  TITLE     Alternative splicing regulates adaptor protein binding,
            trafficking, and activity of the Vps10p domain receptor SorCS2 in
            neuronal development
  JOURNAL   J Biol Chem 299 (9), 105102 (2023)
   PUBMED   37507021
  REMARK    GeneRIF: Alternative splicing regulates adaptor protein binding,
            trafficking, and activity of the Vps10p domain receptor SorCS2 in
            neuronal development.
REFERENCE   2  (bases 1 to 6152)
  AUTHORS   Gospodinova,K.O., Olsen,D., Kaas,M., Anderson,S.M., Phillips,J.,
            Walker,R.M., Bermingham,M.L., Payne,A.L., Giannopoulos,P.,
            Pandya,D., Spires-Jones,T.L., Abbott,C.M., Porteous,D.J., Glerup,S.
            and Evans,K.L.
  TITLE     Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
  JOURNAL   Cell Mol Neurobiol 43 (1), 237-249 (2023)
   PUBMED   34741697
  REMARK    GeneRIF: Loss of SORCS2 is Associated with Neuronal DNA
            Double-Strand Breaks.
REFERENCE   3  (bases 1 to 6152)
  AUTHORS   Tamraz,B., Huang,Y., French,A.L., Kassaye,S., Anastos,K.,
            Nowicki,M.J., Gange,S., Gustafson,D.R., Bacchetti,P.,
            Greenblatt,R.M., Hysi,P.G. and Aouizerat,B.E.
  CONSRTM   Women's Interagency HIV Study
  TITLE     Association of Pharmacogenetic Markers With Atazanavir Exposure in
            HIV-Infected Women
  JOURNAL   Clin Pharmacol Ther 107 (2), 315-318 (2020)
   PUBMED   31562781
  REMARK    GeneRIF: Association of Pharmacogenetic Markers With Atazanavir
            Exposure in HIV-Infected Women.
REFERENCE   4  (bases 1 to 6152)
  AUTHORS   Malik,A.R., Szydlowska,K., Nizinska,K., Asaro,A., van Vliet,E.A.,
            Popp,O., Dittmar,G., Fritsche-Guenther,R., Kirwan,J.A., Nykjaer,A.,
            Lukasiuk,K., Aronica,E. and Willnow,T.E.
  TITLE     SorCS2 Controls Functional Expression of Amino Acid Transporter
            EAAT3 and Protects Neurons from Oxidative Stress and
            Epilepsy-Induced Pathology
  JOURNAL   Cell Rep 26 (10), 2792-2804 (2019)
   PUBMED   30840898
  REMARK    GeneRIF: Findings highlight a protective role for SorCS2 in
            neuronal stress response and provide a possible explanation for
            upregulation of this receptor seen in surviving neurons of the
            human epileptic brain.
REFERENCE   5  (bases 1 to 6152)
  AUTHORS   Smith,A.H., Ovesen,P.L., Skeldal,S., Yeo,S., Jensen,K.P., Olsen,D.,
            Diazgranados,N., Zhao,H., Farrer,L.A., Goldman,D., Glerup,S.,
            Kranzler,H.R., Nykjaer,A. and Gelernter,J.
  TITLE     Risk Locus Identification Ties Alcohol Withdrawal Symptoms to
            SORCS2
  JOURNAL   Alcohol Clin Exp Res 42 (12), 2337-2348 (2018)
   PUBMED   30252935
  REMARK    GeneRIF: We used human neural lineage cells to demonstrate in vitro
            a causal relationship between stress hormone levels and SORCS2
            expression, and show that SORCS2 levels in culture are increased
            upon ethanol exposure and withdrawal
REFERENCE   6  (bases 1 to 6152)
  AUTHORS   Xu,J., Zheng,S.L., Isaacs,S.D., Wiley,K.E., Wiklund,F., Sun,J.,
            Kader,A.K., Li,G., Purcell,L.D., Kim,S.T., Hsu,F.C., Stattin,P.,
            Hugosson,J., Adolfsson,J., Walsh,P.C., Trent,J.M., Duggan,D.,
            Carpten,J., Gronberg,H. and Isaacs,W.B.
  TITLE     Inherited genetic variant predisposes to aggressive but not
            indolent prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 2136-2140 (2010)
   PUBMED   20080650
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6152)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6152)
  AUTHORS   Yosifova,A., Mushiroda,T., Stoianov,D., Vazharova,R., Dimova,I.,
            Karachanak,S., Zaharieva,I., Milanova,V., Madjirova,N.,
            Gerdjikov,I., Tolev,T., Velkova,S., Kirov,G., Owen,M.J.,
            O'Donovan,M.C., Toncheva,D. and Nakamura,Y.
  TITLE     Case-control association study of 65 candidate genes revealed a
            possible association of a SNP of HTR5A to be a factor susceptible
            to bipolar disease in Bulgarian population
  JOURNAL   J Affect Disord 117 (1-2), 87-97 (2009)
   PUBMED   19328558
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6152)
  AUTHORS   Ollila,H.M., Soronen,P., Silander,K., Palo,O.M., Kieseppa,T.,
            Kaunisto,M.A., Lonnqvist,J., Peltonen,L., Partonen,T. and Paunio,T.
  TITLE     Findings from bipolar disorder genome-wide association studies
            replicate in a Finnish bipolar family-cohort
  JOURNAL   Mol Psychiatry 14 (4), 351-353 (2009)
   PUBMED   19308021
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6152)
  AUTHORS   Hampe,W., Rezgaoui,M., Hermans-Borgmeyer,I. and Schaller,H.C.
  TITLE     The genes for the human VPS10 domain-containing receptors are large
            and contain many small exons
  JOURNAL   Hum Genet 108 (6), 529-536 (2001)
   PUBMED   11499680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097382.3, AF286190.1,
            AB037750.1, AC004169.3, DA215907.1 and R37251.1.
            
            On Jun 2, 2019 this sequence version replaced NM_020777.2.
            
            Summary: This gene encodes one family member of vacuolar protein
            sorting 10 (VPS10) domain-containing receptor proteins. The VPS10
            domain name comes from the yeast carboxypeptidase Y sorting
            receptor Vps10 protein. Members of this gene family are large with
            many exons but the CDS lengths are usually less than 3700 nt. Very
            large introns typically separate the exons encoding the VPS10
            domain; the remaining exons are separated by much smaller-sized
            introns. These genes are strongly expressed in the central nervous
            system. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000507866.6/ ENSP00000422185.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC097382.3         206118-206226
            110-210             AC097382.3         206227-206327
            211-1461            AF286190.1         1-1251
            1462-2007           AB037750.1         597-1142
            2008-2008           AC004169.3         60257-60257         c
            2009-2254           AB037750.1         1144-1389
            2255-2255           AC004169.3         57815-57815         c
            2256-2571           DA215907.1         26-341
            2572-4880           AB037750.1         1707-4015
            4881-5965           AC004169.3         30380-31464         c
            5966-6152           R37251.1           19-205              c
FEATURES             Location/Qualifiers
     source          1..6152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..6152
                     /gene="SORCS2"
                     /note="sortilin related VPS10 domain containing receptor
                     2"
                     /db_xref="GeneID:57537"
                     /db_xref="HGNC:HGNC:16698"
                     /db_xref="MIM:606284"
     exon            1..589
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..3589
                     /gene="SORCS2"
                     /note="VPS10 domain receptor protein; SORCS2A S716P;
                     SORCS2C S716P; SORCS2B S716P; SORCS2D S716P"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS2"
                     /protein_id="NP_065828.2"
                     /db_xref="CCDS:CCDS47008.1"
                     /db_xref="GeneID:57537"
                     /db_xref="HGNC:HGNC:16698"
                     /db_xref="MIM:606284"
                     /translation="MAHRGPSRASKGPGPTARAPSPGAPPPPRSPRSRPLLLLLLLLG
                     ACGAAGRSPEPGRLGPHAQLTRVPRSPPAGRAEPGGGEDRQARGTEPGAPGPSPGPAP
                     GPGEDGAPAAGYRRWERAAPLAGVASRAQVSLISTSFVLKGDATHNQAMVHWTGENSS
                     VILILTKYYHADMGKVLESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVI
                     LVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAYTKESKLYVSS
                     DLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKML
                     TAPFAGPIDHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQII
                     STDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDILEVRG
                     VKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWA
                     DNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILY
                     LDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTV
                     FGHISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTS
                     WCIKGRSFTSALTSRVCECRDSDFLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDC
                     ALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGE
                     DVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAEN
                     TAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVLLPLNPNLTVFYWWIGHSL
                     QPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDA
                     YNPNTPEWREDVGLVVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKR
                     SLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGGGGGYWAVVVLFV
                     IGLFAAGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDVQGAVQGNHSGVVL
                     SINSREMHSYLVS"
     exon            590..657
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..757
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..922
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..996
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1061
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1180
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1270
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1450
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1597
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1700
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1777
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1869
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1977
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2098
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2232
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2361
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2533
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2720
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2854
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2978
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3091
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3217
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3317
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3420
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3524
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..6152
                     /gene="SORCS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6133..6138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORCS2"
                     /note="hexamer: ATTAAA"
     polyA_site      6152
                     /gene="SORCS2"
                     /note="major polyA site"
ORIGIN      
        1 cctttctctg cgctctcgct cgcgctcccc agcgccctcc tgctctcccg gccgcggtcc
       61 cctcgtccgc gccgccccgc cgccggctcc gctgccgccc ctggcgacca tggcgcaccg
      121 ggggccctcg cgcgcctcga agggccccgg ccccaccgcc cgagccccga gccccggggc
      181 tccgccgccg ccgcgctcgc cgcgctcgcg gccgctcctg ctgctgctgc tgctgctggg
      241 cgcctgcggg gcggcggggc gctcccctga gcccgggcgc ctgggtcctc acgcccaact
      301 gacccgggtg ccgcggagcc ctcccgcggg gcgcgcggag cccggtggcg gcgaggaccg
      361 gcaggcgcgc ggcacggagc caggcgcccc gggtccgagt cccggtcccg ctcctggtcc
      421 cggcgaggac ggcgcccccg ccgcgggcta ccggcgctgg gagcgggcgg cgccgctggc
      481 cggagtggct tcgcgggcgc aggtctcgct catcagcacg tcgttcgtgc tcaaggggga
      541 cgcgacgcac aaccaggcga tggtgcactg gacgggcgag aacagcagcg tgatcttgat
      601 cctgacgaag tactaccacg cagacatggg gaaggttctg gaaagttctc tgtggcggtc
      661 atcagatttc gggacgtcct acaccaagct caccctccag cctggtgtca ccaccgtcat
      721 cgacaatttc tacatctgcc cgaccaacaa gaggaaggtc atccttgtca gctcctcact
      781 cagtgaccgg gaccagagcc tattcctcag cgcagacgaa ggcgccacct ttcagaagca
      841 gcccattccc ttcttcgtgg aaactctgat tttccaccct aaggaggagg acaaggtcct
      901 cgcctacaca aaggagagca agctctacgt gtcatctgac ttggggaaaa agtggacact
      961 tctgcaagag cgagtgacca aagaccacgt gttctggtct gtgtctgggg tggacgctga
     1021 ccctgacttg gtccacgtgg aagcccaaga cctcggtgga gattttcggt acgtcacctg
     1081 cgcaatccac aattgctccg agaagatgct gacagcccca ttcgcaggcc ccattgacca
     1141 cgggtctctg accgtgcagg acgattacat cttctttaag gcaacatcag caaaccagac
     1201 aaaatactac gtctcttatc gtcgaaatga atttgtcctg atgaagctgc cgaagtatgc
     1261 attgccaaag gatctgcaga tcatcagcac ggacgagagt caggtgttcg tggcggtgca
     1321 ggagtggtac cagatggaca cctacaacct gtaccagtcg gacccacggg gcgtgcgcta
     1381 cgcgctggtg ctgcaggacg tgcgcagctc acggcaggcg gaggagagcg tgctcatcga
     1441 catcctggag gtcagagggg tgaaaggagt cttcctggca aaccaaaaaa ttgatgggaa
     1501 agtgatgacg cttataacct acaacaaggg ccgcgactgg gattacctga ggccacccag
     1561 catggacatg aatggaaaac caaccaactg caagcctcca gactgccacc tgcacctgca
     1621 cctgcgctgg gcagacaacc cctacgtatc aggcaccgtg cacaccaagg acaccgcccc
     1681 aggcctcatc atgggtgcag gtaacctggg ctcacagctg gtggaatata aagaagaaat
     1741 gtacatcacg tcagactgtg gtcacacctg gcggcaggtg tttgaggaag agcatcacat
     1801 cctgtacctg gaccacggcg gcgtgatcgt ggccatcaaa gacacctcca tccctttgaa
     1861 gatcctcaag ttcagtgtgg acgagggcct cacctggagc acgcacaact tcaccagcac
     1921 ctcggtgttt gtggacgggc tgctgagtga gccaggggac gagacgctgg tcatgacggt
     1981 ctttggccac atcagcttcc gctccgattg ggagctggtc aaggtggact tccggccctc
     2041 attctccagg cagtgcggcg aggaggacta cagctcctgg gagctctcca acctgcaggg
     2101 cgaccgctgt atcatgggcc agcagagaag tttccggaaa agaaagtcca cgtcctggtg
     2161 catcaagggg aggagcttca cgtcggcgct cacgtcccgc gtgtgcgagt gccgggactc
     2221 ggacttcctg tgcgactacg gatttgagcg ctcctcctcc tcagagtcca gcaccaacaa
     2281 gtgctctgcc aacttctggt ttaacccatt gtccccgcct gacgactgtg ccctgggcca
     2341 gacctacacc agcagccttg ggtaccggaa agtggtgtcc aacgtgtgtg agggtggggt
     2401 ggacatgcag cagagtcagg tgcagctgca gtgccccctc acgccgcccc ggggcctgca
     2461 ggtcagcatt caaggcgagg cggtggccgt gcggcctgga gaggacgtcc tgtttgtggt
     2521 gcggcaggag cagggtgatg tcctgactac caagtaccag gtagaccttg gggacggctt
     2581 caaggccatg tacgtgaacc ttacactgac cggggagccc atccggcacc gctacgagag
     2641 ccccggcatc taccgcgtgt ccgtcagggc agagaacacg gcaggccacg atgaggcggt
     2701 gctctttgtc caggtcaact cccccctgca ggccctctac ctggaggtgg ttcctgtcat
     2761 tggcctcaac caggaggtga acctcacagc tgtgctgctt cccttgaacc ctaacctcac
     2821 cgtcttctac tggtggatcg gccacagcct gcagcccctc ctttccctgg ataattctgt
     2881 gacaacgcgg ttttcggaca cgggcgacgt gcgtgtgacg gtgcaggccg cctgtgggaa
     2941 ctcggtgctg caggactcca gggtcctccg tgtgctggat caatttcaag tcatgcctct
     3001 gcagttttcc aaggagctgg atgcctacaa ccccaacacc cctgagtgga gggaagacgt
     3061 gggcctggtg gtcacccggc tgctctccaa ggagaccagc gtccctcagg agcttctggt
     3121 gactgtggtg aagccggggc tgcccacttt ggccgatctg tacgtgctcc tgccccctcc
     3181 caggcccaca aggaagagga gcctctcgag tgataagagg ctcgccgcca tccagcaggt
     3241 gctgaacgca cagaagatca gcttcctcct gcgaggcgga gtccgggtcc tggtggccct
     3301 gcgggacaca ggcacaggtg ctgagcagct gggcggcggt ggcggctact gggcggtagt
     3361 ggtgctgttt gtcatcgggc tcttcgcagc gggagccttc atcctctaca agttcaaaag
     3421 gaaacggcca ggcaggaccg tgtacgccca aatgcacaac gagaaggagc aggagatgac
     3481 cagccctgtg agtcacagtg aggacgtcca gggcgctgtc cagggcaacc actcaggcgt
     3541 ggtcctgagc atcaactccc gagagatgca cagctacctg gtgagctgat gccaccccag
     3601 catctgtctt ttcacccacg gagggcacag aaccaccagc aaagccggcg gctggactgg
     3661 cgcccctcag agacctgcgg aaagccccct ccctgagtcg tcgccacacc aggcgacagg
     3721 caccaccccc tctgataaat ccaagcccgc ccaggcccac ggggggccca cgggaccccc
     3781 cgggactccc cggacatggc cctgccccta tgggacacca ggcctgactc aggcaggttc
     3841 tgccccccag accccacaca cggccgcccc acgtgctgtc gctcagcccg aggcctgact
     3901 tctctgggct gaggctggtc gtcctggagc cctcccagta cctcgggctg caagagctgc
     3961 agacccgttc agacactgcg ttgcgggctc cttccccgca gaggccgggg cctccctgac
     4021 tttgcttctt cactcccacc tgtgcggcca cccagtccct ctgtgggagc ccgggtgcca
     4081 ggccctccca acaccacacc accctccagg cccccctgcc ctccggctgg aaactgcagc
     4141 tctgtaaatg cctctctagg tagctgctgg cggtggtggg ggtgtctcac tctctgtctt
     4201 tatagccggc ggtagccacc ggggtggctc tgtcagagtt ccgtactcgg gagccccttt
     4261 ccctgagtgc ccagggtgtc tcctctgccc agaggggcag cagctctccc tggttctccc
     4321 cagggcagac ggggtagggc gggctcagga cccagtgccc atggttcctc actcctacca
     4381 gcaagcagca ccatcccgca ggcttctccc acctgatggc tgttctccca ccgggtctgg
     4441 gctctggaag gagccagatg cccccagaaa ggtgggtggt ggagacggca ccagatgtac
     4501 cagttttctg cagttcctta taggcgaagg gaaccgggtg gaaaccaagc tgggagaggc
     4561 tgaggatggc agggctggaa gggccatcag cgtgaccctc attttcaaga aggggaaact
     4621 gaggcccagg gaggagagta actgaaggtc acagcacggt cacagcagag gtggccgaac
     4681 ccagccctct gcgcgccagt gctgtgcggt ctccacaccc ttacggtttc ctagaatcag
     4741 ggatgttagt gtaagtctat aggaatatag gggggtgggg gggtcacctt ttgccttgaa
     4801 atgggaagtc agtagcccct tcctcctcct ccctcctccc cctcctctct ggcagggatc
     4861 tcagatgacc gtggcctccc tctcagaggg ggagaacgcc agagccctgg ctggtgatgt
     4921 gctggctggg ggtgaatccc aatgagggtc cctctcagag cgggagaacg ccagagccct
     4981 ggatggtgat gcgctggctg ggggtgaatc ccaatgaggg tccctctcag aaagggagaa
     5041 cgccagagcc ctggctggtg acatgctggc tgggggtgaa tccgaatgac agtgcagacg
     5101 ttctcccatc caccatgtct gagcttgggg gaattgcctc atttcccctg gaaaagaaac
     5161 atggtccatt agaggggaaa gcccaggggt gaatcttcac gccccaaaca gtgcccggtg
     5221 gggaggaggc acccgctcct tgttgagtaa aaccacccat ggagactgga acctcatctc
     5281 cctgggtcgg ggggtgttca aggccacagg acaaggggag caccctgggc cacacaggcg
     5341 tggaggtgtc cccacccctt ccacctgtcc cccagaccca aagctctctc cccaccctac
     5401 ctgcccacct ggggctcctg tgccccctcc ccactccaga ggccacccta caagttgtcc
     5461 tcaaggtcat cctggagatg ggatccagga cgtggggcca tgactctctg ggaccttgcc
     5521 acagccccca ttcccctgct tgcagtctgc aaggacacct ttgcagggat tcttgtcctg
     5581 ctggccaccc cacccacacc tgtccctggc cagcaggccg cctgcaagcg tcaggcacac
     5641 agggacagac atggcgagca cagtgcaggc ccggggccca cgggcaacat ggaaccctgg
     5701 gaactgccct cccccttagc tcacagtgcc tgcggtagcc actctaggtc gttggccttc
     5761 cttgaccact ccatttaatt ctctctgctg tttgggttgg gtttttcccc ttagttatct
     5821 gtgggtttcc tgtattttat gttaatattt ctattaagaa catgttgggc atgtggaccc
     5881 aagcacctgg gaaggaggtg gcatctgaga cagcctgata cgttcccgtc tgtgcaccca
     5941 tggagatcca ggcgtgggcc cgtgtctgtc cctggttgta aattcgaggg tctgcatatc
     6001 tgatgttcag gtagacctgg gcgcctggga acgaggccat cagctgccat gcacataaca
     6061 aagagacaat gcattccttc ttatttttcc tttttaaaaa tcgatgaatc atttgtgatg
     6121 cttttaacaa agattaaatg aatttgatca gc
//
