LOCUS       NM_052918               7444 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens sortilin related VPS10 domain containing receptor 1
            (SORCS1), transcript variant 1, mRNA.
ACCESSION   NM_052918
VERSION     NM_052918.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7444)
  AUTHORS   Lee,A.K., Yi,N., Khaled,H., Feller,B. and Takahashi,H.
  TITLE     SorCS1 inhibits amyloid-beta binding to neurexin and rescues
            amyloid-beta-induced synaptic pathology
  JOURNAL   Life Sci Alliance 6 (4), e202201681 (2023)
   PUBMED   36697254
  REMARK    GeneRIF: SorCS1 inhibits amyloid-beta binding to neurexin and
            rescues amyloid-beta-induced synaptic pathology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7444)
  AUTHORS   Huang,P.Z., Peng,S.Y., Yu,H.C., Huang,L., Yao,Q., Wang,X.L.,
            Tan,S.Y., Zhou,J.M., Wang,P.N., Huang,A.P., Bai,L.L., Luo,Y.X. and
            Huang,M.J.
  TITLE     Decreased expression of SorCS1 in colorectal cancer: An independent
            predictor of poor prognosis
  JOURNAL   Neoplasma 67 (1), 119-128 (2020)
   PUBMED   31829024
  REMARK    GeneRIF: SorCS1 is epigenetically inactivated in a substantial
            fraction of colorectal cancers
REFERENCE   3  (bases 1 to 7444)
  AUTHORS   Januliene,D., Manavalan,A., Ovesen,P.L., Pedersen,K.M., Thirup,S.,
            Nykjaer,A. and Moeller,A.
  TITLE     Hidden Twins: SorCS Neuroreceptors Form Stable Dimers
  JOURNAL   J Mol Biol 429 (19), 2907-2917 (2017)
   PUBMED   28827148
  REMARK    GeneRIF: Here the authors have characterized SorCS1, SorCS2 and
            SorCS3 using biochemical methods and electron microscopy. They
            found that their purified extracellular domains co-exist in stable
            dimeric and monomeric populations.
REFERENCE   4  (bases 1 to 7444)
  AUTHORS   Hrovat,A., Kravos,N.A., Goricar,K., Jensterle Sever,M., Janez,A.
            and Dolzan,V.
  TITLE     SORCS1 polymorphism and insulin secretion in obese women with
            polycystic ovary syndrome
  JOURNAL   Gynecol Endocrinol 32 (5), 395-398 (2016)
   PUBMED   27052493
  REMARK    GeneRIF: We report for the first time the relevance of SORCS1
            polymorphisms for glycemic control and glucose stimulated insulin
            secretion in obese women with polycystic ovary syndrome.  SORCS1
            rs1416406 significantly influenced stimulated glucose plasma levels
            and increased glucose stimulated insulin secretion
REFERENCE   5  (bases 1 to 7444)
  AUTHORS   Larsen,J.V., Hermey,G., Sorensen,E.S., Prabakaran,T.,
            Christensen,E.I., Gliemann,J., Madsen,P. and Petersen,C.M.
  TITLE     Human sorCS1 binds sortilin and hampers its cellular functions
  JOURNAL   Biochem J 457 (2), 277-288 (2014)
   PUBMED   24128306
  REMARK    GeneRIF: The propeptide region of sorCS1 contains two separate
            sites for binding to sortilin. One of these sites is removed from
            human sorCS1 during processing.
REFERENCE   6  (bases 1 to 7444)
  AUTHORS   Nielsen,M.S., Keat,S.J., Hamati,J.W., Madsen,P., Gutzmann,J.J.,
            Engelsberg,A., Pedersen,K.M., Gustafsen,C., Nykjaer,A.,
            Gliemann,J., Hermans-Borgmeyer,I., Kuhl,D., Petersen,C.M. and
            Hermey,G.
  TITLE     Different motifs regulate trafficking of SorCS1 isoforms
  JOURNAL   Traffic 9 (6), 980-994 (2008)
   PUBMED   18315530
  REMARK    GeneRIF: Different motifs regulate trafficking of SorCS1 isoforms.
REFERENCE   7  (bases 1 to 7444)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7444)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 7444)
  AUTHORS   Hermey,G., Keat,S.J., Madsen,P., Jacobsen,C., Petersen,C.M. and
            Gliemann,J.
  TITLE     Characterization of sorCS1, an alternatively spliced receptor with
            completely different cytoplasmic domains that mediate different
            trafficking in cells
  JOURNAL   J Biol Chem 278 (9), 7390-7396 (2003)
   PUBMED   12482870
  REMARK    GeneRIF: human sorCS1 has three isoforms, sorCS1a-c, with
            completely different cytoplasmic tails and differential expression
            in tissues
REFERENCE   10 (bases 1 to 7444)
  AUTHORS   Hampe,W., Rezgaoui,M., Hermans-Borgmeyer,I. and Schaller,H.C.
  TITLE     The genes for the human VPS10 domain-containing receptors are large
            and contain many small exons
  JOURNAL   Hum Genet 108 (6), 529-536 (2001)
   PUBMED   11499680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK125464.1, AB209142.1,
            AF284756.1, AL133395.21 and AW137766.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_052918.4.
            
            Summary: This gene encodes one family member of vacuolar protein
            sorting 10 (VPS10) domain-containing receptor proteins. The VPS10
            domain name comes from the yeast carboxypeptidase Y sorting
            receptor Vps10 protein. Members of this gene family are large with
            many exons but the CDS lengths are usually less than 3700 nt. Very
            large introns typically separate the exons encoding the VPS10
            domain; the remaining exons are separated by much smaller-sized
            introns. These genes are strongly expressed in the central nervous
            system. Two of the five family members (sortilin and
            sortilin-related receptor) are synthesized as preproproteins; it is
            not yet known if this encoded protein is also a preproprotein.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 3' UTR and
            coding sequence compared to variant 2. The resulting isoform (a)
            has a shorter and distinct C-terminus compared to isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131597.1, AF284756.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263054.11/ ENSP00000263054.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1856              AK125464.1         3-1858
            1857-2948           AB209142.1         1719-2810
            2949-3908           AF284756.1         2777-3736
            3909-7417           AL133395.21        51578-55086         c
            7418-7444           AW137766.1         17-43               c
FEATURES             Location/Qualifiers
     source          1..7444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.1"
     gene            1..7444
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /note="sortilin related VPS10 domain containing receptor
                     1"
                     /db_xref="GeneID:114815"
                     /db_xref="HGNC:HGNC:16697"
                     /db_xref="MIM:606283"
     exon            1..738
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3687
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; VPS10 domain receptor protein SORCS 1"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS1 isoform
                     a precursor"
                     /protein_id="NP_443150.3"
                     /db_xref="CCDS:CCDS7559.1"
                     /db_xref="GeneID:114815"
                     /db_xref="HGNC:HGNC:16697"
                     /db_xref="MIM:606283"
                     /translation="MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPS
                     SAPRSASTPRGFSHQGRPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVA
                     ARSGRRRRSGADQEKAERGEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRL
                     TSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYE
                     KLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQS
                     LLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHL
                     EARTVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYV
                     SYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTL
                     ALENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPD
                     TDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASKDTAPSIIVASGNIGSELSDTDI
                     SMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYS
                     FTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQ
                     LHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVCTEADFDCDYGYERHSNG
                     QCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPR
                     GLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIK
                     HVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLW
                     PSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAGNAILQDTKTIAV
                     YEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHILVAVLPGLPT
                     TAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVLVHAAHLTA
                     APLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGDSSLRLQ
                     RARHATPPSTPKRGSAGAQYAI"
     exon            739..806
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            807..906
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1065
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1139
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1204
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1323
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1413
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1593
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1740
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1843
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1920
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2012
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2120
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2238
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2369
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2483
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2655
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2842
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2976
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3100
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3213
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3345
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3445
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3551
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..7444
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7180..7185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /note="hexamer: ATTAAA"
     polyA_site      7202
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /note="major polyA site"
     regulatory      7419..7424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
                     /note="hexamer: ATTAAA"
     polyA_site      7444
                     /gene="SORCS1"
                     /gene_synonym="hSorCS"
ORIGIN      
        1 acaagcccag cccgggcaag cggccgccac ctgcccggcg ccgcctccgc ccgcccccac
       61 cgcggcgcaa cttggatgga gttggggtcc tgagcgccgg ccccccacag ccgccagcgc
      121 agagctcgtg ccgccacctt cgttctggga cccctctctc cgctgctctt cgctcccgcg
      181 atgggaaaag ttggcgccgg cggcggctcc caagcccggc tgagcgcgct cctcgccggc
      241 gcggggctct tgatcctctg cgccccgggc gtctgcggcg gcggctcctg ctgcccctcg
      301 ccgcacccca gctccgctcc acgctcggcc tcgaccccta ggggcttttc ccaccagggg
      361 cggccaggca gggctcctgc cacgcccctg cccctcgtag tgcgtcccct gttctcagtg
      421 gcccccgggg accgagcgct atccctggag cgggctcggg gcactggggc atccatggcg
      481 gttgctgcac gctccggccg gaggagacgg agcggagcgg atcaggagaa ggcagaacgg
      541 ggagagggcg cgagtcggag cccccgggga gtgctaagag atggagggca gcaggagcct
      601 gggactcggg agcgggaccc ggacaaagcc acccgcttcc ggatggagga gctgagactg
      661 accagcacca cgtttgcgct gacgggagac tcagcacaca accaagccat ggtccactgg
      721 tctggccaca acagcagcgt gattctcatt ttgacaaagc tctatgacta taacctgggg
      781 agcatcacag agagctcgct ttggaggtca accgattatg gaacaaccta tgagaagctg
      841 aatgataaag ttggtttgaa aaccattttg agctatctct atgtgtgtcc taccaacaag
      901 cgtaagataa tgttactcac agacccggag attgagagca gtttattgat cagctcagat
      961 gaaggggcaa cttatcaaaa gtaccggctg aacttctaca ttcaaagctt gctttttcac
     1021 cccaaacaag aagactggat tctggcatac agtcaagacc aaaagttata cagctctgct
     1081 gaatttggga gaagatggca gcttatccaa gaaggggttg taccaaacag gttctactgg
     1141 tctgtgatgg ggtcaaataa agaaccagac cttgtgcatc ttgaggccag aactgtggat
     1201 ggtcattcac attatctaac ttgccgaatg cagaactgta cagaggccaa caggaatcag
     1261 ccttttccag gctacattga cccagactct ttgattgttc aggatcatta tgtgtttgtt
     1321 cagctgacat caggagggcg gccacattac tacgtgtcct accgaaggaa tgcatttgcc
     1381 caaatgaagc ttccgaaata tgctttgccc aaggacatgc atgttatcag caccgatgag
     1441 aatcaggtgt tcgcagcggt ccaagaatgg aaccagaatg acacgtacaa cctctacatc
     1501 tcagacacac gtggtgtcta cttcaccctg gccttggaga atgtccagag cagcagaggc
     1561 cctgagggca acatcatgat cgacctctat gaggtagcag ggataaaggg aatgttcttg
     1621 gctaacaaga agattgacaa ccaagtgaag actttcatca catataacaa aggcagagac
     1681 tggcgtttgc tgcaggcgcc ggacacggat ctaagggggg accccgtgca ctgcttgctg
     1741 ccctattgct cactacacct tcacctgaag gtctctgaga atccctacac atcagggatc
     1801 attgccagca aagacacagc tccaagcatc atagtggcat caggtaatat aggttctgaa
     1861 ttgtcagaca ctgacatcag catgtttgtc tcttcagatg cagggaacac ctggagacag
     1921 atctttgaag aagagcacag tgttttgtac ctggatcaag gtggagtcct ggttgctatg
     1981 aaacacacat ctctcccaat tcgacatctt tggttgagtt ttgatgaagg gagatcttgg
     2041 agcaaataca gtttcacatc tattccactt tttgtggatg gggttctggg tgagcctgga
     2101 gaagagactc tcatcatgac agtgtttgga cacttcagcc accgctctga atggcagctg
     2161 gtcaaagtag attacaagtc catttttgat agacggtgtg ccgaagagga ctacagacct
     2221 tggcagctgc acagccaggg ggaagcatgt atcatgggag caaaaaggat atataagaag
     2281 cgaaaatcag agcggaagtg tatgcaagga aaatatgcag gagctatgga atctgaaccc
     2341 tgtgtctgca ctgaggctga ttttgattgc gactatggtt atgagcgaca cagcaatggc
     2401 cagtgcctgc cggcattttg gttcaatcca tcctctctgt caaaggattg cagcttggga
     2461 cagagttacc tcaatagtac tgggtacagg aaggtggttt ccaataattg cactgatggc
     2521 gtaagggaac agtacactgc caaaccgcag aagtgcccag ggaaagcccc gcgggggctg
     2581 cggatagtca cggctgatgg aaagctgaca gcggaacaag gacacaacgt cactctcatg
     2641 gtgcaattag aagagggtga tgttcagcgg acactcatcc aagtggactt tggcgatggt
     2701 atcgcggtgt cttacgtcaa tctcagctcc atggaagatg ggatcaaaca cgtctatcag
     2761 aacgtgggca ttttccgtgt gaccgtgcag gtggacaaca gtctgggttc tgacagcgcc
     2821 gtcctgtact tacatgtaac ttgtcccttg gagcacgtgc acctgtctct tccctttgtc
     2881 accacaaaga acaaagaggt caatgcgacg gcagtgctgt ggcccagcca agtgggcacc
     2941 ctcacttacg tgtggtggta cggaaacaac acggagcctt tgatcacctt ggagggaagc
     3001 atatccttca gatttacttc agaaggaatg aataccatca cagtgcaggt ctcagctggg
     3061 aatgccatcc tacaagacac aaagaccatc gcagtatatg aggaattccg gtctcttcgc
     3121 ttgtcctttt ctccaaacct ggatgactac aacccggaca tccctgagtg gaggagggac
     3181 atcggtcgag tcatcaaaaa atccctggtg gaagccacag gggttccagg ccagcacatc
     3241 ctggtggcgg tgctccctgg cttacccacc actgctgaac tctttgtcct accctatcag
     3301 gatccagctg gagaaaacaa aaggtcaact gatgacctgg agcagatatc agaattgctg
     3361 atccacacgc tcaaccaaaa ctcagtacac ttcgagctga agccaggagt ccgagtcctt
     3421 gtccatgctg ctcacttaac agcggccccc ctggtggacc tcactccaac ccacagtgga
     3481 tctgccatgc tgatgctgct ctcagtggtg tttgtggggc tggcagtgtt cgtcatctac
     3541 aagtttaaaa ggagagtagc tttaccctcc cctccctccc cttctactca acctggtgac
     3601 tcatctctcc gattgcaaag agcaagacac gccactccgc cttcaacgcc aaagcgggga
     3661 tctgctgggg cacagtatgc aatttaagga aaacccccaa aggctacagg cgacctgctg
     3721 atcaggaaag aatttcgctc ttgtcaagta catcatcctt catgaccact aactttgtgt
     3781 tttttttctt tcctttgttg ttctgtttcc tattttgcca ggaagtattt ccatagttgc
     3841 tgagaatcaa agcacaaaag aaatccctac ctatgtaaat gtttgaatgg aggacgccag
     3901 taaaaaaaca aaaacaaaaa caaaacaaaa cataaaatat aaacaatcaa aatccaaaca
     3961 aacaaacaaa cactcactgc atcgggactt tttaattctt cagacacaga caacaagggt
     4021 ttttagcttt aagcctgtgc atgtggacaa tactctgaga acatgtctgg aggggcagtg
     4081 tacaggtgct ctattttaat ggaaaacact cccctctccc tctttcttct tctctctctt
     4141 ttttctgatc ggtcgtgttt gtagaaaatt cataacatat ataggccaag gaaatctgca
     4201 tgtatttttg gaaatattct tggctctaga tttatcagct attttagcat taaaggctga
     4261 tgggtggatt agctacccca gctcctttca taagacacaa agacgtgcac aggagtttga
     4321 aaccctgagc tgtttctctg ttccactttc catactgtca tttcccttct aagttagctt
     4381 tggtagctct gttggtcagc agtggccaca aggctgcttt ctgcactctc tgtggccaca
     4441 ggaacaaaga tgcgagttga agatcccttt gtgccggtag aataaggaag gaagggaggc
     4501 agggaggcaa agcatgtcag aaacggacct tggtttcctg ttcacctctt tccaccatga
     4561 ttgcctcccc ttgcagcttt ccctactcct gccccaactg cagtaggaaa tggaatccca
     4621 ttagttaccc attgtcctgt cttcacattt gtttgtcatc catgtgtgac catgatctgt
     4681 tgatatcttt gaatctcttc cctccaaacc ccaagtaagt tgtccttcaa ctgttctcag
     4741 tttttcttcc caaacatatt gctagattct ggacattaac cctgacgttt cctaaatact
     4801 ggcctggcct gtgccgcccc tgcccccact actcacaagt ttctgagccc tttgtcagtt
     4861 ttgtacattc ccaagcatgc cagcttctgt gcccatggac cttgctgcat cctgcacagc
     4921 agggttcagt ttcatgtatc tttgtctttt cctctagaac ctgccttttt caaatatccc
     4981 tgccttttcc cacctggaaa catatactgt atgcgaaaga gttgatatat gcaaagtaat
     5041 tcaaacctgg ccatgtactt tggaaaagaa agcatagaga tgaattgtgg tgttctcaca
     5101 ccttaacgaa aatctcgtgc gatctgattc cagaagattc ttgtgagaaa tgttttgaat
     5161 gtgtgacaat ttcgcagggc aatttcctcc tgtgacggtt gctgttacct ggtatttcca
     5221 ctctcacagt agaatagaaa tgtttgtgaa ataaaactga ttttaactgg aaggagaaac
     5281 aggttaatgg actttgtgtt taagagtgtc aaacagtctg agagaataaa tgggggtctt
     5341 gtcttacatt agggtgagag tttgattatt taggatgatc ccagtgattt catgtgtgct
     5401 ctctgacctc tgagtatcat agtatcatta aagtaaagat ttaagtctgt ataaaggagg
     5461 agagttactg attggcaaaa aagattggca caaagcatga agaaacccca tttttcccag
     5521 ggtaatcatg aaagaaggct cagagaaaga gggaaacaaa agcctgttca gcagaggccc
     5581 ctttagtatt atggactggg caaagcccac tataaactat aggagaaaga agttctgata
     5641 aacctcttag tatgctcagc ctccttcttt gctatgtccc taagccaaca gggtataaca
     5701 caggccctgg tgataatgag ggtgtcctaa agatcctgat gtccatgact tcatgtagtt
     5761 caggcacaga aagaatagca aagctgctgt cagaagtttg tcaggcagag atgtttatgg
     5821 ttgaggatac cccatatgaa tctgggaaat gggctaggcc tgaggcagtc acctatttgt
     5881 agaactcaat tgatccccaa cctgccaggc ttcctatctc ataggaaaca tcctcattga
     5941 tcctcttcag ttggagtctc ccaaatttaa tgtggaagac aaagtgttgg aaaatcaaaa
     6001 gaggctcact caaaccagca cagggagtcc tcagagttgc agttcaattc attttaatta
     6061 gaaaagtatg aaagaggtat aacactctta ttctagcaca gtgccttgcc tagagtagta
     6121 gtatgaaaac tatttgttga agaaataaat gaatggaaag acatagggaa gaatgggctg
     6181 taaatcctaa ttaaaaatag aggtcgacat gagatacctg gcattttggg aagtgaccaa
     6241 agatggccag ctagagattc agcatctcca ggatcctcat gtgcctctcc tcaaagctcc
     6301 ctcccatctg taggagatta gtgaggcaag gtgctgctca gagaggagga cctcattgtt
     6361 cttaggacct tggccagttg ttctcaaagt gtggtacctg gatcagcagt atcactatca
     6421 cttgggctag ttagagatcc agattctgga tccatacccc atacctactg aattagaaac
     6481 tctaggggat gaatagtggt gttctctgtt gctaagtgac agtgggccca gccacctatt
     6541 ttaacaagcc ctcccagtga ttgtgataca tactaaagtt tgagaaccat tgtactaggc
     6601 cattccagct gaatctcaaa cagaaggcag taatgagagc ctacaaatgg gagggaccta
     6661 agtgcctacc tactcgctaa tcgcaggtgc aaacacacaa ggagtttggt gggcttaagg
     6721 tcagaggagt gtgtagggag ggatgtatgt ggaaggtaag attcagggca agctaaaaat
     6781 ccgatactgc aacgttttcc aaaatcccag aaggcaaact gtgcatgttc taccctgaac
     6841 cacccaagca acactttcta ccttgcctta tttttaattg gattcactgt ccaaaatgca
     6901 gaggtttgct ttgctttttt ttcagaagtt ccaaacagca actttgagag cagtggggtg
     6961 cttggcagct gttctgtgtt ttccaggaat ccaactgagc attgaaatct ctcatttgcc
     7021 gacttatttt tataggaagc caattaaaaa aaaaaaaagt tttcttatag tattggaact
     7081 acttctaatt ttaaaatgac ttttttgatg tattttttgt taaatactat gtagtgtaat
     7141 gtataattgc tcttgtttat tgcttttaca atcatattta ttaaacagat aatgtctcta
     7201 aagtctttgc ctcaggtatt ttttttttta atcctaaacc cttggtgttc attctaaata
     7261 tagaagtgtt gcatgtatag gatttcataa aggctaattg cataagaaag agtaaacacc
     7321 acaggcttga ggtttttggc tgttttttac taacaaggca gaatgtatgt actacctgaa
     7381 ttctacctgc atttcaatta actatacaat gtctgtttat taaattactt tgatttaaaa
     7441 atta
//
