LOCUS       NM_005775               3227 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens sorbin and SH3 domain containing 3 (SORBS3),
            transcript variant 1, mRNA.
ACCESSION   NM_005775
VERSION     NM_005775.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3227)
  AUTHORS   Pu,J., Wang,B., Zhang,D., Wang,K., Yang,Z., Zhu,P. and Song,Q.
  TITLE     UBE2T mediates SORBS3 ubiquitination to enhance IL-6/STAT3
            signaling and promote lung adenocarcinoma progression
  JOURNAL   J Biochem Mol Toxicol 38 (6), e23743 (2024)
   PUBMED   38816989
  REMARK    GeneRIF: UBE2T mediates SORBS3 ubiquitination to enhance IL-6/STAT3
            signaling and promote lung adenocarcinoma progression.
REFERENCE   2  (bases 1 to 3227)
  AUTHORS   Park,S.J., Frake,R.A. and Rubinsztein,D.C.
  TITLE     Increased SORBS3 expression in brain ageing contributes to
            autophagic decline via YAP1-WWTR1/TAZ signaling
  JOURNAL   Autophagy 19 (3), 943-944 (2023)
   PUBMED   35822241
  REMARK    GeneRIF: Increased SORBS3 expression in brain ageing contributes to
            autophagic decline via YAP1-WWTR1/TAZ signaling.
REFERENCE   3  (bases 1 to 3227)
  AUTHORS   Park,S.J., Frake,R.A., Karabiyik,C., Son,S.M., Siddiqi,F.H.,
            Bento,C.F., Sterk,P., Vicinanza,M., Pavel,M. and Rubinsztein,D.C.
  TITLE     Vinexin contributes to autophagic decline in brain ageing across
            species
  JOURNAL   Cell Death Differ 29 (5), 1055-1070 (2022)
   PUBMED   34848853
  REMARK    GeneRIF: Vinexin contributes to autophagic decline in brain ageing
            across species.
REFERENCE   4  (bases 1 to 3227)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3227)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 3227)
  AUTHORS   Wakabayashi,M., Ito,T., Mitsushima,M., Aizawa,S., Ueda,K.,
            Amachi,T. and Kioka,N.
  TITLE     Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate
            kinase family protein, with vinexin and beta-catenin at sites of
            cell-cell contact
  JOURNAL   J Biol Chem 278 (24), 21709-21714 (2003)
   PUBMED   12657639
REFERENCE   7  (bases 1 to 3227)
  AUTHORS   Townson,S.M., Dobrzycka,K.M., Lee,A.V., Air,M., Deng,W., Kang,K.,
            Jiang,S., Kioka,N., Michaelis,K. and Oesterreich,S.
  TITLE     SAFB2, a new scaffold attachment factor homolog and estrogen
            receptor corepressor
  JOURNAL   J Biol Chem 278 (22), 20059-20068 (2003)
   PUBMED   12660241
REFERENCE   8  (bases 1 to 3227)
  AUTHORS   Kioka,N.
  TITLE     [A novel adaptor protein family regulating cytoskeletal
            organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]
  JOURNAL   Seikagaku 74 (11), 1356-1360 (2002)
   PUBMED   12510380
  REMARK    GeneRIF: regulates cytoskeletal organization and signal
            transduction--review
            Review article
REFERENCE   9  (bases 1 to 3227)
  AUTHORS   Akamatsu,M., Aota,S., Suwa,A., Ueda,K., Amachi,T., Yamada,K.M.,
            Akiyama,S.K. and Kioka,N.
  TITLE     Vinexin forms a signaling complex with Sos and modulates epidermal
            growth factor-induced c-Jun N-terminal kinase/stress-activated
            protein kinase activities
  JOURNAL   J Biol Chem 274 (50), 35933-35937 (1999)
   PUBMED   10585480
REFERENCE   10 (bases 1 to 3227)
  AUTHORS   Kioka,N., Sakata,S., Kawauchi,T., Amachi,T., Akiyama,S.K.,
            Okazaki,K., Yaen,C., Yamada,K.M. and Aota,S.
  TITLE     Vinexin: a novel vinculin-binding protein with multiple SH3 domains
            enhances actin cytoskeletal organization
  JOURNAL   J Cell Biol 144 (1), 59-69 (1999)
   PUBMED   9885244
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC091514.1, AF037261.1,
            CF456833.1, BM999851.1 and AC037459.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_005775.4.
            
            Summary: This gene encodes an SH3 domain-containing adaptor
            protein. The presence of SH3 domains play a role in this protein's
            ability to bind other cytoplasmic molecules and contribute to
            cystoskeletal organization, cell adhesion and migration, signaling,
            and gene expression. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091514.1, AF037261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240123.12/ ENSP00000240123.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-855               BC091514.1         190-1044
            856-1817            AF037261.1         846-1807
            1818-2285           CF456833.1         134-601
            2286-2934           BM999851.1         18-666              c
            2935-3227           AC037459.16        96298-96590
FEATURES             Location/Qualifiers
     source          1..3227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3227
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /note="sorbin and SH3 domain containing 3"
                     /db_xref="GeneID:10174"
                     /db_xref="HGNC:HGNC:30907"
                     /db_xref="MIM:610795"
     exon            1..96
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            97..253
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2167
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vinexin beta (SH3-containing adaptor molecule-1); sorbin
                     and SH3 domain-containing protein 3"
                     /codon_start=1
                     /product="vinexin isoform 1"
                     /protein_id="NP_005766.3"
                     /db_xref="CCDS:CCDS6031.1"
                     /db_xref="GeneID:10174"
                     /db_xref="HGNC:HGNC:30907"
                     /db_xref="MIM:610795"
                     /translation="MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSN
                     TLNFQFHDPAPRTVCNGGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQN
                     WSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPD
                     LQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFST
                     VLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLE
                     RELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGS
                     ARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQ
                     AQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT
                     YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS
                     YVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRR
                     TGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYR
                     PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV"
     exon            254..371
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            372..565
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            566..629
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            630..668
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            669..735
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            736..826
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..913
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            914..967
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1054
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1101
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1241
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1294
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1341
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1456
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1582
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1894
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1998
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2105
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..3227
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2914..2919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /note="hexamer: AATAAA"
     polyA_site      2934
                     /gene="SORBS3"
                     /gene_synonym="SCAM-1; SCAM1; SH3D4"
                     /note="major polyA site"
ORIGIN      
        1 cttcctcctc gagcgcccgc gccaggcagc agccgggcag ggatgctcct gcgctcccgg
       61 gcggcctcgg gcccagccac ctgctcgccg gggaagagga cacgcagagg agcagctggc
      121 ttgcccggag tcctcccacc ttgacccaag catgcagggc ccaccccgca gcctccgcgc
      181 tgggctcagc ctggacgact tcatccctgg ccacctccag tcccacatag ggtcttcctc
      241 ccgggggaca cgggtgcccg tgatccggaa tggtggctcc aacaccctta atttccagtt
      301 ccacgacccc gcgcccagga ctgtgtgcaa tgggggctac acaccaagac gagatgcttc
      361 ccagcacccg gaccctgcgt ggtatcagac ctggccaggc cctgggagca agccctctgc
      421 aagcacaaag atccctgcct cccagcacac ccagaactgg tcagccacgt ggaccaagga
      481 cagcaagcgt cgggacaagc gctgggtcaa gtacgaggga atcgggcccg tggacgagag
      541 cggcatgccc attgcccccc gatccagcgt tgacagaccc agagactggt accggagaat
      601 gttccagcag attcaccgga aaatgccaga cttgcagctg gactggacct tcgaggagcc
      661 acccagagac cccaggcatc taggagccca gcaaagacct gcccacaggc ccggcccggc
      721 aacatcttcc agtggaagaa gctgggacca ctctgaagag ttacctagaa gcaccttcaa
      781 ctacagacct ggagcattct ccactgtgct gcagccctca aatcaggtgc tcagacgccg
      841 ggaaaaagta gacaatgtct ggacggaaga gtcctggaac cagtttctgc aggaactaga
      901 gactgggcag aggcccaaga aaccgctggt ggacgaccct ggtgagaagc cctcccagcc
      961 cattgaggtg ctgctggaga gagagctggc cgagctgagc gccgagctgg acaaggacct
     1021 gcgggcaatt gagacccgac tgccgtcccc caagagctcg ccggcgcccc gacgggcccc
     1081 ggagcagcgg cccccggccg gcccggcctc agcctggagc tccagctacc cacatgcacc
     1141 ttacctgggt tccgcccggt ccctgagtcc ccacaaaatg gctgatggag gaagcccctt
     1201 cctaggtcgg agggactttg tctacccttc ctcaacccga gaccctagtg cctctaacgg
     1261 agggggcagc ccagccagga gggaagagaa gaagagaaag gccgccaggc tcaagtttga
     1321 cttccaggcg cagtccccca aggagctgac tctgcagaag ggtgacattg tctacatcca
     1381 caaggaggtg gacaagaact ggctggaggg agagcaccac ggccgcctgg gcatcttccc
     1441 tgctaattat gtggaggtgc tgcccgcaga tgagatccct aagcccatca agcccccgac
     1501 ctaccaggtg ctggagtatg gagaggctgt ggcccagtac accttcaagg gggacctgga
     1561 ggtggagctg tccttccgca agggagagca catctgcctg atccgcaagg tgaacgagaa
     1621 ctggtacgag ggacgcatca cgggcacggg gcgccaaggc atattccctg ccagctacgt
     1681 gcaggtgtct cgtgaacccc ggctccggct ctgtgacgac ggcccccagc tccccacgtc
     1741 tccccgcctg accgctgccg cccgctcagc ccgtcacccc agctccccct cagccctgcg
     1801 cagcccagct gaccccatcg acttgggggg acagacctcc ccccgtcgca ctggcttctc
     1861 cttccccacc caggagccta gaccccagac ccagaatctt ggcacccctg gtccagctct
     1921 gtcccactct cgaggtccca gccatcccct ggacctgggg acctcctctc ctaacacctc
     1981 tcagatacac tggaccccgt accgggcgat gtaccagtac aggccccaga acgaagacga
     2041 gctggagctg cgcgaggggg acagggtgga tgtcatgcag cagtgtgacg atggctggtt
     2101 tgtgggtgtc tcccggagga cccagaaatt cggaacgttc cctggaaatt acgttgcccc
     2161 ggtgtgagtg gtctccatgg caacttggag ccagccagga tggggtgggg agcggtggca
     2221 ctcgtgggag ggagaggacc cccgcccaca tcctccttcc ccaggacctg agctcccagc
     2281 atctgcagac gacccccgca gcctttccct cggacccccc tcgaagcccc ctggactgat
     2341 tcccacccac gactcacagg cattcctccc acagcccttt catttcctcc ccaccccact
     2401 ccccaaatac agaggtctgc tttgaagcgg agaccatttc caggccttat tgagaccaga
     2461 ccccaagtcc cccaccccca tcctgctcca gcgtttcctc taacagggac cagctctccg
     2521 ctttgccccc acggggttcc tctaaccaga accagcttcc tagcctcgta gagaccaaag
     2581 gccgcccccg cctgctgggg ttcctcccag caccccagct tgctggctgc cctctttgcc
     2641 ttctggcctc cagctgggtg tgggggggcg gagcaaggcg ggggacagac gcagcacctt
     2701 cttagcgatc taggcctggc aagagctctg gccccaaggc ctcctcttcc caggggctgc
     2761 caagtcctgg ccctggccct ggcatatcac cccgcactgt ggggccaggc accactagcc
     2821 tggctcaaat attccccagg gagactgctg tgtgctgccc gcctgcctgc tggctctccc
     2881 ccagccccac atcccctctg gaagagaatg taaaataaac ctggacacaa gggaccttgt
     2941 ctctgcggcc ttttccttgg ggtaggggat gcctcctcct gtctaggaga tgggaattcc
     3001 ttctgtggag ggctgtgctg ggagacaggt gggacaggtg tgtgtgtaag aggaggagga
     3061 tggaaaaaca ccattattac ctccaaagat ctctgccctt gggtgtcagg caggttgcgg
     3121 cagcccccac aattgggcag ctgtgtggca agaagtgctg ggagaatgaa cagtgccagg
     3181 ccctggtagc agggagacac cagagatggg ggactgaatg tggcctt
//
