LOCUS       NM_001034954            7348 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens sorbin and SH3 domain containing 1 (SORBS1),
            transcript variant 3, mRNA.
ACCESSION   NM_001034954
VERSION     NM_001034954.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7348)
  AUTHORS   Xu,H., Zheng,Y., Wu,J., Zhang,R., Zhao,Q., Chen,S., Peng,W.,
            Cai,D., Gao,Y., Chen,X., Li,D., Yuan,S., Li,G. and Nan,A.
  TITLE     circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p
            and directly binding RUFY3 mRNA
  JOURNAL   J Transl Med 22 (1), 590 (2024)
   PUBMED   38915053
  REMARK    GeneRIF: circSORBS1 inhibits lung cancer progression by sponging
            miR-6779-5p and directly binding RUFY3 mRNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7348)
  AUTHORS   Kong,X., Wan,S.J., Chen,T.B., Jiang,L., Xing,Y.J., Bai,Y.P.,
            Hua,Q., Yao,X.M., Zhao,Y.L., Zhang,H.M., Wang,D.G., Su,Q. and Lv,K.
  TITLE     Increased serum extrachromosomal circular DNA SORBS1circle level is
            associated with insulin resistance in patients with newly diagnosed
            type 2 diabetes mellitus
  JOURNAL   Cell Mol Biol Lett 29 (1), 12 (2024)
   PUBMED   38212723
  REMARK    GeneRIF: Increased serum extrachromosomal circular DNA
            SORBS1[circle] level is associated with insulin resistance in
            patients with newly diagnosed type 2 diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7348)
  AUTHORS   Li,S.H., Zhai,G.Q., He,R.Q., Chen,G., Wang,S.S., Liu,J.L.,
            Cheng,J.W., Yan,H.B. and Huang,Z.G.
  TITLE     Down-regulation and clinical significance of Sorbin and SH3
            domain-containing protein 1 in bladder cancer tissues
  JOURNAL   IET Syst Biol 17 (2), 70-82 (2023)
   PUBMED   36854874
  REMARK    GeneRIF: Down-regulation and clinical significance of Sorbin and
            SH3 domain-containing protein 1 in bladder cancer tissues.
REFERENCE   4  (bases 1 to 7348)
  AUTHORS   Lin,Y., Wang,W., Wang,Y. and Fu,K.
  TITLE     MiR-223-3p increases resistance of colorectal cancer cells to
            5-fluorouracil via targeting SORBS1
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (3), 356-368 (2023)
   PUBMED   37164919
  REMARK    GeneRIF: MiR-223-3p increases resistance of colorectal cancer cells
            to 5-fluorouracil via targeting SORBS1.
REFERENCE   5  (bases 1 to 7348)
  AUTHORS   Wang,C. and Cheng,B.
  TITLE     MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells
            by suppressing sorbin and SH3 domain-containing protein 1 via the
            c-Jun NH2-terminal kinase signaling pathway
  JOURNAL   Bioengineered 13 (3), 4869-4884 (2022)
   PUBMED   35196185
  REMARK    GeneRIF: MicroRNA miR-3646 promotes malignancy of lung
            adenocarcinoma cells by suppressing sorbin and SH3
            domain-containing protein 1 via the c-Jun NH2-terminal kinase
            signaling pathway.
REFERENCE   6  (bases 1 to 7348)
  AUTHORS   Baumann,C.A., Ribon,V., Kanzaki,M., Thurmond,D.C., Mora,S.,
            Shigematsu,S., Bickel,P.E., Pessin,J.E. and Saltiel,A.R.
  TITLE     CAP defines a second signalling pathway required for
            insulin-stimulated glucose transport
  JOURNAL   Nature 407 (6801), 202-207 (2000)
   PUBMED   11001060
REFERENCE   7  (bases 1 to 7348)
  AUTHORS   Asakura,T., Nakanishi,H., Sakisaka,T., Takahashi,K., Mandai,K.,
            Nishimura,M., Sasaki,T. and Takai,Y.
  TITLE     Similar and differential behaviour between the nectin-afadin-ponsin
            and cadherin-catenin systems during the formation and disruption of
            the polarized junctional alignment in epithelial cells
  JOURNAL   Genes Cells 4 (10), 573-581 (1999)
   PUBMED   10583506
REFERENCE   8  (bases 1 to 7348)
  AUTHORS   Mandai,K., Nakanishi,H., Satoh,A., Takahashi,K., Satoh,K.,
            Nishioka,H., Mizoguchi,A. and Takai,Y.
  TITLE     Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized
            at cell-cell and cell-matrix adherens junctions
  JOURNAL   J Cell Biol 144 (5), 1001-1017 (1999)
   PUBMED   10085297
REFERENCE   9  (bases 1 to 7348)
  AUTHORS   Ribon,V., Herrera,R., Kay,B.K. and Saltiel,A.R.
  TITLE     A role for CAP, a novel, multifunctional Src homology 3
            domain-containing protein in formation of actin stress fibers and
            focal adhesions
  JOURNAL   J Biol Chem 273 (7), 4073-4080 (1998)
   PUBMED   9461600
REFERENCE   10 (bases 1 to 7348)
  AUTHORS   Ribon,V., Printen,J.A., Hoffman,N.G., Kay,B.K. and Saltiel,A.R.
  TITLE     A novel, multifuntional c-Cbl binding protein in insulin receptor
            signaling in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 18 (2), 872-879 (1998)
   PUBMED   9447983
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157890.11 and AL158165.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 10, 2020 this sequence version replaced NM_001034954.2.
            
            Summary: This gene encodes a CBL-associated protein which functions
            in the signaling and stimulation of insulin. Mutations in this gene
            may be associated with human disorders of insulin resistance.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF356525.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000371247.7/ ENSP00000360293.2
            RefSeq Select criteria    :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL157890.11        88669-88720         c
            53-138              AL157890.11        18384-18469         c
            139-193             AL158165.15        135834-135888       c
            194-259             AL158165.15        132198-132263       c
            260-355             AL158165.15        129330-129425       c
            356-484             AL158165.15        127156-127284       c
            485-511             AL158165.15        116898-116924       c
            512-624             AL158165.15        116669-116781       c
            625-993             AL158165.15        109202-109570       c
            994-1138            AL158165.15        105341-105485       c
            1139-1168           AL158165.15        100826-100855       c
            1169-1341           AL158165.15        93725-93897         c
            1342-1405           AL158165.15        91928-91991         c
            1406-1480           AL158165.15        89709-89783         c
            1481-1543           AL158165.15        89319-89381         c
            1544-1591           AL158165.15        78946-78993         c
            1592-1721           AL158165.15        78693-78822         c
            1722-1836           AL158165.15        76393-76507         c
            1837-1920           AL158165.15        70681-70764         c
            1921-1986           AL158165.15        66692-66757         c
            1987-2088           AL158165.15        66034-66135         c
            2089-2138           AL158165.15        62358-62407         c
            2139-2311           AL158165.15        52339-52511         c
            2312-2397           AL158165.15        49590-49675         c
            2398-2565           AL158165.15        45917-46084         c
            2566-2612           AL158165.15        41114-41160         c
            2613-2727           AL158165.15        36272-36386         c
            2728-2853           AL158165.15        35993-36118         c
            2854-3048           AL158165.15        33841-34035         c
            3049-3822           AL158165.15        31229-32002         c
            3823-3881           AL158165.15        16671-16729         c
            3882-3994           AL158165.15        13028-13140         c
            3995-7348           AL158165.15        6481-9834           c
FEATURES             Location/Qualifiers
     source          1..7348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..7348
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /note="sorbin and SH3 domain containing 1"
                     /db_xref="GeneID:10580"
                     /db_xref="HGNC:HGNC:14565"
                     /db_xref="MIM:605264"
     exon            1..52
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..138
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..193
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..4062
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ponsin; c-Cbl associated protein; Fas-ligand associated
                     factor 2; SH3 domain protein 5"
                     /codon_start=1
                     /product="sorbin and SH3 domain-containing protein 1
                     isoform 3"
                     /protein_id="NP_001030126.2"
                     /db_xref="CCDS:CCDS31255.1"
                     /db_xref="GeneID:10580"
                     /db_xref="HGNC:HGNC:14565"
                     /db_xref="MIM:605264"
                     /translation="MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPV
                     KTVKNASGLVLPTDMDLTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGL
                     EPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVI
                     VVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRW
                     PHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLL
                     NEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSER
                     RVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSK
                     DWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSP
                     KSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK
                     SSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEP
                     WYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMET
                     LNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIY
                     KSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKL
                     LADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPA
                     RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKA
                     QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSR
                     QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPSSLPH
                     SRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPS
                     LSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIH
                     QDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKIS
                     KKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGR
                     KAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVME
                     KCDDGWFVGTSRRTKQFGTFPGNYVKPLYL"
     exon            194..259
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..355
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..484
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..511
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..624
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..993
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1138
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1168
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1341
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1405
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1480
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1543
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1591
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1721
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1836
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1920
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1986
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2088
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2138
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2311
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2397
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2565
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2612
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2727
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2853
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3048
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3822
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3881
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3882..3994
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3995..7348
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7321..7326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /note="hexamer: AATAAA"
     polyA_site      7348
                     /gene="SORBS1"
                     /gene_synonym="CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgcgag tggggcggac gcgcgcagcc cgcccgcccg gcgaccagca aggagttggc
       61 atcctttgga agagttcgtg aaagctttct gcccagagct cctggaccaa tgcatcttcc
      121 caccacctta aaccactgag cagttcagag ccccagttgc agacgacttg tcctgccacc
      181 accatgagtt ctgaatgtga tggtggttcc aaagctgtga tgaatggctt ggcacctggc
      241 agcaatgggc aagacaaagc aactgccgac cctttacgcg cacgctctat ttctgctgtt
      301 aaaatcattc ctgtgaagac agtgaaaaac gcctcaggcc tagttctccc tacagacatg
      361 gatcttacaa aaatctgcac tgggaaggga gcggtgactc tccgggcctc gtcttcctac
      421 agggaaaccc caagcagtag ccctgcgagc cctcaggaaa cccggcaaca cgaaagcaaa
      481 ccaggtctgg agccagagcc ttcttcagca gatgagtgga ggctttcttc cagtgctgat
      541 gccaatggaa atgcccagcc ctcttcactc gctgccaagg gctacagaag tgtgcatccc
      601 aaccttcctt ctgacaagtc ccaggatgcc acttcctcca gtgcagccca gccggaggta
      661 atagttgtcc ctctctacct ggttaatact gacagagggc aagaaggcac tgccagacct
      721 ccaacacctc tggggcctct tggctgcgtc cccacaatcc cagcgactgc ctctgccgcc
      781 tcacctctga ccttcccgac tctagatgat ttcattcccc ctcatctgca gaggtggccc
      841 caccacagcc agccagcccg cgcctctggc tcctttgccc ccattagcca gacgccacca
      901 tccttctcac caccacctcc gctggtccct cctgccccgg aggacctccg cagagtctcg
      961 gagcctgacc tcacgggagc tgtttcgagt accgattcca gtcctctact aaatgaagtt
     1021 tcttcttccc ttattggaac tgattcccaa gcctttccat cagttagcaa gccttcatcc
     1081 gcctatccct ccacaacgat tgtcaatcct actattgtgc tcttgcaaca caatcgagaa
     1141 cagcaaaaac gactcagtag cctttcagat cctgtctcag aaagaagagt gggagagcag
     1201 gactcagcac caacccagga aaaacccacc tcacctggca aggctattga aaaaagagca
     1261 aaggatgaca gtaggcgggt ggtgaagagc actcaggact taagcgatgt ttccatggat
     1321 gaagtgggca tcccactccg gaacactgag agatcaaaag actggtacaa gactatgttt
     1381 aaacagatcc acaaactgaa cagagacact cctgaagaaa acccttattt ccctacgtac
     1441 aaattccctg aacttcctga aatccagcaa acttccgaag aggacaatcc ttacactccc
     1501 acctaccagt ttcctgcatc tactcctagt cctaaatctg aagatgatga ttcagatctg
     1561 tactctccca gatactcatt ttctgaagac acaaaatctc ccctttctgt gcctcgctca
     1621 aaaagtgaga tgagctacat tgatggtgag aaggtagtca agaggtcggc cacactaccc
     1681 ctcccagccc gctcttcctc actgaagtca agctcagaaa gaaatgactg ggaaccccca
     1741 gataagaaag tagacacaag aaaatatcgt gcagagccca agagcattta cgaatatcag
     1801 cctggcaagt cttccgttct gaccaacgaa aagatgagtc gggatataag cccagaagag
     1861 atagatttaa agaatgaacc ttggtataaa ttcttttcgg aattggagtt tgggaaaccg
     1921 cctcccaaaa agatatggga ttatactcct ggagactgct ctatccttcc tagagaggat
     1981 agaaagacta atctagacaa agatctcagc ctctgccaga cagagttaga ggcagattta
     2041 gaaaaaatgg agacgcttaa taaagcaccc agtgcaaacg tgccacagag ctcagccatc
     2101 agccctactc cggaaatttc ttcagagact cctggatata tatattcttc caacttccat
     2161 gcagtgaaga gggaatcaga cggggctcct ggggatctca ctagcttgga gaatgagaga
     2221 caaatttata aaagtgtctt ggaaggtggt gacatccctc ttcagggcct gagtgggctc
     2281 aagcgaccat ccagctctgc ttccactaaa gattcagaat cgccaagaca ttttatacca
     2341 gctgattact tggaatccac ggaagaattt attcgaagac gtcatgatga taaagagaaa
     2401 cttttagcgg accagagacg acttaaacgc gagcaagaag aggctgatat tgcagctcga
     2461 cgccacacag gcgtcattcc gacgcaccat cagtttatca ctaatgagcg ctttggggac
     2521 ctcctcaata tagacgatac tgcaaaaagg aaatctgggt cagagatgag acctgccaga
     2581 gccaaatttg actttaaagc tcagacacta aaggagcttc ctctgcagaa gggagatatt
     2641 gtttacattt ataagcaaat tgatcagaac tggtatgaag gagaacacca cggccgggtg
     2701 ggaatcttcc cacgcaccta catcgagctt cttcctcctg ctgagaaggc acagcccaaa
     2761 aagttgacac cagtgcaggt tttggaatat ggagaagcta ttgctaagtt taactttaat
     2821 ggtgatacac aagtagaaat gtccttcaga aagggtgaga ggatcacact gctccggcag
     2881 gtagatgaga actggtacga agggaggatc ccggggacat cccgacaagg catcttcccc
     2941 atcacctacg tggatgtgat caagcgacca ctggtgaaaa accctgtgga ttacatggac
     3001 ctgcctttct cctcctcccc aagtcgcagt gccactgcaa gcccacagtt ttccagtcac
     3061 agcaagctca tcacgccagc cccctcatct ctgccccact cccgccgagc cctgtccccc
     3121 gagatgcacg ctgtcacctc tgagtggatc tcactgactg tgggggtccc aggcaggcgt
     3181 tctctggccc tgaccccacc cttgcctcct ctgccagagg cttctatcta taacactgac
     3241 cacctcgcct tgtcaccaag ggccagtccc tccctgtctc tcagcctccc ccatttgagt
     3301 tggtcagatc gtcccacccc acgatcagta gcttctccac tggccctacc ttccccacac
     3361 aaaacctact ccctagcacc tacttcccag gcctcccttc acatgaatgg agacggtggt
     3421 gtccacacgc catcttcagg catccaccaa gatagcttct tgcagctgcc gctggggagc
     3481 tctgatagtg tcatctccca gcttagtgat gcctttagca gccagagcaa gaggcagcca
     3541 tggcgcgaag agagtggaca atatgagagg aaagcagaga ggggggcagg cgaaagaggc
     3601 cctggtggac ccaagatctc taagaagagc tgcttgaagc cttcagacgt ggtcaggtgc
     3661 ctgagtactg aacagagact ctcagatctc aacacccctg aggagagccg gcccggcaag
     3721 cccctgggta gcgcttttcc aggaagtgag gctgagcaga cagagcggca tagaggtggc
     3781 gagcaggcgg ggaggaaagc tgctcggaga ggtgggagcc agcaacctca agcccagcag
     3841 cgaagagtca cccccgacag gagtcaaacc tcacaagatt tatttagcta tcaagcatta
     3901 tatagctata taccacagaa tgatgatgag ttggaactcc gcgatggaga tatcgttgat
     3961 gtcatggaaa aatgtgacga tggatggttt gttggtactt caagaaggac aaagcagttt
     4021 ggtacttttc caggcaacta tgtaaaacct ttgtatctat aagaagactg aaaaccatgg
     4081 agattatttt tattggagga ggaagcatca ttcatgaacc gatcttttta gttgagtcag
     4141 taggaaaatt aatacagtgg ataaagtaag aagcaaaaga cagggacaga gaagtgttgt
     4201 gtttaaaacc caagcctgtc taaggttact gtgtattaga cagggccgaa ctagtgtgct
     4261 gagcaaaaag aattgaagca aattgtattt acttagccgc ttctgggagc cacttcagcc
     4321 tttcccctcc cctccacttc ttgggtaatc tgacctgaag catagtccag gagcagagtt
     4381 agccagaaat gcctcctgct gccccagcct tagagagctc ccatctcaat cattgagcct
     4441 gaaggcttca agcccaagaa tgcaacaaga cccccagcct acatttctca gctcccctgg
     4501 agccagctga tcctgtaacg ctgctggagg tcagtctgag ctaccaagac tgtccctaga
     4561 caaaggtgga gtcccccaca ctgcccaaga ccaaatccct cactcaacct gctgaggtgt
     4621 ggatggggaa acagaggcaa aactgaggca cctgatgcat tcagcctgct gtgcagcagt
     4681 gccattgact gccctgatgt tcagagagaa acgcacacaa ggtttgccca tgagaattgg
     4741 ggagcagatg gccaagcaga taggttatgt ctgttttctg agtgatgaag tcaggaagcc
     4801 ctgtggctct ggaggccact tgtggttcat tcttttccca tatccttggc ttttagaaat
     4861 ggttaccttc aggacagtgc agctgcattt atcagagcac tattgctaag ttttcttttc
     4921 tggcttgtgt ttttctggga cagtttagaa ttgggaggcc tattctcata gaacaccaaa
     4981 aatgatgttc agtgattcat ttaacataca ccaatgtact ctggctgctg gggggacaac
     5041 cataagcaag acatgcccag ggtttgccgt ggctccagat ctactccctg taggagttca
     5101 aggatcacac aaacggtagt aaccagggtt gtgaatctga gtacaccctg gcaaggcttc
     5161 tcttcagact gaagcagcaa ttctgccact accagcagca accaggacgt ctgttctttg
     5221 tgggggccag atcagaagag agaggcccct gtgacgcccg ggctgcttgg tcacaactct
     5281 gtccaattca aggatgttta tcggcctctc ttagatcctg agtgagacaa atacagaaat
     5341 gacccattcc ctgcccacca gaaactcaga ggtgattggg gagactgaca caggaaaatg
     5401 aacttaatca agagagactg tgatatgtgc taagaagggt gtgagggagg gagagatgaa
     5461 ttttccctgg agggatccta gaaagcattg tcatattgcc atctccatta gctcactttt
     5521 aaacaactag ggtgctggaa gaacctttgt ctgagggtag ttcatagctg gaaatacttg
     5581 gaatattttc cagagtctct aaactctcat cttcccccac agatacacat ccaagctcac
     5641 aaataggagt agcaattcta ggtggtaggg ttgtgtacgg aacccctggc tgtctgcata
     5701 tatctcagaa ttaccccagg accattgtcc caaagtctag agtctttaca ggtaggcaaa
     5761 atttgttttc aatgcctgtg cctcagctgc tgtcacaaat acccatctta ggatcccatc
     5821 agcttcccat cccccaccag acagccacag taccctcact ttctccctat tgttctttca
     5881 aatcctgttc tcaggaaaga aactgccact aattcattca cactaaggtg taaatgattg
     5941 ataataggaa tgagttacct cttcccacag acatttgttt ttaagtatga cagagcaggg
     6001 ccttaatccc aagggaaaag gttatggaac tggagggggt gagctttctg ggtagaagga
     6061 gacttcctga atttccttaa aacccagtaa gagtaagacc tgttgttttg gaaggtctgc
     6121 tccaccatct aagagcactg tttttttttt tttgttgttg ttgttgtttt acggtctctg
     6181 agggaatata gtaaaaatgc atatgcacgt gcaatttgca cggcagcatt tcaccgattg
     6241 tggactgtat tggctaatgt gtttcctggt ctttagatgc aaaccattaa taacactatc
     6301 ttatctcata gttttttcag gggtgcttct tgattagtag ggaattttga acacctcttt
     6361 aaatacagct agaaaataaa accaatttgt aaagccacat ttgcatatga tgccagcctc
     6421 acgcatttgt atatctccag aaattcaggt atgcctcacc aatttgcccg tctttaataa
     6481 aatcttgtgt taaaatttgc atcacgtcgc cttcctatgt atgacgaaac aagaaacaga
     6541 gatttccaat tgctcttttg tcttcagaca tttagtaata taaagtacct atttttatgc
     6601 tgaaatgttt atacaggttt attaatagca agtgcaacta actggcggca tgccttgcaa
     6661 cacattttga tatattagcc atgcttccgg gtaaaggcaa gccccaaact ccttatcttt
     6721 tgcagtctct ctgggatcag taaaagaaaa aaaaaataat gtgcttaaga agtgggactg
     6781 taaatatgta tatttaactt tgtatagccc atgtacctac cttgtataga aaaataattt
     6841 taaaaatttg aatggaaggg ggtaaaggaa gtcatgaagt ttttttgcat ttttatttaa
     6901 atgaaggaat tccaaataac tcacctacag atttttagca caaaaatagc cattgtaaag
     6961 tgttaaaatt tacgataagt attctattgg ggaggaaagg taactctgat ctcagttaca
     7021 gttttttttt cctttttaat ttcattattt tgggtttttg gtttttgcag tcctatttat
     7081 ctgcagtcgt attaagtcct attgctagaa taggttacta caaaaaaggt tatattctga
     7141 aagaaaaata actgacatta tatataacca attaatttaa agtattgcca tttaaattac
     7201 acactgagag catgtcctat gcagacatag atttttctgt tcatttattt ttcttcattg
     7261 cagtggattg atttgataaa tagatgtgtt gaattactac atttgctgta catattattt
     7321 aataaacttt attcagaatt gcgtggca
//
