LOCUS       NM_138927               8393 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens SON DNA and RNA binding protein (SON), transcript
            variant f, mRNA.
ACCESSION   NM_138927
VERSION     NM_138927.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8393)
  AUTHORS   Phillips,J.B., Park,S.S., Lin,C.H., Cho,J., Lim,S., Aurora,R.,
            Kim,J.H., Angajala,A., Park,B., Stone,J.K., Wang,B., Kahn,A.G.,
            Lim,S.S., Kim,J.H., Ahn,E.E. and Tan,M.
  TITLE     SON is an essential RNA splicing factor promoting ErbB2 and ErbB3
            expression in breast cancer
  JOURNAL   Br J Cancer 131 (9), 1437-1449 (2024)
   PUBMED   39313574
  REMARK    GeneRIF: SON is an essential RNA splicing factor promoting ErbB2
            and ErbB3 expression in breast cancer.
REFERENCE   2  (bases 1 to 8393)
  AUTHORS   Luo,H., Cortes-Lopez,M., Tam,C.L., Xiao,M., Wakiro,I., Chu,K.L.,
            Pierson,A., Chan,M., Chang,K., Yang,X., Fecko,D., Han,G., Ahn,E.E.,
            Morris,Q.D., Landau,D.A. and Kharas,M.G.
  TITLE     SON is an essential m6A target for hematopoietic stem cell fate
  JOURNAL   Cell Stem Cell 30 (12), 1658-1673 (2023)
   PUBMED   38065069
  REMARK    GeneRIF: SON is an essential m[6]A target for hematopoietic stem
            cell fate.
REFERENCE   3  (bases 1 to 8393)
  AUTHORS   Ohler,U., Shomron,N. and Burge,C.B.
  TITLE     Recognition of unknown conserved alternatively spliced exons
  JOURNAL   PLoS Comput Biol 1 (2), 113-122 (2005)
   PUBMED   16110330
REFERENCE   4  (bases 1 to 8393)
  AUTHORS   Casadei,R., Strippoli,P., D'Addabbo,P., Canaider,S., Lenzi,L.,
            Vitale,L., Giannone,S., Frabetti,F., Facchin,F., Carinci,P. and
            Zannotti,M.
  TITLE     mRNA 5' region sequence incompleteness: a potential source of
            systematic errors in translation initiation codon assignment in
            human mRNAs
  JOURNAL   Gene 321, 185-193 (2003)
   PUBMED   14637006
REFERENCE   5  (bases 1 to 8393)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
REFERENCE   6  (bases 1 to 8393)
  AUTHORS   Sun,C.T., Lo,W.Y., Wang,I.H., Lo,Y.H., Shiou,S.R., Lai,C.K. and
            Ting,L.P.
  TITLE     Transcription repression of human hepatitis B virus genes by
            negative regulatory element-binding protein/SON
  JOURNAL   J Biol Chem 276 (26), 24059-24067 (2001)
   PUBMED   11306577
REFERENCE   7  (bases 1 to 8393)
  AUTHORS   Wynn,S.L., Fisher,R.A., Pagel,C., Price,M., Liu,Q.Y., Khan,I.M.,
            Zammit,P., Dadrah,K., Mazrani,W., Kessling,A., Lee,J.S. and
            Buluwela,L.
  TITLE     Organization and conservation of the GART/SON/DONSON locus in mouse
            and human genomes
  JOURNAL   Genomics 68 (1), 57-62 (2000)
   PUBMED   10950926
REFERENCE   8  (bases 1 to 8393)
  AUTHORS   Greenhalf,W., Lee,J. and Chaudhuri,B.
  TITLE     A selection system for human apoptosis inhibitors using yeast
  JOURNAL   Yeast 15 (13), 1307-1321 (1999)
   PUBMED   10509013
REFERENCE   9  (bases 1 to 8393)
  AUTHORS   Khan,I.M., Fisher,R.A., Johnson,K.J., Bailey,M.E., Siciliano,M.J.,
            Kessling,A.M., Farrer,M., Carritt,B., Kamalati,T. and Buluwela,L.
  TITLE     The SON gene encodes a conserved DNA binding protein mapping to
            human chromosome 21
  JOURNAL   Ann Hum Genet 58 (1), 25-34 (1994)
   PUBMED   8031013
REFERENCE   10 (bases 1 to 8393)
  AUTHORS   Mattioni,T., Hume,C.R., Konigorski,S., Hayes,P., Osterweil,Z. and
            Lee,J.S.
  TITLE     A cDNA clone for a novel nuclear protein with DNA binding activity
  JOURNAL   Chromosoma 101 (10), 618-624 (1992)
   PUBMED   1424986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK307612.1, AF380184.1 and
            AP000303.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 25, 2020 this sequence version replaced NM_138927.3.
            
            Summary: This gene encodes a protein that contains multiple simple
            repeats. The encoded protein binds RNA and promotes pre-mRNA
            splicing, particularly of transcripts with poor splice sites. The
            protein also recognizes a specific DNA sequence found in the human
            hepatitis B virus (HBV) and represses HBV core promoter activity.
            There is a pseudogene for this gene on chromosome 1. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (f) represents the allele encoded
            by the GRCh38 reference genome and encodes isoform (F).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF380184.1, SRR18074967.1366385.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356577.10/ ENSP00000348984.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK307612.1         1-26
            27-1471             AF380184.1         1-1445
            1472-1472           AP000303.2         38088-38088
            1473-3659           AF380184.1         1447-3633
            3660-3660           AP000303.2         40276-40276
            3661-8103           AF380184.1         3635-8077
            8104-8393           AF380184.1         8079-8368
FEATURES             Location/Qualifiers
     source          1..8393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..8393
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /note="SON DNA and RNA binding protein"
                     /db_xref="GeneID:6651"
                     /db_xref="HGNC:HGNC:11183"
                     /db_xref="MIM:182465"
     exon            1..132
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..7336
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /note="isoform F is encoded by transcript variant f;
                     NRE-binding protein; negative regulatory element-binding
                     protein; Bax antagonist selected in Saccharomyces 1; SON
                     DNA binding protein"
                     /codon_start=1
                     /product="protein SON isoform F"
                     /protein_id="NP_620305.3"
                     /db_xref="CCDS:CCDS13629.1"
                     /db_xref="GeneID:6651"
                     /db_xref="HGNC:HGNC:11183"
                     /db_xref="MIM:182465"
                     /translation="MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGN
                     QAGDAAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDE
                     IPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDS
                     EPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVS
                     TSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVL
                     KSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAI
                     EALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPPATSMP
                     ELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTPVPQLS
                     QELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPV
                     TTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALELPGQPSV
                     TGVPELPGLPSATRALELSGQPVATGALELPGPLMAAGALEFSGQSGAAGALELLGQP
                     LATGVLELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALE
                     SYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNTMETHILASNTMDSQMLASNT
                     MDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLAT
                     SSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQML
                     ATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDPY
                     RLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTPDPYRMSPRPYRI
                     APRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSYERSMMSPMAE
                     RSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGA
                     DRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMV
                     PPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPS
                     EESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLT
                     PVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH
                     VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLES
                     STVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEP
                     SVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQ
                     NLAPEIGMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCA
                     AGTSPVGEIGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSK
                     GIEFTTASTLSLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDL
                     PSNNNLVSKDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIE
                     DINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSS
                     EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSE
                     SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSK
                     SRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSR
                     TPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVR
                     LRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAG
                     VPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDEE
                     EEEPPFYHHPFKLSEPKPIFFNLNIAAAKPTPPKSQVTLTKEFPVSSGSQHRKKEADS
                     VYGEWVPVEKNGEENKDDDNVFSSNLPSEPVDISTAMSERALAQKRLSENAFDLEAMS
                     MLNRAQERIDAWAQLNSIPGQFTGSTGVQVLTQEQLANTGAQAWIKKDQFLRAAPVTG
                     GMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRKGLVAVGERAQKRSGNFSAAM
                     KDLSGKHPVSALMEICNKRRWQPPEFLLVHDSGPDHRKHFLFRVLRNGALTRPNCMFF
                     LNRY"
     exon            133..299
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            300..6215
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6216..6376
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6377..6523
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6524..6712
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6713..6823
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6824..6940
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            6941..7088
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            7089..7160
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            7161..7276
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     exon            7277..8393
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8388..8393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /note="hexamer: AATAAA"
     polyA_site      8393
                     /gene="SON"
                     /gene_synonym="BASS1; C21orf50; DBP-5; NREBP; SON3;
                     TOKIMS"
                     /note="major polyA site"
ORIGIN      
        1 atgctgggag cctggaggac tagcgaggag gagttgagag aacggagcgg acgccatggc
       61 gaccaacatc gagcagattt ttaggtcttt cgtggtcagt aaattccggg aaattcaaca
      121 ggagctttcc agtggaagga atgaaggcca gctgaatggt gaaacaaata cacccattga
      181 aggaaaccag gcgggtgatg cagctgcctc tgccaggagt ctaccaaatg aagaaatagt
      241 gcagaagata gaggaagtac tttctggggt cttagataca gaactacgat ataagccaga
      301 cttgaaagag ggctccagaa aaagtagatg cgtatctgta caaacagatc ctactgatga
      361 aattcccact aaaaagtcaa agaagcataa aaagcacaaa aacaaaaaga agaaaaagaa
      421 gaaagaaaag gaaaaaaaat ataaaagaca gccagaagaa tctgagtcaa agacgaaatc
      481 tcatgatgat gggaacatag atttagaatc tgattccttt ttaaagtttg attctgaacc
      541 ttcagctgtg gcgctggagc ttcctacaag agcatttggc ccatctgaga ccaatgaatc
      601 ccctgcagtt gtgctagaac ctcctgtagt atcaatggag gtatcagagc cacacatctt
      661 agaaactctg aagccagcta caaaaactgc agaactgtca gttgtatcta catcagtaat
      721 ctcagagcag tcagagcagt ctgtggcagt aatgccagaa ccatccatga caaagattct
      781 ggattccttt gcagcagcac cagtgcctac tacaacactg gtgttgaagt catctgagcc
      841 agttgtaaca atgtcagtgg agtatcagat gaagtctgtg ctgaaatctg tggagagcac
      901 atctccagag ccatcaaaga tcatgttggt agagccccca gtagcaaaag tgttagagcc
      961 ttcagaaacc cttgtggtat catcagagac acctactgag gtgtaccctg agccaagcac
     1021 atcaacaaca atggattttc cagagtcatc tgcaattgaa gcgctaagat tgccagagca
     1081 gcctgtagac gtaccatcgg agattgcaga ttcatccatg acaagaccgc aggagttgcc
     1141 ggagctgcct aagaccacag cgttggagct gcaggagtcg tcggtggcct cagcgatgga
     1201 gttgccgggg ccacctgcga cctccatgcc ggagttgcag gggccccctg tgactccagt
     1261 gctggagtta cctgggccct ctgctacccc ggtgccagag ttgccagggc ccctttctac
     1321 cccagtgcct gagttgccag ggccccctgc gacagcagtg cctgagttgc cagggccctc
     1381 tgtgacacca gtgccacagt tgtcgcagga attgccaggg cttccagcac catccatggg
     1441 gttggagcca ccacaggagg taccagagcc acctgtgatg gcacaggagt tgccagggct
     1501 gcctttggtg acagcagcag tagagttgcc agagcagcct gcggtaacag tagcaatgga
     1561 gttgaccgaa caacctgtga cgacgacaga gttggagcag cctgtgggga tgacaacggt
     1621 ggaacatcct gggcatcctg aggtgacaac ggcaacaggg ttgctggggc agcctgaggc
     1681 aacgatggtg ctggagttgc caggacagcc agtggcaacg acagcgctgg agttgccggg
     1741 gcagccttcg gtgactgggg tgccagagtt gccagggctg ccttcggcaa ctagggcact
     1801 ggagttgtcg gggcagcctg tggcaactgg ggcactagag ttgcctgggc cgctcatggc
     1861 agctggggca ctggagttct cggggcagtc tggggcagct ggagcactgg agcttttggg
     1921 gcagcctctg gcaacagggg tgctggagtt gccagggcag cctggggcgc cagagttgcc
     1981 tgggcagcct gtggcaactg tggcgctgga gatctctgtt cagtctgtgg tgacaacatc
     2041 ggagctgtca acgatgaccg tgtcgcagtc cctggaggtg ccctcgacga cagcgctgga
     2101 atcctataat acggtagcac aggagctgcc tactacatta gtgggggaga cttctgtaac
     2161 agtaggagtg gatcccttga tggccccaga atcccatata ttagcttcta acaccatgga
     2221 gacccatata ttagcatcca acaccatgga ctcccaaatg ctagcgtcca acaccatgga
     2281 ctcccagatg ctagcatcca acaccatgga ctcccagatg ttagcgtcta gcaccatgga
     2341 ctcccagatg ttagcaacta gctccatgga ctcccagatg ttagcaacta gctccatgga
     2401 ctcccagatg ttagcaacta gcactatgga ctcccagatg ttagcaacca gttccatgga
     2461 ctcccagatg ttagcaacca gctccatgga ctcccagatg ttagcaacca gctccatgga
     2521 ctcccagatg ttagcaacca gctccatgga ctcccagatg ttagcaacca gcaccatgga
     2581 ttctcagatg ttagcaacca gcaccatgga ctcccagatg ttagcaacta gctcaatgga
     2641 ttcccagatg ttagcatctg gcactatgga ctctcaaatg ttagcttctg gcaccatgga
     2701 tgctcagatg ttagcgtctg gtaccatgga tgcccagatg ttagcgtcta gtacccaaga
     2761 ttctgctatg ttgggttcaa aatctcctga tccctatagg ttagctcagg atccttacag
     2821 gttagctcag gatccctata ggttgggcca tgacccctat agattaggtc atgatgctta
     2881 caggttagga caagaccctt atagattagg ccatgatccc tacagactaa ctcctgatcc
     2941 ctataggatg tcacctagac cctacaggat agcacccagg tcctatagaa tagcacccag
     3001 gccatatagg ttagcaccta gacccctgat gttagcatct agacgttcta tgatgatgtc
     3061 ctatgctgca gaacgttcca tgatgtcatc ttacgaacgc tctatgatgt cttatgagcg
     3121 gtctatgatg tcccctatgg ctgaacgctc tatgatgtca gcctacgagc gctctatgat
     3181 gtcagcctac gagcgctcta tgatgtcccc tatggctgag cgctctatga tgtcagctta
     3241 tgaacgctcc atgatgtcag cttatgaacg ctccatgatg tccccaatgg ctgatcgatc
     3301 tatgatgtcc atgggtgctg accggtctat gatgtcgtca tactctgctg ctgaccggtc
     3361 tatgatgtca tcgtactctg cagctgaccg atctatgatg tcatcttata ctgctgatcg
     3421 ttcaatgatg tctatggctg ctgattctta caccgattct tacactgaca catatacaga
     3481 ggcatatatg gtgccacctt tgcctcctga agagccccca acaatgccac cgttgccacc
     3541 tgaggagcca ccaatgacac caccattgcc tcctgaggaa ccaccagagg gtccagcatt
     3601 gcccactgag cagtcagcat taacagctga aaatacttgg cctacagagg tgccatcatc
     3661 accatctgaa gagtctgtat cgcagcctga gcctcctgtg agtcaaagtg agatttcgga
     3721 gccttcagca gtgcctactg attattcagt gtcagcatca gatccctcag ttttagtatc
     3781 agaggctgct gtgactgttc cagaaccacc accagagcca gaatcttcaa ttacgttaac
     3841 acctgtagag tctgcagtag tagcagaaga acatgaagtt gttccagaga gaccagtgac
     3901 ttgtatggta tctgaaactc ccgccatgtc agctgaacca actgtgttag catcagagcc
     3961 tcctgttatg tcagagacag cagaaacatt tgattccatg agagcctcag gacatgttgc
     4021 ctcagaagta tctacatcct tgttggttcc agcagtaact actccagtgc tggcagagag
     4081 cattctggag ccgccagcca tggctgcccc agagtcttca gctatggctg tcctggagtc
     4141 ttcggctgtg accgtcctgg agtcttcgac tgtgactgtc ctggagtctt cgactgtaac
     4201 tgtcctggag ccttcggttg tgactgtccc ggagcctcct gttgtggctg agccagacta
     4261 tgttaccatt cctgtgccag ttgtttctgc gctggagcct tctgtgcctg ttctggaacc
     4321 agcggtgtca gtccttcaac cttctatgat tgtttcagaa ccatctgttt ctgtccagga
     4381 atcgactgtg acagtttcag agcctgctgt cacagtctca gagcagactc aagtaatacc
     4441 aactgaggtg gctatagagt ccacaccaat gatactggaa tctagtatca tgtcatcaca
     4501 tgttatgaaa ggaattaatc tatcctctgg tgatcaaaat cttgctccag agattggcat
     4561 gcaggagatt gcattgcatt caggtgaaga accacatgct gaggaacacc tgaaaggtga
     4621 cttttacgaa agtgaacatg gtataaatat agaccttaat ataaataatc atttaattgc
     4681 taaagagatg gaacataata cagtgtgtgc tgctggtact agtcctgttg gggaaattgg
     4741 tgaagagaaa attttgccca ccagtgagac taaacagcgc acagtattgg atacctaccc
     4801 tggtgttagt gaagctgatg caggagaaac tctatcttct actggtcctt ttgctctgga
     4861 acctgatgca acaggaacta gtaagggtat tgaatttacc acagcatcta ctctcagttt
     4921 agttaataaa tatgatgttg atttatcttt aactactcaa gatactgaac atgacatggt
     4981 aatttccacc agtcctagtg gtggtagtga agctgacatt gaagggcctt tgcctgctaa
     5041 agatattcat cttgatttac catctaataa taaccttgtt agtaaggata cagaagaacc
     5101 attacctgta aaagagagtg accagacatt agcagctctg ctcagcccta aagaaagtag
     5161 tggaggagaa aaagaagtac ctccccctcc taaagagaca ctgcctgatt caggattttc
     5221 tgccaatatt gaggatatta atgaagcaga tttagtgaga ccgttacttc ctaaggacat
     5281 ggaacgtctt acaagcctta gagctggcat tgaaggacct ttacttgcaa gtgatgttgg
     5341 acgtgacaga tctgctgcca gcccggttgt aagtagtatg ccagaaagag cttcagagtc
     5401 ttcttcagag gaaaaagatg attatgaaat ttttgtaaaa gttaaggaca ctcacgaaaa
     5461 aagcaagaaa aataagaacc gtgataaggg ggagaaagag aagaaaagag actcttcatt
     5521 aagatctcga agtaagcgtt ccaaatcttc tgaacacaaa tcacgcaagc gtaccagtga
     5581 atctcgttct agggcaagaa agagatcatc taagtccaag tctcatcgct ctcagacacg
     5641 ttcacggtca cgttcaagac gcaggaggag aagcagcaga tcaagatcaa agtctagagg
     5701 aagaagatct gtatcaaaag agaagcgcaa aagatctcca aagcacagat ccaagtctag
     5761 ggaaagaaaa agaaaaagat caagctccag ggataaccga aagacagtta gagctcgaag
     5821 tcgaacccca agtcgtcgga gtcggagtca tactccaagt cgtcgacgaa ggtctagatc
     5881 tgtgggtaga agaaggagct ttagcatttc cccaagccgc cgcagccgca cccccagccg
     5941 ccgcagccgc acccccagcc gccgcagccg cacccccagc cgccgcagcc gcacccccag
     6001 ccgccggagc cgcaccccta gccgtcggag ccgcacccca agccgccgga gaagatcaag
     6061 gtctgtggta agaagacgaa gcttcagtat ctcaccagtc agattaaggc gatcaagaac
     6121 acccttaaga agaaggttta gcagatctcc catccgtcgt aaaagatcca ggtcttctga
     6181 acgaggcaga tcacccaaac gtctgacaga tttggataag gctcaattac ttgaaatagc
     6241 caaagctaat gcagctgcca tgtgtgctaa ggctggtgtc cctttaccac caaacctaaa
     6301 gcctgcacct ccacctacta tagaagagaa agttgctaaa aagtcaggag gagctactat
     6361 agaagaacta actgagaaat gtaaacagat cgcacagagt aaagaagatg atgatgtaat
     6421 agtgaataaa cctcatgttt cggatgaaga ggaagaagaa cctccttttt atcatcatcc
     6481 ctttaaactc agtgaaccca aacctatttt tttcaatctg aatattgctg cagcaaaacc
     6541 aactccacca aaaagccagg taacattaac aaaagaattc cctgtatcat ctggatctca
     6601 acatcggaaa aaagaagcgg atagtgttta tggagaatgg gttcctgtgg agaaaaatgg
     6661 tgaagaaaac aaagatgatg ataatgtttt cagcagcaat ttgccctcag agcctgtgga
     6721 catctctaca gcaatgagtg aacgggcact tgctcagaaa agactcagtg agaatgcatt
     6781 tgatcttgaa gccatgagca tgttaaatag agctcaggaa aggattgatg cctgggctca
     6841 gctgaactct attcctggcc agttcacagg aagtacagga gtacaggttt tgacacaaga
     6901 acagttggcc aatactggtg cccaagcctg gattaaaaag gatcagttct taagagcagc
     6961 cccggtaact ggaggaatgg gagccgtttt gatgagaaaa atgggctgga gagaaggaga
     7021 aggattagga aaaaacaaag aaggcaataa ggaacccatc ctagttgatt ttaagacaga
     7081 ccgaaaaggt cttgttgcag taggagaaag agcacaaaag aggtctggga acttctctgc
     7141 tgcaatgaaa gatctgtcag gcaaacatcc tgtgtctgct ttgatggaga tctgtaataa
     7201 aagaaggtgg caaccacctg aatttctatt ggtccatgat agtggccctg atcatcgcaa
     7261 acattttctc tttagggtat tgagaaatgg agcccttacc agacccaatt gtatgttttt
     7321 cttgaatagg tattgataaa tggaagcgct taccagccca gctttgccag ccctaataag
     7381 aagcatgcta aagccacagc agctactgtg gttcttcaag caatgggcct tgtaccaaag
     7441 gacctcatgg ctaatgccac ttgcttcagg agtgcctcac gtagatagat tgaggtttta
     7501 taataatcat ttcagaattt tactctgcat cacaatgtat ttcctcttta atgttgtaaa
     7561 tatttggcaa tttaagacat tgtgtaaaaa gcaatctgta aaaacatctc caggctttga
     7621 tttttgtacc atggaaattg tatttaacca tacagggttt tggtatgttt atattgttta
     7681 ccttagtgat gtatttgttt aagtggctaa catccaaacg actgtttgaa ggcatcagag
     7741 taatcttcag tgtggaatgt taaataacgc ttttatactg tattttgtac tatgatgtaa
     7801 ctccccttcc ttatggctag gctactgtaa cacttgcctg taatcagtga agggctgtgc
     7861 accttgtact atttcacaat gggttctgct ggacagataa tgggccagtg ttattgaggt
     7921 gatcaagatc tgttccacag ggctaatgcc accatctccc ctcaaaattt tgtagaggtt
     7981 ctaaaaagaa agtggtatgt tgtgtgatga tcagcactaa gtcctgcatt cctgttaaag
     8041 ccacttgggt cataagaagg gagtaaaaaa tgaagtctga ctagaattct attgcagagg
     8101 ccagtacatt tagtatggca ttgagttgtg atatagtttt actttgatgt gcattttgaa
     8161 tttcagctac acctagatag acgtaaaatg ataattaaaa tgctgtaacc aacttatcta
     8221 ataaaattgg caaccagcca ctattttgtt gactatgaga aagttaaaag tttatgttaa
     8281 tttttagggt ctgatagaat atttcatgtg tattacagtg gtattcatat gctatgtctc
     8341 taaactttat tttcaaaagc ttaaggccca aatacaaact tctctggaat aaa
//
