LOCUS       NM_003102               1416 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens superoxide dismutase 3 (SOD3), mRNA.
ACCESSION   NM_003102
VERSION     NM_003102.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Wang,D., Chen,M., Tao,Z., Du,J., Tian,K., Chen,Z., Yu,B., Chen,Y.
            and Lv,L.
  TITLE     Overexpression of Extracellular Superoxide Dismutase 3 Inhibits
            Cancer Cell Growth and Migration in Colorectal Cancer
  JOURNAL   Turk J Gastroenterol 35 (6), 465-474 (2024)
   PUBMED   39128081
  REMARK    GeneRIF: Overexpression of Extracellular Superoxide Dismutase 3
            Inhibits Cancer Cell Growth and Migration in Colorectal Cancer.
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Gawargi,F.I. and Mishra,P.K.
  TITLE     Deciphering MMP9's dual role in regulating SOD3 through
            protein-protein interactions
  JOURNAL   Can J Physiol Pharmacol 102 (3), 196-205 (2024)
   PUBMED   37992301
  REMARK    GeneRIF: Deciphering MMP9's dual role in regulating SOD3 through
            protein-protein interactions.
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Xu,K., Fei,W., Gao,W., Fan,C., Li,Y., Hong,Y. and Cui,R.
  TITLE     SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways
  JOURNAL   Free Radic Biol Med 212, 65-79 (2024)
   PUBMED   38141889
  REMARK    GeneRIF: SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways.
REFERENCE   4  (bases 1 to 1416)
  AUTHORS   Fukai,T. and Ushio-Fukai,M.
  TITLE     Superoxide dismutases: role in redox signaling, vascular function,
            and diseases
  JOURNAL   Antioxid Redox Signal 15 (6), 1583-1606 (2011)
   PUBMED   21473702
  REMARK    Review article
REFERENCE   5  (bases 1 to 1416)
  AUTHORS   Petersen,S.V., Oury,T.D., Ostergaard,L., Valnickova,Z., Wegrzyn,J.,
            Thogersen,I.B., Jacobsen,C., Bowler,R.P., Fattman,C.L., Crapo,J.D.
            and Enghild,J.J.
  TITLE     Extracellular superoxide dismutase (EC-SOD) binds to type i
            collagen and protects against oxidative fragmentation
  JOURNAL   J Biol Chem 279 (14), 13705-13710 (2004)
   PUBMED   14736885
REFERENCE   6  (bases 1 to 1416)
  AUTHORS   Stern,L.F., Chapman,N.H., Wijsman,E.M., Altherr,M.R. and Rosen,D.R.
  TITLE     Assignment of SOD3 to human chromosome band 4p15.3-->p15.1 with
            somatic cell and radiation hybrid mapping, linkage mapping, and
            fluorescent in-situ hybridization
  JOURNAL   Cytogenet Genome Res 101 (2), 178 (2003)
   PUBMED   14619883
  REMARK    GeneRIF: Chromosome mapping of SOD3 to chromosome band
            4p15.3-->p15.1.
REFERENCE   7  (bases 1 to 1416)
  AUTHORS   Enghild,J.J., Thogersen,I.B., Oury,T.D., Valnickova,Z., Hojrup,P.
            and Crapo,J.D.
  TITLE     The heparin-binding domain of extracellular superoxide dismutase is
            proteolytically processed intracellularly during biosynthesis
  JOURNAL   J Biol Chem 274 (21), 14818-14822 (1999)
   PUBMED   10329680
REFERENCE   8  (bases 1 to 1416)
  AUTHORS   Adachi,T., Ohta,H., Yamada,H., Futenma,A., Kato,K. and Hirano,K.
  TITLE     Quantitative analysis of extracellular-superoxide dismutase in
            serum and urine by ELISA with monoclonal antibody
  JOURNAL   Clin Chim Acta 212 (3), 89-102 (1992)
   PUBMED   1477980
REFERENCE   9  (bases 1 to 1416)
  AUTHORS   Adachi,T., Ohta,H., Hayashi,K., Hirano,K. and Marklund,S.L.
  TITLE     The site of nonenzymic glycation of human extracellular-superoxide
            dismutase in vitro
  JOURNAL   Free Radic Biol Med 13 (3), 205-210 (1992)
   PUBMED   1505778
REFERENCE   10 (bases 1 to 1416)
  AUTHORS   Hjalmarsson,K., Marklund,S.L., Engstrom,A. and Edlund,T.
  TITLE     Isolation and sequence of complementary DNA encoding human
            extracellular superoxide dismutase
  JOURNAL   Proc Natl Acad Sci U S A 84 (18), 6340-6344 (1987)
   PUBMED   3476950
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006390.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_003102.3.
            
            Summary: This gene encodes a member of the superoxide dismutase
            (SOD) protein family. SODs are antioxidant enzymes that catalyze
            the conversion of superoxide radicals into hydrogen peroxide and
            oxygen, which may protect the brain, lungs, and other tissues from
            oxidative stress. Proteolytic processing of the encoded protein
            results in the formation of two distinct homotetramers that differ
            in their ability to interact with the extracellular matrix (ECM).
            Homotetramers consisting of the intact protein, or type C subunit,
            exhibit high affinity for heparin and are anchored to the ECM.
            Homotetramers consisting of a proteolytically cleaved form of the
            protein, or type A subunit, exhibit low affinity for heparin and do
            not interact with the ECM. A mutation in this gene may be
            associated with increased heart disease risk. [provided by RefSeq,
            Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014418.1, J02947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382120.4/ ENSP00000371554.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC006390.8         107613-107691
            80-1416             AC006390.8         111546-112882
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..1416
                     /gene="SOD3"
                     /gene_synonym="EC-SOD"
                     /note="superoxide dismutase 3"
                     /db_xref="GeneID:6649"
                     /db_xref="HGNC:HGNC:11181"
                     /db_xref="MIM:185490"
     exon            1..79
                     /gene="SOD3"
                     /gene_synonym="EC-SOD"
                     /inference="alignment:Splign:2.1.0"
     exon            80..1416
                     /gene="SOD3"
                     /gene_synonym="EC-SOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..818
                     /gene="SOD3"
                     /gene_synonym="EC-SOD"
                     /EC_number="1.15.1.1"
                     /note="testicular tissue protein Li 175; superoxide
                     dismutase 3, extracellular"
                     /codon_start=1
                     /product="extracellular superoxide dismutase [Cu-Zn]
                     preproprotein"
                     /protein_id="NP_003093.2"
                     /db_xref="CCDS:CCDS3430.1"
                     /db_xref="GeneID:6649"
                     /db_xref="HGNC:HGNC:11181"
                     /db_xref="MIM:185490"
                     /translation="MLALLCSCLLLAAGASDAWTGEDSAEPNSDSAEWIRDMYAKVTE
                     IWQEVMQRRDDDGALHAACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALEGF
                     PTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPHPQHPGDFGNFAVRDGSLWRYR
                     AGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGVCGPGLW
                     ERQAREHSERKKRRRESECKAA"
     regulatory      1397..1402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOD3"
                     /gene_synonym="EC-SOD"
                     /note="hexamer: ATTAAA"
     polyA_site      1416
                     /gene="SOD3"
                     /gene_synonym="EC-SOD"
                     /note="major polyA site"
ORIGIN      
        1 agggacagcc tgcgttcctg ggctggctgg gtgcagctct cttttcagga gagaaagctc
       61 tcttggagga gctggaaagg tgcccgactc cagccatgct ggcgctactg tgttcctgcc
      121 tgctcctggc agccggtgcc tcggacgcct ggacgggcga ggactcggcg gagcccaact
      181 ctgactcggc ggagtggatc cgagacatgt acgccaaggt cacggagatc tggcaggagg
      241 tcatgcagcg gcgggacgac gacggcgcgc tccacgccgc ctgccaggtg cagccgtcgg
      301 ccacgctgga cgccgcgcag ccccgggtga ccggcgtcgt cctcttccgg cagcttgcgc
      361 cccgcgccaa gctcgacgcc ttcttcgccc tggagggctt cccgaccgag ccgaacagct
      421 ccagccgcgc catccacgtg caccagttcg gggacctgag ccagggctgc gagtccaccg
      481 ggccccacta caacccgctg gccgtgccgc acccgcagca cccgggcgac ttcggcaact
      541 tcgcggtccg cgacggcagc ctctggaggt accgcgccgg cctggccgcc tcgctcgcgg
      601 gcccgcactc catcgtgggc cgggccgtgg tcgtccacgc tggcgaggac gacctgggcc
      661 gcggcggcaa ccaggccagc gtggagaacg ggaacgcggg ccggcggctg gcctgctgcg
      721 tggtgggcgt gtgcgggccc gggctctggg agcgccaggc gcgggagcac tcagagcgca
      781 agaagcggcg gcgcgagagc gagtgcaagg ccgcctgagc gcggccccca cccggcggcg
      841 gccagggacc cccgaggccc ccctctgcct ttgagcttct cctctgctcc aacagacacc
      901 ctccactctg aggtctcacc ttcgcctttg ctgaagtctc cccgcagccc tctccaccca
      961 gaggtctccc tataccgaga cccaccatcc ttccatcctg aggaccgccc caaccctcgg
     1021 agccccccac tcagtaggtc tgaaggcctc catttgtacc gaaacacccc gctcacgctg
     1081 acagcctcct aggctccctg aggtaccttt ccacccagac cctccttccc caccccataa
     1141 gccctgagac tcccgccttt gacctgacga tcttccccct tcccgccttc aggttcctcc
     1201 taggcgctca gaggccgctc tggggggttg cctcgagtcc ccccacccct ccccacccac
     1261 caccgctccc gcgggaagcc agcccgtgca acggaagcca ggccaactgc cccgcgtctt
     1321 cagctgtttc gcatccaccg ccaccccact gagagctgct cctttggggg aatgtttggc
     1381 aacctttgtg ttacagatta aaaattcagc aattca
//
