LOCUS       NM_014598               8258 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens suppressor of cytokine signaling 7 (SOCS7), mRNA.
ACCESSION   NM_014598 XM_371052
VERSION     NM_014598.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8258)
  AUTHORS   Kanno,H., Matsumoto,S., Yoshizumi,T., Nakahara,K., Shinonaga,M.,
            Kubo,A., Fujii,S., Ishizuka,Y., Tanaka,M., Ichihashi,M. and
            Murata,H.
  TITLE     SOCS7-Derived BC-Box Motif Peptide Mediated Cholinergic
            Differentiation of Human Adipose-Derived Mesenchymal Stem Cells
  JOURNAL   Int J Mol Sci 24 (3), 2786 (2023)
   PUBMED   36769102
  REMARK    GeneRIF: SOCS7-Derived BC-Box Motif Peptide Mediated Cholinergic
            Differentiation of Human Adipose-Derived Mesenchymal Stem Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8258)
  AUTHORS   Ozcep,M., Atsu,N., Solak,N. and Celik,S.K.
  TITLE     Lack of association between SOCS3 and SOCS7 polymorphisms and
            psoriasis
  JOURNAL   Immun Inflamm Dis 10 (10), e695 (2022)
   PUBMED   36169255
  REMARK    GeneRIF: Lack of association between SOCS3 and SOCS7 polymorphisms
            and psoriasis.
REFERENCE   3  (bases 1 to 8258)
  AUTHORS   Huang,P., Zhao,Z., Chen,Y., Yang,B. and Xia,J.
  TITLE     The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1
            signaling in hepatocellular carcinoma
  JOURNAL   Lab Invest 102 (6), 613-620 (2022)
   PUBMED   35042950
  REMARK    GeneRIF: The E3 ubiquitin ligase SOCS-7 reverses immunosuppression
            via Shc1 signaling in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 8258)
  AUTHORS   Zeng,H., Li,L., Gao,Y., Wu,G., Hou,Z. and Liu,S.
  TITLE     Long noncoding RNA UCA1 regulates HCV replication and antiviral
            response via miR-145-5p/SOCS7/IFN pathway
  JOURNAL   Int J Biol Sci 17 (11), 2826-2840 (2021)
   PUBMED   34345210
  REMARK    GeneRIF: Long noncoding RNA UCA1 regulates HCV replication and
            antiviral response via miR-145-5p/SOCS7/IFN pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8258)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 8258)
  AUTHORS   Krebs,D.L., Uren,R.T., Metcalf,D., Rakar,S., Zhang,J.G., Starr,R.,
            De Souza,D.P., Hanzinikolas,K., Eyles,J., Connolly,L.M.,
            Simpson,R.J., Nicola,N.A., Nicholson,S.E., Baca,M., Hilton,D.J. and
            Alexander,W.S.
  TITLE     SOCS-6 binds to insulin receptor substrate 4, and mice lacking the
            SOCS-6 gene exhibit mild growth retardation
  JOURNAL   Mol Cell Biol 22 (13), 4567-4578 (2002)
   PUBMED   12052866
REFERENCE   7  (bases 1 to 8258)
  AUTHORS   Cooney,R.N.
  TITLE     Suppressors of cytokine signaling (SOCS): inhibitors of the
            JAK/STAT pathway
  JOURNAL   Shock 17 (2), 83-90 (2002)
   PUBMED   11837794
  REMARK    Review article
REFERENCE   8  (bases 1 to 8258)
  AUTHORS   Dogusan,Z., Hooghe-Peters,E.L., Berus,D., Velkeniers,B. and
            Hooghe,R.
  TITLE     Expression of SOCS genes in normal and leukemic human leukocytes
            stimulated by prolactin, growth hormone and cytokines
  JOURNAL   J Neuroimmunol 109 (1), 34-39 (2000)
   PUBMED   10969179
REFERENCE   9  (bases 1 to 8258)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
REFERENCE   10 (bases 1 to 8258)
  AUTHORS   Matuoka,K., Miki,H., Takahashi,K. and Takenawa,T.
  TITLE     A novel ligand for an SH3 domain of the adaptor protein Nck bears
            an SH2 domain and nuclear signaling motifs
  JOURNAL   Biochem Biophys Res Commun 239 (2), 488-492 (1997)
   PUBMED   9344857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244092.2, BC128607.1, AB005216.1 and AC244153.3.
            
            On Nov 29, 2018 this sequence version replaced NM_014598.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279871.4407.1,
                                           SRR3476690.868198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612932.6/ ENSP00000482229.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-839               AC244092.2         20112-20950         c
            840-1469            BC128607.1         16-645
            1470-1470           AB005216.1         701-701
            1471-2298           BC128607.1         647-1474
            2299-8258           AC244153.3         187758-193717       c
FEATURES             Location/Qualifiers
     source          1..8258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..8258
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /note="suppressor of cytokine signaling 7"
                     /db_xref="GeneID:30837"
                     /db_xref="HGNC:HGNC:29846"
                     /db_xref="MIM:608788"
     exon            1..1189
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2147
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /note="NCK-associated protein 4; Nck, Ash and
                     phospholipase C binding protein; NAP-4; SOCS-7; nck, Ash
                     and phospholipase C gamma-binding protein"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 7"
                     /protein_id="NP_055413.2"
                     /db_xref="CCDS:CCDS32637.2"
                     /db_xref="GeneID:30837"
                     /db_xref="HGNC:HGNC:29846"
                     /db_xref="MIM:608788"
                     /translation="MQEAELRDGEAAAAAASYRVLSRLLGYGEAAPEPGPPPPPPGHG
                     PPPPPFLARPGPRGSRPPQLMVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPK
                     ALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQP
                     PAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQP
                     PGPELPPVPFPLQDLVPLGRLSRGEQQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKI
                     RLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTRT
                     QSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPT
                     SVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSS
                     SFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGIT
                     HHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTP
                     VQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEV
                     YLSLKEAQLISKQKQEVEPST"
     exon            1190..1254
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1359
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1461
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1592
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1761
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1890
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2026
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2177
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..8258
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2431
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
     regulatory      8238..8243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /note="hexamer: AATAAA"
     polyA_site      8258
                     /gene="SOCS7"
                     /gene_synonym="NAP4; NCKAP4"
                     /note="major polyA site"
ORIGIN      
        1 ggcttggggg cggtgctcgg cggtggcgga gcgcggcctg ggctcgcgct gggctccgcg
       61 cgccccccgc ccccctctat gaggcagagg ccgcggcggc cgttagcgct gtcgctccgg
      121 gggccgcggc gggcggggct ccggcggggc ccggcctagt ccccacccca gcccggctcc
      181 cagccgcccg ccctccctcc ctctccccga tgcaggaggc cgagctccgg gatggcgagg
      241 cggcggcggc ggccgcttcg taccgcgtcc tgagccgcct ccttggctat ggagaggcgg
      301 cccccgagcc aggccctccg ccaccgcccc cgggccatgg ccccccgccg ccacccttcc
      361 tcgcgcggcc cggcccgcgg ggctcccggc cgccgcagct gatggtgttc cgcaacgtgg
      421 gtcggccgcc ggaggaggag gacgtggagg cggccccgga gccgggaccc tcggaactgc
      481 tgtgtccccg gcaccgctgt gccctggacc ccaaggccct gccgccgggc ttggcgctcg
      541 agcggacctg gggcccggcg gctggactag aggcgcagtt ggcggctctg gggctcgggc
      601 agccggcggg gccgggggtc aagacagtcg gtgggggttg ctgcccgtgt ccgtgtcctc
      661 ctcagccgcc ccctccgcag ccccagccgc ctgctgccgc cccgcaggcc ggggaggacc
      721 ccacggaaac gagcgacgcg ctgctggtcc tggagggctt ggaatcggag gccgagagcc
      781 tggagactaa cagctgctcg gaagaggagc tcagcagccc gggtcgcgga ggaggagggg
      841 gcggccggct tctgctgcag cccccaggcc ctgaattacc tccggtgccc ttcccgctgc
      901 aggacttggt ccctctgggg cgcctgagta gaggggagca gcagcagcag cagcagcagc
      961 aacctccccc gcccccgcct cctcccgggc ccctccggcc actcgcgggt ccttctcgga
     1021 agggctcctt caaaatccgc ctcagtcgcc tctttcgcac caagagctgc aacggtggct
     1081 ccggcggtgg ggatgggacc ggcaagaggc cttctggaga gctggctgct tcagctgcga
     1141 gcctgacaga catgggaggc tctgcgggcc gggagctgga cgcggggagg aaacccaagt
     1201 tgacaagaac tcaaagtgcc ttttctccgg tctccttcag ccccctgttc acaggtgaaa
     1261 ctgtgtcgct tgtggatgtg gacatttctc agcggggcct gacctctcca caccctccaa
     1321 ctccccctcc tcctccgaga agaagcctca gcctcctaga tgatatcagt gggacgctgc
     1381 ctacatctgt ccttgtggct ccgatggggt cttccttgca gtctttcccc ctacctccgc
     1441 ctcctccacc ccatgcccca gatgcatttc cccggattgc tcccatccga gcagctgaat
     1501 ccctgcacag ccaaccccca cagcacctcc agtgtcccct ctaccggcct gactcgagca
     1561 gctttgcagc cagccttcga gagttggaga agtgtggttg gtattggggg ccaatgaatt
     1621 gggaagatgc agagatgaag ctgaaaggga aaccagatgg ttctttcctg gtacgagaca
     1681 gttctgatcc tcgttacatc ctgagcctca gtttccgatc acagggtatc acccaccaca
     1741 ctagaatgga gcactacaga ggaaccttca gcctgtggtg tcatcccaag tttgaggacc
     1801 gctgtcaatc tgttgtagag tttattaaga gagccattat gcactccaag aatggaaagt
     1861 ttctctattt cttaagatcc agggttccag gactgccacc aactcctgtc cagctgctct
     1921 atccagtgtc ccgattcagc aatgtcaaat ccctccagca cctttgcaga ttccggatac
     1981 gacagctcgt caggatagat cacatcccag atctcccact gcctaaacct ctgatctctt
     2041 atatccgaaa gttctactac tatgatcctc aggaagaggt atacctgtct ctaaaggaag
     2101 cgcagctcat ttccaaacag aagcaagagg tggaaccctc cacgtagcga ggggctccct
     2161 gctggtcacc accaagggca tttggttgcc aagctccagc tttgaagaac caaattaagc
     2221 taccatgaaa agaagaggaa aagtgaggga acaggaaggt tgggattctc tgtgcagaga
     2281 ctttggttcc ccacgcagcc ctggggcttg gaagaagcac atgaccgtac tctgcgtggg
     2341 gctccacctc acacccaccc ctgggcatct taggactgga ggggctcctt ggaaaactgg
     2401 aagaagtctc aacactgttt ctttttcaga agttttgttt ttgatattta tattacttgg
     2461 tatggaaaac tcaccttgaa ggcagttggg gtttgtgccc gttggattga aagtggtgcg
     2521 aagggtgagc aggtccaaag aaggggtggg aggagggaac aggggacggc cattcagctg
     2581 gtgccaaagg cagagttaga gtctgtgctg tgggcctgga agatgggagg aggggcttga
     2641 ggtttgcaaa ggactgggag ttcctgagga agggggaatc tgcctcttgt tgccatgggc
     2701 agctgttgta ggagcaggag agaaaggagg gtgggtggtc tcgaaaagaa tattgggcaa
     2761 aacctagcca attggcctta gctgggagaa gtagtgactc ctgcatcctt ttttaaggtt
     2821 taggaacctg agttcagaaa cacctctcat ggaagctgta ctagttgtga tttacttaat
     2881 tccttaagtt ccatgacctg aagttaaccc cgttcttcct ctgctctcaa cccattgccc
     2941 cttgagataa ctgtacatgt cactctgatc atggtaacag catccctatt gcttctgcca
     3001 gctgtcatgg caatcgtgtt tcccatcacc tgggcggttc agagccagtc atgggctgct
     3061 gaatttaatg gagcatgttt ccaggttctt catggcaaac tgtactcatg acttaggagt
     3121 gagtgttact tccatgtgcc tgtcagcttg tgagggggaa tgtggaggaa ggtgagaaat
     3181 acagctccca cagttgtgct cttcctagag gaagctctca gaacgcagcc ctcacgggat
     3241 ttccttaggt cagaggagag catcgcatct cacgttttta ggtttatcac tgccatccca
     3301 cttctgggat gggaggtagc aagggcttct gtattttctt gtgttcattc tagcaaccca
     3361 gacatttccg gatcagatcc tgctggtctc cactcactgg aaagtctgcc agatgccgat
     3421 ttgagagctg cctgtccctg ctttcaggag gagcggggag aaaaactcca atggtcttta
     3481 atggtttctg cagctggcca tggccaattc atatgacatt gtgagtttgc tttcttatag
     3541 agctgctctg gggagaggtt tgctattgag atgtaacagt ggagctgttg ggtcttcatg
     3601 actcctttgc gtgtgttcca tgggactctc tttctgggtt ccccatgctt atagttgcct
     3661 cgtgtcacaa gacagatact aatgtcaggt ttgtggcttc ctgatggttt gggtggggcc
     3721 ccagtgtcct ggtaatttat aggactgcct catctgggag cattgccttc ttccttagtc
     3781 ccacgtggag tgaccagtct tcctccttgt agctgaacag ggaggaaact tgcaccatta
     3841 cctgactgtg gaagggtggc ccacaagatg agctgtgcac cataaacaca gcccacctct
     3901 gatttgtcat gtggtacctc ttctttcctt ggcttccatg gtagtattat caactaagca
     3961 agattgtgat cccagaaatt ggcttagcat gtgagtgttg cctcgtgaga gtacaagtaa
     4021 tataactcgc catcttgcag gaagtgccac cccaatatag agcctgaagt tggaatctgt
     4081 tgagatcctt gggtggctga tatacagcct gggatctttc ttttttttgt tccttttcaa
     4141 ccacccataa ttttaatatt attttttagt gtgtgtgtgc ctggctttgc gctagatatt
     4201 gtagaaaaca aaaaaggtaa aagacgtaat atgtggccta agggagcttt taggtgactg
     4261 ctgcacatca agcagaaaat caaggactat ctaaagacgt ttatagtaga taagatcagg
     4321 gtagaccaga tggtctggga aagttctgtg cctctgaggc tttgggttgt agtcaatggc
     4381 aggacagaca gtgagatgaa aaacacatga gcaaaagcaa ggaagcagaa atctgcatgg
     4441 catgtactga acagtgcaca gccctgttag agcaacatgg ttaaagaatc ctttccagtg
     4501 cggttttcta gatggaagct tcccagccac caggcagacc tgagtgccaa ggggttatga
     4561 tggtgaggtg gagcccaaag cccaaaggag tcagcaaggc tcctgcccat tgccagggcc
     4621 tcactatggt cagctcaggc catgtgaggg aggcagagcc tctgcacccc ctgtgttact
     4681 ggggtttctt ctggagaact catacattca ggtacaaaac aaaccaactg aggaggtgtg
     4741 acccaacctc accacccacc tttctcctcc tggggagtgt cgtgttgaac tgtgtctgtg
     4801 tcagtgcact ggtcccagcc ctggccgcag cctagtcctt tctctgtgga gtgggctgca
     4861 aaacagcagc gcaagaggag acagtcttcg tcaggtgtgg gtgtttggtg cctgcatggg
     4921 tggccttgca cagagcagtt aggggaagat gagggggagg catggggctg ggccagctct
     4981 ctgggataca gcctggtcag agagtaaatg gagcagagga gcaggtgtgg cagcacctgc
     5041 ccttcacctc cctgaccagg cccgtccctc cttcgccagt gctgtgcaga gctcatttaa
     5101 atgtattcct ttctaggtct gggcgcggtg gctcacgcct gtaatcccag cactttggga
     5161 ggctgaggtg ggtggatcat gaggtcggga gttcaagacc agcttggcca aacagtgaaa
     5221 ccctatctct actaaaatac aaaaattagc tgggcatggt ggcatgcgcc tgtagtccca
     5281 gctacttggg aggctgagac aggagaattg cttgaaccca ggaggcggag gttgcactga
     5341 gccgagattg cgccactgcc ctctagccta gacgacagag tgagactcca tctcaaaaaa
     5401 aataaataat ttctttctgg ttgtattttc aagtcacaaa ttggaaaagg cttacatcta
     5461 gggacccact gttgattcct aagttgtggg tgggtgatat cagtggcctc agtgcctgca
     5521 taaccctcac ctgtttatga ctgatctact gtaaccttcc tcaggttgag agtgagctgc
     5581 tgtgagccag tgacaactac tgctacaact tgctgttact tgaaattcgt gtgctatgtt
     5641 ggtagcacag gagtaggcgg gcgggggttt tggtgtgggc actaggtaag tgggtggcaa
     5701 ccggctcttt gggaccattg gtgctgacct ttgcctggtc acctgcctgt gcctaggcca
     5761 agtgaatgtt acatcttgga acctgagcca tggaggtggc gccacctccc tgaggagaaa
     5821 ggtgtggcca aaggaaactc ctgcatggct cctgctcctt ccccttccct acatttcact
     5881 tgggctaatg atgtaagccc cccttgaggt tggggatggt gtggagatag ctgcagacac
     5941 ccctgtaaca gacatccagg aagaattagg gagtgggggt aattatagtt cctaggtcta
     6001 ggggtgagag gtgggagtag aaccagaagt gccctggaat ccagccgtgt cagccctcac
     6061 cccagggccc ccaggaaagc atggcctgct tgaagccctc tgctccctgc agaaactggg
     6121 gcgaggagga gctttttcct tcagttagat ctttcccttc cctgctgcct cgctccctta
     6181 gctttggagc cctaaagtta gtggacaaga cactgggata aagctctatg gctgctggaa
     6241 ggaggtctga gtctgtgtgt gtgcatatgc atgcatgtgt gtgtgtgtgt gtgtcctcat
     6301 ttgcagaagt cttgctacca gttagggtgt taagagcatc tccactgggc ggagacctgg
     6361 catttgtttt ccactgttaa gagaatgaca caccccctgt catgtaaggg aggagctatt
     6421 gagttagaca ttttccctat gggaatcctc ggtttggttt gtgggaaagg agggaatgga
     6481 taagtgattt ttatctctaa tcgtcaacac agctgttctt ccactgaatt tgtgctattg
     6541 catacatgta gccatctttc ttttcactgc agcagtgttt atcagtagtt caaaatgatt
     6601 tatttgctcc tggggagtaa aacctttttt attaaaaaaa gaaaaagaaa aaaaaaagaa
     6661 agaaaagtgt gcccccctcc tatgctgcga tagctataaa atgattgggt cacaaaggtc
     6721 aagtctgcac gtccctgtgg tagaccctgc tttcacattg gagccttcac actcagcaca
     6781 aaatgattgg aggccttgat aaaatggaga gcaaagtctt gggagcagtg aaatgggggt
     6841 tggatcatag agacaggcgc tggggactcg ggtactgcag ttaggaaagt agcgttatga
     6901 gttgtactga aaatgttgat tctctaatct gccagaaaag gacctgtctt ttcatgcaga
     6961 tttcatattg tctttgtcct tttcattgct tcttgacctt cctggcaggt gtcgctcagt
     7021 ttcttcctgt ttcccttcct gtcctctcca cacctgctat cccgtcccac tcccatctac
     7081 ctcccgggaa gccagccctg catgctgagt ttgtgacctg cttcattccc atttcatttc
     7141 tagagggttt agaggtgacc tggaaccgtt ccctttccct ctcctacccc ctcctctgca
     7201 acaccaagag gcctggaggg gcagacagaa agcagccagc cacggcggga agacatgcat
     7261 gtttggttgc agctggactg cgatcgtagt tcctcctgga gatagagtgt gaggaactta
     7321 ggacactctt cctcagactc tgggatcatc acataccaca ctgccccgct cagagtttcg
     7381 tcctgagctc cctaaccagc tcaggtggag cagaagcctg ctctcactcc tccatctctg
     7441 gtgctccctt gggcggggac ctgtccctca ctcttaggcc cagaacctgt ccaagggaca
     7501 ggtagggtcc aggtgccact ttgggtagct ggctgttgga atgcccacac tggtgctgcc
     7561 tgtggcatag ccactgctgt acgtttttgg ttgtttttaa gaaactcgat gaagaggggt
     7621 gtcattctgg gctcggggtg gttgccaatt tttcaccaga aagggagcca ccccttgcaa
     7681 ccacttctgt ctccgttagc cccccctctg ccctcctcca agccaaagcg tggcctggct
     7741 tttgtcttcc catttagttt tcctctttta cccttccttt tgtgcttaat ttattaaaat
     7801 agttgctgta taatttattt tcataaacta taaaaaaata ctaaatggtt aaaatagact
     7861 tgcaggccaa tcttaaatgg ggtgggaggg gtctgagggt gggatgggga aagggaaaga
     7921 ggttttgata taaacaaaac aaatgcactt tgggtgtgtt ttggtatttt tctggggata
     7981 gagggggtgg ggttagggat gtccctgtag attagttcca gaatggggtg tctgtatata
     8041 ctgtattaat aggcatgttt gactctcgta aagggacgtt agtagctgct gcaggtcctg
     8101 tttggaaacc ccatgtacaa ttcccagttt tttgtaagtg tcagtgcgag agacatttga
     8161 ctcttgtgtt tgtatctcct ttttatgatt gctgtaccta cccatgtctt tttggggagg
     8221 ggtgaaaaga gatttgaaat aaaaatgttt agaaatta
//
