LOCUS       NM_004232               5703 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA.
ACCESSION   NM_004232
VERSION     NM_004232.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5703)
  AUTHORS   Li,Z.B., Li,Z.Z., Li,L., Chu,H.T. and Jia,M.
  TITLE     Publisher Correction: MiR-21 and miR-183 can simultaneously target
            SOCS6 and modulate growth and invasion of hepatocellular carcinoma
            (HCC) cells
  JOURNAL   Eur Rev Med Pharmacol Sci 28 (9), 3290 (2024)
   PUBMED   38766781
  REMARK    GeneRIF: Publisher Correction: MiR-21 and miR-183 can
            simultaneously target SOCS6 and modulate growth and invasion of
            hepatocellular carcinoma (HCC) cells.
            Correction to:[Eur Rev Med Pharmacol Sci. 2015 Sep;19(17):3208-17..
            PMID: 26400524]
REFERENCE   2  (bases 1 to 5703)
  AUTHORS   Sun,L., Ke,M., Yin,M., Zeng,Y., Ji,Y., Hu,Y., Fu,S. and Zhang,C.
  TITLE     Extracellular vesicle-encapsulated microRNA-296-3p from
            cancer-associated fibroblasts promotes ovarian cancer development
            through regulation of the PTEN/AKT and SOCS6/STAT3 pathways
  JOURNAL   Cancer Sci 115 (1), 155-169 (2024)
   PUBMED   37972389
  REMARK    GeneRIF: Extracellular vesicle-encapsulated microRNA-296-3p from
            cancer-associated fibroblasts promotes ovarian cancer development
            through regulation of the PTEN/AKT and SOCS6/STAT3 pathways.
REFERENCE   3  (bases 1 to 5703)
  AUTHORS   Li,S., Lu,X., Zheng,D., Chen,W., Li,Y. and Li,F.
  TITLE     Methyltransferase-like 3 facilitates lung cancer progression by
            accelerating m6A methylation-mediated primary miR-663 processing
            and impeding SOCS6 expression
  JOURNAL   J Cancer Res Clin Oncol 148 (12), 3485-3499 (2022)
   PUBMED   35907010
  REMARK    GeneRIF: Methyltransferase-like 3 facilitates lung cancer
            progression by accelerating m6A methylation-mediated primary
            miR-663 processing and impeding SOCS6 expression.
REFERENCE   4  (bases 1 to 5703)
  AUTHORS   Xue,X., Liu,M., Wang,Y., Yang,Y., Li,Z., Shi,R. and Miao,Y.
  TITLE     MicroRNA-494-3p Exacerbates Renal Epithelial Cell Dysfunction by
            Targeting SOCS6 under High Glucose Treatment
  JOURNAL   Kidney Blood Press Res 47 (4), 247-255 (2022)
   PUBMED   35038704
  REMARK    GeneRIF: MicroRNA-494-3p Exacerbates Renal Epithelial Cell
            Dysfunction by Targeting SOCS6 under High Glucose Treatment.
REFERENCE   5  (bases 1 to 5703)
  AUTHORS   Ouyang,J., An,T., Wang,Y., Lu,X., Zhang,Y., Wang,X., Zhang,X. and
            Zhang,C.
  TITLE     Down-regulation of SOCS6: an unfavorable prognostic factor for
            gastrointestinal stromal tumor proven by survival analysis
  JOURNAL   Diagn Pathol 16 (1), 113 (2021)
   PUBMED   34895274
  REMARK    GeneRIF: Down-regulation of SOCS6: an unfavorable prognostic factor
            for gastrointestinal stromal tumor proven by survival analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5703)
  AUTHORS   Bayle,J., Letard,S., Frank,R., Dubreuil,P. and De Sepulveda,P.
  TITLE     Suppressor of cytokine signaling 6 associates with KIT and
            regulates KIT receptor signaling
  JOURNAL   J Biol Chem 279 (13), 12249-12259 (2004)
   PUBMED   14707129
REFERENCE   7  (bases 1 to 5703)
  AUTHORS   Krebs,D.L., Uren,R.T., Metcalf,D., Rakar,S., Zhang,J.G., Starr,R.,
            De Souza,D.P., Hanzinikolas,K., Eyles,J., Connolly,L.M.,
            Simpson,R.J., Nicola,N.A., Nicholson,S.E., Baca,M., Hilton,D.J. and
            Alexander,W.S.
  TITLE     SOCS-6 binds to insulin receptor substrate 4, and mice lacking the
            SOCS-6 gene exhibit mild growth retardation
  JOURNAL   Mol Cell Biol 22 (13), 4567-4578 (2002)
   PUBMED   12052866
REFERENCE   8  (bases 1 to 5703)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   9  (bases 1 to 5703)
  AUTHORS   Mooney,R.A., Senn,J., Cameron,S., Inamdar,N., Boivin,L.M., Shang,Y.
            and Furlanetto,R.W.
  TITLE     Suppressors of cytokine signaling-1 and -6 associate with and
            inhibit the insulin receptor. A potential mechanism for
            cytokine-mediated insulin resistance
  JOURNAL   J Biol Chem 276 (28), 25889-25893 (2001)
   PUBMED   11342531
REFERENCE   10 (bases 1 to 5703)
  AUTHORS   Masuhara,M., Sakamoto,H., Matsumoto,A., Suzuki,R., Yasukawa,H.,
            Mitsui,K., Wakioka,T., Tanimura,S., Sasaki,A., Misawa,H.,
            Yokouchi,M., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of novel CIS family genes
  JOURNAL   Biochem Biophys Res Commun 239 (2), 439-446 (1997)
   PUBMED   9344848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020082.1 and AC023395.8.
            
            On Nov 22, 2018 this sequence version replaced NM_004232.3.
            
            Summary: The protein encoded by this gene contains a SH2 domain and
            a CIS homolog domain. The protein thus belongs to the
            cytokine-induced STAT inhibitor (CIS), also known as suppressor of
            cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI),
            protein family. CIS family members are known to be
            cytokine-inducible negative regulators of cytokine signaling. The
            expression of this gene can be induced by GM-CSF and EPO in
            hematopoietic cells. A high expression level of this gene was found
            in factor-independent chronic myelogenous leukemia (CML) and
            erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.214235.1,
                                           SRR1660807.205991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397942.4/ ENSP00000381034.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2617              BC020082.1         19-2635
            2618-5702           AC023395.8         144498-147582
            5703-5703           AC023395.8         147583-147583
FEATURES             Location/Qualifiers
     source          1..5703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.2"
     gene            1..5703
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /note="suppressor of cytokine signaling 6"
                     /db_xref="GeneID:9306"
                     /db_xref="HGNC:HGNC:16833"
                     /db_xref="MIM:605118"
     exon            1..46
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /inference="alignment:Splign:2.1.0"
     exon            47..5703
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1780
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /note="STAT induced STAT inhibitor-4; suppressor of
                     cytokine signaling 4; cytokine-inducible SH2 protein 4"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 6"
                     /protein_id="NP_004223.2"
                     /db_xref="CCDS:CCDS11998.1"
                     /db_xref="GeneID:9306"
                     /db_xref="HGNC:HGNC:16833"
                     /db_xref="MIM:605118"
                     /translation="MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFG
                     SCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADED
                     TFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVH
                     SSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQ
                     DYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVA
                     PEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEA
                     HVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRW
                     EAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEG
                     HTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVI
                     RQYTRIDLIQKLPLPNKMKDYLQEKHY"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /note="hexamer: ATTAAA"
     polyA_site      2622
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /note="major polyA site"
     regulatory      5681..5686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /note="hexamer: AATAAA"
     polyA_site      5703
                     /gene="SOCS6"
                     /gene_synonym="CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6;
                     SOCS4; SSI4; STAI4; STATI4"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgccg gcgctgggcg aggaagcgga gccgggccgc ctccggaaaa tggctccaaa
       61 ggttaaatga agcaggaaaa atacatagat gcagccttgc agcctctcca gatgtttggg
      121 gataatattc cagatagaaa tattgatccc ttggattagg taactagtca taatgaagaa
      181 aattagtctt aaaaccttac ggaaatcttt taacttgaat aaaagtaaag aagaaactga
      241 tttcatggta gtacaacaac catcgctagc cagtgacttt ggaaaagatg attccttatt
      301 tggtagctgc tatggtaaag atatggccag ctgcgatatc aacggtgaag atgaaaaagg
      361 cggaaaaaac agatcaaaaa gcgagagcct gatgggtacg ctaaaaaggc ggctttctgc
      421 aaaacagaag tcaaaaggca aggcgggcac accctctggg agctctgccg acgaggacac
      481 cttctcctcc tcctcagcac ccatagtctt taaagacgtg agagctcaga ggccgataag
      541 gtccacgtcg ctccgcagcc atcactacag tcccgcgccg tggcctctgc ggcccacaaa
      601 ctccgaggag acctgcatca agatggaggt gagagtcaag gccttggttc actcttccag
      661 cccgagtcca gccctgaatg gcgtccggaa ggatttccac gacctccagt ctgagaccac
      721 gtgccaggag caagccaatt cactgaagag ctcggcttct cataatggag acctgcatct
      781 tcacctggat gaacatgtgc ctgtcgttat tggacttatg cctcaggact acattcagta
      841 tactgtgcct ttagatgagg ggatgtatcc tttggaagga tcacggagct attgtctgga
      901 cagctcttct cccatggaag tctctgcggt tcctcctcaa gtgggagggc gcgctttccc
      961 cgaggatgag agtcaggtag accaggacct agttgtcgcc ccagagatct tcgtggatca
     1021 gtccgtgaat ggcttgttga ttggcaccac gggagtcatg ttgcagagcc cgagagcggg
     1081 tcacgatgat gtccctccac tctcaccatt gctacctcca atgcagaata atcaaatcca
     1141 aaggaacttc agtggactca ctggcacaga agcccacgtg gctgaaagta tgcgctgtca
     1201 tttgaatttt gatccgaact ctgctcctgg ggttgcaaga gtttatgact cagtgcaaag
     1261 tagtggtccc atggttgtga caagccttac agaggagctg aaaaaacttg caaagcaagg
     1321 atggtactgg ggaccaatca cacgttggga ggcagaaggg aagctagcaa acgtgccaga
     1381 tggttctttt cttgttcggg acagttctga cgaccgttac cttttaagct tgagctttcg
     1441 ctcccatggt aaaacacttc acactagaat tgagcactca aatggtaggt ttagctttta
     1501 tgaacagcca gatgtggaag gacatacgtc catagttgat ctaattgagc attcaatcag
     1561 ggactctgaa aatggagctt tttgttattc aaggtctcgg ctgcctggat ctgcaactta
     1621 ccccgtcaga ctgaccaacc cagtgtcccg gttcatgcag gtgcgctcgt tgcagtacct
     1681 gtgtcgtttt gttatacgtc agtataccag aatagactta attcagaaac tgcctttgcc
     1741 aaacaaaatg aaggattatt tacaggagaa gcactactga aagattgaga accctgcatc
     1801 ttgcactttg ggaataagaa caagagattg aaatacagtt tacaaacttt cattgccatc
     1861 aaaatctttt gctgccataa ctatttcagt tttatgtgta aaagagtcat cagtttgttt
     1921 aggggtgggg aagtgtcagc aaggtgtctt gggtttattt tggttcttta aaaaagggaa
     1981 gtcttgaggt tttagaggtg tgaattatgt ttcatcaatg tgcagaataa tcacaatgtg
     2041 aattatcaaa ttctcctcaa tgcccccccc gcccagtcct ttgctgctat ccactgtgat
     2101 ttttatgcat taaaagcaca tttcatgtgt attcaaccct aagtaaagtt gaatgaaact
     2161 taacagaatg gaaattgcta tgtcttttta aatggtccat tttcaaaaga cagtgttgaa
     2221 taaacatacc tgtgtgataa aacacagaat ttacatatac actgaagatg agtttttaat
     2281 ctcttacttt aaaaagattt atttagaatc gtgaattgac ataatcttgg gtaatggaac
     2341 ggagatctgc aacatatctt ttaacaacac ttttttctaa attatttcta aggttgtgct
     2401 aattcttttg gttgtgaaaa gttgaatttt tctgttgcct tcgttttcat cttctagttt
     2461 gtctatttta ataaatggcc ttacattaaa aaattgtaaa gaaatgtata ccaccaattt
     2521 agaaattgtt gccttttctg taattaaact cgggtacaaa ttggcataac atgaaaacct
     2581 atggaactag aattattatt aaagaaatat tagatgatca tagcttcctg tgatagcatt
     2641 tttttgtgtg ttacctatcc ttttggtaaa atgttttatc tgtgatttct ttagcttagt
     2701 caacattttc ttgggtgaac ttgattgtca actaattttc ataaatggac tggattctct
     2761 tgcaacatta atgtttataa aaagttttaa attgatttga atagaaagaa aacattgttt
     2821 taaagttgga tttatatttt tcttctatgt agttactata aaagtgtgct ggatttgacc
     2881 aatccttacc cccactataa agagaacccg tgatgacttt agtttaaaaa ttgtggaaat
     2941 tgtggagcaa tttttctcac aatgtgagaa aaattctaaa ccatattaga taatgtggaa
     3001 gtcatattgt ctatcatata tactgccatt taaaaatagg tttttaaaat ttagctaagt
     3061 cttaagtaat ttgccgttgc taataatttt atctccttga gtcggttgtt ggggagagat
     3121 gttatattca ataattttta gttattttgt aatgcagagt gtttattcat ttcacagttc
     3181 tgcaatggat gtagtatttt gggattgccc tgtccagaaa attttcagct acacaccttt
     3241 aaaggaaaat gtttctatct cagatgaaac atgtaatttg ggatggttct tcctttgtca
     3301 cttaaaggaa gagataggaa aagtctctta cccactttaa acatgagggt aaaggtttag
     3361 gtcaaactta ctggctttgt cattcaagca tatctgaatc ctcacttttt tctctttgct
     3421 ttttagggtc agaactgaga tattaccaag aaaaggcaca atgccataat attatggtgt
     3481 tatggtattt tgacttaaag gggaaaaggt acttaatttt ggtgggatgt tgattgtacc
     3541 ttgttaaaaa gactctcatt ttctcatatg ttttctccta ataagatgga atatggagta
     3601 tactgtaata atataagtgt tcattataag ctatttggat taagaactat tgcagagttg
     3661 taagcttgtt atcaaattaa tgcaagacat ttaaactatt tttttgcaaa actatttatt
     3721 tttaaaacaa cttaaagtat atctagggtg agttaaaagt ccctgtgcat ctatattaga
     3781 tggcaggttt tgtcacagag tcactgtgta ttaataataa atgttgaaat ggcttctccg
     3841 tgtctccaga agcatttaca tgtcctcctt gtgagatcat ggtgcacaga ggtctttgga
     3901 ctgccctgaa cccgtcttat gtggacataa cctattccct tcgttttctc atcatgccat
     3961 gtgtttaaga tctacccgct tagtgtcaag attattgaga ttttcatcta aatgttttta
     4021 aaattgtatt ttgtgtttta gtggaggaca gtcttgatac tgttctaatt cagaaagcca
     4081 aattttgatg cgcttttgta tattcataat atatacttta atatgcccta ttctaatcta
     4141 gtttgaaatt gttagattct gatagtataa tgataaaatc aaactatttg ccaaaaagtt
     4201 aaatttacaa gcagaaagat gttttgcgat attttctact tttgtgtaga aagataacca
     4261 tttggggtag gcagcacaac agaatgtgaa agattggctt tatatgatac taacacagtc
     4321 cagttaaaag tggaaacagg gaaaagagag agagaaaact catcatttag tttggtctag
     4381 acacaatttg gttaaatttt aggattctat tggcagttaa catagatgac atggacacag
     4441 cctatgagtg ctttttaaat acgtgcttct aaaaatctga gctcaaagca agaaaaagaa
     4501 aacaggaaag ctgtatccat ttgccataat agatgaatca gaattgtttt ctattaaata
     4561 tttcatcacg aaatatgatg gaggccagaa gctattttta ggcttactat aacactatta
     4621 tgcattttta taaataagaa gaaggctgta gaaagtactt gaaaaatatc taattctctt
     4681 tctgtctaag gaaaactctt tctacttggt gcaataatct gaaaatttag aaggtcaaaa
     4741 tatgtcacag gaaatgatca tagacctaaa aatagttttt aaggaaacca gctacacggg
     4801 gcaaccaacc atcttgctgt tgaagaaaac agttccaaaa ggctaaatca ttggcataaa
     4861 ggaaacaaaa cccaaagtat gcgttgtaat tcttgagcca gtattactga aacaggataa
     4921 aagttataaa atctaacata ggttaatgca atgtctctgc tagtgctaca agtctaaaat
     4981 atctttgtaa caatgctttc agaaatgcca gttttaatta catttcacat tgtatatgag
     5041 agatactgct ttatgaatga atcggaataa tacattttca tttaaatctt aattgctttt
     5101 cattaaatgc gaagtcttaa tttcaaaatg aaatcacact accagcaata gacagttttc
     5161 ttgaaaactc taataaggaa caatagccag ttccgtaaat aactttaaaa ttctaaaagt
     5221 gttggtacac tagcaatcac aaatatggtt tcttttaata cttttttaat cctgtaaaga
     5281 agggttttta taaacattct ttttattaat cagtcataac atggcgaagt gtgtagttgc
     5341 tgtttctgaa aagtgatcca aactctacat ccagagatta tgaaaaattc ttatagaatt
     5401 ttgtaacaag tatttacatg ttgggtgaaa gaaatttcat agtcgttgga gtgccatgaa
     5461 attaatactt gcaattcaga ttgcggtagt ttacactttt tctgtatgtt tcaaatcagg
     5521 tgtgtaccat ttgtactgag aacaccacag aatgaattat ccaaagtcca ttgattttaa
     5581 tacgtgtttt ggtttgtaaa caaattatag taatttcttg cacatttttg gaaattaatt
     5641 gtataagaat ttatgtatct gcttctagat acagtgtgta aataaaaaat ttcgttcaca
     5701 aga
//
