LOCUS       NM_144949               4766 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens suppressor of cytokine signaling 5 (SOCS5), transcript
            variant 2, mRNA.
ACCESSION   NM_144949
VERSION     NM_144949.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4766)
  AUTHORS   Lei,Y., He,J., Hu,F., Zhu,H., Gu,J., Tang,L. and Luo,M.
  TITLE     Sequential inspiratory muscle exercise-noninvasive positive
            pressure ventilation alleviates oxidative stress in COPD by
            mediating SOCS5/JAK2/STAT3 pathway
  JOURNAL   BMC Pulm Med 23 (1), 385 (2023)
   PUBMED   37828534
  REMARK    GeneRIF: Sequential inspiratory muscle exercise-noninvasive
            positive pressure ventilation alleviates oxidative stress in COPD
            by mediating SOCS5/JAK2/STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4766)
  AUTHORS   Hussain,S., Rasool,R., Shafi,T., Gull,A., Qureshi,T.A., Jan,R. and
            Shah,Z.A.
  TITLE     Evaluation of SOCS5 mRNA and its association with serum IL-12
            levels and rs41379147 SNP in various subsets of allergic disorders:
            A case control study
  JOURNAL   Mol Immunol 162, 102-110 (2023)
   PUBMED   37672963
  REMARK    GeneRIF: Evaluation of SOCS5 mRNA and its association with serum
            IL-12 levels and rs41379147 SNP in various subsets of allergic
            disorders: A case control study.
REFERENCE   3  (bases 1 to 4766)
  AUTHORS   Liu,C.W., Peng,H.Y., Siao,A.C., Tsuei,Y.W., Lin,Y.Y., Shiah,S.G.,
            Shih,L.J., Yeh,C.C., Lee,S.W. and Kao,Y.H.
  TITLE     Resistin stimulates PC-3 prostate cancer cell growth through
            stimulation of SOCS3 and SOCS5 genes
  JOURNAL   Exp Biol Med (Maywood) 248 (20), 1695-1707 (2023)
   PUBMED   37646261
  REMARK    GeneRIF: Resistin stimulates PC-3 prostate cancer cell growth
            through stimulation of SOCS3 and SOCS5 genes.
REFERENCE   4  (bases 1 to 4766)
  AUTHORS   Yu,J., Han,L., Yang,F., Zhao,M., Zhou,H. and Hu,L.
  TITLE     SOCS5 contributes to temozolomide resistance in glioblastoma by
            regulating Bcl-2-mediated autophagy
  JOURNAL   Bioengineered 13 (6), 14125-14137 (2022)
   PUBMED   35730472
  REMARK    GeneRIF: SOCS5 contributes to temozolomide resistance in
            glioblastoma by regulating Bcl-2-mediated autophagy.
REFERENCE   5  (bases 1 to 4766)
  AUTHORS   Zhang,J., Guo,Y., Sun,Y., Chang,L. and Wang,X.
  TITLE     Inhibition of microRNA-448 suppresses CD4+ T cell inflammatory
            activation via up-regulating suppressor of cytokine signaling 5 in
            systemic lupus erythematosus
  JOURNAL   Biochem Biophys Res Commun 596, 88-96 (2022)
   PUBMED   35121374
  REMARK    GeneRIF: Inhibition of microRNA-448 suppresses CD4(+) T cell
            inflammatory activation via up-regulating suppressor of cytokine
            signaling 5 in systemic lupus erythematosus.
REFERENCE   6  (bases 1 to 4766)
  AUTHORS   Wang,J. and Campbell,I.L.
  TITLE     Cytokine signaling in the brain: putting a SOCS in it?
  JOURNAL   J Neurosci Res 67 (4), 423-427 (2002)
   PUBMED   11835308
  REMARK    Review article
REFERENCE   7  (bases 1 to 4766)
  AUTHORS   Cooney,R.N.
  TITLE     Suppressors of cytokine signaling (SOCS): inhibitors of the
            JAK/STAT pathway
  JOURNAL   Shock 17 (2), 83-90 (2002)
   PUBMED   11837794
  REMARK    Review article
REFERENCE   8  (bases 1 to 4766)
  AUTHORS   Krebs,D.L. and Hilton,D.J.
  TITLE     SOCS proteins: negative regulators of cytokine signaling
  JOURNAL   Stem Cells 19 (5), 378-387 (2001)
   PUBMED   11553846
  REMARK    Review article
REFERENCE   9  (bases 1 to 4766)
  AUTHORS   Magrangeas,F., Apiou,F., Denis,S., Weidle,U., Jacques,Y. and
            Minvielle,S.
  TITLE     Cloning and expression of CIS6, chromosome assignment to 3p22 and
            2p21 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 78-81 (2000)
   PUBMED   10773671
REFERENCE   10 (bases 1 to 4766)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF073958.1, AB014571.1,
            AI433294.1 and AC020604.9.
            
            On Nov 22, 2018 this sequence version replaced NM_144949.2.
            
            Summary: The protein encoded by this gene contains a SH2 domain and
            a SOCS BOX domain. The protein thus belongs to the suppressor of
            cytokine signaling (SOCS) family, also known as STAT-induced STAT
            inhibitor (SSI) protein family. SOCS family members are known to be
            cytokine-inducible negative regulators of cytokine signaling. The
            specific function of this protein has not yet been determined. Two
            alternatively spliced transcript variants encoding an identical
            protein have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.182125.1,
                                           SRR1660803.80508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394861.3/ ENSP00000378330.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-913               AF073958.1         86-998
            914-4418            AB014571.1         919-4423
            4419-4425           AI433294.1         2-8                 c
            4426-4766           AC020604.9         115977-116317
FEATURES             Location/Qualifiers
     source          1..4766
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..4766
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /note="suppressor of cytokine signaling 5"
                     /db_xref="GeneID:9655"
                     /db_xref="HGNC:HGNC:16852"
                     /db_xref="MIM:607094"
     exon            1..155
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /inference="alignment:Splign:2.1.0"
     exon            156..4766
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1778
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /note="cytokine-inducible SH2 protein 6; CIS-6;
                     cytokine-inducible SH2-containing protein 5"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 5"
                     /protein_id="NP_659198.1"
                     /db_xref="CCDS:CCDS1830.1"
                     /db_xref="GeneID:9655"
                     /db_xref="HGNC:HGNC:16852"
                     /db_xref="MIM:607094"
                     /translation="MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKN
                     ISIGDSTPQQQSSPLRENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCV
                     TPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSS
                     VHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKC
                     PFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGV
                     DPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQ
                     SRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAE
                     ALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSS
                     TVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPS
                     MLQDFLKEYHYKQKVRVRWLEREPVKAK"
     polyA_site      4239
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
     regulatory      4277..4282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /note="hexamer: AAGAAA"
     polyA_site      4303
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /note="major polyA site"
     regulatory      4395..4400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /note="hexamer: AATACA"
     polyA_site      4420
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
     regulatory      4742..4747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
                     /note="hexamer: AATACA"
     polyA_site      4766
                     /gene="SOCS5"
                     /gene_synonym="CIS6; Cish5; CISH6; SOCS-5"
ORIGIN      
        1 gtccggagga agcgacgctg cgctcgctgg gcagtcggag gggacgggac gcaccggagg
       61 gcaggcggac tcgccctgtc ggtgactgcg ccgtccgggc ccgtcctgcc tggccgcagg
      121 tgccctggat gaggccgccc cgcgcgcccc aaacgatttt ataatcaatg gataaagtgg
      181 gaaaaatgtg gaataacttc aaatacaggt gtcagaatct cttcggtcat gagggaggaa
      241 gccgtagtga aaatgtggac atgaactcca acagatgttt gtctgtcaaa gagaaaaaca
      301 tcagcatagg agactcaact cctcagcaac aaagcagtcc cttaagagaa aatattgcct
      361 tacaactggg attaagccct tcgaagaatt cttcaaggag aaatcaaaat tgtgccacag
      421 aaatccctca aattgttgaa ataagcatcg aaaaggataa tgattcttgt gttaccccag
      481 gaacaagact tgcacgaaga gattcctact ctcgacatgc tccatggggt gggaagaaaa
      541 aacattcctg ttctacaaag acccagagtt cattggatgc tgataaaaag tttggtagaa
      601 ctcgaagtgg acttcaaagg agagagaggc gctacggcgt aagttctgta cacgacatgg
      661 acagtgtttc cagcagaact gtaggaagtc gctctctaag acagaggttg caggatactg
      721 tgggcttgtg ttttcccatg agaacttaca gcaagcagtc aaagcctctc ttttccaata
      781 aaagaaaaat ccatctctct gaattaatgc ttgagaaatg cccttttcct gctggctcag
      841 atttagccca aaaatggcat ttgattaaac agcatacagc tcctgtgagc ccacattcaa
      901 cattttttga tacatttgat ccatctttgg tttctacaga agatgaagaa gataggctta
      961 gagagagaag gcggcttagt attgaagaag gggttgatcc ccctcccaat gcacaaatac
     1021 atacatttga agctactgca caggttaatc cattatataa actgggacca aaattagctc
     1081 ctggaatgac tgaaataagt ggggacagtt ctgcaattcc acaagctaat tgtgactcgg
     1141 aagaggatac aaccaccctg tgtttgcagt cacggaggca gaagcagcgt cagatatctg
     1201 gagacagcca tacccatgtt agcagacagg gagcttggaa agtccacaca cagattgatt
     1261 acatacactg cctcgtgcct gatttgcttc aaattacagg gaatccctgt tactggggag
     1321 tgatggaccg ttatgaagca gaagcccttc tcgaagggaa acctgaaggc acgtttttgc
     1381 tcagggactc tgcgcaagag gactacctct tctctgtgag cttccgccgc tacaacagat
     1441 ccctgcatgc ccgaattgag cagtggaatc acaactttag tttcgacgcc catgacccgt
     1501 gtgtatttca ctcctccact gtaacgggac ttttagaaca ttataaagat cccagttcgt
     1561 gcatgttttt tgaaccattg cttactatat cactaaatag gactttccct tttagcctgc
     1621 agtatatctg tcgcgcggta atctgcaggt gcactacgta tgatggaatt gatgggctcc
     1681 ctctaccctc aatgttacag gattttttaa aagagtatca ttataaacaa aaagttagag
     1741 ttcgctggtt ggaacgagaa ccagtcaagg caaagtaaac tctccggtcc ccaaaggttg
     1801 ttaactaggt ccgctttcat gtgcatcaga cagtacacct atagcaagca cacgtagcag
     1861 tgttaggctt tttcatacag tatgtaagct tagtgttagt atctgtcaga tgctacctgc
     1921 tgttacttat tcagataaac atggtgccta ttggaacaat agcggataga gctacaggtg
     1981 ttcagtaaga ctacaaaaac attttgccta tttcgctaac agtttggttt ttaatggctg
     2041 tggtatttga gtgaggcaac tctggggcat ttgttatgaa gaattctatt tcttactgaa
     2101 gaacaaatta ttaatattgg atgagtattt caacagtgtg actaatgttt gaaattattt
     2161 tttctaagag tttttctata accttccaaa agtcgtgatg tttgtagtta ctataaatca
     2221 agctttggaa gtccaaaaag aataaaagac tgccttcctt ttagaaaaaa atgcaatttt
     2281 ctggccacaa gggcatagtg cagttcactt acgtgttgat gtagtttata atcagacgcc
     2341 ttttctcttc tgcaaaaggt actgttaagt aaaccagatt ttctaaatag gcattcttaa
     2401 aatttcagac ttacaaagct agtagtagaa ttttattgaa aggcctaggt attaattttt
     2461 taaatgagtg ctttaactta aaacaggcgt ttggaatagc tgctgcaatg tagtcttgtg
     2521 tgtgattttt ttttaagttg atgtgcagtc taattgttgt ttcataaaag ttggatctgt
     2581 tcctatgccc aggatgattt tgtgaaccgt gaagtacgtg agactagaag acgcccaaac
     2641 aagtcagata atagtaacta caatggttgc tgatgttgag attattgttg aactataatt
     2701 aataatttgg atggcagaat ttatctcttt tttgtaaact ctcataactg aattgcttaa
     2761 gtataattta tagaatttca gtgcagttca ttcttaatgg aaaatctgaa acctaaattg
     2821 cagatttaaa aggtactgta caaccattat atctgtaaat aacttagcac ctttttgtca
     2881 cttagaataa tatgtactac tacttgagtg agcgcttttg gaagttatat caagttctag
     2941 tgtttgcttc ttagtaactg aactgaattt acagttctgt cctagacatt ttgcactaaa
     3001 gtagccgaat ccactctcat gtcttttcgt taatgtgctc tgtaccactg gtgagtgctc
     3061 catagtttcc ttacctgctg ctacagaatg ttattttaca tccctatggc tattgccaag
     3121 gctacaaaaa aggaaagcta tatttgtatg caacactaac cttttgactg ctaatgtatg
     3181 tttctgcttg ctgtgccttg ttatggctgc tttttttgtg ctaataaagt atgtttggtg
     3241 ttctccttgt atatctgctg ttttatacat ttgcaacaat ttctcttgta aatggaatgg
     3301 tttggggttt ttaaataagc attaactaac aacctttcta tagttaatgc agagttaatg
     3361 aacagtctaa tattgactta tcagaataag ctaactctaa atttaatgct ctacatctta
     3421 tcagtcataa ttatatatac tgtggaacag tatctgtagt tactgcaaat tactgtacag
     3481 tttaggttat aacagaaaac tgacagagaa gtaataaacc tattgatttc tctgcttata
     3541 aatgaaagat tgaaactatc caatgacata ttatagtaaa tgagtatctg taacctccca
     3601 ctgcatcaga agcaggttaa atgaagtctt gtgaatttgt aatagatcag taccatttat
     3661 tggtttgggg accatcttaa ttaaaaataa atgcccaaaa tgtagaactt taaccaaaga
     3721 cttgtccctt ttaaagcaaa atggggattg aagggactta taatttctgt tgtttctaat
     3781 taaagtccct gaagatcata taccaaagtg tttgagaact tcatccaaac ctactttaaa
     3841 gcattatgtg caattaagtt gttatgacat aattatattg cctaattgtt gggtcttttt
     3901 tcttgagctt ataatgtacc tggaaaataa acctcttgag aaaaagaaaa gttcatactg
     3961 attattggaa aaggactata tatgtgagca agattgtgtt ttagagagga aacttgaaac
     4021 tccaagaaag cacttgatgt ttttatatgc ttgtagcaaa ttgatgttct aactgtagtt
     4081 ttatagaaag tattaatgct tttatgtatt tcaaaacttt catatgttaa atggaaattg
     4141 ttttaaatgt gtttgagttt atgtaagcat gtatacactg tgctaaaagt cacatgtttc
     4201 agtttgtgta taatattaat atgcaatttt tggtttaaat ttttgtctta aaatattagt
     4261 ggcttacatt ttaaaaaaga aaaatcacca gcatgaactt gcacctaagt ctatattcac
     4321 tgtgtccttt tctgaatccc attgtagcct gtcaactaaa tttgagtgtt aacggtcttt
     4381 ttaaagtgca tttaaataca aaccaggaat ttctttagaa gttgagatac atctttatag
     4441 ttgaaataat taacccaaga aaaggttgct ttgatttgta cccattctca ttcattttct
     4501 tcattccctt acacacacac acacacctct cccttccgca tacatataag tgtgtattat
     4561 atatttatgt atgcacatat atacatttat gttgttaata ttactttaga tggcatttcc
     4621 acctgataca aaaacattta gagatcttat tctatagata ttacctaaag agtattcttg
     4681 tactattcga attttattat ctgcactaaa agtttagcct tgctacttta gccttgttta
     4741 taatacagtc accttacaaa gagaaa
//
