LOCUS       NM_199421               6903 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens suppressor of cytokine signaling 4 (SOCS4), transcript
            variant 1, mRNA.
ACCESSION   NM_199421
VERSION     NM_199421.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6903)
  AUTHORS   Song,W., Chen,Y., Zhu,G., Xie,H., Yang,Z. and Li,L.
  TITLE     Exosome-mediated miR-9-5p promotes proliferation and migration of
            renal cancer cells both in vitro and in vivo by targeting SOCS4
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1216-1224 (2020)
   PUBMED   32819588
  REMARK    GeneRIF: Exosome-mediated miR-9-5p promotes proliferation and
            migration of renal cancer cells both in vitro and in vivo by
            targeting SOCS4.
REFERENCE   2  (bases 1 to 6903)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6903)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6903)
  AUTHORS   Nafar,M., Kalantari,S., Omrani,M.D., Samavat,S., Arsang-Jang,S.,
            Taheri,M. and Ghafouri-Fard,S.
  TITLE     Suppressor of cytokine signaling genes in renal transplant
            receivers: Association with transplant fate
  JOURNAL   Transpl Immunol 56, 101228 (2019)
   PUBMED   31398463
  REMARK    GeneRIF: SOCS4 expression was lower in T-cell-mediated kidney
            allograft rejection group compared with non-rejected individuals
REFERENCE   5  (bases 1 to 6903)
  AUTHORS   Wu,X., Cai,D., Zhang,F., Li,M. and Wan,Q.
  TITLE     Long noncoding RNA TUSC7 inhibits cell proliferation, migration and
            invasion by regulating SOCS4 (SOCS5) expression through targeting
            miR-616 in endometrial carcinoma
  JOURNAL   Life Sci 231, 116549 (2019)
   PUBMED   31200002
  REMARK    GeneRIF: Mechanistic investigations demonstrated that TUSC7 can
            interact with miR-616 and decrease its expression, thereby
            upregulating the expression of miR-616's targets SOCS4 (SOCS5).
REFERENCE   6  (bases 1 to 6903)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6903)
  AUTHORS   Bullock,A.N., Rodriguez,M.C., Debreczeni,J.E., Songyang,Z. and
            Knapp,S.
  TITLE     Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS
            box interface and the molecular basis for SOCS-dependent EGFR
            degradation
  JOURNAL   Structure 15 (11), 1493-1504 (2007)
   PUBMED   17997974
  REMARK    GeneRIF: The structure of the SOCS4-ElonginC-ElonginB complex
            reveals a distinct SOCS structural class.
REFERENCE   8  (bases 1 to 6903)
  AUTHORS   Kario,E., Marmor,M.D., Adamsky,K., Citri,A., Amit,I., Amariglio,N.,
            Rechavi,G. and Yarden,Y.
  TITLE     Suppressors of cytokine signaling 4 and 5 regulate epidermal growth
            factor receptor signaling
  JOURNAL   J Biol Chem 280 (8), 7038-7048 (2005)
   PUBMED   15590694
  REMARK    GeneRIF: the expression of SOCS5 and its closest homolog SOCS4 is
            elevated in cells following treatment with EGF, similar to several
            negative feedback regulators of EGFR whose expression is
            up-regulated upon receptor activation.
REFERENCE   9  (bases 1 to 6903)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   10 (bases 1 to 6903)
  AUTHORS   Naka,T., Fujimoto,M. and Kishimoto,T.
  TITLE     Negative regulation of cytokine signaling: STAT-induced STAT
            inhibitor
  JOURNAL   Trends Biochem Sci 24 (10), 394-398 (1999)
   PUBMED   10500304
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD109883.1, BC060790.1,
            AK126195.1 and BX648734.1.
            
            On Nov 22, 2018 this sequence version replaced NM_199421.1.
            
            Summary: The protein encoded by this gene contains a SH2 domain and
            a SOCS BOX domain. The protein thus belongs to the suppressor of
            cytokine signaling (SOCS), also known as STAT-induced STAT
            inhibitor (SSI), protein family. SOCS family members are known to
            be cytokine-inducible negative regulators of cytokine signaling.
            Two alternatively spliced transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            it has an additional exon in the 5' region.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.72798.1,
                                           SRR1803617.82473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555846.2/ ENSP00000452522.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CD109883.1         138-149
            13-4125             BC060790.1         1-4113
            4126-6852           AK126195.1         1979-4705
            6853-6903           BX648734.1         6620-6670
FEATURES             Location/Qualifiers
     source          1..6903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..6903
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /note="suppressor of cytokine signaling 4"
                     /db_xref="GeneID:122809"
                     /db_xref="HGNC:HGNC:19392"
                     /db_xref="MIM:616337"
     exon            1..236
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /inference="alignment:Splign:2.1.0"
     exon            237..365
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /inference="alignment:Splign:2.1.0"
     exon            366..6903
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..1778
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /note="suppressor of cytokine signaling 7; SH2 domain
                     containing SOCS box protein; SOCS-4; SOCS-7"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 4"
                     /protein_id="NP_955453.1"
                     /db_xref="CCDS:CCDS9722.1"
                     /db_xref="GeneID:122809"
                     /db_xref="HGNC:HGNC:19392"
                     /db_xref="MIM:616337"
                     /translation="MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSE
                     SYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQC
                     FPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDE
                     WVSTDLSQTELRDGQLKRRNMEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLV
                     SNNSIEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVP
                     DLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHAR
                     IEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHI
                     CRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC"
     regulatory      6877..6882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /note="hexamer: ATTAAA"
     polyA_site      6903
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /note="major polyA site"
ORIGIN      
        1 acggaagtgg tggcggcgcc cagggaaccg gcggaggcga tgaccgtgac ggctgggttg
       61 ggaccggaac gccgaagcgg ggttgggggt ggcagaaaag catctgcttt gtaagaccta
      121 cacgaggtgc aggagtggtt gggcctcccc tctccactta agcaagcgcc cagactgatg
      181 gcgatggtga tggcagcagt tactcgcaca accccagtta agctgcgctc cgggaggagt
      241 tcatctgttg tctgctctcc agtgacttcc gtttgtggag cctaagtgtt tctacagaat
      301 ccaactcaaa tatcaaggac tatgatcaga atgctttcaa ggagtttttg ggcacatgat
      361 ggcagataca tccagaaagt gcccagaaga aacttcctgc tggaaaaaat gaaaaagcag
      421 tatttataac attagaatct ggataatttg ttaacatggc agaaaataat gaaaatatta
      481 gtaaaaatgt agatgtaagg cccaaaacta gtcggagcag aagtgccgac agaaaagacg
      541 gttatgtgtg gagtggaaag aagttatctt ggtcaaaaaa gagtgagagt tattcagatg
      601 ctgagacagt gaatggtata gagaaaaccg aagtgtcttt aaggaaccaa gaaaggaagc
      661 acagctgttc atccattgag ttggacttag atcattcctg tgggcatcga tttttaggcc
      721 gatctcttaa acagaaactg caagatgccg tggggcagtg ttttccaata aagaattgta
      781 gtagtcggca ctcttcaggg cttccgtcta aaaggaaaat tcatatcagt gaactcatgt
      841 tagataagtg tcctttccca cctcgatcag atttagcctt taggtggcat tttattaaac
      901 gacacactgc tcctataaat tccaaatcag atgaatgggt aagcacagac ttgtctcaga
      961 ctgaattgag ggatggtcag ctaaaacgaa gaaatatgga agaaaatata aactgtttct
     1021 cacataccaa tgttcagccc tgtgtcataa ccaccgacaa tgctttgtgt agagaaggtc
     1081 ctatgactgg ctctgtgatg aacctggttt caaataacag tatagaagat agtgatatgg
     1141 attccgatga tgaaattcta acactttgca caagttccag aaaaagaaac aaacccaaat
     1201 gggatttgga tgatgaaatc ctgcagttgg aaacacctcc taaataccac acgcagattg
     1261 attatgtcca ctgtcttgta ccagacctcc ttcagatcaa taacaaccca tgttactggg
     1321 gagtgatgga taaatacgca gccgaagcac tactggaagg aaaaccagag ggtacctttt
     1381 tacttcgaga ctcagcacag gaagactatt tattctctgt tagttttaga cgctatagtc
     1441 gttctcttca tgctagaatt gaacagtgga atcacaactt tagctttgat gcacatgacc
     1501 cctgtgtctt ccattctcct gacattactg ggctcctaga acattataag gacccaagcg
     1561 cctgtatgtt ctttgaacca cttctatcca ctcccttaat tcggactttc cctttttccc
     1621 tgcagcatat atgcagaaca gttatttgta actgtacaac ttatgatggc atcgatgccc
     1681 ttccaattcc ttcttctatg aaattatatc tgaaggaata tcattataaa tcaaaagtta
     1741 gagtactcag gattgatgca ccagaacagc aatgctagta acaggatggg aacatgggaa
     1801 tgataatata tattttttct tttaatattt tatttttctt tttatgccac tttggatttt
     1861 tctacaaagg cagtggtgtc caaaataaaa tctctgccct aaattttact aataaatcca
     1921 tttttctagt gatacacaaa ttgtttaagg ttatacactc gagcttaaat agatattttt
     1981 aaccaggtgt ttggtttttg tttttaccgt gtaggttgta tacttacatt ttttctttcc
     2041 ttaatttata catgatcctt tttccttaat ttatacatga tccaggcaca tttgaaattt
     2101 ggtaggcatt gcaaacacat ttgaatattg tgtatttcat actattcttt aaaagtaatc
     2161 ttatgtcctt tcctacatgt aaaatatttt gttaatctat gccattagta gtattatata
     2221 taaaatatag ttccccgtcc cccttttcat tgagtttgat attcttcagt aaagctgaat
     2281 gttgtaattc accattcata ctaatgttat tgacttttgt aacttactaa tagggatgtt
     2341 aaaagtaaca aaaccaagtc aaacttggtg tatttttatt ttaaatatta actctaaagc
     2401 aggattacta aatttgatta atctggtcaa tgagaatcaa atggaaacat atcattctgg
     2461 aggtgcactt actcttctac aatgtggccg gatcatttgt cattcctgaa taggtctttc
     2521 tctcaacctg caagagctaa accatcttca aaacataaat cttgttcctt tctcattgga
     2581 agctttgaaa ataatgataa cactattagt agctagtagt tactaaagtg ctaaagtaat
     2641 tgtggggttt ttctgtatta gcttatgaac tgttgcttct acttagccct tttatagaaa
     2701 ctctgagctg ttactttggg gaaattccac aatgtattag cagccacaaa tttccactgg
     2761 taaccaaaga gtacctaagt agtttttcat tattttaagt tgaatttgaa taaagattcc
     2821 agaaataaac atggagctca gtattcagga agcttaatac tgtttttgat ctacaagatc
     2881 caaataatta tccctatctt cagaattaac ttagtctgta atgtggcttc aaaaaaagaa
     2941 agccttttga cagctacatg acttacacca tacagaacag tactggacaa aaggggtgat
     3001 attttaaatt tactatccca gaaacagggc aacgttttta gaaacatctt tagcccaaag
     3061 taactagtaa aaataaatgg agtggtatcc tatcttcttt ttttaaggaa tcaatgaata
     3121 ataaatgtag atagacaatt ttcttctggt gagctgtcta accctttgta cacattgaca
     3181 tttttaatat cgtaactgat ttcttgatgc tagtttagct atattaggaa actgcttcta
     3241 cctagattga aagaaatttg actcataaac ttccaagtta gaacaaatat ttcttcatta
     3301 ttgttgcttt tatgtgagta gcatttccct atcttgcagt tctgttaaca tgaaaatggc
     3361 atttttccat aatagcttta aaataatttt ttagtaatta ttacaaaatt aaggaaaatc
     3421 tctattaccg ttatctttta gcattttttt tttcctcagt gatctcaaga ttgtcttagt
     3481 ctcaatgaga tgtagctaca aaaatggcac ctcttagcag tgatgaggct caggatatcg
     3541 gatatcataa caccaatgtc aggataaata tctcttctaa agacgatatt taccttttac
     3601 aaggttagaa aagtctcata ctacctcatc tttattgtgg cgcttttgta gatcactgag
     3661 aagcttatct tattaaccaa tataccactt cctaaatatc catctttggt gaaagaaaat
     3721 agtgtggtaa gagtacccat gattatagtt ttttatcaga atttgataag attttctgtt
     3781 tctgtgaaac aattatttta aatatttttc ttttaaaaat aactttttat cagtacagaa
     3841 aaacctaagg gatgactagc ttacaaatat tctgttaagg ggtagtttta taaagaaaaa
     3901 tgatatatag ttatgttgtc ttttatagtg ttaaaattag tatttatatg aaagtcaaga
     3961 tctaagtacc ttttcatata attcaaactg attgcttgtg atatgttttc tctggctttt
     4021 ttattttttc aacttcaagg tattaacagc tgttaacact taaaaagtac tgccacatat
     4081 gtagccttga agtagttgat ctaataaatg agagcaggga ggagattcat tgactctgaa
     4141 atgattttta tttttccttt ggtatttgct acagtgaaaa gaagtttgga aagtagatac
     4201 ataaagactt gagaagggaa ttgtttaagg gaaaagaaaa gagtaataat tttttttaaa
     4261 acattaagga attggaattc agaaaggtta cccccttcct ctgtgtcttt gtaaggatac
     4321 atttggaaga acatacagta ttcagaaact aacctatata aaatgtaaac aatatattga
     4381 ttgcactata taaatgagta aattttgaga ggaacaatgt gggaatgtat aaatttgtct
     4441 aaaattttat aactgttgaa caaagggaag atttgaacag tgtaaattcc agagttgaga
     4501 aagcatttag catggtggaa atgtggagag cttattggtg agagaggatg gagctaagag
     4561 aaataagatc aaatattaaa attaggaatt taggcattac ctcagggaaa agccttgaca
     4621 gtgaaaagaa actacttaat cgctaatagc tagtctggac cagacactta actgcgcttt
     4681 gggaatcatc ctgggctaat caggaaataa acttgacttt tctatttttc tctgaagctt
     4741 tacaggacat actcccactc ccattttttt ctaagcctac agcatcttga ttcatagtat
     4801 aattcctgaa gtatgctgaa tggacttttt aaggttcctt tagcattttt gtatagagtt
     4861 atatgtgatc tttctataac catgccattc acttaaataa ttcatgaagg gaatggttta
     4921 atttaaagga agacctaata ggaagaagat taaaggaagc ttttagtcag cctgtggcta
     4981 gatttattga tttggtgatc aaacctgtgc tatttcctga atttcagcta atggccaact
     5041 gtggtcaaag aatggctttc agttaaagtt ttgacttctt attataaata atataaagaa
     5101 tgtctcagta attagaaatc ccttaataag tagaacaaat gtggcaagta ggactcctat
     5161 cggtatacaa attccatttc tttttataag aaaaacacat aaaccattat catttattca
     5221 tgagccaaag ccattaagaa gataaatcca gttatcagct tcctgtctct gaagtttgga
     5281 tcattttata gatccacgca atagagagct tccttcctat gaaacaaaaa ccttgagatc
     5341 tctttttttt tgagacagag tctcgctgtt gtcagcccag gctggagtgc aatggcgcaa
     5401 tctcggttca ctgcaacctc tgccttccag gttccagcaa ttctcctacc tcagctccca
     5461 agtagctgag atgacaggcg tgtgccacca cgcccagcta atttttgtat ttttagtagc
     5521 gatggtgttt cactacattg gccaggctgg tctcgaactc ctgacctcag gtgaccaccc
     5581 gcctcagcct cccaaagtgc tgggattaca ggcatgagcc actgtgcccg gccaagatct
     5641 aactcacgct tacttttcat taaaatattt cttgtcgctt ttagctattg tcagaatcca
     5701 ataaacagct tacgcattca ttttggtaaa gcaaatttca caggaaaata gacaaaatta
     5761 taagagattc ctggagacaa cacaaggaaa acaatgttta aaagcaaaat agcctgtgta
     5821 atgttaggta atgtaatgcc caagtgaata aaagattttt cgtcaagcaa actactgttt
     5881 ctactttggg ggaaaaaagt cagttttaca tttgtaattt aaggaaagaa cagaaagcac
     5941 aaaggttttt cttttcttta ttaatggcct actagaaatg agcagtgcaa gagtctacct
     6001 gtactattct aatacagtaa gatattggac acaaaatgga ggtaactttt taaaatagat
     6061 tggcttggaa gttgaaatgt agattaatgg atataaccca atagaaaggg attttcaaat
     6121 aaaaccaaag tctatttttt tatttacttt ctaattttga acagatgact cagtcctaaa
     6181 tctttgcctt tatttcctat aaaatgtagg tgatacttgt aactcgactt cctggagtta
     6241 attcttcagc aagaggtgac cctgggagcg tactttaaaa taattgctgt acagccattg
     6301 agtactaaca tgatgatagg ttttcaaaat atctttgtag tggatgctgc ataattacat
     6361 tcacttctct tagactgtaa aagactttct tgacttgttt taacagtaga gatagcagta
     6421 caatttgaat ttatggttta ggctctgcaa ttagaggaac aattgcagtt tcctcctacc
     6481 cttcatatgg tctgtgtaaa actgatgttt gcttaactta ttttaaaagt tgattacgtt
     6541 ttcagaaaat aaagataatc acttttgcca tggttataat caaatctaag ctttcagact
     6601 tgagagccat ggtgtaaaac tcaaggaggt ttatttaaat tatgctgact ttgctagaat
     6661 tggataaatt ctgtataagc caagtatgag ttcacatgta ctcgaatata cagttttcac
     6721 aaagctatta ctctcatcag tcaggcttgt atgatctatt ccttaccaca aaagaagtag
     6781 acaattgcca cttttatttc taatccttaa gttgaatgtt tcttcttgga tgtaagttca
     6841 aataaattga tctggataaa ttttcatttc tacttaatta aaacttccta tgtaaaatcc
     6901 aaa
//
