LOCUS       NP_955453                440 aa            linear   PRI 27-APR-2025
DEFINITION  suppressor of cytokine signaling 4 [Homo sapiens].
ACCESSION   NP_955453
VERSION     NP_955453.1
DBSOURCE    REFSEQ: accession NM_199421.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Song,W., Chen,Y., Zhu,G., Xie,H., Yang,Z. and Li,L.
  TITLE     Exosome-mediated miR-9-5p promotes proliferation and migration of
            renal cancer cells both in vitro and in vivo by targeting SOCS4
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1216-1224 (2020)
   PUBMED   32819588
  REMARK    GeneRIF: Exosome-mediated miR-9-5p promotes proliferation and
            migration of renal cancer cells both in vitro and in vivo by
            targeting SOCS4.
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 440)
  AUTHORS   Nafar,M., Kalantari,S., Omrani,M.D., Samavat,S., Arsang-Jang,S.,
            Taheri,M. and Ghafouri-Fard,S.
  TITLE     Suppressor of cytokine signaling genes in renal transplant
            receivers: Association with transplant fate
  JOURNAL   Transpl Immunol 56, 101228 (2019)
   PUBMED   31398463
  REMARK    GeneRIF: SOCS4 expression was lower in T-cell-mediated kidney
            allograft rejection group compared with non-rejected individuals
REFERENCE   5  (residues 1 to 440)
  AUTHORS   Wu,X., Cai,D., Zhang,F., Li,M. and Wan,Q.
  TITLE     Long noncoding RNA TUSC7 inhibits cell proliferation, migration and
            invasion by regulating SOCS4 (SOCS5) expression through targeting
            miR-616 in endometrial carcinoma
  JOURNAL   Life Sci 231, 116549 (2019)
   PUBMED   31200002
  REMARK    GeneRIF: Mechanistic investigations demonstrated that TUSC7 can
            interact with miR-616 and decrease its expression, thereby
            upregulating the expression of miR-616's targets SOCS4 (SOCS5).
REFERENCE   6  (residues 1 to 440)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 440)
  AUTHORS   Bullock,A.N., Rodriguez,M.C., Debreczeni,J.E., Songyang,Z. and
            Knapp,S.
  TITLE     Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS
            box interface and the molecular basis for SOCS-dependent EGFR
            degradation
  JOURNAL   Structure 15 (11), 1493-1504 (2007)
   PUBMED   17997974
  REMARK    GeneRIF: The structure of the SOCS4-ElonginC-ElonginB complex
            reveals a distinct SOCS structural class.
REFERENCE   8  (residues 1 to 440)
  AUTHORS   Kario,E., Marmor,M.D., Adamsky,K., Citri,A., Amit,I., Amariglio,N.,
            Rechavi,G. and Yarden,Y.
  TITLE     Suppressors of cytokine signaling 4 and 5 regulate epidermal growth
            factor receptor signaling
  JOURNAL   J Biol Chem 280 (8), 7038-7048 (2005)
   PUBMED   15590694
  REMARK    GeneRIF: the expression of SOCS5 and its closest homolog SOCS4 is
            elevated in cells following treatment with EGF, similar to several
            negative feedback regulators of EGFR whose expression is
            up-regulated upon receptor activation.
REFERENCE   9  (residues 1 to 440)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   10 (residues 1 to 440)
  AUTHORS   Naka,T., Fujimoto,M. and Kishimoto,T.
  TITLE     Negative regulation of cytokine signaling: STAT-induced STAT
            inhibitor
  JOURNAL   Trends Biochem Sci 24 (10), 394-398 (1999)
   PUBMED   10500304
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD109883.1, BC060790.1,
            AK126195.1 and BX648734.1.
            
            Summary: The protein encoded by this gene contains a SH2 domain and
            a SOCS BOX domain. The protein thus belongs to the suppressor of
            cytokine signaling (SOCS), also known as STAT-induced STAT
            inhibitor (SSI), protein family. SOCS family members are known to
            be cytokine-inducible negative regulators of cytokine signaling.
            Two alternatively spliced transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            it has an additional exon in the 5' region.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.72798.1,
                                           SRR1803617.82473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555846.2/ ENSP00000452522.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     Protein         1..440
                     /product="suppressor of cytokine signaling 4"
                     /note="suppressor of cytokine signaling 7; SH2 domain
                     containing SOCS box protein; SOCS-4; SOCS-7"
                     /calculated_mol_wt=50492
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WXH5.1)"
     Region          58..111
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          275..375
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(283,285)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(293,311,313,321,334)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(344,346,364)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          384..439
                     /region_name="SOCS_SOCS4"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS4-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. The general
                     function of the SOCS box is the...; cd03738"
                     /db_xref="CDD:239707"
     Site            order(385..390,396,403,409,414)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239707"
     CDS             1..440
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /coded_by="NM_199421.2:456..1778"
                     /db_xref="CCDS:CCDS9722.1"
                     /db_xref="GeneID:122809"
                     /db_xref="HGNC:HGNC:19392"
                     /db_xref="MIM:616337"
ORIGIN      
        1 maennenisk nvdvrpktsr srsadrkdgy vwsgkklsws kksesysdae tvngiektev
       61 slrnqerkhs cssieldldh scghrflgrs lkqklqdavg qcfpikncss rhssglpskr
      121 kihiselmld kcpfpprsdl afrwhfikrh tapinsksde wvstdlsqte lrdgqlkrrn
      181 meenincfsh tnvqpcvitt dnalcregpm tgsvmnlvsn nsiedsdmds ddeiltlcts
      241 srkrnkpkwd lddeilqlet ppkyhtqidy vhclvpdllq innnpcywgv mdkyaaeall
      301 egkpegtfll rdsaqedylf svsfrrysrs lharieqwnh nfsfdahdpc vfhspditgl
      361 lehykdpsac mffepllstp lirtfpfslq hicrtvicnc ttydgidalp ipssmklylk
      421 eyhykskvrv lridapeqqc
//
