LOCUS       NM_003955               2734 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens suppressor of cytokine signaling 3 (SOCS3), transcript
            variant 1, mRNA.
ACCESSION   NM_003955
VERSION     NM_003955.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Huang,Y.L., Huang,G.Y., Chen,H., Lv,J., Wang,J., Shen,J. and
            Zhao,S.Y.
  TITLE     Exploring the clinical and cellular mechanisms of
            LncRNA-KCNQ1OT1/miR-29a-3p/SOCS3 molecular axis in cases of
            unexplained recurrent spontaneous abortion
  JOURNAL   J Matern Fetal Neonatal Med 37 (1), 2337723 (2024)
   PUBMED   38637274
  REMARK    GeneRIF: Exploring the clinical and cellular mechanisms of
            LncRNA-KCNQ1OT1/miR-29a-3p/SOCS3 molecular axis in cases of
            unexplained recurrent spontaneous abortion.
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Shin,J.J., Suk,K. and Lee,W.H.
  TITLE     LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory
            activation via the miR-30b-5p/SOC3 axis in THP-1 cells
  JOURNAL   Sci Rep 14 (1), 25726 (2024)
   PUBMED   39468152
  REMARK    GeneRIF: LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated
            inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Glover,L., Lilly,A.G., Justice,A.E., Howard,A.G., Staley,B.S.,
            Wang,Y., Kamens,H.M., Ferrier,K., Bressler,J., Loehr,L.,
            Raffield,L.M., Sims,M., North,K.E. and Fernandez-Rhodes,L.
  TITLE     DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect
            of socioeconomic status on elevated body mass index in African
            American adults
  JOURNAL   Hum Mol Genet 33 (20), 1748-1757 (2024)
   PUBMED   39079086
  REMARK    GeneRIF: DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the
            effect of socioeconomic status on elevated body mass index in
            African American adults.
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Morelli,M., Madonna,S. and Albanesi,C.
  TITLE     SOCS1 and SOCS3 as key checkpoint molecules in the immune responses
            associated to skin inflammation and malignant transformation
  JOURNAL   Front Immunol 15, 1393799 (2024)
   PUBMED   38975347
  REMARK    GeneRIF: SOCS1 and SOCS3 as key checkpoint molecules in the immune
            responses associated to skin inflammation and malignant
            transformation.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2734)
  AUTHORS   Tine,M., Balestro,E., Carpi,S., Neri,T., Biondini,D., Conti,M.,
            Casara,A., Bernardinello,N., Cocconcelli,E., Turato,G., Baraldo,S.,
            Celi,A., Spagnolo,P., Cosio,M.G., Saetta,M. and Bazzan,E.
  TITLE     Suppressor of cytokine signaling-3 expression and its regulation in
            relation to inflammation in Chronic Obstructive Pulmonary Disease
  JOURNAL   Front Immunol 15, 1320077 (2024)
   PUBMED   38533493
  REMARK    GeneRIF: Suppressor of cytokine signaling-3 expression and its
            regulation in relation to inflammation in Chronic Obstructive
            Pulmonary Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2734)
  AUTHORS   Sasaki,A., Yasukawa,H., Suzuki,A., Kamizono,S., Syoda,T.,
            Kinjyo,I., Sasaki,M., Johnston,J.A. and Yoshimura,A.
  TITLE     Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus
            tyrosine kinase by binding through the N-terminal kinase inhibitory
            region as well as SH2 domain
  JOURNAL   Genes Cells 4 (6), 339-351 (1999)
   PUBMED   10421843
REFERENCE   7  (bases 1 to 2734)
  AUTHORS   Zhang,J.G., Farley,A., Nicholson,S.E., Willson,T.A., Zugaro,L.M.,
            Simpson,R.J., Moritz,R.L., Cary,D., Richardson,R., Hausmann,G.,
            Kile,B.T., Kent,S.B., Alexander,W.S., Metcalf,D., Hilton,D.J.,
            Nicola,N.A. and Baca,M.
  TITLE     The conserved SOCS box motif in suppressors of cytokine signaling
            binds to elongins B and C and may couple bound proteins to
            proteasomal degradation
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2071-2076 (1999)
   PUBMED   10051596
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi:
            10.1073/pnas.1507812112.. Kile, B J [corrected to Kile, Benjamin
            T]. PMID: 25956176]
REFERENCE   8  (bases 1 to 2734)
  AUTHORS   Dey,B.R., Spence,S.L., Nissley,P. and Furlanetto,R.W.
  TITLE     Interaction of human suppressor of cytokine signaling (SOCS)-2 with
            the insulin-like growth factor-I receptor
  JOURNAL   J Biol Chem 273 (37), 24095-24101 (1998)
   PUBMED   9727029
REFERENCE   9  (bases 1 to 2734)
  AUTHORS   Masuhara,M., Sakamoto,H., Matsumoto,A., Suzuki,R., Yasukawa,H.,
            Mitsui,K., Wakioka,T., Tanimura,S., Sasaki,A., Misawa,H.,
            Yokouchi,M., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of novel CIS family genes
  JOURNAL   Biochem Biophys Res Commun 239 (2), 439-446 (1997)
   PUBMED   9344848
REFERENCE   10 (bases 1 to 2734)
  AUTHORS   Minamoto,S., Ikegame,K., Ueno,K., Narazaki,M., Naka,T.,
            Yamamoto,H., Matsumoto,T., Saito,H., Hosoe,S. and Kishimoto,T.
  TITLE     Cloning and functional analysis of new members of STAT induced STAT
            inhibitor (SSI) family: SSI-2 and SSI-3
  JOURNAL   Biochem Biophys Res Commun 237 (1), 79-83 (1997)
   PUBMED   9266833
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC061992.11.
            
            On Mar 13, 2020 this sequence version replaced NM_003955.4.
            
            Summary: This gene encodes a member of the STAT-induced STAT
            inhibitor (SSI), also known as suppressor of cytokine signaling
            (SOCS), family. SSI family members are cytokine-inducible negative
            regulators of cytokine signaling. The expression of this gene is
            induced by various cytokines, including IL6, IL10, and interferon
            (IFN)-gamma. The protein encoded by this gene can bind to JAK2
            kinase, and inhibit the activity of JAK2 kinase. Studies of the
            mouse counterpart of this gene suggested the roles of this gene in
            the negative regulation of fetal liver hematopoiesis, and placental
            development. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060858.1, AK314212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146982, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330871.3/ ENSP00000330341.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC061992.11        21989-22316         c
            329-2734            AC061992.11        19017-21422         c
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2734
                     /gene="SOCS3"
                     /gene_synonym="ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3"
                     /note="suppressor of cytokine signaling 3"
                     /db_xref="GeneID:9021"
                     /db_xref="HGNC:HGNC:19391"
                     /db_xref="MIM:604176"
     exon            1..328
                     /gene="SOCS3"
                     /gene_synonym="ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..2734
                     /gene="SOCS3"
                     /gene_synonym="ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..1094
                     /gene="SOCS3"
                     /gene_synonym="ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3"
                     /note="STAT-induced STAT inhibitor 3; cytokine-inducible
                     SH2 protein 3"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 3"
                     /protein_id="NP_003946.3"
                     /db_xref="CCDS:CCDS11756.1"
                     /db_xref="GeneID:9021"
                     /db_xref="HGNC:HGNC:19391"
                     /db_xref="MIM:604176"
                     /translation="MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
                     GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSF
                     SLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSP
                     PRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFL
                     DQYDAPL"
     regulatory      2706..2711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS3"
                     /gene_synonym="ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3"
                     /note="hexamer: AATAAA"
     polyA_site      2734
                     /gene="SOCS3"
                     /gene_synonym="ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3"
                     /note="major polyA site"
ORIGIN      
        1 ggctccgact tggactccct gctccgctgc tgccgcttcg gccccgcacg cagccagccg
       61 ccagccgccc gcccggccca gctcccgccg cggccccttg ccgcggtccc tctcctggtc
      121 ccctcccggt tggtccgggg gtgcgcaggg ggcagggcgg gcgcccaggg gaagctcgag
      181 ggacgcgcgc gcgaaggctc ctttgtggac ttcacggccg ccaacatctg ggcgcagcgc
      241 gggccaccgc tggccgtctc gccgccgcgt cgccttgggg acccgagggg gctcagcccc
      301 aaggacggag acttcgattc gggaccagcc ccccgggatg cggtagcggc cgctgtgcgg
      361 aggccgcgaa gcagctgcag ccgccgccgc gcagatccac gctggctccg tgcgccatgg
      421 tcacccacag caagtttccc gccgccggga tgagccgccc cctggacacc agcctgcgcc
      481 tcaagacctt cagctccaag agcgagtacc agctggtggt gaacgcagtg cgcaagctgc
      541 aggagagcgg cttctactgg agcgcagtga ccggcggcga ggcgaacctg ctgctcagtg
      601 ccgagcccgc cggcaccttt ctgatccgcg acagctcgga ccagcgccac ttcttcacgc
      661 tcagcgtcaa gacccagtct gggaccaaga acctgcgcat ccagtgtgag gggggcagct
      721 tctctctgca gagcgatccc cggagcacgc agcccgtgcc ccgcttcgac tgcgtgctca
      781 agctggtgca ccactacatg ccgccccctg gagccccctc cttcccctcg ccacctactg
      841 aaccctcctc cgaggtgccc gagcagccgt ctgcccagcc actccctggg agtcccccca
      901 gaagagccta ttacatctac tccgggggcg agaagatccc cctggtgttg agccggcccc
      961 tctcctccaa cgtggccact cttcagcatc tctgtcggaa gaccgtcaac ggccacctgg
     1021 actcctatga gaaagtcacc cagctgccgg ggcccattcg ggagttcctg gaccagtacg
     1081 atgccccgct ttaaggggta aagggcgcaa agggcatggg tcgggagagg ggacgcaggc
     1141 ccctctcctc cgtggcacat ggcacaagca caagaagcca accaggagag agtcctgtag
     1201 ctctgggggg aaagagggcg gacaggcccc tccctctgcc ctctccctgc agaatgtggc
     1261 aggcggacct ggaatgtgtt ggagggaagg gggagtacca cctgagtctc cagcttctcc
     1321 ggaggagcca gctgtcctgg tgggacgata gcaaccacaa gtggattctc cttcaattcc
     1381 tcagcttccc ctctgcctcc aaacagggga cacttcggga atgctgaact aatgagaact
     1441 gccagggaat cttcaaactt tccaacggaa cttgtttgct ctttgatttg gtttaaacct
     1501 gagctggttg tggagcctgg gaaaggtgga agagagagag gtcctgaggg ccccagggct
     1561 gcgggctggc gaaggaaatg gtcacacccc ccgcccaccc caggcgagga tcctggtgac
     1621 atgctcctct ccctggctcc ggggagaagg gcttggggtg acctgaaggg aaccatcctg
     1681 gtaccccaca tcctctcctc cgggacagtc accgaaaaca caggttccaa agtctacctg
     1741 gtgcctgaga gcccagggcc cttcctccgt tttaaggggg aagcaacatt tggaggggat
     1801 ggatgggctg gtcagctggt ctccttttcc tactcatact ataccttcct gtacctgggt
     1861 ggatggagcg ggaggatgga ggagacggga catctttcac ctcaggctcc tggtagagaa
     1921 gacaggggat tctactctgt gcctcctgac tatgtctggc taagagattc gccttaaatg
     1981 ctccctgtcc catggagagg gacccagcat aggaaagcca catactcagc ctggatgggt
     2041 ggagaggctg agggactcac tggagggcac caagccagcc cacagccagg gaagtgggga
     2101 gggggggcgg aaacccatgc ctcccagctg agcactggga atgtcagccc agtaagtatt
     2161 ggccagtcag gcgcctcgtg gtcagagcag agccaccagg tcccactgcc ccgagccctg
     2221 cacagccctc cctcctgcct gggtggggga ggctggaggt cattggagag gctggactgc
     2281 tgccaccccg ggtgctcccg ctctgccata gcactgatca gtgacaattt acaggaatgt
     2341 agcagcgatg gaattacctg gaacagtttt ttgtttttgt ttttgttttt gtttttgtgg
     2401 gggggggcaa ctaaacaaac acaaagtatt ctgtgtcagg tattgggctg gacagggcag
     2461 ttgtgtgttg gggtggtttt tttctctatt tttttgtttg tttcttgttt tttaataatg
     2521 tttacaatct gcctcaatca ctctgtcttt tataaagatt ccacctccag tcctctctcc
     2581 tcccccctac tcaggccctt gaggctatta ggagatgctt gaagaactca acaaaatccc
     2641 aatccaagtc aaactttgca catatttata tttatattca gaaaagaaac atttcagtaa
     2701 tttataataa agagcactat tttttaatga aaaa
//
