LOCUS       NM_001270471            2386 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens suppressor of cytokine signaling 2 (SOCS2), transcript
            variant 6, mRNA.
ACCESSION   NM_001270471
VERSION     NM_001270471.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Noroozi,R., Rudnicka,J., Pisarek,A., Wysocka,B., Masny,A.,
            Boron,M., Migacz-Gruszka,K., Pruszkowska-Przybylska,P., Kobus,M.,
            Lisman,D., Zielinska,G., Iljin,A., Wiktorska,J.A., Michalczyk,M.,
            Kaczka,P., Krzysztofik,M., Sitek,A., Ossowski,A., Spolnicka,M.,
            Branicki,W. and Pospiech,E.
  TITLE     Analysis of epigenetic clocks links yoga, sleep, education, reduced
            meat intake, coffee, and a SOCS2 gene variant to slower epigenetic
            aging
  JOURNAL   Geroscience 46 (2), 2583-2604 (2024)
   PUBMED   38103096
  REMARK    GeneRIF: Analysis of epigenetic clocks links yoga, sleep,
            education, reduced meat intake, coffee, and a SOCS2 gene variant to
            slower epigenetic aging.
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   Yang,B., Yao,L., Yang,L., Zhao,F. and Zhou,W.
  TITLE     Inhibition of miR-578 through SOCS2-dependent manner reverses
            gefitinib resistance in NSCLC cells
  JOURNAL   Environ Toxicol 39 (3), 1283-1293 (2024)
   PUBMED   37948135
  REMARK    GeneRIF: Inhibition of miR-578 through SOCS2-dependent manner
            reverses gefitinib resistance in NSCLC cells.
REFERENCE   3  (bases 1 to 2386)
  AUTHORS   Lv,Y., Xie,X., Zou,G., Kong,M., Yang,J., Chen,J. and Xiang,B.
  TITLE     SOCS2 inhibits hepatoblastoma metastasis via downregulation of the
            JAK2/STAT5 signal pathway
  JOURNAL   Sci Rep 13 (1), 21814 (2023)
   PUBMED   38071211
  REMARK    GeneRIF: SOCS2 inhibits hepatoblastoma metastasis via
            downregulation of the JAK2/STAT5 signal pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2386)
  AUTHORS   Cai,S., Zhang,B., Huang,C., Deng,Y., Wang,C., Yang,Y., Xiang,Z.,
            Ni,Y., Wang,Z., Wang,L., Zhang,B., Guo,X., He,J., Ma,K. and Yu,Z.
  TITLE     CTRP6 protects against ferroptosis to drive lung cancer progression
            and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4
            pathway
  JOURNAL   Cancer Lett 579, 216465 (2023)
   PUBMED   38084702
  REMARK    GeneRIF: CTRP6 protects against ferroptosis to drive lung cancer
            progression and metastasis by destabilizing SOCS2 and augmenting
            the xCT/GPX4 pathway.
REFERENCE   5  (bases 1 to 2386)
  AUTHORS   Ramachandran,S., Makukhin,N., Haubrich,K., Nagala,M., Forrester,B.,
            Lynch,D.M., Casement,R., Testa,A., Bruno,E., Gitto,R. and Ciulli,A.
  TITLE     Structure-based design of a phosphotyrosine-masked covalent ligand
            targeting the E3 ligase SOCS2
  JOURNAL   Nat Commun 14 (1), 6345 (2023)
   PUBMED   37816714
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2386)
  AUTHORS   Lopaczynski,W.
  TITLE     Differential regulation of signaling pathways for insulin and
            insulin-like growth factor I
  JOURNAL   Acta Biochim Pol 46 (1), 51-60 (1999)
   PUBMED   10453981
  REMARK    Review article
REFERENCE   7  (bases 1 to 2386)
  AUTHORS   Dey,B.R., Spence,S.L., Nissley,P. and Furlanetto,R.W.
  TITLE     Interaction of human suppressor of cytokine signaling (SOCS)-2 with
            the insulin-like growth factor-I receptor
  JOURNAL   J Biol Chem 273 (37), 24095-24101 (1998)
   PUBMED   9727029
REFERENCE   8  (bases 1 to 2386)
  AUTHORS   Masuhara,M., Sakamoto,H., Matsumoto,A., Suzuki,R., Yasukawa,H.,
            Mitsui,K., Wakioka,T., Tanimura,S., Sasaki,A., Misawa,H.,
            Yokouchi,M., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of novel CIS family genes
  JOURNAL   Biochem Biophys Res Commun 239 (2), 439-446 (1997)
   PUBMED   9344848
REFERENCE   9  (bases 1 to 2386)
  AUTHORS   Minamoto,S., Ikegame,K., Ueno,K., Narazaki,M., Naka,T.,
            Yamamoto,H., Matsumoto,T., Saito,H., Hosoe,S. and Kishimoto,T.
  TITLE     Cloning and functional analysis of new members of STAT induced STAT
            inhibitor (SSI) family: SSI-2 and SSI-3
  JOURNAL   Biochem Biophys Res Commun 237 (1), 79-83 (1997)
   PUBMED   9266833
REFERENCE   10 (bases 1 to 2386)
  AUTHORS   Pezet,A., Buteau,H., Kelly,P.A. and Edery,M.
  TITLE     The last proline of Box 1 is essential for association with JAK2
            and functional activation of the prolactin receptor
  JOURNAL   Mol Cell Endocrinol 129 (2), 199-208 (1997)
   PUBMED   9202403
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300183.1, AK313165.1,
            BC010399.1, CD699665.1, BJ996504.1 and AI129818.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001270471.1.
            
            Summary: This gene encodes a member of the suppressor of cytokine
            signaling (SOCS) family. SOCS family members are cytokine-inducible
            negative regulators of cytokine receptor signaling via the Janus
            kinase/signal transducer and activation of transcription pathway
            (the JAK/STAT pathway). SOCS family proteins interact with major
            molecules of signaling complexes to block further signal
            transduction, in part, by proteasomal depletion of receptors or
            signal-transducing proteins via ubiquitination. The expression of
            this gene can be induced by a subset of cytokines, including
            erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by
            cytokine receptors such as growth horomone receptor. The protein
            encoded by this gene interacts with the cytoplasmic domain of
            insulin-like growth factor-1 receptor (IGF1R) and is thought to be
            involved in the regulation of IGF1R mediated cell signaling. This
            gene has pseudogenes on chromosomes 20 and 22. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (6) differs in the 5' UTR,
            compared to variant 5. Variants 1-6 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP277599.1, SRR1803614.49626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000551556.2/ ENSP00000449227.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DC300183.1         159-168
            11-200              AK313165.1         215-404
            201-1843            BC010399.1         190-1832
            1844-1995           CD699665.1         119-270             c
            1996-2371           BJ996504.1         1-376               c
            2372-2386           AI129818.1         7-21                c
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..2386
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /note="suppressor of cytokine signaling 2"
                     /db_xref="GeneID:8835"
                     /db_xref="HGNC:HGNC:19382"
                     /db_xref="MIM:605117"
     exon            1..362
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..820
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /note="cytokine-inducible SH2 protein 2; CIS-2;
                     STAT-induced STAT inhibitor 2"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 2"
                     /protein_id="NP_001257400.1"
                     /db_xref="CCDS:CCDS9047.1"
                     /db_xref="GeneID:8835"
                     /db_xref="HGNC:HGNC:19382"
                     /db_xref="MIM:605117"
                     /translation="MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELG
                     QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDG
                     KFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSA
                     PSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV"
     exon            363..2386
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /note="hexamer: AATAAA"
     polyA_site      1844
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /note="major polyA site"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /note="hexamer: AATAAA"
     polyA_site      2386
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
ORIGIN      
        1 ctctttgtag gcgatcagtg ggtgaccgcg gctgcgaggg actttgtcat ccgtcctcca
       61 ggatctgggg agaaagagcc ccatcccttc tctctctgcc accatttcgg acaccccgca
      121 gggactcgtt ttgggattcg cactgacttc aaggaaggac gcgaaccctt ctctgacccc
      181 agctcgggcg gccacctgtc tttgccgcgg tgacccttct ctcatgaccc tgcggtgcct
      241 tgagccctcc gggaatggcg gggaagggac gcggagccag tgggggaccg cggggtcggc
      301 ggaggagcca tccccgcagg cggcgcgtct ggcgaaggcc ctgcgggagc tcggtcagac
      361 aggatggtac tggggaagta tgactgttaa tgaagccaaa gagaaattaa aagaggcacc
      421 agaaggaact ttcttgatta gagatagctc gcattcagac tacctactaa caatatctgt
      481 taaaacatca gctggaccaa ctaatcttcg aatcgaatac caagacggaa aattcagatt
      541 ggactctatc atatgtgtca aatccaagct taaacaattt gacagtgtgg ttcatctgat
      601 cgactactat gttcagatgt gcaaggataa gcggacaggt ccagaagccc cccggaacgg
      661 cactgttcac ctttatctga ccaaaccgct ctacacgtca gcaccatctc tgcagcatct
      721 ctgtaggctc accattaaca aatgtaccgg tgccatctgg ggactgcctt taccaacaag
      781 actaaaagat tacttggaag aatataaatt ccaggtataa atgtttctct ttttttaaac
      841 atgtctcaca tagagtatct ccgaatgcag ctatgtaaaa gagaaccaaa acttgagtgc
      901 tctggataac tatatggaat gctttctaag aacagctgaa gctaatctaa tttaaattta
      961 acagcttgaa gaggtagcta ggtgtttaaa gttcctccag atacttttac ctgagtgatg
     1021 cttcccttcc taaggctgac caagacctgt tgatcctttt agattaaaaa taaaatgtcg
     1081 catgtaaagg ctgaagtcgc gttttatcag aatgccttgc cttcttaggt tcttttccat
     1141 tatgtcaaag gtccaggctc cagtaggaga gaaagaactc ctcataggaa tactgaagaa
     1201 gtgggaagga accaagctga cacaggcctc actgcaattt gatatgcctg ctgatcagag
     1261 tctcttgggc attttatatt ttgcattctg atgtacctag gagttttgtt aaacagatga
     1321 tgtatgtgag tatttatccc attttatgca attaaccaaa tcaaccaaaa aaagtgacca
     1381 tgaagtcctg tatttgtctt tttactacat gtaggaactc tcatgtgaat gagtactgta
     1441 gtaatccatt ctatgggagc cttatttcag aaatatttca aactggtgca aatggaaaag
     1501 actttctctt ttcctttaaa gctaaagaca agaatatcat gctatacagg tgcaactcaa
     1561 tccccgttaa taaaaaccaa tgtaggtata ggcattctac cctttgaaat agctgtgtcc
     1621 caacctgttg ccattgattt tttggaaatg gctttagaaa tatccaagtt gtccttgaat
     1681 tgtctaacca tggacataaa cagttgtctc ccttctactg tgtagaatac tttgacttaa
     1741 ttttcttcca gatacagggg gatacctgcc tgtttttcaa agtgtttatt tactgctgtt
     1801 actatttgat tagaatgtat taaataaaaa aaacctgatt tctacaagtt gcacttattg
     1861 agttctagag aacgtacact ttcatggtaa tagaggattg ccataaaaac ttacgtcaag
     1921 tgaaataagc caattattca acaaaaggta gaacattact tgccattctg taaagttatg
     1981 ggctgtacct gccccctttg caatttggaa agcatggttt agaaactaca ggcattgtca
     2041 agtggccggg tcttttataa tttgaatagg cataacactg atgtcctctg tgtttccaaa
     2101 aacatggttt agaaactaca aacattatga catggccagt cttttacaag ttgagtaggc
     2161 ataatactaa agaaaaatac aaagttttgt ggccacttat tttttgctat gttagtctgc
     2221 ataactgtta taaatgtacc atcttttcta gagtccagac attatttatt ttatggcttt
     2281 aaaattttcc tgcatagcta caatcctgtg gtgtgtcacc ataaaggtgg accctgtgtg
     2341 aatgagaaaa ttcagttata aattgtaata aaacctgctt actgga
//
