LOCUS       NP_001257400             198 aa            linear   PRI 12-JUN-2025
DEFINITION  suppressor of cytokine signaling 2 [Homo sapiens].
ACCESSION   NP_001257400
VERSION     NP_001257400.1
DBSOURCE    REFSEQ: accession NM_001270471.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 198)
  AUTHORS   Noroozi,R., Rudnicka,J., Pisarek,A., Wysocka,B., Masny,A.,
            Boron,M., Migacz-Gruszka,K., Pruszkowska-Przybylska,P., Kobus,M.,
            Lisman,D., Zielinska,G., Iljin,A., Wiktorska,J.A., Michalczyk,M.,
            Kaczka,P., Krzysztofik,M., Sitek,A., Ossowski,A., Spolnicka,M.,
            Branicki,W. and Pospiech,E.
  TITLE     Analysis of epigenetic clocks links yoga, sleep, education, reduced
            meat intake, coffee, and a SOCS2 gene variant to slower epigenetic
            aging
  JOURNAL   Geroscience 46 (2), 2583-2604 (2024)
   PUBMED   38103096
  REMARK    GeneRIF: Analysis of epigenetic clocks links yoga, sleep,
            education, reduced meat intake, coffee, and a SOCS2 gene variant to
            slower epigenetic aging.
REFERENCE   2  (residues 1 to 198)
  AUTHORS   Yang,B., Yao,L., Yang,L., Zhao,F. and Zhou,W.
  TITLE     Inhibition of miR-578 through SOCS2-dependent manner reverses
            gefitinib resistance in NSCLC cells
  JOURNAL   Environ Toxicol 39 (3), 1283-1293 (2024)
   PUBMED   37948135
  REMARK    GeneRIF: Inhibition of miR-578 through SOCS2-dependent manner
            reverses gefitinib resistance in NSCLC cells.
REFERENCE   3  (residues 1 to 198)
  AUTHORS   Lv,Y., Xie,X., Zou,G., Kong,M., Yang,J., Chen,J. and Xiang,B.
  TITLE     SOCS2 inhibits hepatoblastoma metastasis via downregulation of the
            JAK2/STAT5 signal pathway
  JOURNAL   Sci Rep 13 (1), 21814 (2023)
   PUBMED   38071211
  REMARK    GeneRIF: SOCS2 inhibits hepatoblastoma metastasis via
            downregulation of the JAK2/STAT5 signal pathway.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 198)
  AUTHORS   Cai,S., Zhang,B., Huang,C., Deng,Y., Wang,C., Yang,Y., Xiang,Z.,
            Ni,Y., Wang,Z., Wang,L., Zhang,B., Guo,X., He,J., Ma,K. and Yu,Z.
  TITLE     CTRP6 protects against ferroptosis to drive lung cancer progression
            and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4
            pathway
  JOURNAL   Cancer Lett 579, 216465 (2023)
   PUBMED   38084702
  REMARK    GeneRIF: CTRP6 protects against ferroptosis to drive lung cancer
            progression and metastasis by destabilizing SOCS2 and augmenting
            the xCT/GPX4 pathway.
REFERENCE   5  (residues 1 to 198)
  AUTHORS   Ramachandran,S., Makukhin,N., Haubrich,K., Nagala,M., Forrester,B.,
            Lynch,D.M., Casement,R., Testa,A., Bruno,E., Gitto,R. and Ciulli,A.
  TITLE     Structure-based design of a phosphotyrosine-masked covalent ligand
            targeting the E3 ligase SOCS2
  JOURNAL   Nat Commun 14 (1), 6345 (2023)
   PUBMED   37816714
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 198)
  AUTHORS   Masuhara,M., Sakamoto,H., Matsumoto,A., Suzuki,R., Yasukawa,H.,
            Mitsui,K., Wakioka,T., Tanimura,S., Sasaki,A., Misawa,H.,
            Yokouchi,M., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of novel CIS family genes
  JOURNAL   Biochem Biophys Res Commun 239 (2), 439-446 (1997)
   PUBMED   9344848
REFERENCE   7  (residues 1 to 198)
  AUTHORS   Minamoto,S., Ikegame,K., Ueno,K., Narazaki,M., Naka,T.,
            Yamamoto,H., Matsumoto,T., Saito,H., Hosoe,S. and Kishimoto,T.
  TITLE     Cloning and functional analysis of new members of STAT induced STAT
            inhibitor (SSI) family: SSI-2 and SSI-3
  JOURNAL   Biochem Biophys Res Commun 237 (1), 79-83 (1997)
   PUBMED   9266833
REFERENCE   8  (residues 1 to 198)
  AUTHORS   Pezet,A., Buteau,H., Kelly,P.A. and Edery,M.
  TITLE     The last proline of Box 1 is essential for association with JAK2
            and functional activation of the prolactin receptor
  JOURNAL   Mol Cell Endocrinol 129 (2), 199-208 (1997)
   PUBMED   9202403
REFERENCE   9  (residues 1 to 198)
  AUTHORS   Jones,S.S., D'Andrea,A.D., Haines,L.L. and Wong,G.G.
  TITLE     Human erythropoietin receptor: cloning, expression, and biologic
            characterization
  JOURNAL   Blood 76 (1), 31-35 (1990)
   PUBMED   2163696
REFERENCE   10 (residues 1 to 198)
  AUTHORS   Leung,D.W., Spencer,S.A., Cachianes,G., Hammonds,R.G., Collins,C.,
            Henzel,W.J., Barnard,R., Waters,M.J. and Wood,W.I.
  TITLE     Growth hormone receptor and serum binding protein: purification,
            cloning and expression
  JOURNAL   Nature 330 (6148), 537-543 (1987)
   PUBMED   2825030
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300183.1, AK313165.1,
            BC010399.1, CD699665.1, BJ996504.1 and AI129818.1.
            
            Summary: This gene encodes a member of the suppressor of cytokine
            signaling (SOCS) family. SOCS family members are cytokine-inducible
            negative regulators of cytokine receptor signaling via the Janus
            kinase/signal transducer and activation of transcription pathway
            (the JAK/STAT pathway). SOCS family proteins interact with major
            molecules of signaling complexes to block further signal
            transduction, in part, by proteasomal depletion of receptors or
            signal-transducing proteins via ubiquitination. The expression of
            this gene can be induced by a subset of cytokines, including
            erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by
            cytokine receptors such as growth horomone receptor. The protein
            encoded by this gene interacts with the cytoplasmic domain of
            insulin-like growth factor-1 receptor (IGF1R) and is thought to be
            involved in the regulation of IGF1R mediated cell signaling. This
            gene has pseudogenes on chromosomes 20 and 22. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (6) differs in the 5' UTR,
            compared to variant 5. Variants 1-6 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP277599.1, SRR1803614.49626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000551556.2/ ENSP00000449227.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     Protein         1..198
                     /product="suppressor of cytokine signaling 2"
                     /note="cytokine-inducible SH2 protein 2; CIS-2;
                     STAT-induced STAT inhibitor 2"
                     /calculated_mol_wt=22041
     Region          1..75
                     /region_name="Interaction with AREL1.
                     /evidence=ECO:0000269|PubMed:31578312"
                     /note="propagated from UniProtKB/Swiss-Prot (O14508.1)"
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O14508.1)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O14508.1)"
     Region          40..142
                     /region_name="SH2_SOCS2"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10383"
                     /db_xref="CDD:198246"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:31578312; propagated from
                     UniProtKB/Swiss-Prot (O14508.1)"
     Site            order(55,73,75,83,96)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198246"
     Site            order(106,108,129)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198246"
     Region          158..198
                     /region_name="SOCS_SOCS2"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS2-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. SOCS2 has
                     recently been shown to regulate...; cd03736"
                     /db_xref="CDD:239705"
     Site            order(159..164,170,175,181,186)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239705"
     CDS             1..198
                     /gene="SOCS2"
                     /gene_synonym="CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2"
                     /coded_by="NM_001270471.2:224..820"
                     /db_xref="CCDS:CCDS9047.1"
                     /db_xref="GeneID:8835"
                     /db_xref="HGNC:HGNC:19382"
                     /db_xref="MIM:605117"
ORIGIN      
        1 mtlrclepsg nggegtrsqw gtagsaeeps pqaarlakal relgqtgwyw gsmtvneake
       61 klkeapegtf lirdsshsdy lltisvktsa gptnlrieyq dgkfrldsii cvksklkqfd
      121 svvhlidyyv qmckdkrtgp eaprngtvhl yltkplytsa pslqhlcrlt inkctgaiwg
      181 lplptrlkdy leeykfqv
//
