LOCUS       NM_003745               1238 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA.
ACCESSION   NM_003745
VERSION     NM_003745.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1238)
  AUTHORS   Yu,J., Mei,J., Zuo,D., Zhang,M., Yu,S., Li,F., Wang,J., Bi,D.,
            Ma,S., Wang,J. and Yin,Z.J.
  TITLE     Inflammatory factor-mediated miR-155/SOCS1 signaling axis leads to
            Treg impairment in systemic lupus erythematosus
  JOURNAL   Int Immunopharmacol 141, 113013 (2024)
   PUBMED   39213866
  REMARK    GeneRIF: Inflammatory factor-mediated miR-155/SOCS1 signaling axis
            leads to Treg impairment in systemic lupus erythematosus.
REFERENCE   2  (bases 1 to 1238)
  AUTHORS   Zhou,J., Luo,W., Xie,Z., Xia,C. and Zhao,J.
  TITLE     KLF4-induced upregulation of SOCS1 ameliorates myocardial
            ischemia/reperfusion injury by attenuating AC16 cardiomyocyte
            damage and enhancing M2 macrophage polarization
  JOURNAL   J Biochem Mol Toxicol 38 (9), e23816 (2024)
   PUBMED   39185902
  REMARK    GeneRIF: KLF4-induced upregulation of SOCS1 ameliorates myocardial
            ischemia/reperfusion injury by attenuating AC16 cardiomyocyte
            damage and enhancing M2 macrophage polarization.
REFERENCE   3  (bases 1 to 1238)
  AUTHORS   Morelli,M., Madonna,S. and Albanesi,C.
  TITLE     SOCS1 and SOCS3 as key checkpoint molecules in the immune responses
            associated to skin inflammation and malignant transformation
  JOURNAL   Front Immunol 15, 1393799 (2024)
   PUBMED   38975347
  REMARK    GeneRIF: SOCS1 and SOCS3 as key checkpoint molecules in the immune
            responses associated to skin inflammation and malignant
            transformation.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1238)
  AUTHORS   Mirbahari,S.N., Fatemi,N., Savabkar,S., Chaleshi,V., Zali,N.,
            Taleghani,M.Y., Mirzaei,E., Rejali,L., Moghadam,P.K. and
            Mojarad,E.N.
  TITLE     Unmasking early colorectal cancer clues: in silico and in vitro
            investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G in
            SSA polyps
  JOURNAL   Mol Biol Rep 51 (1), 764 (2024)
   PUBMED   38874740
  REMARK    GeneRIF: Unmasking early colorectal cancer clues: in silico and in
            vitro investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G
            in SSA polyps.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1238)
  AUTHORS   Gregorieff,A., Pyronnet,S., Sonenberg,N. and Veillette,A.
  TITLE     Regulation of SOCS-1 expression by translational repression
  JOURNAL   J Biol Chem 275 (28), 21596-21604 (2000)
   PUBMED   10764816
REFERENCE   6  (bases 1 to 1238)
  AUTHORS   Schluter,G., Boinska,D. and Nieman-Seyde,S.C.
  TITLE     Evidence for translational repression of the SOCS-1 major open
            reading frame by an upstream open reading frame
  JOURNAL   Biochem Biophys Res Commun 268 (2), 255-261 (2000)
   PUBMED   10679190
REFERENCE   7  (bases 1 to 1238)
  AUTHORS   Minamoto,S., Ikegame,K., Ueno,K., Narazaki,M., Naka,T.,
            Yamamoto,H., Matsumoto,T., Saito,H., Hosoe,S. and Kishimoto,T.
  TITLE     Cloning and functional analysis of new members of STAT induced STAT
            inhibitor (SSI) family: SSI-2 and SSI-3
  JOURNAL   Biochem Biophys Res Commun 237 (1), 79-83 (1997)
   PUBMED   9266833
REFERENCE   8  (bases 1 to 1238)
  AUTHORS   Endo,T.A., Masuhara,M., Yokouchi,M., Suzuki,R., Sakamoto,H.,
            Mitsui,K., Matsumoto,A., Tanimura,S., Ohtsubo,M., Misawa,H.,
            Miyazaki,T., Leonor,N., Taniguchi,T., Fujita,T., Kanakura,Y.,
            Komiya,S. and Yoshimura,A.
  TITLE     A new protein containing an SH2 domain that inhibits JAK kinases
  JOURNAL   Nature 387 (6636), 921-924 (1997)
   PUBMED   9202126
REFERENCE   9  (bases 1 to 1238)
  AUTHORS   Starr,R., Willson,T.A., Viney,E.M., Murray,L.J., Rayner,J.R.,
            Jenkins,B.J., Gonda,T.J., Alexander,W.S., Metcalf,D., Nicola,N.A.
            and Hilton,D.J.
  TITLE     A family of cytokine-inducible inhibitors of signalling
  JOURNAL   Nature 387 (6636), 917-921 (1997)
   PUBMED   9202125
REFERENCE   10 (bases 1 to 1238)
  AUTHORS   Yoshimura,A., Ohkubo,T., Kiguchi,T., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Hara,T. and Miyajima,A.
  TITLE     A novel cytokine-inducible gene CIS encodes an SH2-containing
            protein that binds to tyrosine-phosphorylated interleukin 3 and
            erythropoietin receptors
  JOURNAL   EMBO J 14 (12), 2816-2826 (1995)
   PUBMED   7796808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009121.8.
            
            On Oct 26, 2020 this sequence version replaced NM_003745.1.
            
            Summary: This gene encodes a member of the STAT-induced STAT
            inhibitor (SSI), also known as suppressor of cytokine signaling
            (SOCS), family. SSI family members are cytokine-inducible negative
            regulators of cytokine signaling. The expression of this gene can
            be induced by a subset of cytokines, including IL2, IL3
            erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The
            protein encoded by this gene functions downstream of cytokine
            receptors, and takes part in a negative feedback loop to attenuate
            cytokine signaling. Knockout studies in mice suggested the role of
            this gene as a modulator of IFN-gamma action, which is required for
            normal postnatal growth and survival. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000734.1, SRR11853560.10636.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332029.4/ ENSP00000329418.2
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 10679190
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC009121.8         107799-107924
            127-1238            AC009121.8         108475-109586
FEATURES             Location/Qualifiers
     source          1..1238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..1238
                     /gene="SOCS1"
                     /gene_synonym="AISIMD; CIS1; CISH1; JAB; SOCS-1; SSI-1;
                     SSI1; TIP-3; TIP3"
                     /note="suppressor of cytokine signaling 1"
                     /db_xref="GeneID:8651"
                     /db_xref="HGNC:HGNC:19383"
                     /db_xref="MIM:603597"
     exon            1..126
                     /gene="SOCS1"
                     /gene_synonym="AISIMD; CIS1; CISH1; JAB; SOCS-1; SSI-1;
                     SSI1; TIP-3; TIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      52..183
                     /regulatory_class="uORF"
                     /gene="SOCS1"
                     /gene_synonym="AISIMD; CIS1; CISH1; JAB; SOCS-1; SSI-1;
                     SSI1; TIP-3; TIP3"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10679190]"
                     /note="this uORF is predicted to encode a 43 aa peptide
                     (PMID:10679190)"
     exon            127..1238
                     /gene="SOCS1"
                     /gene_synonym="AISIMD; CIS1; CISH1; JAB; SOCS-1; SSI-1;
                     SSI1; TIP-3; TIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      143..175
                     /regulatory_class="uORF"
                     /gene="SOCS1"
                     /gene_synonym="AISIMD; CIS1; CISH1; JAB; SOCS-1; SSI-1;
                     SSI1; TIP-3; TIP3"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10679190]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:10679190)"
     CDS             177..812
                     /gene="SOCS1"
                     /gene_synonym="AISIMD; CIS1; CISH1; JAB; SOCS-1; SSI-1;
                     SSI1; TIP-3; TIP3"
                     /note="STAT induced SH3 protein 1; Tec-interacting protein
                     3; JAK binding protein; cytokine-inducible SH2 protein 1;
                     STAT-induced STAT inhibitor 1"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 1"
                     /protein_id="NP_003736.1"
                     /db_xref="CCDS:CCDS10546.1"
                     /db_xref="GeneID:8651"
                     /db_xref="HGNC:HGNC:19383"
                     /db_xref="MIM:603597"
                     /translation="MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPA
                     VPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFL
                     VRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRR
                     MLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI"
ORIGIN      
        1 gaacagagcg agctgcggcc gtggcagctg cacggctcct ggccccggag catgcgcgag
       61 agccgccccg gagcgccccg gagccccccg ccgtcccgcc cgcggcgtcc cgcgccccgc
      121 cgccagcgca cccccggacg ctatggccca cccctccggc tggccccttc tgtaggatgg
      181 tagcacacaa ccaggtggca gccgacaatg cagtctccac agcagcagag ccccgacggc
      241 ggccagaacc ttcctcctct tcctcctcct cgcccgcggc ccccgcgcgc ccgcggccgt
      301 gccccgcggt cccggccccg gcccccggcg acacgcactt ccgcacattc cgttcgcacg
      361 ccgattaccg gcgcatcacg cgcgccagcg cgctcctgga cgcctgcgga ttctactggg
      421 ggcccctgag cgtgcacggg gcgcacgagc ggctgcgcgc cgagcccgtg ggcaccttcc
      481 tggtgcgcga cagccgccag cggaactgct ttttcgccct tagcgtgaag atggcctcgg
      541 gacccacgag catccgcgtg cactttcagg ccggccgctt tcacctggat ggcagccgcg
      601 agagcttcga ctgcctcttc gagctgctgg agcactacgt ggcggcgccg cgccgcatgc
      661 tgggggcccc gctgcgccag cgccgcgtgc ggccgctgca ggagctgtgc cgccagcgca
      721 tcgtggccac cgtgggccgc gagaacctgg ctcgcatccc cctcaacccc gtcctccgcg
      781 actacctgag ctccttcccc ttccagattt gaccggcagc gcccgccgtg cacgcagcat
      841 taactgggat gccgtgttat tttgttatta cttgcctgga accatgtggg taccctcccc
      901 ggcctgggtt ggagggagcg gatgggtgta ggggcgaggc gcctcccgcc ctcggctgga
      961 gacgaggccg cagacccctt ctcacctctt gagggggtcc tccccctcct ggtgctccct
     1021 ctgggtcccc ctggttgttg tagcagctta actgtatctg gagccaggac ctgaactcgc
     1081 acctcctacc tcttcatgtt tacatatacc cagtatcttt gcacaaacca ggggttgggg
     1141 gagggtctct ggctttattt ttctgctgtg cagaatccta ttttatattt tttaaagtca
     1201 gtttaggtaa taaactttat tatgaaagtt tttttttt
//
