LOCUS       NM_018013               6225 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens sine oculis binding protein homolog (SOBP), mRNA.
ACCESSION   NM_018013 XM_001127018 XM_939686
VERSION     NM_018013.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6225)
  AUTHORS   Zhang,Y., Li,Z., Zhang,Y., Shen,C., Zhang,Z., Ren,X., Guo,C.,
            Yang,S., Wang,Z. and Hu,H.
  TITLE     circSOBP Inhibits Bladder Cancer Proliferation and Metastasis by
            Regulating the miR-200a-3p/PTEN Axis and Participating in the
            Immune Response
  JOURNAL   Cell Transplant 32, 9636897231165874 (2023)
   PUBMED   37026617
  REMARK    GeneRIF: circSOBP Inhibits Bladder Cancer Proliferation and
            Metastasis by Regulating the miR-200a-3p/PTEN Axis and
            Participating in the Immune Response.
REFERENCE   2  (bases 1 to 6225)
  AUTHORS   Lei,J., He,Z.Y., Wang,J., Hu,M., Zhou,P., Lian,C.L., Hua,L.,
            Wu,S.G. and Zhou,J.
  TITLE     Identification of MEG8/miR-378d/SOBP axis as a novel regulatory
            network and associated with immune infiltrates in ovarian carcinoma
            by integrated bioinformatics analysis
  JOURNAL   Cancer Med 10 (8), 2924-2939 (2021)
   PUBMED   33742531
  REMARK    GeneRIF: Identification of MEG8/miR-378d/SOBP axis as a novel
            regulatory network and associated with immune infiltrates in
            ovarian carcinoma by integrated bioinformatics analysis.
REFERENCE   3  (bases 1 to 6225)
  AUTHORS   Chao,F., Song,Z., Wang,S., Ma,Z., Zhuo,Z., Meng,T., Xu,G. and
            Chen,G.
  TITLE     Novel circular RNA circSOBP governs amoeboid migration through the
            regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer
  JOURNAL   Clin Transl Med 11 (3), e360 (2021)
   PUBMED   33784000
  REMARK    GeneRIF: Novel circular RNA circSOBP governs amoeboid migration
            through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in
            prostate cancer.
REFERENCE   4  (bases 1 to 6225)
  AUTHORS   Matsumoto,Y., Chinen,Y., Shimura,Y., Nagoshi,H., Sasaki,N.,
            Muramatsu,A., Kuriyama,K., Ohshiro,M., Hirakawa,Y., Iwai,T.,
            Uchiyama,H., Taki,T., Horiike,S., Kuroda,J. and Taniwaki,M.
  TITLE     Recurrent intragenic exon rearrangements of SOBP and AUTS2 in
            non-Hodgkin B-cell lymphoma
  JOURNAL   Int J Hematol 111 (1), 75-83 (2020)
   PUBMED   31686349
  REMARK    GeneRIF: The intragenic exon rearrangements (IERs) involved in SOBP
            (6q21) exon 2 and 3 and AUTS2 (7q11.22) exon 2-4 were the molecular
            lesions specific to tumors and were frequently detected in
            non-Hodgkin B cell lymphoma (B-NHL) samples. These IERs constitute
            novel genetic alterations of B-NHL, which might be associated with
            tumorigenesis and be useful as genetic biological markers.
REFERENCE   5  (bases 1 to 6225)
  AUTHORS   Sun,H. and Hunter,T.
  TITLE     Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins
            identified through a string search
  JOURNAL   J Biol Chem 287 (50), 42071-42083 (2012)
   PUBMED   23086935
REFERENCE   6  (bases 1 to 6225)
  AUTHORS   Birk,E., Har-Zahav,A., Manzini,C.M., Pasmanik-Chor,M.,
            Kornreich,L., Walsh,C.A., Noben-Trauth,K., Albin,A., Simon,A.J.,
            Colleaux,L., Morad,Y., Rainshtein,L., Tischfield,D.J., Wang,P.,
            Magal,N., Maya,I., Shoshani,N., Rechavi,G., Gothelf,D., Maydan,G.,
            Shohat,M. and Basel-Vanagaite,L.
  TITLE     SOBP is mutated in syndromic and nonsyndromic intellectual
            disability and is highly expressed in the brain limbic system
  JOURNAL   Am J Hum Genet 87 (5), 694-700 (2010)
   PUBMED   21035105
  REMARK    GeneRIF: This study shows mutated SOBP involvement in syndromic and
            nonsyndromic ID with psychosis in humans.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX442875.2, AL121957.15,
            BC014859.1, AL096816.12, BC113966.1 and BM684094.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018013.3.
            
            Summary: The protein encoded by this gene is a nuclear zinc finger
            protein that is involved in development of the cochlea. Defects in
            this gene have also been linked to intellectual disability.
            [provided by RefSeq, Mar 2011].
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ507800.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317357.10/ ENSP00000318900.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BX442875.2         5-87
            84-247              AL121957.15        49353-49516         c
            248-1885            BC014859.1         1-1638
            1886-2738           AL096816.12        91248-92100         c
            2739-3224           BC113966.1         36-521
            3225-5574           AL096816.12        65675-68024         c
            5575-6225           BM684094.1         20-670              c
FEATURES             Location/Qualifiers
     source          1..6225
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..6225
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="sine oculis binding protein homolog"
                     /db_xref="GeneID:55084"
                     /db_xref="HGNC:HGNC:29256"
                     /db_xref="MIM:613667"
     exon            1..596
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             501..3122
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="jackson circler protein 1"
                     /codon_start=1
                     /product="sine oculis-binding protein homolog"
                     /protein_id="NP_060483.3"
                     /db_xref="CCDS:CCDS43488.1"
                     /db_xref="GeneID:55084"
                     /db_xref="HGNC:HGNC:29256"
                     /db_xref="MIM:613667"
                     /translation="MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLG
                     WYGYDKVELKDGEDIEFRSYPTDGESRQHISVLKENSLPKPKLPEDSVISPYNISTGY
                     SGLATGNGLSDSPAGSKDHGSVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIK
                     RYSLSMGSEVKSFCSEKCFAACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKN
                     NCELLVCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKETQANLPAGLC
                     STLHPPMENKAEGTGVQLLTPDSWNIPLTDARRKAPSPVATAGQSQGPGPSASTTVSP
                     SDTANCSVTKIPTPVPKSIPISETPNIPPVSVQPPASIGPPLGVPPRSPPMVMTNRGP
                     VPLPIFMEQQIMQQIRPPFIRGPPHHASNPNSPLSNPMLPGIGPPPGGPRNLGPTSSP
                     MHRPMLSPHIHPPSTPTMPGNPPGLLPPPPPGAPLPSLPFPPVSMMPNGPMPVPQMMN
                     FGLPSLAPLVPPPTLLVPYPVIVPLPVPIPIPIPIPHVSDSKPPNGFSSNGENFIPNA
                     PGDSAAAGGKPSGHSLSPRDSKQGSSKSADSPPGCSGQALSLAPTPAEHGRSEVVDLT
                     RRAGSPPGPPGAGGQLGFPGVLQGPQDGVIDLTVGHRARLHNVIHRALHAHVKAEREP
                     SAAERRTCGGCRDGHCSPPAAGDPGPGAPAGPEAAAACNVIVNGTRGAAAEGAKSAEP
                     PPEQPPPPPPPAPPKKLLSPEEPAVSELESVKENNCASNCHLDGEAAKKLMGEEALAG
                     GDKSDPNLNNPADEDHAYALRMLPKTGCVIQPVPKPAEKAAMAPCIISSPMLSAGPED
                     LEPPLKRRCLRIRNQNK"
     exon            597..735
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            736..921
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1073
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1169
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..3125
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..6225
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4402..4407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="hexamer: AAGAAA"
     regulatory      4423..4428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="hexamer: AAGAAA"
     polyA_site      4432
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="major polyA site"
     polyA_site      4440
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="major polyA site"
     regulatory      4507..4512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="hexamer: AATAAA"
     polyA_site      4528
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
     regulatory      4874..4879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="hexamer: AAGAAA"
     polyA_site      4891
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
     regulatory      5045..5050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="hexamer: AAGAAA"
     polyA_site      5090
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
     regulatory      6205..6210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
                     /note="hexamer: TATAAA"
     polyA_site      6225
                     /gene="SOBP"
                     /gene_synonym="JXC1; MRAMS"
ORIGIN      
        1 gctctcccgg gctcacacac agccgcgcac gcacgcccgg ggccgctctc cgcgccggcc
       61 cttgctcccc gcgcccatgc ggacggaccg agcgacggaa gatggctgac gactccacgg
      121 ggccccgagg atgcggcccg gcggcggcgg cggcgggagc ggcagcggca gcgagggcgg
      181 caggggcagc ggcagcagcg gcggcgttgg ctgcggcggc ggcggcggcg gcagcaggag
      241 ccggagcgac ggcggcggca tccccgagac tctccgcact atccttaccc gtgacagcca
      301 ctgacgtcct ccgccgctag aagagacccc gcttctcggc gcctgccctc cccctcgcgg
      361 ctcggtccgg ccccgccagc accgctacct ccgccagcct cgccaccatc agcaccacct
      421 ccaccgccgc cgccgccgcc accaccaccg ccggcggcgg cagcagccat ttcatctcca
      481 cagaaaccag acacaaaaac atggcagaaa tggagaaaga agggagacct cccgaaaata
      541 aacggagcag gaagccggct cacccagtga aaagggagat caatgaggag atgaagaact
      601 ttgcagaaaa caccatgaat gaactccttg gctggtatgg ctatgataag gttgaattaa
      661 aagatggtga ggatattgaa ttcaggagct accctacaga tggggagagc cggcagcaca
      721 tttctgttct caaagaaaat tctttgccaa aaccaaaatt acccgaggac agtgttattt
      781 caccatacaa tataagcaca ggctattcag ggcttgccac tggaaatgga ctcagtgact
      841 cacctgcagg gtcaaaggat catggcagtg tgcccattat tgtaccttta attccaccac
      901 ctttcataaa gccaccagca gaagatgatg tgtcaaatgt acaaataatg tgtgcctggt
      961 gccagaaagt gggaatcaag cgctattccc tgagtatggg aagtgaggtg aaaagcttct
     1021 gcagcgagaa gtgctttgcg gcctgccgac gagcctactt caagagaaat aaggctagag
     1081 atgaagatgg acatgctgaa aattttcccc agcagcacta tgctaaggaa actccaaggc
     1141 ttgccttcaa gaataactgc gaactacttg tatgtgactg gtgtaagcac ataagacaca
     1201 caaaagaata cctggatttt ggggacgggg aaagaaggct tcagttctgc agtgcaaaat
     1261 gtctcaatca atacaaaatg gacattttct acaaagagac ccaggccaat cttccagctg
     1321 ggctgtgcag cacattacac cctcccatgg aaaataaagc agaaggcacc ggggtgcagc
     1381 tgctcactcc agactcttgg aatatcccgc taacagatgc tcggaggaag gccccctccc
     1441 cggtggctac agctggccaa agccagggcc ctggcccgtc ggcgtccacc accgtctctc
     1501 catctgacac tgccaactgc tctgtcacta aaatccccac gccagtgccc aagtccatcc
     1561 ccatcagcga gactccaaat atccctcctg tctccgtcca gccacctgct agcatcgggc
     1621 ctccccttgg cgtcccgcct cggagccctc ccatggtgat gaccaaccgc ggcccggtgc
     1681 cgctgcccat cttcatggag cagcagatca tgcagcagat ccgcccgccc ttcatccgcg
     1741 ggcctccgca ccatgcctcc aaccccaaca gccccctgtc caaccccatg cttcccggca
     1801 tcgggccccc gcccggtggc cccagaaacc tgggccccac ttccagcccc atgcaccggc
     1861 ccatgctatc gccccacatc caccccccga gcacccccac catgcccggg aaccccccag
     1921 gcctgctgcc cccgccgcct ccgggcgccc cgctgccgag tcttcccttc ccgccagtga
     1981 gcatgatgcc aaatggcccg atgccggtgc cccagatgat gaatttcggg ctgccgtcgc
     2041 ttgccccgct ggtgccgccc ccgaccctgc tcgtgccgta ccccgtgatc gtgcccctac
     2101 cggtgcccat ccccatcccc atccctatcc ctcacgtcag cgactccaag ccccccaacg
     2161 ggttctccag caacggggag aacttcattc cgaacgcccc tggcgactcc gcggcggcgg
     2221 gcggcaagcc aagcggacac tccctgtccc cccgggactc caagcagggc tcgtccaagt
     2281 ccgcggactc gccccccggc tgctcgggcc aggccctgag cctggcgccc acgcccgccg
     2341 agcatggccg gagcgaggtg gtggacctga cgcggcgcgc cggcagcccc ccgggccccc
     2401 cgggcgcggg cggccagctc ggcttcccag gcgtgctgca gggcccgcag gacggcgtca
     2461 tcgacctgac cgtgggccac cgagcccggc tgcacaacgt gatccaccgc gcgctgcacg
     2521 cgcacgtcaa ggcggagcgc gagccgagcg ccgcggagcg caggacctgc ggcggctgca
     2581 gggacggcca ctgcagcccg cccgccgccg gcgacccagg cccgggcgcc ccggcgggcc
     2641 ccgaggcggc cgcggcctgc aacgtcatcg tgaacggcac gcgcggcgcc gccgccgagg
     2701 gcgctaagag cgcggagccg cctcccgagc agccgccgcc gccgccgccg cccgcgcccc
     2761 ccaagaagct gctgtcgcct gaggaaccgg cggtgagcga gctagagtcg gtcaaggaga
     2821 ataactgtgc ttccaactgc cacctggacg gggaggcggc caaaaagctg atgggcgagg
     2881 aggccctggc ggggggcgac aagtcagacc cgaaccttaa taaccccgcg gacgaggacc
     2941 atgcctatgc tctgcggatg ctgcccaaga ccggctgcgt gatccagcct gtgccaaaac
     3001 ccgcggagaa ggctgccatg gcaccgtgca tcatctcctc gcccatgctc agcgccgggc
     3061 ctgaggacct ggagccgccg ctcaaaagga ggtgcctccg aattagaaat cagaataagt
     3121 aaaaggaacg ttcactcaca gggtacgctc atggagagag ggcgcagagc aaaccatgtc
     3181 acgccatcca atgacaccag ctggtcagct caccaccccc tctggctaaa actcaagcaa
     3241 ataaagccgc ttcctgtcat taagcatctc agaggaagca gccctccctc gatggcctct
     3301 agcccagaga agcccgcgca tcttggaccc accaagcagg cccagccttc ctgctgccac
     3361 catctctgct tctccccaga ggaacttagg gatttcaccc ctggctttta aaaaaaacga
     3421 aataccgaca agccacaagg accaatgtag gtattctccc cgccccatct tcaaggctca
     3481 gcgactgagg ctggaagatg atatggattg gaacacaaaa aatctttttt taatcttttt
     3541 aaaaactgct gtggttttgc tgctacacta agaattgtga tttgcattgt acggttttgg
     3601 acctatattg ttcacgtttt gatggcggag aggggtggtc ctggaggccc aatgcttcag
     3661 agtcatctct gtcctgcccg ggatgcactt ttaaatgaag agttagaata ttttattggc
     3721 taatatactt ttcttgttat ttttacaaag gccaccttta tcctttttga tgccatattt
     3781 tcagtgttac acttttatgg cttttaattt tcgatttgac agatgtaaga agcagcatga
     3841 atagtttata ctgtggtttt tcagagactg aatgccaaga gaactcggta aatgtttatt
     3901 cttctcagct ttctctttaa attcccctaa atagcgcccc atttgggaac agagcaagag
     3961 tgttgaactg aagaccaaaa tgccctcaag gtgtaaaata atccgagggg gaatatttgc
     4021 tgggcgtcag gaaagactca gatgaaattt caaccctgat ggttttcggt gatccaggaa
     4081 gtcagtgaga caatctctct atatgcagag ccctttcatg ataattagaa tggtatggac
     4141 aaaccaatga aaacaagagg gaaagtgaga aagatcaccc atgattctgt ttcactgttt
     4201 gctttctcct gtcatggtta agagaaatgt gcaattcgat cctcaatcag tgggtggagg
     4261 ataacagggt agattcactt gtgtgcactt gtacagttgt agctgcgagt ccagaagtcc
     4321 tctagagcat gtgtactggc actgagttgg tgagacagtt gtggagtatc ccattctgat
     4381 gagtacagaa aaaaaaagaa aaagaaaaga agagaaaaaa ttaagaaaaa aatcaaaaaa
     4441 ggaagaaaac taaaaaaaaa aaaaatcaaa tcaccttgtg attcagtgta tctgtttact
     4501 aactcaaata aagcaattgt tccctctgga ggggtccagg tgcccccgcc ccacaaggcc
     4561 gcggagcctc agcaggaggg gtggcgagtt gcgggtgggc agggccagga cggtgtggcg
     4621 ccagccttga agcaccacgg cccaaggatg cggtgtacat actgtatttc tagattctcc
     4681 tttgtacaga gtcacttcac aagtcaagct actgttttac aggtgctcct tatttattag
     4741 agctgtgaga gcttggggga cacacctggc gagcaagctc gctttttaaa aatgaaattt
     4801 gggggcaggg gaaggggagg cgggagggag gggaagctcg caagcccggg gagagattta
     4861 taaaagtaaa caaaagaaaa ccttccagca acaaattaaa aaataataac aaatcaaccc
     4921 cagcaccaaa cccacccagg caggaagaag ccgcccctcc tctggggcca tatttttctg
     4981 ctgggtcaca acattctcct ctccctgact ggtgtcagat tcatcaaaca aaaaataaat
     5041 ctcgaagaaa aaaaatgcac ttacatgtgc ttatttggct tttctcatta ttatgactac
     5101 tgtttttttt tgttttttgt tttttgtttt attacagagg tgttcatttt tctccccctg
     5161 ggaaacattt taaaaaatag aactaaggag ttttaaaaga tggtaagcta ctgggatggc
     5221 actgtctctt cctgacctgc tagaccacgc ttgtctgcag acaagagccc actccgtccg
     5281 ttccagggcc tgcttcctaa ccatgcccat cactgacagc acacagtgca tgggaagtga
     5341 gtgtttaggc tgtagaccca ggtgtggtgt cccttccaag tgctcttcaa gtcctgatct
     5401 tttttggctc caagggttca ggcctgaggt tcaagaagca ccatcaaatg gaggcaaaca
     5461 tgctccacgg gttccactca catccacaca ccatctcacc ccactgacta gagagacttt
     5521 tatttcagcc ttatgtgaat ggggtgggtc cgtttggctc tttgatacct gagttaaata
     5581 tcagaaagtt cctaaggtgg aaagtatgct aatatctagt tctagtcatt gtaaatctag
     5641 ttcagttctc ttgttctaca tatgaaaaaa cagaagccta gaaaagcaac tcgacctgtt
     5701 cagagtctcg cacttagttg atttagcttc tcaaaaaaat gaatgttcat taaaatctga
     5761 ggcaccacga gcagctccct tgaagtgatc atcctgtgga ttccggagac ctgattttct
     5821 tctcccatgg agcccgagag aatcttggag gcttcctggt gcagagttat atttatggcg
     5881 gtgactccgt ctgaactctg ccgaggcaag cccagccaag gacgtgccag cggccgaggc
     5941 acccggctgt ggttgtcctg atagcattat tcatctggtc ttggccatgg agacagtcat
     6001 ccaggatatt gattttgctt ttgtctgtag tccaagattg tcaagcaaac attttgaccc
     6061 ttctggaaac aaaaggtacc tttgttccag catagaaaga ttctgtggca tctcataagc
     6121 catcagcacc ccttttcctc ctcttccttc tcacgatctt actgctgtct gaatgcacaa
     6181 ttctcttggg atatcaaaac catatataaa gagaaataga aacaa
//
