LOCUS       NM_003578               2073 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sterol O-acyltransferase 2 (SOAT2), mRNA.
ACCESSION   NM_003578
VERSION     NM_003578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2073)
  AUTHORS   Wang,Z., Cao,Z. and Dai,Z.
  TITLE     ACAT2 may be a novel predictive biomarker and therapeutic target in
            lung adenocarcinoma
  JOURNAL   Cancer Rep (Hoboken) 7 (2), e1956 (2024)
   PUBMED   38213102
  REMARK    GeneRIF: ACAT2 may be a novel predictive biomarker and therapeutic
            target in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 2073)
  AUTHORS   Xiao,Y., Huang,Y., Jiang,J., Chen,Y. and Wei,C.
  TITLE     Identification of the prognostic value of Th1/Th2 ratio and a novel
            prognostic signature in basal-like breast cancer
  JOURNAL   Hereditas 160 (1), 2 (2023)
   PUBMED   36694223
  REMARK    GeneRIF: Identification of the prognostic value of Th1/Th2 ratio
            and a novel prognostic signature in basal-like breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2073)
  AUTHORS   Sun,H.Y., Chen,T.Y., Tan,Y.C., Wang,C.H. and Young,K.C.
  TITLE     Sterol O-acyltransferase 2 chaperoned by apolipoprotein J
            facilitates hepatic lipid accumulation following viral and nutrient
            stresses
  JOURNAL   Commun Biol 4 (1), 564 (2021)
   PUBMED   33980978
  REMARK    GeneRIF: Sterol O-acyltransferase 2 chaperoned by apolipoprotein J
            facilitates hepatic lipid accumulation following viral and nutrient
            stresses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2073)
  AUTHORS   Amato,F., Castaldo,A., Castaldo,G., Cernera,G., Corso,G.,
            Ferrari,E., Gelzo,M., Monzani,R., Villella,V.R. and Raia,V.
  TITLE     Impaired cholesterol metabolism in the mouse model of cystic
            fibrosis. A preliminary study
  JOURNAL   PLoS One 16 (1), e0245302 (2021)
   PUBMED   33412572
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2073)
  AUTHORS   Ran,S., He,X., Jiang,Z.X., Liu,Y., Zhang,Y.X., Zhang,L., Gu,G.S.,
            Pei,Y., Liu,B.L., Tian,Q., Zhang,Y.H., Wang,J.Y. and Deng,H.W.
  TITLE     Whole-exome sequencing and genome-wide association studies identify
            novel sarcopenia risk genes in Han Chinese
  JOURNAL   Mol Genet Genomic Med 8 (8), e1267 (2020)
   PUBMED   32478482
  REMARK    GeneRIF: Whole-exome sequencing and genome-wide association studies
            identify novel sarcopenia risk genes in Han Chinese.
REFERENCE   6  (bases 1 to 2073)
  AUTHORS   Chang,C.C., Sakashita,N., Ornvold,K., Lee,O., Chang,E.T., Dong,R.,
            Lin,S., Lee,C.Y., Strom,S.C., Kashyap,R., Fung,J.J., Farese,R.V.
            Jr., Patoiseau,J.F., Delhon,A. and Chang,T.Y.
  TITLE     Immunological quantitation and localization of ACAT-1 and ACAT-2 in
            human liver and small intestine
  JOURNAL   J Biol Chem 275 (36), 28083-28092 (2000)
   PUBMED   10846185
REFERENCE   7  (bases 1 to 2073)
  AUTHORS   Oelkers,P., Behari,A., Cromley,D., Billheimer,J.T. and Sturley,S.L.
  TITLE     Characterization of two human genes encoding acyl coenzyme
            A:cholesterol acyltransferase-related enzymes
  JOURNAL   J Biol Chem 273 (41), 26765-26771 (1998)
   PUBMED   9756920
REFERENCE   8  (bases 1 to 2073)
  AUTHORS   Cases,S., Novak,S., Zheng,Y.W., Myers,H.M., Lear,S.R., Sande,E.,
            Welch,C.B., Lusis,A.J., Spencer,T.A., Krause,B.R., Erickson,S.K.
            and Farese,R.V. Jr.
  TITLE     ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase.
            Its cloning, expression, and characterization
  JOURNAL   J Biol Chem 273 (41), 26755-26764 (1998)
   PUBMED   9756919
REFERENCE   9  (bases 1 to 2073)
  AUTHORS   Chang,T.Y., Chang,C.C. and Cheng,D.
  TITLE     Acyl-coenzyme A:cholesterol acyltransferase
  JOURNAL   Annu Rev Biochem 66, 613-638 (1997)
   PUBMED   9242919
  REMARK    Review article
REFERENCE   10 (bases 1 to 2073)
  AUTHORS   Yang,H., Bard,M., Bruner,D.A., Gleeson,A., Deckelbaum,R.J.,
            Aljinovic,G., Pohl,T.M., Rothstein,R. and Sturley,S.L.
  TITLE     Sterol esterification in yeast: a two-gene process
  JOURNAL   Science 272 (5266), 1353-1356 (1996)
   PUBMED   8650549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073573.27 and AF059203.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003578.3.
            
            Summary:This gene is a member of a small family of acyl coenzyme
            A:cholesterol acyltransferases. The gene encodes a membrane-bound
            enzyme localized in the endoplasmic reticulum that produces
            intracellular cholesterol esters from long-chain fatty acyl CoA and
            cholesterol. The cholesterol esters are then stored as cytoplasmic
            lipid droplets inside the cell. The enzyme is implicated in
            cholesterol absorption in the intestine and in the assembly and
            secretion of apolipoprotein B-containing lipoproteins such as very
            low density lipoprotein (VLDL). Several alternatively spliced
            transcript variants of this gene have been described, but their
            full-length nature is not known. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF059203.1, BC096090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301466.8/ ENSP00000301466.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC073573.27        38083-38086
            5-45                AC073573.27        38087-38127
            46-1724             AF059203.1         5-1683
            1725-1790           AC073573.27        58784-58849
            1791-2073           AF059203.1         1755-2037
FEATURES             Location/Qualifiers
     source          1..2073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2073
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /note="sterol O-acyltransferase 2"
                     /db_xref="GeneID:8435"
                     /db_xref="HGNC:HGNC:11178"
                     /db_xref="MIM:601311"
     exon            1..174
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1661
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /EC_number="2.3.1.26"
                     /note="acyl-CoA:cholesterol acyltransferase 2; acyl
                     coenzyme A:cholesterol acyltransferase 2; acyl Co-A:
                     cholesterol acyltransferase 2; ACAT-2"
                     /codon_start=1
                     /product="sterol O-acyltransferase 2"
                     /protein_id="NP_003569.1"
                     /db_xref="CCDS:CCDS8847.1"
                     /db_xref="GeneID:8435"
                     /db_xref="HGNC:HGNC:11178"
                     /db_xref="MIM:601311"
                     /translation="MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRH
                     MEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQK
                     VFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSF
                     GQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHV
                     AVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLF
                     CPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTR
                     ALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYR
                     TWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVML
                     ILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQAT
                     FWGLVTPRSWSCHT"
     exon            175..230
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..367
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..427
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..535
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..800
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..870
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..955
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1001
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1131
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1229
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1328
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1464
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1610
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..2073
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /note="hexamer: AATAAA"
     polyA_site      2073
                     /gene="SOAT2"
                     /gene_synonym="ACACT2; ACAT2; ARGP2"
                     /note="major polyA site"
ORIGIN      
        1 gagtgggaca agagctctac agggcaggcc acactgcgaa ggaaggaggc aacacgggca
       61 agggctgcct gctgcccgct ggagaccgca ccatggagcc aggcggggcc cgtctgcgtc
      121 tgcagaggac agaagggctg ggaggggagc gggagcgcca accctgtgga gatggaaaca
      181 ctgagacgca cagagccccg gacttggtac aatggacccg acacatggag gctgtgaagg
      241 cacaattgct ggagcaagcg cagggacaac tgagggagct gctggatcgg gccatgcggg
      301 aggctataca atcctaccca tcacaagaca aacctctgcc cccacctccc ccaggttcct
      361 tgagcaggac ccaggagcca tccctgggga aacagaaagt tttcatcatc cgcaagtccc
      421 tgcttgatga gctgatggag gtgcagcatt tccgcaccat ctaccacatg ttcatcgctg
      481 gcctgtgtgt cttcatcatc agcaccctgg ccatcgactt cattgatgag ggcaggctgc
      541 tgctggagtt tgacctactg atcttcagct tcggacagct gccattggcg ctggtgacct
      601 gggtgcccat gtttctgtcc accctgttgg cgccgtacca ggccctacgg ctgtgggcca
      661 ggggcacctg gacgcaggcg acgggcctgg gctgtgcgct gctagccgcc cacgccgtgg
      721 tgctctgcgc gctgccggtc cacgtggccg tggagcatca gctcccgccg gcctcccgtt
      781 gtgtcctggt cttcgagcag gttaggttcc tgatgaaaag ctactccttc ctgagagagg
      841 ctgtgcctgg gacccttcgt gccagacgag gtgaggggat ccaggccccc agtttctcca
      901 gctacctcta cttcctcttc tgcccaacac tcatctacag ggagacttac cctaggacgc
      961 cctatgtcag gtggaattat gtggccaaga actttgccca ggccctggga tgtgtgctct
     1021 atgcctgctt catcctgggc cgcctctgtg ttcctgtctt tgccaacatg agccgagagc
     1081 ccttcagcac ccgtgccctg gtgctctcta tcctgcatgc cacgttgcca ggcatcttca
     1141 tgctgctgct catcttcttt gccttcctcc attgctggct caacgccttt gccgagatgc
     1201 tacgatttgg agacaggatg ttctaccggg actggtggaa ctcaacgtcc ttctccaact
     1261 actaccgcac ttggaacgtg gtggtccatg actggctgta cagctacgtg tatcaggatg
     1321 ggctgcggct ccttggtgcc cgggcccgag gggtagccat gctgggtgtg ttcctggtct
     1381 ccgcagtggc ccatgagtat atcttctgct tcgtcctggg gttcttctat cccgtcatgc
     1441 tgatactctt ccttgtcatt ggaggaatgt tgaacttcat gatgcatgac cagcgcaccg
     1501 gcccggcatg gaacgtgctg atgtggacca tgctgtttct aggccaggga atccaggtca
     1561 gcctgtactg ccaggagtgg tacgcacggc ggcactgccc cttaccccag gcaactttct
     1621 gggggctggt gacacctcga tcttggtcct gccataccta gaggtcggga cagacgacgc
     1681 tacctgccca gacaccacca agttctctgc ctgcaaaacc tgggaccagg actcctgtct
     1741 gcattcccaa atttggctct gagtcgaggc aacctgcaca caagacccca ccaaggaatg
     1801 tgcaaggact gagatctgca gacttgtggg taactgatca cagacctcag catgggggtg
     1861 accagggtga ctcttcaatc cctatcccca tgggctgggt acaggatatc ctcctacccc
     1921 atgactgtct tagggagact tggggtacct tatggatttg atgaatgtgg gggaactcag
     1981 aggaactggg gccaccaagg ttggaaaagg gtttggttct tgactttgta ttccttccaa
     2041 tacagcaata aactttgtct ccctttttat tca
//
