LOCUS       NM_013321               4704 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens sorting nexin 8 (SNX8), mRNA.
ACCESSION   NM_013321
VERSION     NM_013321.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4704)
  AUTHORS   Li,X., Xiang,C., Zhu,S., Guo,J., Liu,C., Wang,A., Cao,J., Lu,Y.,
            Neculai,D., Xu,P. and Feng,X.H.
  TITLE     SNX8 enables lysosome reformation and reverses lysosomal storage
            disorder
  JOURNAL   Nat Commun 15 (1), 2553 (2024)
   PUBMED   38519472
  REMARK    GeneRIF: SNX8 enables lysosome reformation and reverses lysosomal
            storage disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4704)
  AUTHORS   Hu,Y., He,W., Huang,Y., Xiang,H., Guo,J., Che,Y., Cheng,X., Hu,F.,
            Hu,M., Ma,T., Yu,J., Tian,H., Tian,S., Ji,Y.X., Zhang,P., She,Z.G.,
            Zhang,X.J., Huang,Z., Yang,J. and Li,H.
  TITLE     Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8
            as a Therapeutic Target for NAFLD
  JOURNAL   Hepatology 74 (5), 2508-2525 (2021)
   PUBMED   34231239
  REMARK    GeneRIF: Fatty Acid Synthase-Suppressor Screening Identifies
            Sorting Nexin 8 as a Therapeutic Target for NAFLD.
REFERENCE   3  (bases 1 to 4704)
  AUTHORS   Suzuki,S.W., Oishi,A., Nikulin,N., Jorgensen,J.R., Baile,M.G. and
            Emr,S.D.
  TITLE     A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive
            endosomal recycling
  JOURNAL   Elife 10, e69883 (2021)
   PUBMED   34524084
  REMARK    GeneRIF: A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1
            drive endosomal recycling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4704)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4704)
  AUTHORS   Wei,J., Guo,W., Lian,H., Yang,Q., Lin,H., Li,S. and Shu,H.B.
  TITLE     SNX8 mediates IFNgamma-triggered noncanonical signaling pathway and
            host defense against Listeria monocytogenes
  JOURNAL   Proc Natl Acad Sci U S A 114 (49), 13000-13005 (2017)
   PUBMED   29180417
  REMARK    GeneRIF: SNX8 mediates IFNG-triggered non-canonical signaling
            pathway and host defense against Listeria monocytogenes.
REFERENCE   6  (bases 1 to 4704)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   7  (bases 1 to 4704)
  AUTHORS   Dyve,A.B., Bergan,J., Utskarpen,A. and Sandvig,K.
  TITLE     Sorting nexin 8 regulates endosome-to-Golgi transport
  JOURNAL   Biochem Biophys Res Commun 390 (1), 109-114 (2009)
   PUBMED   19782049
REFERENCE   8  (bases 1 to 4704)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   9  (bases 1 to 4704)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   10 (bases 1 to 4704)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC021565.1, AC004971.3 and AL713633.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013321.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021565.1, AK074544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222990.8/ ENSP00000222990.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-748               BC021565.1         24-771
            749-749             AC004971.3         100246-100246
            750-1147            BC021565.1         773-1170
            1148-1148           AC004971.3         107226-107226
            1149-1471           BC021565.1         1172-1494
            1472-4326           AC004971.3         109595-112449
            4327-4704           AL713633.1         2826-3203
FEATURES             Location/Qualifiers
     source          1..4704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..4704
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /note="sorting nexin 8"
                     /db_xref="GeneID:29886"
                     /db_xref="HGNC:HGNC:14972"
                     /db_xref="MIM:614905"
     exon            1..114
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1418
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /codon_start=1
                     /product="sorting nexin-8"
                     /protein_id="NP_037453.1"
                     /db_xref="CCDS:CCDS5331.1"
                     /db_xref="GeneID:29886"
                     /db_xref="HGNC:HGNC:14972"
                     /db_xref="MIM:614905"
                     /translation="MTGRAMDPLPAAAVGAAAEAEADEEADPPASDLPTPQAIEPQAI
                     VQQVPAPSRMQMPQGNPLLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRF
                     KSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVA
                     RHPLFSEDVVLKLFLSFSGSDVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQF
                     AISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAAL
                     NSSTWGSLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERH
                     EKGVLHKHQRALHKYSLMKRQMMSATAQNREPESVEQLESRIVEQENAIQTMELRNYF
                     SLYCLHQETQLIHVYLPLTSHILRAFVNSQIQGHKEMSKVWNDLRPKLSCLFAGPHST
                     LTPPCSPPEDGLCPH"
     exon            115..320
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..438
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..560
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..641
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..802
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..935
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1004
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1154
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1304
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..4704
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /note="hexamer: ACTAAA"
     polyA_site      1471
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /note="major polyA site"
     regulatory      4680..4685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /note="hexamer: AATAAA"
     polyA_site      4704
                     /gene="SNX8"
                     /gene_synonym="Mvp1"
                     /note="major polyA site"
ORIGIN      
        1 acgtgggagc gcgggctcac atgactggcc gcgcgatgga cccgctgccc gcggctgcag
       61 tcggggcggc agctgaggcg gaggctgacg aggaggcgga tcccccggcg tcagatctgc
      121 cgacacccca ggccatcgag ccccaggcca tcgtgcagca ggtcccagcc cccagtcgaa
      181 tgcagatgcc gcaggggaac ccgctgctgc tgtcccacac cctgcaggag ctgctggcca
      241 gggacaccgt gcaggtggag ctcattccgg agaagaaggg cctcttcctg aagcatgtgg
      301 agtatgaggt ttccagccag cgcttcaagt cctcggtata cagacggtac aatgacttcg
      361 tggtcttcca ggagatgctc ctgcacaagt tcccctaccg tatggtgcct gccctgccac
      421 ccaagagaat gctgggagct gacagggagt tcatcgaggc caggaggaga gccctgaagc
      481 gcttcgtcaa cctggtggcg cgacaccccc tgttctccga ggatgtggtc ctcaagctct
      541 tcctgtcctt cagcggctcg gatgtgcaga acaagttaaa ggagtcagca cagtgcgtcg
      601 gggacgaatt cctgaactgt aagctggcta ccagggccaa ggacttcctc ccagctgaca
      661 tccaggctca gtttgccatc agccgggagc tgatccggaa catctacaat agctttcaca
      721 agcttcgcga cagggccgag cggatcgcat cgcgggccat cgacaatgcg gcagatcttc
      781 tcatattcgg gaaggagcta agtgcaatag ggtctgacac gaccccgctg ccctcctggg
      841 ccgctctgaa tagcagcacg tgggggtccc tgaagcaggc tctgaaaggc ctgtctgtgg
      901 aattcgcgct gctcgccgac aaggctgcac aacagggtaa gcaggaagag aacgacgtgg
      961 tggagaagct gaacctcttc ttggatctgc tgcagtccta taaggacctg tgcgagcggc
     1021 atgagaaggg cgtgttgcac aagcaccagc gggccctgca caagtacagc ctgatgaaga
     1081 ggcagatgat gagcgccacc gcgcagaacc gcgagccgga gtccgtggag cagctggagt
     1141 cccgcattgt ggagcaggag aacgcgattc agacgatgga gctgcggaac tacttctccc
     1201 tgtactgcct gcaccaggag acgcagctca tccacgtcta cctgcccctc acctcccaca
     1261 tcctccgcgc cttcgtcaac tctcagatcc aagggcacaa ggagatgagc aaggtgtgga
     1321 acgacctgag gcccaagctc agctgcctct ttgcgggacc acacagcacc ctgaccccac
     1381 cgtgctcccc gccggaggac ggcctgtgtc ctcactagcg cctgaggctg aggtggtgct
     1441 ccctgcggcc gcactaaaac ctctttccaa acggtgtgtc ccggtgtaat tccctttgga
     1501 cggcagctcc cctccccgcc acgccccgtg ctgcagctgg agcagaggag ctcacgcctg
     1561 cgggtcggga ggcgcatccg tggaccatgg gggcagctgg gccacactgt ccttcgccct
     1621 gtggcctgct agcctggtcg agagaggtgg tggggttctc tggaatggtt tcctcctgac
     1681 acccagagct gtgcggggag gcagggatct ctcatctcac agagattgtg cctgggggag
     1741 cgtggaggca gggcctccag gtgctggaac agtcgggagg ggcagcatca tggtgctcgg
     1801 tcagccgagg agagagggca gggctgccct gcagcccagg catgggactg accacggaca
     1861 gcgaggggac agccagtggt gctgaggctg ggagggaggg ccattgggcg tggggcacgc
     1921 acggtgaatt ttctagggaa attgctgcag tcaacacctg gagccctggt ctgggagtgg
     1981 cctgtggggt ccagtggcct catgccctgt gcccatatga tgaccccatg tgtgcctgtg
     2041 tccacaccat gaccctgtgt gtgcccaggc ctggaagaca aaggcgtgac ggagagctgg
     2101 ggctctgaga gtgggcgcta cagcagctgt gttctcgtcc cctggactcc cttgatttct
     2161 ggtggccagt gttggggtct gcaccgtgtg gcactgaggc tggatgggct ggcagaggac
     2221 aggtgggggc gtgggggggc gtgttccatt ccagctgagg ctttagagga gggacagccc
     2281 ccttttaagt ggatttcctt ctctgaggca cctagagccc tcctcccagc ctcccgtcac
     2341 gcacttgccg gcccagccac ctgctcacag agggaaccag tggtctttca ggccccttcc
     2401 ctgctctgga tgaagaaggc cattctcctg agctctgtgg ggctggactg tccgcctcag
     2461 gcctgggtct gcttctgccc gaaccccttt tgtggaaggt acatgggagc ccagtggacc
     2521 cctgcacttc tccggagcct gacgcccctc cctggccggg gaggggtgct ggaagaggcc
     2581 cgccgggctc cagggtttcc gaggtccctc cgctccgcag atgctcactg gcctctgggg
     2641 cgttcactcc tctcacggag ggtgcttccc ttccgcctgt acctacgggc agctcacggc
     2701 cgtgggatgg agaggggact cctgtgtgtg ccccgcaggc aggtgatcca tcgtccactg
     2761 cgagccggcc agagggaacg gccgtgcctt ctggccccgt gggctgtgct gactcggtgg
     2821 ctgtggggct cgggcccagc ctgccctgcc ctgtgggttc tgctgctgcc ttcctgctgt
     2881 gaggtgggct gcttccttct ggccagatga gcagagggca gcgttccctt tggagcccga
     2941 tgggtgggct gtcccgtgag tccctagtcc acccgagtct tgggctgcgc tgccttctga
     3001 cgcccctctg cagagacagg ttctcagttg ccatgaatgg caccatgaca cccgagccat
     3061 gaagcgtgac cccgtgtggg cagaaggctg caaggcctct ccgtccaccc cgcaccttcc
     3121 tggggcctgt ccagctgcag gaccatagag gctgtgggga gtcgtggagg gcatcaggtg
     3181 ctggggcctc tgtgtctcca gagtaggcaa ggcacgcgct cctgacagcc cccaaggatt
     3241 gagcaagact tcagaatgag cttttctgaa ggagctttcc tggcagggac tccggggtca
     3301 gtgagtgtat gagaggccac atacctggcg gcatctccct gtgttggaaa cttcaagagc
     3361 agggtctcag ggtcctcatg tccagaggct gaggatggag gtggaaggct ggagggcagg
     3421 ggtgaggagg gagcaggagg gcaggagttg ggggagcagg agggcagggg tcaggagaac
     3481 aggagaacag gggtaaggga gggcaggggt gagggggagc agaagaggga tgagggggag
     3541 caggagggca ggcgttggga caggagggca ggggtgagag agcaaggggg caggggtgag
     3601 agagcaggag agcaggggtg aggagagcag gagagtaggg gtgatgggga ataggagggc
     3661 aggggtgagg agggagcagg agaacgggta agggagggca ggggtgaggg ggagcaggag
     3721 ggcaggggtg aggagagagc aagagggcag gggtgaggag agcaagaggg caggggtggg
     3781 aaggcaggag ggaggtgggg gggcaggaag gcaggggtgg gagggtcagg agggcagggt
     3841 gaaggggggg ctggagggca gcggtgacga gggcagcctg tctcccacgt gtggtggctg
     3901 cttcctgtgt gccctggggt tggctctgtg gaggggtggg cactggcttt ggaacacctc
     3961 cctccccttc ctcctctgcc acccagtgcc ttctaaaggg cagcagaaag aggcctgcta
     4021 ggcaggggtg gcggaggcca ccttccttct cacaaatact tcttggccct ggccctgtgc
     4081 tgcccgggca ggtccccagg ctcaggggct gagaggctgc ttactgctgc aggtggaggc
     4141 cccatgccgg agggagagcg gggttccccc catgcctctc cagccctcct gctgcccacg
     4201 gcccaagccc aagcttgtgc cggtcattac ggccttgcct agctggcagg gacagctgcg
     4261 tgtgatgctg gtggagatgc cagatgccgc ctgccctgtg aggacggctg gcggggccgt
     4321 gggagggggg ttgtgggctg gcggggctgt gggaaggggg ctgccgatca tggtgaaagg
     4381 ggacattttc attgggtcct cgtggtccgt gtcctgggta ctcggggtca ccgtgcagac
     4441 agctgccctt tgtctgccgg acacagtgca ggcaggggag acaggtttag ggctctgaca
     4501 tggggcacag ggactccgag ccaagggatg tcagggcagc tctgtgcatc tgaggccttt
     4561 gcccttgctt tgcgggtcag ttcatgtcca aagcacttta ggaggctgca gggatcaata
     4621 cccaatatac ccaacaactg gaattgttta cacatgacct acattttgga cggtttatca
     4681 ataaacatgt gtgaacaact gtta
//
