LOCUS       NM_015976               1736 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sorting nexin 7 (SNX7), transcript variant 1, mRNA.
ACCESSION   NM_015976
VERSION     NM_015976.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1736)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1736)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1736)
  AUTHORS   Anton,Z., Betin,V.M.S., Simonetti,B., Traer,C.J., Attar,N.,
            Cullen,P.J. and Lane,J.D.
  TITLE     A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates
            ATG9A trafficking for efficient autophagosome assembly
  JOURNAL   J Cell Sci 133 (14) (2020)
   PUBMED   32513819
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1736)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1736)
  AUTHORS   Xu,S., Zhang,L. and Brodin,L.
  TITLE     Overexpression of SNX7 reduces Abeta production by enhancing
            lysosomal degradation of APP
  JOURNAL   Biochem Biophys Res Commun 495 (1), 12-19 (2018)
   PUBMED   29080748
  REMARK    GeneRIF: Overexpression of SNX7 in HEK293T cells reduces the levels
            of secreted Abeta and beta-cleaved N-terminal APP fragments
            (sAPPbeta). Moreover, SNX7 overexpression caused a significant
            reduction of the steady-state levels of APP as well as of the cell
            surface APP levels.
REFERENCE   6  (bases 1 to 1736)
  AUTHORS   Zhang,X., Bocca,S., Franchi,A., Anderson,S., Kaur,M., Bajic,V.B.
            and Oehninger,S.
  TITLE     Do GnRH analogues directly affect human endometrial epithelial cell
            gene expression?
  JOURNAL   Mol Hum Reprod 16 (5), 347-360 (2010)
   PUBMED   20203127
REFERENCE   7  (bases 1 to 1736)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   8  (bases 1 to 1736)
  AUTHORS   Orlacchio,A., Kawarai,T., Gaudiello,F., St George-Hyslop,P.H.,
            Floris,R. and Bernardi,G.
  TITLE     New locus for hereditary spastic paraplegia maps to chromosome
            1p31.1-1p21.1
  JOURNAL   Ann Neurol 58 (3), 423-429 (2005)
   PUBMED   16130112
REFERENCE   9  (bases 1 to 1736)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   10 (bases 1 to 1736)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627442.10.
            
            On Nov 23, 2018 this sequence version replaced NM_015976.4.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region
            like some family members, and its exact function is unknown.
            Alternative splicing results in multiple transcript variants. A
            related pseudogene has been identified on chromosome 11. [provided
            by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.906165.1,
                                           SRR1660803.41473.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306121.8/ ENSP00000304429.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AL627442.10        948-1138
            192-374             AL627442.10        24112-24294
            375-485             AL627442.10        30302-30412
            486-650             AL627442.10        30762-30926
            651-849             AL627442.10        34745-34943
            850-1049            AL627442.10        37933-38132
            1050-1136           AL627442.10        41044-41130
            1137-1289           AL627442.10        77464-77616
            1290-1736           AL627442.10        99281-99727
FEATURES             Location/Qualifiers
     source          1..1736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.3"
     gene            1..1736
                     /gene="SNX7"
                     /note="sorting nexin 7"
                     /db_xref="GeneID:51375"
                     /db_xref="HGNC:HGNC:14971"
                     /db_xref="MIM:614904"
     exon            1..191
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1367
                     /gene="SNX7"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sorting nexin-7 isoform a"
                     /protein_id="NP_057060.2"
                     /db_xref="CCDS:CCDS755.2"
                     /db_xref="GeneID:51375"
                     /db_xref="HGNC:HGNC:14971"
                     /db_xref="MIM:614904"
                     /translation="MEGERRASQAPSSGLPAGGANGESPGGGAPFPGSSGSSALLQAE
                     VLDLDEDEDDLEVFSKDASLMDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDE
                     PESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPL
                     PEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWELSSH
                     KKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYK
                     EEREYFDEMKEYGPIHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPV
                     VHEYVLYSEMLMGVMKRRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANN
                     ALKADWERWKQNMQNDIKLAFTDMAEENIHYYEQCLATWESFLTSQTNLHLEEASEDK
                     P"
     exon            192..374
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     exon            375..485
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     exon            486..650
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     exon            651..849
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1049
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1136
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1289
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1736
                     /gene="SNX7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX7"
                     /note="hexamer: AATAAA"
     polyA_site      1736
                     /gene="SNX7"
                     /note="major polyA site"
ORIGIN      
        1 gcactctcgg gatggagggc gagcgccggg catcgcaggc gccctcctcg ggcctcccgg
       61 ccgggggcgc caacggggag agcccggggg gcggcgcccc ctttccgggc agcagtggct
      121 cttccgccct gctgcaggcg gaggtgctgg atctggacga ggacgaggac gacctggagg
      181 tgttcagcaa ggatgcctca ttgatggaca tgaactcctt cagccctatg atgccaacat
      241 cccctttatc aatgataaac caaatcaagt ttgaggatga accagattta aaggatctct
      301 tcatcacagt tgatgaacct gaaagtcatg ttactacaat agaaactttc attacgtata
      361 ggattattac taagacatct cgtggggaat ttgactccag tgaatttgaa gttaggagac
      421 gatatcaaga tttcctttgg ttgaagggaa aactggaaga agcacacccc actctgatta
      481 ttccaccatt gccagaaaag tttatagtaa aaggaatggt ggaacgcttt aacgatgact
      541 tcattgagac acgcaggaag gctttacata aatttttgaa ccgaattgct gatcatccaa
      601 ctttaacatt taatgaagac ttcaaaattt ttctcactgc acaagcttgg gaactctctt
      661 ctcacaagaa gcaaggtcct ggcttgctaa gcaggatggg gcaaaccgtc agagctgttg
      721 cgtcctcaat gagaggagtt aaaaaccgcc cagaggagtt catggaaatg aataacttta
      781 ttgaactatt tagccagaaa ataaatttga tagataaaat atctcagaga atttataagg
      841 aagaaaggga atattttgat gaaatgaaag aatatggccc aattcatatt ctgtggtcag
      901 cgtcagaaga ggatctggtt gatactctaa aggatgttgc cagctgcatt gacagatgct
      961 gtaaggccac tgaaaagcgg atgtctggac tctcagaggc cctgcttcct gttgtacatg
     1021 agtacgtgct ttatagtgaa atgttaatgg gtgttatgaa aagaagagac caaatacaag
     1081 cagaactgga ttccaaagtt gaagttttga cctataaaaa ggcagatact gatctgcttc
     1141 cagaggagat tggaaaactt gaagataaag tggaatgtgc taataatgcc ctgaaagcag
     1201 attgggagag atggaaacaa aatatgcaaa atgatatcaa gttagcattt acagatatgg
     1261 ctgaggagaa tatccattat tatgaacagt gccttgctac gtgggagtca ttccttacat
     1321 cacagaccaa ccttcacttg gaagaagcct ctgaagataa accttaatcc cattgaggac
     1381 ttctgtttga tctttgggag acagcattta ttaaccaaag ttattctttc tggatctgcc
     1441 gtgtccttat aaagtggatg aaaaatgttt tgtacccatc tggaaaacca acaacttgaa
     1501 atctcaggta ttccaggtca ctgacatgaa tttgaagata tatctatctg tatggatata
     1561 tatctatatg tatatagata tataaataca gagagatatc tggcttggtt ttaattatgt
     1621 tcttaaattt gtgtgccaat aattgcatat agattttttt tcttaaatat ttgactgtgg
     1681 aacatgccat tttaaatatg ttgtaaggac tgttttaata aaaagtttag tatgaa
//
