LOCUS       NP_689419                406 aa            linear   PRI 27-APR-2025
DEFINITION  sorting nexin-6 isoform b [Homo sapiens].
ACCESSION   NP_689419
VERSION     NP_689419.3
DBSOURCE    REFSEQ: accession NM_152233.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Ghosh,C., Xing,Y., Li,S., Hoyle,R.G., Sun,M., Li,J. and Sun,Y.
  TITLE     Sorting nexin 6 interacts with Cullin3 and regulates programmed
            death ligand 1 expression
  JOURNAL   FEBS Lett 595 (20), 2558-2569 (2021)
   PUBMED   34510437
  REMARK    GeneRIF: Sorting nexin 6 interacts with Cullin3 and regulates
            programmed death ligand 1 expression.
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 406)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (residues 1 to 406)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 406)
  AUTHORS   Camargo,L.M., Collura,V., Rain,J.C., Mizuguchi,K., Hermjakob,H.,
            Kerrien,S., Bonnert,T.P., Whiting,P.J. and Brandon,N.J.
  TITLE     Disrupted in Schizophrenia 1 Interactome: evidence for the close
            connectivity of risk genes and a potential synaptic basis for
            schizophrenia
  JOURNAL   Mol Psychiatry 12 (1), 74-86 (2007)
   PUBMED   17043677
REFERENCE   7  (residues 1 to 406)
  AUTHORS   Ishibashi,Y., Maita,H., Yano,M., Koike,N., Tamai,K., Ariga,H. and
            Iguchi-Ariga,S.M.
  TITLE     Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from
            cytoplasm to nucleus
  JOURNAL   FEBS Lett 506 (1), 33-38 (2001)
   PUBMED   11591366
REFERENCE   8  (residues 1 to 406)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
REFERENCE   9  (residues 1 to 406)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   10 (residues 1 to 406)
  AUTHORS   Wurthner,J.U., Frank,D.B., Felici,A., Green,H.M., Cao,Z.,
            Schneider,M.D., McNally,J.G., Lechleider,R.J. and Roberts,A.B.
  TITLE     Transforming growth factor-beta receptor-associated protein 1 is a
            Smad4 chaperone
  JOURNAL   J Biol Chem 276 (22), 19495-19502 (2001)
   PUBMED   11278302
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB021488.1, U83194.1,
            BI870378.1, AF121856.2, AK124315.1 and AI446034.1.
            
            On Oct 10, 2018 this sequence version replaced NP_689419.2.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein associates with the long isoform of the
            leptin receptor, the transforming growth factor-beta family of
            receptor serine-threonine kinases, and with receptor tyrosine
            kinases for platelet-derived growth factor, insulin, and epidermal
            growth factor. This protein may form oligomeric complexes with
            family member proteins through interactions of both the PX domain
            and the coiled coil regions of the molecules. Translocation of this
            protein from the cytoplasm to the nucleus occurs after binding to
            proviral integration site 1 protein. This gene results in two
            transcripts encoding two distinct isoforms. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.119176.1,
                                           SRR1803617.10341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362031.10/ ENSP00000355217.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.1"
     Protein         1..406
                     /product="sorting nexin-6 isoform b"
                     /note="tumor necrosis factor receptor-associated factor
                     4(TRAF4)-associated factor 2; TRAF4-associated factor 2"
                     /calculated_mol_wt=46518
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:19413330,
                     ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9UNH7.1)"
     Region          2..179
                     /region_name="Interaction with PIM1.
                     /evidence=ECO:0000269|PubMed:11591366"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNH7.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylmethionine, in Sorting nexin-6,
                     N-terminally processed.
                     /evidence=ECO:0007744|PubMed:19413330,
                     ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378;
                     propagated from UniProtKB/Swiss-Prot (Q9UNH7.1)"
     Region          30..170
                     /region_name="PX_SNX6"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 6; cd07292"
                     /db_xref="CDD:132825"
     Site            order(69..71,96..97,140)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132825"
     Site            116
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UNH7.1)"
     Region          182..199
                     /region_name="Membrane-binding amphipathic helix.
                     /evidence=ECO:0000303|PubMed:23085988"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNH7.1)"
     Region          186..403
                     /region_name="BAR_SNX6"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Sorting
                     Nexin 6; cd07662"
                     /db_xref="CDD:153346"
     Site            194
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9UNH7.1)"
     Site            order(216,219..220,223..224,226..227,230,233..234,237,
                     244..245,247..248,251,254..255,258..259,274,363,366..367,
                     369..371,374,377..378,380..382,384..385,388..389,391..392,
                     395..396,398..399)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153346"
     CDS             1..406
                     /gene="SNX6"
                     /gene_synonym="MSTP010; TFAF2"
                     /coded_by="NM_152233.4:33..1253"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS41942.2"
                     /db_xref="GeneID:58533"
                     /db_xref="HGNC:HGNC:14970"
                     /db_xref="MIM:606098"
ORIGIN      
        1 mmeglddgpd flseedrglk ainvdlqsda alqvdisdal serdkvkftv htksslpnfk
       61 qnefsvvrqh eefiwlhdsf venedyagyi ippapprpdf dasreklqkl gegegsmtke
      121 eftkmkqele aeylaifkkt vamhevflcr vaahpilrrd lnfhvfleyn qdlsvrgknk
      181 kekledffkn mvksadgviv sgvkdvddff ehertflley hnrvkdasak sdrmtrshks
      241 aaddynrigs slyalgtqds tdickfflkv selfdktrki earvsadedl klsdllkyyl
      301 resqaakdll yrrsrslvdy enankaldka raknkdvlqa etsqqlccqk fekisesakq
      361 elidfktrrv aafrknlvel aelelkhakg nlqllqncla vlngdt
//
