LOCUS       NM_014426               2341 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens sorting nexin 5 (SNX5), transcript variant 2, mRNA.
ACCESSION   NM_014426
VERSION     NM_014426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2341)
  AUTHORS   Cabrera-Reyes,F., Contreras-Palacios,T., Ulloa,R., Jara-Wilde,J.,
            Caballero,M., Quiroga,C., Feijoo,C.G., Diaz-Munoz,J. and
            Yuseff,M.I.
  TITLE     SNX5 promotes antigen presentation in B cells by dual regulation of
            actin and lysosomal dynamics
  JOURNAL   Life Sci Alliance 8 (1), e202402917 (2024)
   PUBMED   39448266
  REMARK    GeneRIF: SNX5 promotes antigen presentation in B cells by dual
            regulation of actin and lysosomal dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2341)
  AUTHORS   Tornero-Ecija,A., Zapata-Del-Bano,A., Anton-Esteban,L., Vincent,O.
            and Escalante,R.
  TITLE     The association of lipid transfer protein VPS13A with endosomes is
            mediated by sorting nexin SNX5
  JOURNAL   Life Sci Alliance 6 (6), e202201852 (2023)
   PUBMED   36977596
  REMARK    GeneRIF: The association of lipid transfer protein VPS13A with
            endosomes is mediated by sorting nexin SNX5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2341)
  AUTHORS   Li,Z.
  TITLE     Overexpression of lncRNA HOXA-AS2 promotes the progression of oral
            squamous cell carcinoma by mediating SNX5 expression
  JOURNAL   BMC Mol Cell Biol 23 (1), 59 (2022)
   PUBMED   36528556
  REMARK    GeneRIF: Overexpression of lncRNA HOXA-AS2 promotes the progression
            of oral squamous cell carcinoma by mediating SNX5 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2341)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2341)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2341)
  AUTHORS   Wassmer,T., Attar,N., Bujny,M.V., Oakley,J., Traer,C.J. and
            Cullen,P.J.
  TITLE     A loss-of-function screen reveals SNX5 and SNX6 as potential
            components of the mammalian retromer
  JOURNAL   J Cell Sci 120 (Pt 1), 45-54 (2007)
   PUBMED   17148574
  REMARK    GeneRIF: SNX5 and SNX6 may constitute functional equivalents of
            Vps17p in mammalian retromer
REFERENCE   7  (bases 1 to 2341)
  AUTHORS   Merino-Trigo,A., Kerr,M.C., Houghton,F., Lindberg,A., Mitchell,C.,
            Teasdale,R.D. and Gleeson,P.A.
  TITLE     Sorting nexin 5 is localized to a subdomain of the early endosomes
            and is recruited to the plasma membrane following EGF stimulation
  JOURNAL   J Cell Sci 117 (Pt 26), 6413-6424 (2004)
   PUBMED   15561769
  REMARK    GeneRIF: SNX5 is localized to a subdomain of the early endosomes
            and is recruited to the cell membrane following EGF stimulation.
REFERENCE   8  (bases 1 to 2341)
  AUTHORS   Towler,M.C., Gleeson,P.A., Hoshino,S., Rahkila,P., Manalo,V.,
            Ohkoshi,N., Ordahl,C., Parton,R.G. and Brodsky,F.M.
  TITLE     Clathrin isoform CHC22, a component of neuromuscular and
            myotendinous junctions, binds sorting nexin 5 and has increased
            expression during myogenesis and muscle regeneration
  JOURNAL   Mol Biol Cell 15 (7), 3181-3195 (2004)
   PUBMED   15133132
REFERENCE   9  (bases 1 to 2341)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
REFERENCE   10 (bases 1 to 2341)
  AUTHORS   Otsuki,T., Kajigaya,S., Ozawa,K. and Liu,J.M.
  TITLE     SNX5, a new member of the sorting nexin family, binds to the
            Fanconi anemia complementation group A protein
  JOURNAL   Biochem Biophys Res Commun 265 (3), 630-635 (1999)
   PUBMED   10600472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB118420.1, BC093623.1 and
            BC000100.3.
            
            On Jun 2, 2019 this sequence version replaced NM_014426.3.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein functions in endosomal sorting, the
            phosphoinositide-signaling pathway, and macropinocytosis. This gene
            may play a role in the tumorigenesis of papillary thyroid
            carcinoma. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Sep
            2013].
            
            Transcript Variant: This variant (2) represents the longest
            transcript. Variants 1 and 2 encode the same protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001793.1, AK129505.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377759.9/ ENSP00000366988.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                DB118420.1         1-74
            75-1639             BC093623.1         1-1565
            1640-2341           BC000100.3         1434-2135
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..2341
                     /gene="SNX5"
                     /note="sorting nexin 5"
                     /db_xref="GeneID:27131"
                     /db_xref="HGNC:HGNC:14969"
                     /db_xref="MIM:605937"
     exon            1..420
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..1584
                     /gene="SNX5"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-5 isoform a"
                     /protein_id="NP_055241.1"
                     /db_xref="CCDS:CCDS13130.1"
                     /db_xref="GeneID:27131"
                     /db_xref="HGNC:HGNC:14969"
                     /db_xref="MIM:605937"
                     /translation="MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
                     VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGP
                     REKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDR
                     NFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLIN
                     YYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKL
                     RKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSK
                     DVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVS
                     LLQSCIDLFKNN"
     exon            421..525
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            526..636
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            637..758
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            759..882
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            883..978
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1084
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1160
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1200
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1287
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1447
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1533
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..2341
                     /gene="SNX5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX5"
                     /note="hexamer: AATAAT"
     polyA_site      2341
                     /gene="SNX5"
                     /note="major polyA site"
ORIGIN      
        1 ctttctctag acgcgtcttg ctgggagagt gtccgttgct tcccgtccgt gtcgcggccc
       61 tgcggttggc ggcctcctcg tggagcggag caagggtagg ccccacgtgg cgtctttgcc
      121 cggctccaag atggacggca gcggggactg ggaggctgct ctgggggagc acgtggcgcc
      181 ctgctcgcct gctcccgggg cagctgggat ggtggcggag tccggaggcc tcctgccgcc
      241 gtcgggcagg gaggccggcg gaggcggggc cgtggccgcc cccgagaggc gcccaggcgg
      301 cggcggcggc ggcccagctt cttctttcct cgcacagcca ggcggcccct gctcgagtcc
      361 cgcgtcgcca tggccgcggt tcccgagttg ctgcagcagc aggaggagga ccgcagcaag
      421 ctgagatctg tatctgtgga cctgaatgtt gatccctcgc ttcagattga catacctgat
      481 gcgctcagtg agagagacaa agtcaaattt acagtgcaca caaagaccac actgcccacg
      541 tttcagagcc cagagttttc tgttacaagg caacatgaag actttgtgtg gctacatgac
      601 actcttattg aaacaacaga ctatgctggg cttattattc cacctgctcc tacgaagccc
      661 gactttgatg gtcctcgaga gaagatgcag aaactgggag aaggtgaagg gtctatgacc
      721 aaagaagaat ttgccaagat gaaacaagaa ctggaagctg agtatctcgc tgtgtttaag
      781 aagactgtgt cctcccatga agtctttctt cagcggcttt cttctcaccc tgttctcagt
      841 aaagatcgca actttcatgt tttcctggaa tatgatcagg atctaagtgt taggcggaaa
      901 aatactaaag agatgtttgg tggcttcttc aaaagtgtgg tgaaaagtgc tgatgaagtc
      961 ctttttactg gagttaagga ggtagatgac ttctttgagc aagagaagaa cttccttatt
     1021 aactattaca ataggatcaa agattcttgt gtgaaagctg acaaaatgac cagatctcat
     1081 aaaaatgttg ccgatgacta tatccacacc gcagcctgct tacatagcct ggctttagaa
     1141 gagcccacag tcatcaaaaa gtacctattg aaggttgctg agctatttga aaaactaagg
     1201 aaagtagagg gtcgagtttc atcagatgaa gatttgaagc taacagagct cctccgatac
     1261 tacatgctca acattgaagc tgctaaggat ctcttataca gacgcaccaa agccctcatt
     1321 gactatgaga actcaaacaa agctctggat aaggcccggt taaagagcaa agacgtcaag
     1381 ttggctgagg cacaccagca ggagtgctgc cagaaatttg aacaactttc cgaatctgca
     1441 aaagaagaac tgataaattt caaacggaag agagtggcag catttagaaa gaatctaatt
     1501 gaaatgtctg aactggaaat aaaacatgcc aggaacaatg tctccctttt gcagagctgt
     1561 attgacttgt tcaagaataa ctgatatgcc ttcactcaga agaaaagaaa tgaatgtgaa
     1621 agaaagccaa gcatcacttg cacttaaatc attaccacgg aagatatatt agcttcaact
     1681 ttagtttaaa attatgtgaa taaatatttt gatttctaca aatcttaaca tttaaccatg
     1741 ttggtttaaa aatattattg cttgctactt ggacataact aatttttcct tgtgcattta
     1801 atacctctgg gcagaatcca aatactgggt tctcccgtag ttcgtcttta gttactaaga
     1861 aagggtgtag gacacattag ccttctggaa acaagtagaa gccatcacct ggcccatgtc
     1921 cctacaaacc catgattgtc agggaggtgc cagttacagc aggtgattca gctacttgag
     1981 gtcggtaaca gaccttccat tcctcactga aggtggggtt tgtgtttttg ttttgccctg
     2041 ttactccact ggtagtcatc tggtgtttgt actataacaa cagcaagaaa atctcattta
     2101 tctttatata ctctttgcac ctcctttttt tagtcgagat ataaatattt gaggggagag
     2161 aaatatctac aggtatatat ggaaacaaat aatgtggtct gctttataag atggccagat
     2221 ctacattagg aaaagtataa gccccctccc taatggccgc tggggggtga gggcggtgtg
     2281 ttgtatgtct ttgggtgttt gtttttttat aaagcatata ataaaataat cgtgctacta
     2341 a
//
