LOCUS       NM_153271               8002 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens sorting nexin 33 (SNX33), transcript variant 1, mRNA.
ACCESSION   NM_153271
VERSION     NM_153271.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8002)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8002)
  AUTHORS   Takada-Takatori,Y.
  TITLE     [Donepezil Reduces Amyloid Precursor Protein Endocytosis by
            Resulting from Increase in the Expression of Sorting Nexin Protein
            33]
  JOURNAL   Yakugaku Zasshi 141 (6), 851-856 (2021)
   PUBMED   34078793
  REMARK    GeneRIF: [Donepezil Reduces Amyloid Precursor Protein Endocytosis
            by Resulting from Increase in the Expression of Sorting Nexin
            Protein 33].
            Review article
REFERENCE   3  (bases 1 to 8002)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 8002)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 8002)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 8002)
  AUTHORS   Zhang,J., Zhang,X., Guo,Y., Xu,L. and Pei,D.
  TITLE     Sorting nexin 33 induces mammalian cell micronucleated phenotype
            and actin polymerization by interacting with Wiskott-Aldrich
            syndrome protein
  JOURNAL   J Biol Chem 284 (32), 21659-21669 (2009)
   PUBMED   19487689
  REMARK    GeneRIF: SNX33 plays a role in maintaining cell shape and cell
            cycle progression through its interaction with WASp
REFERENCE   7  (bases 1 to 8002)
  AUTHORS   Heiseke,A., Schobel,S., Lichtenthaler,S.F., Vorberg,I.,
            Groschup,M.H., Kretzschmar,H., Schatzl,H.M. and Nunziante,M.
  TITLE     The novel sorting nexin SNX33 interferes with cellular PrP
            formation by modulation of PrP shedding
  JOURNAL   Traffic 9 (7), 1116-1129 (2008)
   PUBMED   18419754
  REMARK    GeneRIF: SNX33 interferes with cellular PrP formation by modulation
            of PrP shedding
REFERENCE   8  (bases 1 to 8002)
  AUTHORS   Schobel,S., Neumann,S., Hertweck,M., Dislich,B., Kuhn,P.H.,
            Kremmer,E., Seed,B., Baumeister,R., Haass,C. and Lichtenthaler,S.F.
  TITLE     A novel sorting nexin modulates endocytic trafficking and
            alpha-secretase cleavage of the amyloid precursor protein
  JOURNAL   J Biol Chem 283 (21), 14257-14268 (2008)
   PUBMED   18353773
  REMARK    GeneRIF: identifies SNX33 as a new endocytic protein, which
            modulates amyloid precursor protein endocytosis and APP
            alpha-secretase cleavage, and demonstrates that the rate of APP
            endocytosis is a major control factor for APP alpha-secretase
            cleavage
REFERENCE   9  (bases 1 to 8002)
  AUTHORS   Seet,L.F. and Hong,W.
  TITLE     The Phox (PX) domain proteins and membrane traffic
  JOURNAL   Biochim Biophys Acta 1761 (8), 878-896 (2006)
   PUBMED   16782399
  REMARK    Review article
REFERENCE   10 (bases 1 to 8002)
  AUTHORS   Karkkainen,S., Hiipakka,M., Wang,J.H., Kleino,I., Vaha-Jaakkola,M.,
            Renkema,G.H., Liss,M., Wagner,R. and Saksela,K.
  TITLE     Identification of preferred protein interactions by phage-display
            of the human Src homology-3 proteome
  JOURNAL   EMBO Rep 7 (2), 186-191 (2006)
   PUBMED   16374509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105020.18.
            
            On Aug 6, 2019 this sequence version replaced NM_153271.1.
            
            Summary: The protein encoded by this gene is involved in
            cytoskeletal reorganization, vesicle trafficking, endocytosis, and
            mitosis. The encoded protein is essential for the creation of the
            cleavage furrow during mitosis and for completion of mitosis. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.431661.1,
                                           SRR14038195.2241598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308527.6/ ENSP00000311427.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2662              AC105020.18        63842-66503         c
            2663-8002           AC105020.18        52114-57453         c
FEATURES             Location/Qualifiers
     source          1..8002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..8002
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /note="sorting nexin 33"
                     /db_xref="GeneID:257364"
                     /db_xref="HGNC:HGNC:28468"
                     /db_xref="MIM:619107"
     exon            1..2662
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /inference="alignment:Splign:2.1.0"
     CDS             1192..2916
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     and PX domain containing 3; SH3 and PX domain-containing
                     protein 3"
                     /codon_start=1
                     /product="sorting nexin-33 isoform 1"
                     /protein_id="NP_695003.1"
                     /db_xref="CCDS:CCDS10283.1"
                     /db_xref="GeneID:257364"
                     /db_xref="HGNC:HGNC:28468"
                     /db_xref="MIM:619107"
                     /translation="MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNS
                     RGETGLFPASYVEIVRSGISTNHADYSSSPAGSPGAQVSLYNSPSVASPARSGGGSGF
                     LSNQGSFEEDDDDDWDDWDDGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRP
                     KPPLERQDSLASAKRGSVVGRNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGP
                     RGPQWKANPHPFACSVEDPTKQTKFKGIKSYISYKLTPTHAASPVYRRYKHFDWLYNR
                     LLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLS
                     CLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSV
                     LQLSTVASELVRKHVGGFRKEFQKLGSAFQAISHSFQMDPPFCSEALNSAISHTGRTY
                     EAIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRM
                     VQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEK
                     TLRMYDNL"
     exon            2663..8002
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4309..4314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /note="hexamer: GATAAA"
     polyA_site      4333
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /note="major polyA site"
     regulatory      7935..7940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /note="hexamer: ATTAAA"
     polyA_site      7952
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
     regulatory      7982..7987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
                     /note="hexamer: ATTAAA"
     polyA_site      8002
                     /gene="SNX33"
                     /gene_synonym="SH3PX3; SH3PXD3C; SNX30"
ORIGIN      
        1 gcctttttgt tttggagctg ccttctcgct ggcggagcgg agggtctgcg agcgccgggg
       61 aaggcaggct gggggcgcag cccgcccccc actggccggg ccccgcaggg cggagaggag
      121 gacggacgga cagacggctg gccgcgccat ctgctcgccg gagctcactc tccaaactcc
      181 aaactgttga gtgtgtgcgt gcacgcgagg gtggtgatcg ggggtcgtaa gtcccgggtg
      241 aggaaccggt ttctgctggg gttacctttg gacggggttc ctgggattca gagcagggtc
      301 agcgtcaggc tcagaaactg ctgaggaatt aggcaaacaa aagagaccac tcagcgagtg
      361 gctagaagtc gcccgacagc ctcgtcgcgc cccctccttc ctccggggtt ggggctggcc
      421 acttctgggg cggggagagg gcgcccgagc cggcgggggc tccggctgcg cagccggggt
      481 cgaagagttg gcggcctgtt gtgtaagcct cagtccttgt tttcccggcc tggctcgttg
      541 tgaagccgga cacatccacc cttggactcg attcaggcgg ctgctgcttt tctccttgcc
      601 cctcttggat tttccggatt tttgaaaacc cagtggccca ggagcaagag gaggaaggag
      661 gaaggggcag atctgcagag gaatgtgaga gcctcccaaa gcgagagccg ccaaaagaat
      721 ctgggagcca gagggacagc cgagccctgc ccgggtttct ggaatggtgg tttcagagtg
      781 agtctcttct attttagaac gttgttccag tggaaagtgt cgaatttttc ccctcgcagg
      841 gcagatttct ccaggtcact tgacttttct tctgggagta ggagttagga gagattcccc
      901 tctaaccccc cagaggctgc taagggagga ggagactgtg gacatgagcc ctccctgctc
      961 acaagcatat gcccggagac ctgatagggc agtttctggg ccatggacat tgctttgaag
     1021 agggggagac tggacagcat ctgtgggtgc tgagacccca ccttaggacc tgagagattg
     1081 aactgtgtaa gcgccattca gctgcgagtg cattcttgga ctgccttgtg agcatccccg
     1141 gtctgggcag gaccctctcc ttcccatctt tctataccac ccagcccagc catggcactg
     1201 aaaggccgag ccctctatga ctttcacagt gagaacaagg aggaaatcag catccagcag
     1261 gatgaggacc tggtcatctt tagcgagacc tcactggatg gctggctgca gggccagaac
     1321 agccgtgggg agacagggct ctttcctgcc tcttatgtgg agatcgtccg ttctggcatc
     1381 agcaccaacc atgctgacta ctccagcagc cctgcaggct ctcccggagc ccaggtgagc
     1441 ttgtacaaca gccccagtgt ggccagccca gctaggagtg gtgggggcag tggcttcctc
     1501 tcaaaccagg gtagctttga ggaggatgat gatgatgact gggatgactg ggacgacgga
     1561 tgcacagtgg tggaggagcc acgggctggt gggctgggca ccaacgggca ccctcccctc
     1621 aacctctcct accctggtgc ctaccccagc cagcacatgg ccttccggcc caagccacca
     1681 ctggagcggc aggacagcct ggcatctgcc aagcgaggca gtgtggtggg ccgtaacctc
     1741 aaccgtttct catgctttgt gcgttctgga gtggaggcct tcatcctggg tgatgtgccc
     1801 atgatggcca agatcgctga gacatactcc attgaaatgg gccctcgtgg cccccagtgg
     1861 aaggccaatc cccacccatt tgcctgctct gtggaggacc ccacaaaaca gaccaaattc
     1921 aagggcatca aaagctacat ctcctacaag ctcacaccca cccatgctgc ctcacccgtc
     1981 taccggcgct acaaacactt tgactggctc tataaccgcc tgctacacaa gttcactgtc
     2041 atctcggtgc cccacctgcc tgagaagcag gccactggcc gcttcgagga ggacttcatc
     2101 gaaaagcgga agcggagact catcctctgg atggaccaca tgaccagcca ccctgtgctc
     2161 tcccagtacg aaggcttcca gcatttcctc agctgcctgg atgacaagca gtggaagatg
     2221 ggcaaacgcc gggcggagaa ggatgagatg gtgggtgcca gcttcctgct caccttccag
     2281 atccccaccg agcaccagga cttgcaggac gtggaagatc gcgtggacac tttcaaggcc
     2341 ttcagtaaga agatggacga cagcgtcctg cagctcagca ctgtggcatc agagctggtg
     2401 cgtaaacatg tggggggctt ccgcaaggaa ttccagaagc tgggcagtgc cttccaggcc
     2461 atcagtcatt ccttccagat ggaccccccc ttttgctctg aggccctcaa cagtgccatt
     2521 tctcacacgg gccgtaccta tgaagccatc ggggagatgt ttgctgagca gcccaagaat
     2581 gacctcttcc agatgctgga cacactgtct ctctaccagg gcctgctctc caacttccct
     2641 gacatcatcc atctacaaaa aggcgccttc gccaaggtga aggagagcca acgcatgagt
     2701 gacgagggcc gcatggtgca ggacgaggca gacggcattc gcaggcgctg ccgcgtggtg
     2761 ggtttcgccc tgcaggccga gatgaaccac ttccaccagc gccgtgagct cgacttcaag
     2821 cacatgatgc agaactactt gcgccagcag atcctcttct accagcgggt gggccagcag
     2881 ctggagaaga ccctgcgcat gtatgacaac ctctgaccgc gtgtgcctgg gccccctcct
     2941 tcccctgggc ctggtcactg cagtgtaccc cactttcccg acctccctat accagcagtg
     3001 actgggggag gggtcagcgg tgggggagat aagcggcctg tcctgcctcc tgggagaagg
     3061 agctttcaag gagtcatggg tgcccctggg aaattcccca ctccttagaa gtggggcaca
     3121 gcaggggtga gaatagagtc aggagccctc gaggccaagg cctgggctgc cggtcagtca
     3181 gtgaaggtca ggccagggtc tcagcctccc ctagagccta ttttgcttgc tcacctggcc
     3241 actgctgcct tatccattca gcagacaccg aggcctgctg cacccttggg tcggatgctg
     3301 ggcacccagg gctgtgacat gcctgctctt caggagtcct cagtgaaggt cggggtcaga
     3361 cacagacaga gtcaatgcag tatgactgat gtttaagtga gggatttctg gaagctcata
     3421 gaagggacca cagcattcca ctggtcaggg aagactccat agagtaggca acatttgggc
     3481 agtgttttga agaatgacaa gggcctgcca gacagtacat gggggagaag gactttcagg
     3541 ggagaggaac agcatgggca aagttatgga ggcatgcaaa catctccctc ttctctccct
     3601 tactttccaa gcaagttagg tacgctttcc atggggattc tggcctgtgt ggtaggaagg
     3661 gatctccctt gctcccatgt tgctggctgt ccgtacatca ccctgtcccc tgcaggaggg
     3721 ggctacaggc catctccctc ctgtaggcct ctgactcccc tccacttttg ggccctcagc
     3781 ttatctcggg caggggacca ttgcagcatc ctcccctcct cggactcaag gtgctgaggt
     3841 ataagccctg ggccccagat ccctggtgac accttcctgg agaagactct caaaagtgac
     3901 tgtatatttg agttcaccag caataactcc ccacactcga agcaggtcca aacccaggat
     3961 ctcagggtcc ttgggctctg tggcactgtc ttcccaagat ccttcctgtt gcacaatggg
     4021 aaacctaaga ggaaaaagac aggggcctgc ttgcccagcc atgcgaggga ttccatgccc
     4081 acctgccctc tgtctgcctc gctggaatgt gggcccctgc tccccgtcag gttgtgctgt
     4141 ctctgaccta tgtttacatc cccgaggggt ttctgcctcc tccccaccca ggtcagggtg
     4201 tggtccagca gcttgctgtg gggtgctgac atgtgtcacc actgcccccc ttgcccccgg
     4261 gggggtcatg gtctcctcct ggatgctgct ccttgaatct tttttcttga taaacctttt
     4321 acaattaaga taacacaagc atgacttttt ctgtttggat cccagaaagg cggagggcag
     4381 gagaaggata gagccctaat tgctcctgag agccattgga tgagattctg aggtcgtggt
     4441 gggcacaaat tttccacaga acctcaaaag ttcaggggag ggctatgctg gtggaaggtg
     4501 ccagcaggca ggaggagcta gaggcggctg tggacccctg ggtggatcca tccctcccta
     4561 gaacgcactc ttgtctctaa aacaggtgga gtgctgccca ggggactggc tgtactgcct
     4621 tgtgatctgg ggctgagggt tgtatgagga agggacagga cgctgtgccc taggacaatt
     4681 aatagatggt ggctcctctc cccaaggagc catgccctgg ccttgccctt gaaaagccct
     4741 agtccagggg agggaagtgg gggactcaga agctgtgtct cttccccaaa ccgtcctggg
     4801 tacccagccc tgcggaggct cccacattgg aaactgaaga ggacgctggc tgttgggggt
     4861 gccctgatca ggatgagcgg accttgctct tggatctgtt catccacaga tgagaggagg
     4921 gtactggttg agacttggct ctcctttgga ggcaatgggg acttggtgga gggagggctt
     4981 ccagggtcaa ggccgtcagg gaaggttggc tagaccaggg accagggagc ttgtgcagga
     5041 agatggagaa gggccagcag gtgcggtggg ggaaggggcg ggcaggactc cctgttcagg
     5101 gcatagcgtc ctcagaggaa cttctggaat gggtccccct ggcccttggt caacattagg
     5161 tcagatttgg gactttctga ggaattttcc cctctctcca ccctgcccca ttttctaacc
     5221 catccgagga acttcccgcc cttaacctct tctcagctct gccatccatg tagccatctg
     5281 cagaaggggc tctgagcagt gggggctggg ccaggccgag gcagggctgg tgggaatgct
     5341 cctcctaacc catggtgcct ggaaagtccc ctgctcatgc ttcctgctct gggaacagtg
     5401 ttgtcctctg tgtgccttcc ttgagagggg accacctccc aggccttcca tcctcagggt
     5461 gaggccatca gtctgatact tttctcagga gggacttgga tccaggagaa gcatcaggaa
     5521 gtggagtctt gggataatgc caggcctgct cctggtatcc tgaggtctct gggctggggc
     5581 aggtgtgtgt gtggcaggga gggaggctgt cctggccctc ctctctcttt tctttctgcc
     5641 tctatggggg tgggggtatt gggggaactt ggggccgttc tggggtagct aagccccttt
     5701 cagcaggaga ttgggggacc agtgttgggg gcatcctggt gatggccgat tcctgcctcg
     5761 tcacatgcca ggcagatgtt cccgactcgg ctggacccag ctgcctcgtt tcctccctta
     5821 ctttgctctg agggggtgga aaacaaggct tctctttctg ccctggacag ctaccagcac
     5881 ccggggtagg ggatcccctg gtcaccagtc ttggcccagt acaggaaaag gaatccgctt
     5941 tgtggccaca gatgggggct ggggatggaa gcagacctca gatcctgcat ctcttcaccc
     6001 gctggacaca ggagggctat gaaccactgt gccgtggctg caccactggc tggagcagag
     6061 ccaggcctgg gagaggcagg tggccccatc ggcccctgct ctgcaccacc cctcccagat
     6121 gacagagcca tatgtcttcc acgtgtctac acactcacag actcacgaat gtaatcgctc
     6181 agtctcacaa caagcacacg cagtcacaca cctgcccaca ggcacatacg ccacataagc
     6241 atgcctgtat gctcacacag tcatactgcc acacgctatt acacattcac agccacagcc
     6301 acacatgcct tgccatccat tcaaagcacc agtggctact ttgtcagaca cagccacacc
     6361 acagtcctat gcacatggtc atagcctcac acagtgacac atactcgggc acacaccgcc
     6421 acaaagccat gcttgcacag agcaaaggtg tcataagcat ctctgtgcct ggactgcacc
     6481 tgcatgacct cccagggtcc ccacctcatc agagattaag gagagctttg cttggagaca
     6541 ccacccctgg agggggtgtc tccaaggggg agtagagcca gtcacaagca ccacatacag
     6601 gcacacagcc tgaggtctag ggatgcaatt gggatgactg gataccacca agttcagctc
     6661 cttattgaac agatgggcgc ctgaggccca gggagcagtg gtggctggcc ttatcaccca
     6721 gcagggcagg ggatactctg gggccagagc ctggctctgg gcagactctg tttcctggcc
     6781 ctgccctccc ctgggccaat cctctgggcc aggctgcctc tgaaggcccc tggctgaacc
     6841 gatccagcag agctccaggc agctcccttc tcaagctaga gctgagctgc agtggccacg
     6901 ggagccggag ccaggatgcg gtgggcaggg cctaggcctg ggcgggagga acattcctgc
     6961 accatctcct ccccaagcat gtgaggaccc agcccgccct gcccgcctgc ccgctgactc
     7021 aggcctccag gagccaagcc tgctcagctc ccccacccac cctaacctgc ttccccacta
     7081 gttcggctct ggttcccctc tccactggct ggggcaggag aagacggtga gccctggtag
     7141 gaagaccatg gggaaaaatc aaacctcacc accccccgac atagctcaga agggctgatt
     7201 gtgaaaccca gctctgttca acatagttga acacaaactt tttttttctt ttggtttggt
     7261 tttgttttgt tggtcaaacc ccagtgcagt gcagtctgtt taagaagtag tgtcgcatag
     7321 ctgtggcctg gatctgctca gcagccccag taggcagcat ttattccctt tcgcaacaaa
     7381 gagactgaga cttggccaga gggaagatgg gacctgccta ggttcacaca gggaatctct
     7441 ggcggggctg gactcaaacc cagctccctg ccatcactcc ttagagtcac actgatgaac
     7501 tcatttaggg ccaaaggaag aaggggaggc agatttcccc tctagatgag tgaagggata
     7561 ggaggctggt gaacccaacg gctgaaatgt gaagggtgag agggtagggt gagtcccccc
     7621 agccctgagg gatgaagggt ctgaagatgg cactgcacgg tgacagctgc agtgactcag
     7681 gagctccgtt tacaaaggaa catgagtgag gaacataact taattttttt ttatatctga
     7741 cctgaatttc tgttttcctc ccccattccc cacatggtag aagtgtaatc tcacatcaat
     7801 ttggggaccc tttctttccc cagggatgtg tagaactttt ggggatggca catttgaaga
     7861 ccttagggag ctttgcattt taaaggctga atcccacact ctatcataca tattaatatt
     7921 tacctgcatt ccacattaaa gggttcagtt tatgacttgt gtcctgtctt gtagatactt
     7981 aattaaacgg tattaatttt ga
//
