LOCUS       NM_152760               1681 bp    mRNA    linear   PRI 24-JAN-2025
DEFINITION  Homo sapiens sorting nexin 32 (SNX32), mRNA.
ACCESSION   NM_152760
VERSION     NM_152760.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Wang,D., Zhao,X., Wang,P. and Liu,J.J.
  TITLE     SNX32 Regulates Sorting and Trafficking of Activated EGFR to the
            Lysosomal Degradation Pathway
  JOURNAL   Traffic 25 (7), e12952 (2024)
   PUBMED   39073202
  REMARK    GeneRIF: SNX32 Regulates Sorting and Trafficking of Activated EGFR
            to the Lysosomal Degradation Pathway.
REFERENCE   2  (bases 1 to 1681)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1681)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1681)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1681)
  AUTHORS   Maruzs,T., Lorincz,P., Szatmari,Z., Szeplaki,S., Sandor,Z.,
            Lakatos,Z., Puska,G., Juhasz,G. and Sass,M.
  TITLE     Retromer Ensures the Degradation of Autophagic Cargo by Maintaining
            Lysosome Function in Drosophila
  JOURNAL   Traffic 16 (10), 1088-1107 (2015)
   PUBMED   26172538
REFERENCE   6  (bases 1 to 1681)
  AUTHORS   Michailidou,K., Hall,P., Gonzalez-Neira,A., Ghoussaini,M.,
            Dennis,J., Milne,R.L., Schmidt,M.K., Chang-Claude,J., Bojesen,S.E.,
            Bolla,M.K., Wang,Q., Dicks,E., Lee,A., Turnbull,C., Rahman,N.,
            Fletcher,O., Peto,J., Gibson,L., Dos Santos Silva,I.,
            Nevanlinna,H., Muranen,T.A., Aittomaki,K., Blomqvist,C., Czene,K.,
            Irwanto,A., Liu,J., Waisfisz,Q., Meijers-Heijboer,H., Adank,M., van
            der Luijt,R.B., Hein,R., Dahmen,N., Beckman,L., Meindl,A.,
            Schmutzler,R.K., Muller-Myhsok,B., Lichtner,P., Hopper,J.L.,
            Southey,M.C., Makalic,E., Schmidt,D.F., Uitterlinden,A.G.,
            Hofman,A., Hunter,D.J., Chanock,S.J., Vincent,D., Bacot,F.,
            Tessier,D.C., Canisius,S., Wessels,L.F., Haiman,C.A., Shah,M.,
            Luben,R., Brown,J., Luccarini,C., Schoof,N., Humphreys,K., Li,J.,
            Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Couch,F.J., Wang,X.,
            Vachon,C., Stevens,K.N., Lambrechts,D., Moisse,M., Paridaens,R.,
            Christiaens,M.R., Rudolph,A., Nickels,S., Flesch-Janys,D.,
            Johnson,N., Aitken,Z., Aaltonen,K., Heikkinen,T., Broeks,A.,
            Veer,L.J., van der Schoot,C.E., Guenel,P., Truong,T.,
            Laurent-Puig,P., Menegaux,F., Marme,F., Schneeweiss,A., Sohn,C.,
            Burwinkel,B., Zamora,M.P., Perez,J.I., Pita,G., Alonso,M.R.,
            Cox,A., Brock,I.W., Cross,S.S., Reed,M.W., Sawyer,E.J.,
            Tomlinson,I., Kerin,M.J., Miller,N., Henderson,B.E., Schumacher,F.,
            Le Marchand,L., Andrulis,I.L., Knight,J.A., Glendon,G.,
            Mulligan,A.M., Lindblom,A., Margolin,S., Hooning,M.J.,
            Hollestelle,A., van den Ouweland,A.M., Jager,A., Bui,Q.M.,
            Stone,J., Dite,G.S., Apicella,C., Tsimiklis,H., Giles,G.G.,
            Severi,G., Baglietto,L., Fasching,P.A., Haeberle,L., Ekici,A.B.,
            Beckmann,M.W., Brenner,H., Muller,H., Arndt,V., Stegmaier,C.,
            Swerdlow,A., Ashworth,A., Orr,N., Jones,M., Figueroa,J.,
            Lissowska,J., Brinton,L., Goldberg,M.S., Labreche,F., Dumont,M.,
            Winqvist,R., Pylkas,K., Jukkola-Vuorinen,A., Grip,M., Brauch,H.,
            Hamann,U., Bruning,T., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Devilee,P., Tollenaar,R.A., Seynaeve,C., van
            Asperen,C.J., Jakubowska,A., Lubinski,J., Jaworska,K., Durda,K.,
            Mannermaa,A., Kataja,V., Kosma,V.M., Hartikainen,J.M.,
            Bogdanova,N.V., Antonenkova,N.N., Dork,T., Kristensen,V.N.,
            Anton-Culver,H., Slager,S., Toland,A.E., Edge,S., Fostira,F.,
            Kang,D., Yoo,K.Y., Noh,D.Y., Matsuo,K., Ito,H., Iwata,H., Sueta,A.,
            Wu,A.H., Tseng,C.C., Van Den Berg,D., Stram,D.O., Shu,X.O., Lu,W.,
            Gao,Y.T., Cai,H., Teo,S.H., Yip,C.H., Phuah,S.Y., Cornes,B.K.,
            Hartman,M., Miao,H., Lim,W.Y., Sng,J.H., Muir,K., Lophatananon,A.,
            Stewart-Brown,S., Siriwanarangsan,P., Shen,C.Y., Hsiung,C.N.,
            Wu,P.E., Ding,S.L., Sangrajrang,S., Gaborieau,V., Brennan,P.,
            McKay,J., Blot,W.J., Signorello,L.B., Cai,Q., Zheng,W.,
            Deming-Halverson,S., Shrubsole,M., Long,J., Simard,J.,
            Garcia-Closas,M., Pharoah,P.D., Chenevix-Trench,G., Dunning,A.M.,
            Benitez,J. and Easton,D.F.
  CONSRTM   Breast and Ovarian Cancer Susceptibility Collaboration; Hereditary
            Breast and Ovarian Cancer Research Group Netherlands (HEBON);
            kConFab Investigators; Australian Ovarian Cancer Study Group;
            GENICA (Gene Environment Interaction and Breast Cancer in Germany)
            Network
  TITLE     Large-scale genotyping identifies 41 new loci associated with
            breast cancer risk
  JOURNAL   Nat Genet 45 (4), 353-361 (2013)
   PUBMED   23535729
REFERENCE   7  (bases 1 to 1681)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   8  (bases 1 to 1681)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   9  (bases 1 to 1681)
  AUTHORS   Seet,L.F. and Hong,W.
  TITLE     The Phox (PX) domain proteins and membrane traffic
  JOURNAL   Biochim Biophys Acta 1761 (8), 878-896 (2006)
   PUBMED   16782399
  REMARK    Review article
REFERENCE   10 (bases 1 to 1681)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD638068.1 and BC045563.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152760.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040981.2, SRR5189652.96038.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308342.7/ ENSP00000310620.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               CD638068.1         69-195
            128-1681            BC045563.1         101-1654
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1681
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /note="sorting nexin 32"
                     /db_xref="GeneID:254122"
                     /db_xref="HGNC:HGNC:26423"
                     /db_xref="MIM:621073"
     exon            1..139
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1315
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /note="sorting nexin-6B"
                     /codon_start=1
                     /product="sorting nexin-32"
                     /protein_id="NP_689973.2"
                     /db_xref="CCDS:CCDS8113.2"
                     /db_xref="GeneID:254122"
                     /db_xref="HGNC:HGNC:26423"
                     /db_xref="MIM:621073"
                     /translation="METYAEVGKEGKPSCASVDLQGDSSLQVEISDAVSERDKVKFTV
                     QTKSCLPHFAQTEFSVVRQHEEFIWLHDAYVENEEYAGLIIPPAPPRPDFEASREKLQ
                     KLGEGDSSVTREEFAKMKQELEAEYLAIFKKTVAMHEVFLQRLAAHPTLRRDHNFFVF
                     LEYGQDLSVRGKNRKELLGGFLRNIVKSADEALITGMSGLKEVDDFFEHERTFLLEYH
                     TRIRDACLRADRVMRAHKCLADDYIPISAALSSLGTQEVNQLRTSFLKLAELFERLRK
                     LEGRVASDEDLKLSDMLRYYMRDSQAAKDLLYRRLRALADYENANKALDKARTRNREV
                     RPAESHQQLCCQRFERLSDSAKQELMDFKSRRVSSFRKNLIELAELELKHAKASTLIL
                     RNTLVALKGEP"
     exon            140..244
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            245..355
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            356..477
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            478..601
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            602..706
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            707..812
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            813..888
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            889..928
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1015
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1175
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1261
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1681
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /note="hexamer: AATAAA"
     polyA_site      1681
                     /gene="SNX32"
                     /gene_synonym="SNX6B"
                     /note="major polyA site"
ORIGIN      
        1 gtcagctgag agcatcctca ctcggtcagt tcctcgggcg agttacgggg acgacctgcg
       61 ggagcacgcg ggcagtggcc ggacgctgaa gcccaggaga gcgatggaga cgtatgcgga
      121 ggttgggaag gagggcaagc cttcctgtgc atcggtggat ctgcagggag acagctcctt
      181 acaggtggag atttctgacg cagtgagtga gcgggacaag gtgaaattca ctgttcaaac
      241 aaagagctgc ctccctcact tcgcccagac cgagttctca gtcgtgcggc agcacgagga
      301 gttcatctgg ctgcatgatg cctacgtgga gaatgaggag tacgccggcc tcatcatccc
      361 cccagcccct ccgaggccag actttgaggc ttcgagggaa aagctacaga aattgggcga
      421 gggggacagc tctgtcactc gggaagagtt tgccaagatg aagcaggagc tggaagcgga
      481 gtacctggcc atctttaaga agacagttgc gatgcacgaa gtctttctgc agcgcctggc
      541 ggcccacccc accctgcgtc gagaccacaa cttctttgtg tttttggaat atggacagga
      601 tctgagtgtc cgggggaaga acaggaagga gctcctcgga gggtttctga ggaatattgt
      661 gaagtccgcg gatgaagccc tcatcacggg catgtcaggg ctcaaggagg tggatgactt
      721 ctttgagcat gagaggacct tcctgttgga gtatcacacc cgtatccgag atgcctgcct
      781 gcgggccgac cgcgtcatgc gcgcccacaa gtgcctggca gacgattata tccctatctc
      841 agctgcgctg agcagtctgg gaacacagga agtcaaccag ctaaggacga gcttcctcaa
      901 attggcagag ctctttgaac ggctgaggaa gctggagggc cgggtggctt ccgatgagga
      961 cctgaagctg tcagacatgc tgaggtacta catgcgtgac tcacaggcag ccaaggacct
     1021 gctgtaccgg cggctgcggg cactggccga ctacgagaat gccaacaagg cgctggacaa
     1081 ggcgcgcacc aggaaccggg aggtgcggcc cgccgagagc caccagcagc tgtgctgcca
     1141 acgcttcgag cgcctctccg actccgccaa gcaagagctc atggacttca agtcccgccg
     1201 ggtctcctct tttcgaaaga atctcattga gctggcagag ctggagctca aacacgccaa
     1261 ggccagcacc ctgattctcc ggaacaccct tgttgcccta aagggggagc cttagagtag
     1321 ccagagctca gccagaccct aatctgggat ctccagtgac cagggtatcc cagacccctc
     1381 tctccggcaa gatgtctcct tccctagcag tgccactagc cacaccctca ctctgcccca
     1441 catcctctca gggaaagccc aaacccccta tcaccaccac cacaggtgcc aggccctgca
     1501 agacacaggg cagcatgggc atcataactg gccacagtca gcagagcccc agggaccctg
     1561 acacctctcc ccaggaagct gaggaacagc ctctaccctc acccatagcc ctgaaggaat
     1621 catagctcac ttgatcccgg cctgttctcc ttcgcaaata aaaaccctgg ttttgtagca
     1681 a
//
