LOCUS       NM_152628               2450 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sorting nexin 31 (SNX31), transcript variant 1, mRNA.
ACCESSION   NM_152628
VERSION     NM_152628.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2450)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2450)
  AUTHORS   McNally,K.E., Faulkner,R., Steinberg,F., Gallon,M., Ghai,R.,
            Pim,D., Langton,P., Pearson,N., Danson,C.M., Nagele,H.,
            Morris,L.L., Singla,A., Overlee,B.L., Heesom,K.J., Sessions,R.,
            Banks,L., Collins,B.M., Berger,I., Billadeau,D.D., Burstein,E. and
            Cullen,P.J.
  TITLE     Retriever is a multiprotein complex for retromer-independent
            endosomal cargo recycling
  JOURNAL   Nat Cell Biol 19 (10), 1214-1225 (2017)
   PUBMED   28892079
REFERENCE   3  (bases 1 to 2450)
  AUTHORS   Vieira,N., Deng,F.M., Liang,F.X., Liao,Y., Chang,J., Zhou,G.,
            Zheng,W., Simon,J.P., Ding,M., Wu,X.R., Romih,R., Kreibich,G. and
            Sun,T.T.
  TITLE     SNX31: a novel sorting nexin associated with the
            uroplakin-degrading multivesicular bodies in terminally
            differentiated urothelial cells
  JOURNAL   PLoS One 9 (6), e99644 (2014)
   PUBMED   24914955
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2450)
  AUTHORS   Seet,L.F. and Hong,W.
  TITLE     The Phox (PX) domain proteins and membrane traffic
  JOURNAL   Biochim Biophys Acta 1761 (8), 878-896 (2006)
   PUBMED   16782399
  REMARK    Review article
REFERENCE   5  (bases 1 to 2450)
  AUTHORS   Kurth,J., Perniok,A., Schmitz,R., Iking-Konert,C., Chiorazzi,N.,
            Thompson,K.M., Winkler,T., Rajewsky,K. and Kuppers,R.
  TITLE     Lack of deleterious somatic mutations in the CD95 gene of
            plasmablasts from systemic lupus erythematosus patients and
            autoantibody-producing cell lines
  JOURNAL   Eur J Immunol 32 (12), 3785-3792 (2002)
   PUBMED   12516573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001205.3, AK093906.1, CD106024.1 and BQ012274.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152628.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093906.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311812.7/ ENSP00000312368.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AP001205.3         58133-58147         c
            16-367              AK093906.1         16-367
            368-407             AP001205.3         44379-44418         c
            408-670             AK093906.1         408-670
            671-1339            CD106024.1         82-750
            1340-2444           AK093906.1         1340-2444
            2445-2450           BQ012274.1         20-25               c
FEATURES             Location/Qualifiers
     source          1..2450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..2450
                     /gene="SNX31"
                     /note="sorting nexin 31"
                     /db_xref="GeneID:169166"
                     /db_xref="HGNC:HGNC:28605"
                     /db_xref="MIM:619839"
     exon            1..217
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1474
                     /gene="SNX31"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sorting nexin-31 isoform 1"
                     /protein_id="NP_689841.3"
                     /db_xref="CCDS:CCDS6288.1"
                     /db_xref="GeneID:169166"
                     /db_xref="HGNC:HGNC:28605"
                     /db_xref="MIM:619839"
                     /translation="MKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGW
                     NEQLRRVFGNCLPPFPPKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFL
                     KLAQLNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYF
                     GLFLIRFGKEGKLSVVKKLADFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCR
                     VAVDLLYMQAIQDIEKGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDP
                     CTCDYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQVTFLGTLLDTDG
                     PQRTLNQNLELRFQYSEDSCWQWFVIYTKQAFLLSSCLKKMISEKMVKLAAENTEMQI
                     EVPEQSKSKKYHIQQSQQKDYSSFLSRKSKIKIAKDDCVFGNIKEEDL"
     exon            218..292
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            293..407
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            408..472
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            473..583
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            584..674
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            675..762
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            763..832
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            833..925
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1129
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1243
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1321
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1378
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..2450
                     /gene="SNX31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX31"
                     /note="hexamer: AATAGA"
     polyA_site      1831
                     /gene="SNX31"
     regulatory      2429..2434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX31"
                     /note="hexamer: AATACA"
     polyA_site      2450
                     /gene="SNX31"
                     /note="major polyA site"
ORIGIN      
        1 agatgtcccc ggccggcgag agcgggcgcc ggggttcgct ctgagtcgcg tggcaggccg
       61 cgctgcgtcc accgctgccg agttcagagc cgcgcaccgc ccgccgccgc aggtcgggtt
      121 cccagcgcta ctcccaagac accgctcagc catgaagatg catttctgta tcccggtgtc
      181 ccagcagcgg tccgacgcgc tggggggccg ctacgtgctg tactccgtgc acctggacgg
      241 gttcctcttc tgcagggtgc gctacagcca gctgcacggt tggaacgaac agctaaggcg
      301 ggtctttgga aattgcctgc cacccttccc accaaagtac tatctggcaa tgaccacagc
      361 tatggctgat gagaggaggg accaactgga acaatatttg caaaatgtaa ccatggaccc
      421 aaacgtgttg agaagtgatg tcttcgttga gtttttaaaa ctggcgcagc tgaatacatt
      481 tgacatcgcc accaagaaag cttatctgga catatttctg cccaatgaac agagtattag
      541 aatcgaaatt ataacatcag acactgctga aagagtccta gaggtggtgt cacacaaaat
      601 tggactgtgt cgagagctct tgggctactt cggcctcttt ctcattcggt ttggcaagga
      661 gggcaagctc tctgttgtga aaaaattggc tgactttgaa ctcccttatg ttagtcttgg
      721 aagttctgag gtggaaaact gtaaggttgg actccgaaag tggtatatgg ctccatccct
      781 cgactccgtg ctgatggact gcagggtggc ggtagatttg ctctacatgc aggcaataca
      841 ggacattgaa aaaggatggg ccaaacccac acaggcacag aggcagaaat tagaagcttt
      901 ccagaaagaa gacagtcaaa caaagttttt ggagctggcc cgggaggtac ggcactatgg
      961 atacctgcag ctggatcctt gtacctgtga ctacccagaa tcaggctctg gagctgttct
     1021 ttctgttggc aataatgaga tcagctgctg catcaccctg cctgacagcc agacccagga
     1081 catcgttttc cagatgagca gggtgaagtg ctggcaggtc actttccttg gaactctgct
     1141 ggatacggat gggccccaga gaactctcaa ccagaactta gagctcagat ttcaatacag
     1201 tgaggatagt tgctggcagt ggtttgttat ttacaccaaa caggcttttt tgctgagtag
     1261 ctgcttgaaa aagatgatct cagaaaagat ggtaaagcta gctgctgaga atacagaaat
     1321 gcagattgaa gttccggaac aaagcaaaag taaaaaatac cacattcaac aaagccagca
     1381 gaaagactat tctagttttc tatcaagaaa aagcaagatt aagatagcta aagatgactg
     1441 cgtttttggg aacataaagg aagaagatct ctgaagaaag ctctcatatt ttaaaatatc
     1501 cttggaggct atctcaagac agtgaaagaa cttggggatt caggtgggct acctaccatc
     1561 agtggaggaa atttgacctc ttcccatttt tttggcatta acatggactg tattcatcaa
     1621 ggtattatac cacagcactc tatggaaatc tcaagattag aaaaaaaaaa agaaccaagt
     1681 tatagagtta gtttttattt tatttttgca cttcgtcatg acagtataga gtttgttttt
     1741 aatgtctcat aaatgacaag tggcaaattc aaatcaactc atataaaact cattctattt
     1801 tttctctaaa atagatcttt atatggcttc atgaagtctt ttatgtgttt tgaatttaca
     1861 taaatgaaag tctcataaaa tatcataaag atattttgga tcgatttcta aagatgtgac
     1921 tcttcaacgg aggagaatag ggctctgaga aatggaatca ctgaaaaaga aacctgggtt
     1981 ctctgatcta tccacacaga actagagcaa ggaggtgatg aaatactgat ctctttcctc
     2041 acataagtct gagcctacca atatggatgt actcaaagtg aaacgctgcc ctgttctctg
     2101 cttgaccatt gttataattt tattctgtcc ttagagtact gaaggcagtt caataatcaa
     2161 catgctattt ggaatgtttt aatttggaaa gcaataaggc tctgcacctg atatcagata
     2221 ccttataatt ctcttagctt taaaaatatg tatactttct cacaaggttt ttccttatct
     2281 agcttcattt ctctcatggt aattaatgta attatgtata gaattaagac cacaataagg
     2341 gagatgatca gaggaatctg tatagtgtaa ttagaaaaag tacaatattc taatgttcta
     2401 actgggttgt atacctaatt atataataaa tacaaaataa ttccagtgaa
//
