LOCUS       NM_001012994            7700 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens sorting nexin family member 30 (SNX30), mRNA.
ACCESSION   NM_001012994 XM_376902 XM_941246
VERSION     NM_001012994.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7700)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 7700)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7700)
  AUTHORS   Anton,Z., Betin,V.M.S., Simonetti,B., Traer,C.J., Attar,N.,
            Cullen,P.J. and Lane,J.D.
  TITLE     A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates
            ATG9A trafficking for efficient autophagosome assembly
  JOURNAL   J Cell Sci 133 (14) (2020)
   PUBMED   32513819
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7700)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 7700)
  AUTHORS   van Weering,J.R., Sessions,R.B., Traer,C.J., Kloer,D.P.,
            Bhatia,V.K., Stamou,D., Carlsson,S.R., Hurley,J.H. and Cullen,P.J.
  TITLE     Molecular basis for SNX-BAR-mediated assembly of distinct endosomal
            sorting tubules
  JOURNAL   EMBO J 31 (23), 4466-4480 (2012)
   PUBMED   23085988
REFERENCE   6  (bases 1 to 7700)
  AUTHORS   Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
            Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
            Vieira,A.R.
  TITLE     Follow-up association studies of chromosome region 9q and
            nonsyndromic cleft lip/palate
  JOURNAL   Am J Med Genet A 152A (7), 1701-1710 (2010)
   PUBMED   20583170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390067.19, BX367137.2, BG699098.1, AK127013.1, AL360235.12,
            AL139041.17 and AA401207.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001012994.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.258802.1, ERR279851.540.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374232.8/ ENSP00000363349.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL390067.19        112850-112943
            95-168              BX367137.2         1-74
            169-169             BG699098.1         91-91
            170-526             BX367137.2         75-431
            527-646             BG699098.1         454-573
            647-1126            AK127013.1         257-736
            1127-1188           AL360235.12        88480-88541
            1189-1792           AK127013.1         799-1402
            1793-7156           AL139041.17        23635-28998
            7157-7700           AA401207.1         11-554              c
FEATURES             Location/Qualifiers
     source          1..7700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..7700
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /note="sorting nexin family member 30"
                     /db_xref="GeneID:401548"
                     /db_xref="HGNC:HGNC:23685"
                     /db_xref="MIM:620955"
     exon            1..398
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1556
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /codon_start=1
                     /product="sorting nexin-30"
                     /protein_id="NP_001013012.1"
                     /db_xref="CCDS:CCDS43865.1"
                     /db_xref="GeneID:401548"
                     /db_xref="HGNC:HGNC:23685"
                     /db_xref="MIM:620955"
                     /translation="MAGGPPKALPSTGPHSLRDMPHPLAGSSSEEAVGGDSTPSPDLL
                     MARSFGDKDLILPNGGTPAGTSSPASSSSLLNRLQLDDDIDGETRDLFVIVDDPKKHV
                     CTMETYITYRITTKSTRVEFDLPEYSVRRRYQDFDWLRSKLEESQPTHLIPPLPEKFV
                     VKGVVDRFSEEFVETRRKALDKFLKRITDHPVLSFNEHFNIFLTAKDLNAYKKQGIAL
                     LTRMGESVKHVTGGYKLRTRPLEFAAIGDYLDTFALKLGTIDRIAQRIIKEEIEYLVE
                     LREYGPVYSTWSALEGELAEPLEGVSACIGNCSTALEELTDDMTEDFLPVLREYILYS
                     DSMKSVLKKRDQVQAEYEAKLEAVALRKEDRPKVPADVEKCQDRMECFNADLKADMER
                     WQNNKRQDFRQLLMGMADKNIQYYEKCLMAWESIIPLLQEKQEAK"
     exon            399..590
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     exon            591..701
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     exon            702..860
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1056
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1256
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1343
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1496
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..7700
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7673..7678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /note="hexamer: AATAAA"
     polyA_site      7700
                     /gene="SNX30"
                     /gene_synonym="ATG24A"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgtgc tgccagcgga cccgcggcgg gctcgggcgc ggagcggggg cgcgcggcgc
       61 ggagcggagc gtctgagcgc cggcagagac cagccggcgg gtggcggcgg cccccagcac
      121 ggccggtgca aggcctcggg ttaagcggcg gccgagcggg gctcggcccg gggtgctcgg
      181 ggagctcgcc gcggcgggca gcaggaggaa gcggcggcgg cgcgtcccga gcggtgcgcg
      241 ccatggcggg cgggcccccc aaggccctgc cgtccacggg gccccactcc ctgcgcgaca
      301 tgccgcaccc gctggccggc tccagcagcg aggaggccgt gggtggtgac agcacgccca
      361 gcccggacct gctgatggcc cgcagcttcg gtgacaagga tctcattttg cccaacggtg
      421 gtactccagc aggtacttca agtccagctt cttcatcttc ccttctcaac agacttcagc
      481 ttgatgatga tattgatggt gagactagag atctcttcgt tatagttgat gatcccaaga
      541 agcatgtgtg tacaatggag acttacatca cctataggat caccaccaaa agtactcggg
      601 tggagtttga cctgccagaa tattctgttc gtcgaagata ccaggatttt gactggttga
      661 ggagcaaact ggaagaatcc cagcccactc atctcattcc ccctcttccc gagaagtttg
      721 tggtaaaagg tgttgtggat cgtttttcag aagagtttgt ggagaccaga agaaaagctt
      781 tggataaatt tctaaaaaga attacggacc atcctgtgct gtctttcaat gaacacttta
      841 atattttcct tactgctaag gacctgaacg cctacaagaa gcaagggata gcattgctga
      901 ccagaatggg cgagtcagtc aagcacgtca ctggcggcta caagctgagg actcggccgc
      961 ttgagtttgc tgccataggt gactacttag atacatttgc actcaaactg ggaaccattg
     1021 atcgaatagc ccagcggatc atcaaagaag aaatagagta ccttgtggag ctgagagaat
     1081 acgggcctgt gtactccaca tggagcgcct tggagggtga gctggctgaa cccctggagg
     1141 gtgtgtcagc ttgcattggg aactgctcta cagccttaga agagctgaca gatgacatga
     1201 cagaagactt cctacctgtg ctcagggaat atattttata ctctgactcc atgaagagtg
     1261 tattgaagaa gagggaccaa gttcaagcag agtatgaagc caaactggaa gctgtggctc
     1321 tgcggaagga agaccgcccc aaggtaccgg cggacgtcga gaaatgtcag gatcggatgg
     1381 agtgtttcaa tgctgacctg aaagctgaca tggagaggtg gcagaacaac aagaggcagg
     1441 acttccggca gctactcatg gggatggctg acaagaacat ccagtattat gagaagtgcc
     1501 tcatggcgtg ggagtcgatt attccactac tgcaggagaa acaagaggcc aagtaaagtt
     1561 ctttcttggg acggagactc ttctacctac acagggcctg gcaccctata ccggaatgtc
     1621 cctgcagtgc cagagacgca gtgctgggaa aacaaccaca gaaacatctc tcctttgtgt
     1681 atttttccct cccccacctt tcaccccaca gtggttttca attagtattt attccatggt
     1741 ggagtctgtg aggctagaat atctctcagc aagagcagca tacctccatg ttgtgaaggc
     1801 atctgttcag tgaagcacta cgaaaatttg aaaccaaggg acaagacaac ctgcagctga
     1861 cgctctgaca tttcatgaca gtttcctctt tagggacagc tgagttgcca gttgtgggag
     1921 agaacccggg gcctgctttt caaggatgag gaggaggcag gaacagaagg cagctgctgc
     1981 tttctgtgga aacctggccc ctctggaatt ggcctctgtg ggcattgact cgtcttggcc
     2041 taggaggcat tggtgcctcc ctggcaagtc cttaacgtac agtacctgta gctgtgagtg
     2101 tggcctgctg cctgcttgtg atgagtgata ccgtcttact gtttctgttt cacataggga
     2161 catttaaatc aatgtcaatg tgcgtccatg cttgagtgag caagccagcg tccttgtcct
     2221 cctgcaatgc ctttgggaag ctcaggggaa tgctccccaa gcttgtttct gacactagaa
     2281 tgcaacagat tggaaacttt ttgtgtaaaa tgaaaaaaac aaagtgctgg tttttttttt
     2341 ttttctgtga aggtcttcag tgttttgctt gttcactgtc atcagagcag ggattagacc
     2401 tgttagggaa tatctattgt cttgaagtca gagtagctcc ccattgttga gatcagtggg
     2461 catataccaa gctccacccc cagtgtcagc tttgtgcaat ttgcctttac ctcaccaaaa
     2521 atacctactt taatatttcc tcctgtgtcc tctgaatgtc tgggcgagct tttggtgaga
     2581 gggctggtat gtcatgttgt tatgatacag tcgaaatttg tcaatgcagt gtgaatgttc
     2641 tacataaagt gctttaaccc ttaacatttc ctggtcagga aggaaaatca gtacctggac
     2701 gggcctcgaa aatgacaaat gcaacagcga gccctttgtg tccagctaag ctaaagtctc
     2761 ctcagtgtgc agccagattc ctggggactg ctgagtgtgg ttacaggctg catttcagac
     2821 aatgaccagg tttacttttc agatcacaaa gcaaacagtc accaaggatc tgtcttccaa
     2881 ctcttttttt tttctgctga aatgaagcta catgtcatgt ttgtgttctt tcatctgtgg
     2941 ctcatccctg taaaactacg aatctgagcc tcaaataagc agtagttttt ttgttgttta
     3001 tttttaatga aacagctgtg ttaaggcgct gcttcagatg caagttcacc tggaaatact
     3061 ggtcagcggg cagcacgtca aggtcactta agcccacttt taactgcagg tcatcctcgc
     3121 atcagccaag gctgtggtgc tgttgatgcc gcagttggac agcataggac ggcttggttc
     3181 tgtttcattg tgtttgacaa tgttgcagtt taaatgataa tgtttaaatc aattggtact
     3241 tgcctgtagt gttaaaccct atttgtgcca ttctcaagtc ctttgatgtg aattttcagt
     3301 ttggtacagt tagaaatgac tcattgatgc ggacaggtaa gaacaaccca tgtacccccg
     3361 agtgattgca tgctttattc tacctctaag ccatcgtgtt gacgtgggta tggacgcctg
     3421 ggtctgacct gacactgtgc tgggagaatc aggatgtgtg tctaatggcg agctgacagc
     3481 cctctgctga tatttggcag aaggcaccag accagcccag cagcaaatgc tcatctttgg
     3541 gaacatagga agctttacct tggggaaggt atgctttaca aatgtccagt gtaatgaatg
     3601 tttggaaaaa actggagtta caggaaaatg aaatctgact atctgctagt tgccaaaacc
     3661 cagaaacatt cctgtgtaat ggttagttgg gaaagaaggc agcacttgaa aaaatttacc
     3721 aggttcctca ctgggagatg tgggaagggg cgtgggacgc acgcggtcac tccctctcct
     3781 agtgagaggc agatggctgg ctctgaaggg aggcaggcac cgtgggattt gggcttgctc
     3841 tgcttggtcc ccatgtgatg ccctgtgctg taagatatca gaaagacctg gaacaaggca
     3901 aactttatgt cctcctggca tgttattgat aacagagcca ggaagtccag tgtacattac
     3961 agattttctg ggagaaatag tccttccaga gaaaggattc cttcccagcc tccaggctgg
     4021 tgtctcatga ggtgaggagg ctggcccaga aggaagggga cgttaggtgg tgaagcaggc
     4081 tcccctgggc ctctgagggc cagcagtccc aaccatttgc ctcttcgttt tgaccaagca
     4141 caaaagagat attccctaga agtgtcacac ggaggcttct gtgccaaaga ctgccttgta
     4201 gaggtctcat cacctcacac ttcttgactt cacaaaattg tggccctgag atcagtactc
     4261 ctctcttaag tatttattat tattattatt tactttacct caagcagaca gacataggtt
     4321 ttgaggcttg aatacatggc agtggaatac aaggccctcc ctagcagccg ccccaggcct
     4381 ggaaagtggg agatttcatt cgcccgggtt aaaaatccag aggaagacag aagagaggag
     4441 tcctaggaac tgagcagatt ttagagacgc aaatgatgtt taagagagcc ttgtgatttg
     4501 tagcaagcat gggcactgct ttttcttact aatgtggtag atctacacga acattctagg
     4561 ctgttctgct cagagcgagg aaccactgct cctcaatggg gagggaacat accacccagc
     4621 caggcttagc attgggtttt atcctttaat aaaagtttta taatgaatcc tgttcacctt
     4681 aaagtgtgat tatggagatg attggctcca tattccacca cgtcattcct tcaactcacc
     4741 agacaccttt ctttagttga aataaaccag catgacctgg agatcatggt gactgtaagc
     4801 taagtctgtt ttcatgccag atttcagccc cacccagagt gtgctctaga tgttgttgat
     4861 ttgaatggtt ttcccagttc ccactccaca tggggaagtt gaatgaatgc acacctgctg
     4921 ctcacttctt gtgaggctgc cttttgtgat caaataacag gaagttctgc tttagaggag
     4981 ggcacgatga ccatgtggca gtctgcaagt ggaattttgg gatggcagcc cgaggaacat
     5041 ccagagttac tgtgtgactt ggtcctgcca tcgttagctt tgaaatcaca ggcattgggc
     5101 tctgttttga caccattcat tggactgcgg gacagtcatt ctttacgttc tctcttgagc
     5161 tggtgagaga ggaggaagag ggaagtcaag agcaacctcc aaggcctatg tcagcctctt
     5221 ctccttgggt cttggggtgg gttagaactg ggttccagtc tggccagatg ggttgctggc
     5281 tgcactgagg gtgattcttc tcagaagatg ggctgcctgt ggtcaggaca gggcatacca
     5341 gtctggactc caccttccca gacacctact ttaaggacct gtggaaactg ggtgatccaa
     5401 ttatagggct ggggcaaccc tgctttggcc accctcattt acaaacttag gttgggagct
     5461 tgggtttcct gtctcacttc caaaagcctt caagatggca gcagatggac acaccctctc
     5521 atttcttgtg tcttgtctgt cagatggcag gaggcctgta tcagtaaatt tgaggaaaat
     5581 gttctctcct gggccagcct cacagcttgc gttgggtgtg ttggaattgt tctcttcggc
     5641 cttgttctgc cttgtgatct tttcaattca gtgaataaac caggaatcca ttttttcacc
     5701 aacccaccct gtagattgtc agctttttgt ttgagagatg cctggtctca cagttacatg
     5761 tatcagagtg tgtgtaagtt gtctgtgtta gaaaggttgg ggtgggggct ttgttgcagg
     5821 ggattagact gttctttctt catcataatt tgagatacat cctgagtatg actgtctaac
     5881 cctttctgtg tggcagaaaa atatgttttc caggtagttt ttactactac agagagtctg
     5941 taaataagtg ctttaaaaaa ataacaaacc aataagatat ttgtctccta tataaacatt
     6001 ctgtgtattt agcacttgaa aatcaacaaa tccagaattt aaaaaaatgc cacagacttt
     6061 tcaaagccca actctacttt tttgagaatt tgtccgtacc tactaatatg ccttattctt
     6121 cttcacctag tgttttaaaa gtcctgggta gaaagagttt tagaaatgta atcagttgtt
     6181 cagcttcaat aatatagaga tctaacatag tcagtcctca ggccccctaa agaaacaagc
     6241 aagaaagtga gggccatcac tagggttggc tttggggagg ggaaaactaa ggactgcttt
     6301 tgccaaatga tatttttgat aatgtaagga aacacaggga ccacaaaacc tttttttttt
     6361 ttttaagtgt gaaagattag tgccttttgg catacttttg attttagagg atatagtatc
     6421 ggcattgaca aatcacgtag aaacaaagaa tgctatagat gacaacagta ttaaatgtta
     6481 ctcctgattc tgcagaacag cttttgaaga tactgggggg tatcttcaag cctcagagca
     6541 gcttgtttca gatagaaatt ctctatgggt tgaaatgcca aaaacagaaa acatgatgtt
     6601 gactcatgta atttagtcca ttttagcaga gcctttagtg ttaacaccag tggcgaggag
     6661 cattgcatat tctctgtcag cagcagcact cccacaccag gtggttctgg gctctctgta
     6721 ggctggtcct agtaggtgac acccagcaac acccctgttg gacaggattg attgttcgca
     6781 gtcttagacc aacacttcag tcagaaatgt tactgggagg aggaaaggaa aatcactttt
     6841 tttcctccat gtggaaatga ggagagagga aagtggattg caaaccaaaa tgtgagtcag
     6901 tgtgatgaag cagtggctct gtcatctcgg cctttatcca ataacaaacc agcatctctt
     6961 aaaggcgctt ttggcctaga cacccctgaa gtttggatga agtctggtgg attccctgtc
     7021 tgttgtattt ctgtgtgcct gttcccttca ttgctgtgag ttgggagtgc attgagagat
     7081 gatgtccatc tgatatattc ctgtgaaata aactgccagc aaactttcta acttgtattt
     7141 taactgttaa agaagagatt aaaaacttcg gctttggaca tgtccacatt atggactgtc
     7201 atcttatttt taaaagtcat tctttacgtt taaaatttta aaataaaaac cttctgaggt
     7261 attgatgtag tccaccgtgt aaatgttacc ttctctccat gctgccatta tgccaaaaca
     7321 aaagctgtga taaaaaaagt gcttgagaga gtgtgttgat aagaaagtga tttatttaca
     7381 gatggaagtc tttgtttcat gaagctacca aactttaaaa agaatgtcac cctttttttt
     7441 gtttgttatg gaaaccagag attgtaaaat ggaaaaagaa tcgttttttt gttgactttt
     7501 tgatgctggc acgaggtttt tgtccacttt tttcatatat ctgtgtataa aaaaattgtt
     7561 gtttactatg gaattagtat tacattttga ggtaaacaaa agaatttgta ttgcttgata
     7621 aatattagct tgtaaattta aagtttcttt acttcaatta acttaaagga ccaataaacc
     7681 cataaaagat gctttcttta
//
