LOCUS       NM_003795               1535 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA.
ACCESSION   NM_003795
VERSION     NM_003795.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1535)
  AUTHORS   Lu,J., Xu,S., Huo,Y., Sun,D., Hu,Y., Wang,J., Zhang,X., Wang,P.,
            Li,Z., Liang,M., Wu,Z. and Liu,P.
  TITLE     Sorting nexin 3 induces heart failure via promoting
            retromer-dependent nuclear trafficking of STAT3
  JOURNAL   Cell Death Differ 28 (10), 2871-2887 (2021)
   PUBMED   33947971
  REMARK    GeneRIF: Sorting nexin 3 induces heart failure via promoting
            retromer-dependent nuclear trafficking of STAT3.
REFERENCE   2  (bases 1 to 1535)
  AUTHORS   Cai,Q., Zhao,X., Wang,Y., Li,S., Wang,J., Xin,Z. and Li,F.
  TITLE     LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3
            axis
  JOURNAL   Cell Signal 83, 109985 (2021)
   PUBMED   33753211
  REMARK    GeneRIF: LINC01614 promotes osteosarcoma progression via
            miR-520a-3p/SNX3 axis.
REFERENCE   3  (bases 1 to 1535)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1535)
  AUTHORS   Klose,M., Salloum,J.E., Gonschior,H. and Linder,S.
  TITLE     SNX3 drives maturation of Borrelia phagosomes by forming a hub for
            PI(3)P, Rab5a, and galectin-9
  JOURNAL   J Cell Biol 218 (9), 3039-3059 (2019)
   PUBMED   31337623
  REMARK    GeneRIF: sorting nexin SNX3 is transported with Rab5a vesicles and
            that its PX domain enables vesicle-phagosome contact by binding to
            PI(3)P in the phagosomal coat. Moreover, the C-terminal region of
            SNX3 recruits galectin-9, a lectin implicated in protein and
            membrane recycling, which we identify as a further regulator of
            phagosome compaction.
REFERENCE   5  (bases 1 to 1535)
  AUTHORS   McGough,I.J., de Groot,R.E.A., Jellett,A.P., Betist,M.C.,
            Varandas,K.C., Danson,C.M., Heesom,K.J., Korswagen,H.C. and
            Cullen,P.J.
  TITLE     SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A
            complex to mediate Wntless sorting and Wnt secretion
  JOURNAL   Nat Commun 9 (1), 3737 (2018)
   PUBMED   30213940
  REMARK    GeneRIF: an evolutionary conserved MON2:DOPEY2:ATP9A complex is
            required for SNX3 retromer mediation of Wntless sorting and Wnt
            secretion
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1535)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 1535)
  AUTHORS   Vervoort,V.S., Viljoen,D., Smart,R., Suthers,G., DuPont,B.R.,
            Abbott,A. and Schwartz,C.E.
  TITLE     Sorting nexin 3 (SNX3) is disrupted in a patient with a
            translocation t(6;13)(q21;q12) and microcephaly, microphthalmia,
            ectrodactyly, prognathism (MMEP) phenotype
  JOURNAL   J Med Genet 39 (12), 893-899 (2002)
   PUBMED   12471201
  REMARK    GeneRIF: Sorting nexin 3 (SNX3) is disrupted in a patient with a
            translocation t(6;13)(q21;q12) and microcephaly, microphthalmia,
            ectrodactyly, prognathism (MMEP) phenotype
REFERENCE   8  (bases 1 to 1535)
  AUTHORS   Xu,Y., Hortsman,H., Seet,L., Wong,S.H. and Hong,W.
  TITLE     SNX3 regulates endosomal function through its PX-domain-mediated
            interaction with PtdIns(3)P
  JOURNAL   Nat Cell Biol 3 (7), 658-666 (2001)
   PUBMED   11433298
REFERENCE   9  (bases 1 to 1535)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   10 (bases 1 to 1535)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY023148.1, AF034546.1,
            BQ432490.1 and CA442762.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003795.5.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region,
            like most family members. This protein interacts with
            phosphatidylinositol-3-phosphate, and is involved in protein
            trafficking. A pseudogene of this gene is present on the sex
            chromosomes. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.156253.1,
                                           SRR3476690.827852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230085.13/ ENSP00000230085.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                HY023148.1         222-303
            83-1244             AF034546.1         7-1168
            1245-1279           BQ432490.1         363-397
            1280-1535           CA442762.1         23-278              c
FEATURES             Location/Qualifiers
     source          1..1535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..1535
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /note="sorting nexin 3"
                     /db_xref="GeneID:8724"
                     /db_xref="HGNC:HGNC:11174"
                     /db_xref="MIM:605930"
     exon            1..281
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..608
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /note="isoform a is encoded by transcript variant 1;
                     sorting nexin 3A"
                     /codon_start=1
                     /product="sorting nexin-3 isoform a"
                     /protein_id="NP_003786.1"
                     /db_xref="CCDS:CCDS5064.1"
                     /db_xref="GeneID:8724"
                     /db_xref="HGNC:HGNC:11174"
                     /db_xref="MIM:605930"
                     /translation="MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRG
                     RFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLP
                     FRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIR
                     HA"
     exon            282..377
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            378..502
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            503..1535
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /note="hexamer: AATAAA"
     polyA_site      1244
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /note="major polyA site"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /note="hexamer: ATTAAA"
     polyA_site      1535
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
ORIGIN      
        1 ctcttcgcga ccgctgcgcg cgagccccgt gtccccacgg cgggcagcag cggcggcggc
       61 ggcggctgaa cgcggagggg gcggagggag cccgcggcgg cggcagcagc tacagcgaaa
      121 tggcggagac cgtggctgac acccggcggc tgatcaccaa gccgcagaac ctgaatgacg
      181 cctacggacc ccccagcaac ttcctcgaga tcgatgtgag caacccgcaa acggtggggg
      241 tcggccgggg ccgcttcacc acttacgaaa tcagggtcaa gacaaatctt cctattttca
      301 agctgaaaga atctactgtt agaagaagat acagtgactt tgaatggctg cgaagtgaat
      361 tagaaagaga gagcaaggtc gtagttcccc cgctccctgg gaaagcgttt ttgcgtcagc
      421 ttccttttag aggagatgat ggaatatttg atgacaattt tattgaggaa agaaaacaag
      481 ggctggagca gtttataaac aaggtcgctg gtcatcctct ggcacagaac gaacgttgtc
      541 ttcacatgtt tttacaagat gaaataatag ataaaagcta tactccatct aaaataagac
      601 atgcctgaaa tttggcaaga aggggcaaaa acgtgactat taatgattga taagcaccag
      661 tgaagaagtt ctaactttta gcatgctgca cagaaactgg tataacatgc cttcagtata
      721 ctaacactca tatgctcagt tttgttttgt tttggcagtt gacaagaagt taatttgctt
      781 tagtaaaaat ccctcattcc agcctttcta tataaatagc tctttcttgc tgttttaatg
      841 tggtgcacac tatagcctca caaacctgtt attccagtgt aatctgcagt gtcgtaacta
      901 aagttactgg cttggtctta tttgcacagt ttttgcgtct tgtttgcttc ttgcatctga
      961 ttaactagaa tatttctctt tccccctttt aatttgtgat gtcacttgac cccatttatg
     1021 tgtaggagca ctacaccatt ggtttccaat actgcacaca taagatacat acttgtgtgc
     1081 agaaagtatc ttcctccagg cttgtaatac ccttcacatg gaagattaat gagggaaatc
     1141 tttatattct gtataaaaac aaaagcaaat ttatatacta aaatcatttg tctaaaaatt
     1201 taagttgttt tcaaataaaa attaaaatgc atttctgata tgcactgatt gtgttgcctc
     1261 cagctttttt tgctctctat gagtgactac ttaagtcact tgttgagagg gattatttac
     1321 taattatata cttctcattc ctgtaactcc attcccttta aacagtggtg atatcaaata
     1381 tacttccatc cattgaatgg ggtattttta acaacaacaa aagtgatata ctaaaaaatg
     1441 tattgcttaa ggcttattga atcattttga agcactttgt gtatttgaaa actgctttat
     1501 aatctcattt attaaaagga ctttcaaaga taaaa
//
